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Category:indirect food additives: adhesives and components of coatings
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Appearance: | white powder (est) |
| Assay: | 95.00 to 100.00
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| Food Chemicals Codex Listed: | No |
| Melting Point: | 178.00 to 210.00 °C. @ 760.00 mm Hg
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| Flash Point: | 32.00 °F. TCC ( 0.00 °C. ) (est)
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| logP (o/w): | 1.347 (est) |
| Soluble in: |
| | water, 1e+006 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
| BOC Sciences |
| For experimental / research use only. |
| Dowicil75 95%
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| Dow Chemical |
| ACUDYNE™ SCP
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| HallStar |
| CoSept(tm) 200
Odor: characteristic Use: CoSept 200 is a broad-spectrum antimicrobial designed specifically for the preservation of cosmetics and personal care products. It is especially effective against pseudomonads, as well as other bacteria, yeast and mold at low concentrations of 0.02 - 0.30%. CoSept 200 is active in the pH range of 4 - 10 and is compatible with anionic, nonionic and cationic systems. It has excellent water solubility, is cost effective and has a good safety history. CoSept 200 does not contain free formaldehyde and has the unique advantage of withstanding microbial challenge, providing better shelf life protection than other preservative systems. |
Safety Information:
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| Hazards identification |
| |
| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
| |
| Pictogram | |
| |
| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
oral-rat LD50 500 mg/kg
Pesticide Chemicals Official Compendium, Association of the American Pesticide Control Officials, Inc., 1966. Vol. -, Pg. 455, 1966.
oral-rabbit LD50 78.50 mg/kg
Journal of the American College of Toxicology. Vol. 5(3), Pg. 61, 1986.
oral-guinea pig LD50 710 mg/kg
Journal of the American College of Toxicology. Vol. 5(3), Pg. 61, 1986.
oral-chicken LD50 2000 mg/kg
Pesticide Chemicals Official Compendium, Association of the American Pesticide Control Officials, Inc., 1966. Vol. -, Pg. 455, 1966.
oral-rabbit LD50 78500 ug/kg
Journal of the American College of Toxicology. Vol. 5(3), Pg. 61, 1986.
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| Dermal Toxicity: |
skin-rabbit LD50 565 mg/kg
Journal of the American College of Toxicology. Vol. 5(3), Pg. 61, 1986.
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| Inhalation Toxicity: |
|
Not determined
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Safety in Use Information:
| Category: | | indirect food additives: adhesives and components of coatings |
| Recommendation for quaternium-15 usage levels up to: | | | not for fragrance use.
|
| |
| Recommendation for quaternium-15 flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | acudyne SCP | | N-(3- | chlorallyl)hexaminium chloride | | 1-[(2E)-3- | chloro-2-propen-1-yl]-3,5,7-triaza-1-azoniatricyclo[3.3.1.13,7]decane chloride | | 1-(3- | chloro-2-propenyl)-3,5,7-triaza-1-azoniatricyclo[3.3.1.13,7]decane chloride | | 1-(3- | chloroallyl)-3,5,7-triaza-1-azoniaadamantane chloride | | 1-(3- | chloroallyl)-3,5,7-triaza-1-azoniadamatane chloride | | N-(3- | chloroallyl)hexaminium chloride | | 1-[(2E)-3- | chloroprop-2-en-1-yl]-3,5,7-triaza-1-azoniatricyclo[3.3.1.13,7]decane chloride | | | cosept 200 | | | dowicide Q | | | dowicil 75 | | 3,5,7- | triaza-1-azoniaadamantane, 1- (3-chloroallyl)-, chloride | | 3,5,7- | triaza-1-azoniaadamantane, 1-(3-chloroallyl)-, chloride | | 3,5,7- | triaza-1-azoniatricyclo[3.3.1.13,7]decane, 1-(3-chloro-2-propenyl)-, chloride | | 3,5,7- | triaza-1-azoniatricyclo[3.3.1.13,7]decane, 1-[(2E)-3-chloro-2-propen-1-yl]-, chloride (1:1) | | 3,5,7- | triaza-1-azoniatricyclo[3.3.1.13,7]decane, 1-[(2E)-3-chloro-2-propenyl]-, chloride |
Articles:
| PubMed:Contact sensitivity to preservatives in Singapore: frequency of sensitization to 11 common preservatives 2006-2011. |
| PubMed:Patch Testing with Formaldehyde 2.0% in Parallel with 1.0% by the Swedish Contact Dermatitis Research Group. |
| PubMed:Cutaneous delayed-type hypersensitivity in patients with atopic dermatitis: reactivity to topical preservatives. |
| PubMed:Patch testing for allergic contact dermatitis to cigarettes: Smoked/unsmoked components and formaldehyde factors. |
| PubMed:Allergic contact dermatitis of the vulva. |
| PubMed:North American Contact Dermatitis Group patch test results: 2009 to 2010. |
| PubMed:The triggering role of allergic contact dermatitis in discoid lupus erythematosus. |
| PubMed:North American Contact Dermatitis Group patch test results for 2007-2008. |
