EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

keratin
cheratina

Supplier Sponsors

CAS Number: 68238-35-7
Other(deleted CASRN):9008-18-8
ECHA EC Number:269-409-1
FDA UNII: Search
MDL:MFCD00131434
Category:cosmetic agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Food Chemicals Codex Listed: No
 
Organoleptic Properties:
Odor Strength:none
Odor Description:at 100.00 %. bland
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: hair conditioning
skin conditioning
 
Suppliers:
BOC Sciences
For experimental / research use only.
Keratins 95%
Croda
Keratec™ IFP PE
Odor: bland
Use: Keratec IFP is a patented keratin derived active that provides a 'protein shield' to help protect the hair from environmental damage. Capable of creating a coherent film on the surface of the hair, Keratec IFP offers excellent cuticle smoothing benefits. Biomimetics has been a strong trend in recent years. In sections of the market, the logic of protecting and replenishing the keratin fibres of the hair with keratin derivatives is experiencing a major resurgence. Our keratin biopolymers protect and nourish by replacing key proteins found naturally in the hair.
ICHIMARU PHARCOS
Keratin
Odor: characteristic
Use: We successfully developed a process for carefully extracting and refining natural keratins from select wools so as to preserve their molecular structure. The excellent permeability and layering properties of this substance help protect hair from a wide range of damage.
Sigma-Aldrich: Sigma
For experimental / research use only.
Keratin from human epidermis, aqueous solution
sds
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intravenous-rat LD50 45 mg/kg
LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA
Bolletino della Societe Italiana di Biologia Sperimentale. Vol. 44, Pg. 1685, 1968.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
cosmetic agents
Recommendation for keratin usage levels up to:
 not for fragrance use.
 
Recommendation for keratin flavor usage levels up to:
 not for flavor use.
 
Safety References:
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):68238-35-7
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
Chemidplus:0068238357
 
References:
Pubchem (sid):135332555
 
Other Information:
HMDB (The Human Metabolome Database):Search
VCF-Online:VCF Volatile Compounds in Food
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 found in nature
 
Synonyms:
 cheratina
 keratec IFP PE
animal keratin
 keratin from human epidermis, aqueous solution
 

Articles:

