hexamidine diisethionate, 659-40-5

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CODE130039 CODE130039
Product(s):
659-40-5 4-[6-(4-carbamimidoylphenoxy)hexoxy]benzenecarboximidamide; 2-hydroxyethanesulfonic acid 98%

Glentham Life Sciences Ltd

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Product(s):
GK9166 Hexamidine diisethionate

Jiangyin Healthway International Trade Co., Ltd

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We provide custom synthesis and contract manufacturing from milligrams to metric tonnes.
Jiangyin Healthway International Trade Co., Ltd is a professional company, main engaged in manufacturing and exporting aroma chemicals ,food additives , cosmetic ingredient ,pharmaceutical intermediates & other fine chemicals; especially on aroma chemicals , as the major manufacturer of heterocyclic and sulphur aroma compounds , we are the leading independent ingredients supplier to the flavour and fragrance industries in China, can offer hundreds of different high quality aroma chemicals.
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CODE130039 CODE130039
Product(s):
HLC-1105 Hexamidine Diisethionate

CAS Number:	659-40-5	3D/inchi
ECHA EINECS - REACH Pre-Reg:	211-533-5
FDA UNII:	023XA5Z50L
Molecular Weight:	606.71686000
Formula:	C24 H38 N4 O10 S2
NMR Predictor:	Predict (works with chrome, Edge or firefox)

Category:preservatives

US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:

Google Scholar:	Search
Google Books:	Search
Google Scholar: with word "volatile"	Search
Google Scholar: with word "flavor"	Search
Google Scholar: with word "odor"	Search
Google Patents:	Search
US Patents:	Search
EU Patents:	Search
Pubchem Patents:	Search
PubMed:	Search
NCBI:	Search

Physical Properties:

Assay:	95.00 to 100.00
Food Chemicals Codex Listed:	No
Boiling Point:	548.60 °C. @ 760.00 mm Hg (est)
Flash Point:	546.00 °F. TCC ( 285.60 °C. ) (est)
logP (o/w):	3.003 (est)
Soluble in:
	water, 9.136 mg/L @ 25 °C (est)

Organoleptic Properties:

Odor and/or flavor descriptions from others (if found).

Cosmetic Information:

CosIng:	cosmetic data
Cosmetic Uses:	antifoaming agents preservatives skin conditioning skin conditioning - emollient

Suppliers:

BOC Sciences

For experimental / research use only.

4-[6-(4-carbamimidoylphenoxy)hexoxy]benzenecarboximidamide; 2-hydroxyethanesulfonic acid 98%

Glentham Life Sciences

Hexamidine diisethionate

Jiangyin Healthway

Hexamidine Diisethionate

New functional food ingredients

Minasolve

MinaCare Hexam (Hexamidine)

Odor: characteristic

Use: MinaCare Hexam (Hexamidine Diisethionate) is a hydrosoluble antimicrobial cationic substance with a wide spectrum of activity against bacteria, fungi and yeasts. Hexamidine may be used as a polyvalent preservative, as well as a cutaneous aseptizer, more and more used by the cosmetic industry.

Sigma-Aldrich

For experimental / research use only.

Hexamidine Diisethionate European Pharmacopoeia (EP) Reference Standard

Safety Information:


Hazards identification

Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements

Pictogram

Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined

Safety in Use Information:

Category:
preservatives
Recommendation for hexamidine diisethionate usage levels up to:
	not for fragrance use.

Recommendation for hexamidine diisethionate flavor usage levels up to:
	not for flavor use.

Safety References:

EPI System: View

AIDS Citations:Search

Cancer Citations:Search

Toxicology Citations:Search

EPA ACToR:Toxicology Data

EPA Substance Registry Services (SRS):Registry

Laboratory Chemical Safety Summary :3080571

National Institute of Allergy and Infectious Diseases:Data

WGK Germany:2

4-[6-(4-carbamimidoylphenoxy)hexoxy]benzenecarboximidamide;2-hydroxyethanesulfonic acid

Chemidplus:0000659405

References:

	4-[6-(4-carbamimidoylphenoxy)hexoxy]benzenecarboximidamide;2-hydroxyethanesulfonic acid
NIST Chemistry WebBook:	Search Inchi
Pubchem (cid):	3080571
Pubchem (sid):	135227638

Other Information:

(IUPAC):	Atomic Weights of the Elements 2011 (pdf)
Videos:	The Periodic Table of Videos
tgsc:	Atomic Weights use for this web site
(IUPAC):	Periodic Table of the Elements
HMDB (The Human Metabolome Database):	Search
ChemSpider:	View
Wikipedia:	View

Potential Blenders and core components note

None Found

Potential Uses:

preservatives

Occurrence (nature, food, other):note

not found in nature

Synonyms:

4-[6-(4-	carbamimidoylphenoxy)hexoxy]benzenecarboximidamide;2-hydroxyethanesulfonic acid
	desmedine
	desomedine
	esomedina
	ethanesulfonic acid, 2-hydroxy-, compd. with 4,4'-(1,6-hexanediylbis(oxy))bis(benzenecarboximidamide) (2:1) (9CI)
	ethanesulfonic acid, 2-hydroxy-, compd. with 4,4'-(hexamethylenedioxy)dibenzamidine (2:1) (8CI)
	hexamidin 2-hydroxyethansulfonat
	hexamidine isethionate
	hexomedine
2-	hydroxyethanesulphonic acid, compound with 4,4'-(hexane-1,6-diylbis(oxy))bis(benzenecarboxamidine) (2:1)
	ophtamedine

Articles:

PubMed:Prognostic factors associated with the need for surgical treatments in acanthamoeba keratitis.

PubMed:A double-blind randomized controlled comparison of APDDR-0901, a novel cosmeceutical formulation, and 0.1% adapalene gel in the treatment of mild-to-moderate acne vulgaris.

PubMed:Microsporidial keratoconjunctivitis in the tropics: a case series.

PubMed:Final report on the safety assessment of Hexamidine and Hexamidine Diisethionate.

PubMed:A keratitis rat model for evaluation of anti-Acanthamoeba polyphaga agents.

PubMed:Plasmid-mediated resistance to antimicrobial agents among listeriae.

PubMed:Successful treatment of Acanthamoeba keratitis by hexamidine.

PubMed:Hexamidine isethionate: a sensitizer in topical pharmaceutical products and cosmetics.

PubMed:Ring-shaped positive allergic patch test reactions to allergens in liquid vehicles.

PubMed:Quantitative determination of hexamidine isethionate in pharmaceutical preparations by high-performance liquid chromatography.

Notes:

None found

hexamidine diisethionate ethanesulfonic acid, 2-hydroxy-, compd. with 4,4'-(hexamethylenedioxy)dibenzamidine (2:1) (8CI)

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Articles:

hexamidine diisethionate
ethanesulfonic acid, 2-hydroxy-, compd. with 4,4'-(hexamethylenedioxy)dibenzamidine (2:1) (8CI)