PubMed:A Clinical Trial to Investigate the Effect of Cynatine HNS on Hair and Nail Parameters.
PubMed:Excess NF-κB Induces Ectopic Odontogenesis in Embryonic Incisor Epithelium.
PubMed:Chitin and chitosan composites for bone tissue regeneration.
PubMed:Morphology of the Lingual and Buccal Papillae in Alpaca (Vicugna pacos) - Light and Scanning Electron Microscopy.
PubMed:The promoting effect of carbamide peroxide teeth bleaching gel in a preclinical model of head and neck cancer in hamster buccal pouch.
PubMed:Intrinsically water-stable keratin nanoparticles and their in vivo biodistribution for targeted delivery.
PubMed:Biodegradation of hard keratins by two bacillus strains.
PubMed:The glossopharyngeal nerve controls epithelial expression of Sprr2a and Krt13 around taste buds in the circumvallate papilla.
PubMed:Production of feather hydrolysates with antioxidant, angiotensin-I converting enzyme- and dipeptidyl peptidase-IV-inhibitory activities.
PubMed:In-situ modification, regeneration, and application of keratin biopolymer for arsenic removal.
PubMed:Melanin-based color of plumage: role of condition and of feathers' microstructure.
PubMed:The sheep genome illuminates biology of the rumen and lipid metabolism.
PubMed:Cytotoxicity and metabolic stress induced by acetaldehyde in human intestinal LS174T goblet-like cells.
PubMed:Tavaborole (AN-2690) for the treatment of onychomycosis of the toenail in adults.
PubMed:Biodegradation of prions in compost.
PubMed:Influence of feed restriction on the wool proteome: a combined iTRAQ and fiber structural study.
PubMed:Detecting free radicals in sunscreens exposed to UVA radiation using chemiluminescence.
PubMed:Pitfalls in comparing modern hair and fossil bone collagen C and N isotopic data to reconstruct ancient diets: a case study with cave bears (Ursus spelaeus).
PubMed:Three-dimensional architecture of macrofibrils in the human scalp hair cortex.
PubMed:Keratin decomposition by trogid beetles: evidence from a feeding experiment and stable isotope analysis.
PubMed:Evaluation of the effects of titanium dioxide nanoparticles on cultured Rana catesbeiana tailfin tissue.
PubMed:DNA microarray analysis on gene candidates possibly related to tetrodotoxin accumulation in pufferfish.
PubMed:Protein oxidation: identification and utilisation of molecular markers to differentiate singlet oxygen and hydroxyl radical-mediated oxidative pathways.
PubMed:Parkin induces upregulation of 40S ribosomal protein SA and posttranslational modification of cytokeratins 8 and 18 in human cervical cancer cells.
PubMed:Scanning probe acoustic microscopy of extruded starch materials: direct visual evidence of starch crystal.
PubMed:A randomized, double-blind, placebo-controlled clinical trial to investigate the effect of Cynatine(®) HNS on skin characteristics.
PubMed:Identification and quantification of different species in animal fibres by LC/ESI-MS analysis of keratin-derived proteolytic peptides.
PubMed:Solubilization and identification of hen eggshell membrane proteins during different times of chicken embryo development using the proteomic approach.
PubMed:Stable isotope evidence of meat eating and hunting specialization in adult male chimpanzees.
PubMed:Transcriptome analysis of pigeon milk production - role of cornification and triglyceride synthesis genes.
PubMed:Microbial communities and greenhouse gas emissions associated with the biodegradation of specified risk material in compost.
PubMed:The diet-body offset in human nitrogen isotopic values: a controlled dietary study.
PubMed:Histological and immunohistochemical study of the expression of p53 and ki-67 proteins in the mucosa of the tongue, pharynx and larynx of rats exposed to cigarette smoke.
PubMed:Isolation and molecular characterisation of alkaline protease producing Bacillus thuringiensis.
PubMed:Immobilization of keratinolytic metalloprotease from Chryseobacterium sp. strain kr6 on glutaraldehyde-activated chitosan.
PubMed:Decomposition of insoluble and hard-to-degrade animal proteins by enzyme E77 and its potential applications.
PubMed:Ex vivo expansion of limbal stem cells is affected by substrate properties.
PubMed:Dissecting the causes of atopic dermatitis in children: less foods, more mites.
PubMed:3,3'-Diindolylmethane increases serum interferon-γ levels in the K14-HPV16 transgenic mouse model for cervical cancer.
PubMed:Interspecies comparison of morphology, ultrastructure, and proteome of mammalian keratin fibers of similar diameter.
PubMed:Feasibility of a porcine oral mucosa equivalent: a preclinical study.
PubMed:Bromelain-induced apoptosis in GI-101A breast cancer cells.
PubMed:Development of a glutathione production process from proteinaceous biomass resources using protease-displaying Saccharomyces cerevisiae.
PubMed:In situ identification of keratin-hydrolyzing organisms in swine manure inoculated anaerobic digesters.
PubMed:Progesterone receptor up-regulation: a diagnostic tool for the illicit use of oestrogens in adult beef cattle.
PubMed:Clinical and nutritional benefits of cysteine-enriched protein supplements.
PubMed:Bioplastics from feather quill.
PubMed:Acetylation of chicken feathers for thermoplastic applications.
PubMed:Ichthyosis prematurity syndrome: clinical evaluation of 17 families with a rare disorder of lipid metabolism.
PubMed:No evidence of selenosis from a selenium-rich diet in the Brazilian Amazon.
PubMed:Visualization of protein digestion in the midgut of the acarid mite Lepidoglyphus destructor.
PubMed:Photochemical cross-linking of plastically compressed collagen gel produces an optimal scaffold for corneal tissue engineering.
PubMed:Transgenic rescue of desmoglein 3 null mice with desmoglein 1 to develop a syngeneic mouse model for pemphigus vulgaris.
PubMed:Rapid multiplex immunohistochemistry using the 4-antibody cocktail YANA-4 in differentiating primary adenocarcinoma from squamous cell carcinoma of the lung.
PubMed:Serum cytokeratin 18 M30 antigen level and its correlation with nutritional parameters in middle-aged Japanese males with nonalcoholic fatty liver disease (NAFLD).
PubMed:Bioprospecting keratinous materials.
PubMed:Essence of keratin in lips and associated structures of a freshwater fish Puntius sophore in relation to its feeding ecology: histochemistry and scanning electron microscope investigation.
PubMed:Advances in natural stable isotope ratio analysis of human hair to determine nutritional and metabolic status.
PubMed:Atopic dermatitis with possible polysensitization and monkey esophagus reactivity.
PubMed:Anaerobic digestion of specified risk materials with cattle manure for biogas production.
PubMed:Efficient DNA extraction from nail clippings using the protease solution from Cucumis melo.
PubMed:Cooperation and individuality among man-eating lions.
PubMed:Cytokeratin 8/18 as a new marker of mouse liver preneoplastic lesions.
PubMed:Functional morphology of unguiculiform papillae of the reticular groove in the ruminant stomach.
PubMed:DZNep is a global histone methylation inhibitor that reactivates developmental genes not silenced by DNA methylation.
PubMed:Actinomadura keratinilytica sp. nov., a keratin-degrading actinobacterium isolated from bovine manure compost.
PubMed:Dietary and physiological controls on the hydrogen and oxygen isotope ratios of hair from mid-20th century indigenous populations.
PubMed:Angiotensin I-converting enzyme-inhibitory peptides obtained from chicken collagen hydrolysate.
PubMed:Microanatomy of the palatal mucosa of the semiaquatic malayan box turtle, Cuora amboinensis, and functional implications.
PubMed:Organic elemental composition in fingernail plates varies between sexes and changes with increasing age in healthy humans.
PubMed:Use of GeneSearch breast lymph node assay to detect sentinel node metastases in early stage breast cancer.
PubMed:Cryopreservation of human limbal stem cells ex vivo expanded on amniotic membrane.
PubMed:Keratinase production and keratin degradation by a mutant strain of Bacillus subtilis.
PubMed:The utility of the K6/ODC transgenic mouse as an alternative short term dermal model for carcinogenicity testing of pharmaceuticals.
PubMed:Three-dimensional growth of bovine hoof as recorded by carbon stable isotope ratios.
PubMed:Malassezia slooffiae-associated dermatitis in a goat.
PubMed:Regeneration of the adult thymus is preceded by the expansion of K5+K8+ epithelial cell progenitors and by increased expression of Trp63, cMyc and Tcf3 transcription factors in the thymic stroma.
PubMed:Isolation, culture and immortalisation of hepatic oval cells from adult mice fed a choline-deficient, ethionine-supplemented diet.
PubMed:Cerebellar leptomeningeal carcinomatosis in a dog.
PubMed:Conditional targeting of plectin in prenatal and adult mouse stratified epithelia causes keratinocyte fragility and lesional epidermal barrier defects.
PubMed:Influence of soil chemistry on metal and bioessential element concentrations in nymphal and adult periodical cicadas (Magicicada spp.).
PubMed:Using hooves for high-resolution isotopic reconstruction of bovine dietary history.
PubMed:Interspecific resource partitioning in sympatric ursids.
PubMed:Human rectal mucosal gene expression after consumption of digestible and non-digestible carbohydrates.
PubMed:Blends of cysteine-containing proteins.
PubMed:Estrogenic chemicals in plastic and oral contraceptives disrupt development of the fetal mouse prostate and urethra.
PubMed:Utilization of keratin-containing biowaste to produce biohydrogen.
PubMed:Diagnosis and treatment of basal cell and squamous cell carcinomas.
PubMed:Hydrolysis of the amyloid prion protein and nonpathogenic meat and bone meal by anaerobic thermophilic prokaryotes and streptomyces subspecies.
PubMed:The impact of proteomics on products and processes.
PubMed:Probiotics for the skin: a new area of potential application?
PubMed:Effects of zinc histidine and zinc sulfate on natural human keratinocytes.
PubMed:Toxicity of methylsulfonylmethane in rats.
PubMed:Stabilization of Solutions of Feather Keratins by Sodium Dodecyl Sulfate.
PubMed:Partially carboxymethylated feather keratins. 2. Thermal and mechanical properties of films.
PubMed:Partially carboxymethylated feather keratins. 1. Properties in aqueous systems.
PubMed:Chirality and its implications in transdermal drug development.
PubMed:Glycine-rich cell wall proteins act as specific antigen targets in autoimmune and food allergic disorders.
PubMed:Insulin-like growth factor 1 and hair growth.
PubMed:Irritant contact stomatitis: a review of the condition.
PubMed:Stability of protease Q against autolysis and in sodium dodecyl sulfate and urea solutions.
PubMed:Interspecies variations in response to topical application of selected zinc compounds.
PubMed:Establishment and characterization of an epithelial cell line from the rat submandibular gland.
PubMed:Local variations in the staining patterns of keratin antigens and blood group antigens in normal rodent oral epithelia.
PubMed:Evaluation of in vitro predictive tests for irritation and allergic sensitization.
PubMed:Relevance of in vitro tests to in vivo acute skin inflammation: potential in vitro applications of skin keratome slices, neutrophils, fibroblasts, mast cells and macrophages.
PubMed:A histomorphometric study of the effect of chronic vitamin A deficiency on the circumvallate papilla of the rat.
PubMed:Selective habitation of bacteria on "intermediate soft" keratin surfaces of the rat tongue.
PubMed:[The effect of nutritional factors on the ruminal mucosa. 3. Condition of the mucosa after infusion of propionic acid, acetic acid and butyric acid].
PubMed:Light and scanning electron microscopic studies on the esophageal spines in the Pacific ridley turtle, Lepidochelys olivacea.
 
Notes:
a class of fibrous proteins or scleroproteins that represents the principal constituent of epidermis; hair; nails; horny tissues, and the organic matrix of tooth enamel. two major conformational groups have been characterized, alpha-keratin, whose peptide backbone forms a coiled-coil alpha helical structure consisting of type i keratin and a type ii keratin, and beta-keratin, whose backbone forms a zigzag or pleated sheet structure. alpha-keratins have been classified into at least 20 subtypes. in addition multiple isoforms of subtypes have been found which may be due to gene duplication. tsca definition 2008: natural, fibrous proteins occurring in vertebrates. they contain all of the common amino acids and are characterized by high cystine content.
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