| PubMed:Occupational contact dermatitis in hairdressers/cosmetologists: retrospective analysis of north american contact dermatitis group data, 1994 to 2010. |
| PubMed:Frequency of positive patch test reactions to preservatives: The Australian experience. |
| PubMed:Follow-up of the monitored levels of preservative sensitivity in Europe: overview of the years 2001-2008. |
| PubMed:Patch testing with 2.0% (0.60 mg/cm 2) formaldehyde instead of 1.0% (0.30 mg/cm 2) detects significantly more contact allergy. |
| PubMed:Is quaternium-15 a formaldehyde releaser? Correlation between positive patch test reactions to formaldehyde and quaternium-15. |
| PubMed:Occupational contact dermatitis in painters: an analysis of patch test data from the Danish Contact Dermatitis Group. |
| PubMed:Comparative study of IQ-ultra and Finn Chambers test methodologies in detecting 10 common standard allergens that cause allergic contact dermatitis. |
| PubMed:Non-fragrance allergens in specific cosmetic products. |
| PubMed:Patch testing with formaldehyde and formaldehyde-releasers: multicentre study in Spain (2005-2009). |
| PubMed:Contact sensitization to quaternium-15 acting as a warning sign for curare allergy. |
| PubMed:Positive patch test reactions in older individuals: retrospective analysis from the North American Contact Dermatitis Group, 1994-2008. |
| PubMed:Contact allergy to preservatives. Analysis of IVDK data 1996-2009. |
| PubMed:Patch testing and contact allergens in Ethiopia--results of 514 contact dermatitis patients using the European baseline series. |
| PubMed:Relationship between formaldehyde and quaternium-15 contact allergy. Influence of strength of patch test reactions. |
| PubMed:Frequency of sensitization to common allergens: comparison between Europe and the USA. |
| PubMed:Positive concomitant test reactions to allergens in the standard patch test series. |
| PubMed:Final report of the amended safety assessment of Quaternium-15 as used in cosmetics. |
| PubMed:Twenty-five years quaternium-15 in the European baseline series: does it deserve its place there? |
| PubMed:Formaldehyde-releasers in cosmetics in the USA and in Europe. |
| PubMed:Temporal trends of preservative allergy in Denmark (1985-2008). |
| PubMed:Formaldehyde-releasers in cosmetics: relationship to formaldehyde contact allergy. Part 2. Patch test relationship to formaldehyde contact allergy, experimental provocation tests, amount of formaldehyde released, and assessment of risk to consumers allergic to formaldehyde. |
| PubMed:Formaldehyde-releasers in cosmetics: relationship to formaldehyde contact allergy. Part 1. Characterization, frequency and relevance of sensitization, and frequency of use in cosmetics. |
| PubMed:Allergic contact dermatitis in Operation Iraqi Freedom: use of the T.R.U.E. Test in the combat environment. |
| PubMed:Hand dermatitis: a focus on allergic contact dermatitis to biocides. |
| PubMed:Patch-test results of the North American Contact Dermatitis Group 2005-2006. |
| PubMed:[Contact allergy to quaternium-15]. |
| PubMed:Effect of Prolonged Repeated Exposure to Formaldehyde Donors with Doses Below the EC3 Value on Draining Lymph Node Responses. |
| PubMed:Contact allergy in children referred for patch testing: North American Contact Dermatitis Group data, 2001-2004. |
| PubMed:Contact hypersensitivity to selected excipients of dermatological topical preparations and cosmetics in patients with chronic eczema. |
| PubMed:Anogenital dermatitis in patients referred for patch testing: retrospective analysis of cross-sectional data from the North American Contact Dermatitis Group, 1994-2004. |
| PubMed:Occupational dermatoses in health care workers evaluated for suspected allergic contact dermatitis. |
| PubMed:Allergic contact dermatitis in children: the Ottawa hospital patch-testing clinic experience, 1996 to 2006. |
| PubMed:A review of 241 subjects who were patch tested twice: could fragrance mix I cause active sensitization? |
| PubMed:Prevalence of patch test results from 1970 to 2002 in a multi-centre population in North America (NACDG). |
| PubMed:Contact dermatitis of the hands: cross-sectional analyses of North American Contact Dermatitis Group Data, 1994-2004. |
| PubMed:Contact allergy to pentylene glycol. |
| PubMed:Comparison of reactivity to allergens using the TRUE Test and IQ chamber system. |
| PubMed:[Contact allergy to preservatives contained in cosmetics]. |
| PubMed:Sensitizations to allergens of TRUE test in 864 consecutive eczema patients in Israel. |
| PubMed:Preservatives sensitivity in Israel: a 10-year overview (1995-2004). |
| PubMed:Allergic contact dermatitis to quaternium 15 in a moisturizing lotion. |
| PubMed:North American Contact Dermatitis Group patch-test results, 2001-2002 study period. |
| PubMed:Etiology of hand dermatitis among patients referred for patch testing. |
| PubMed:Prevalence and relevance of contact dermatitis allergens: a meta-analysis of 15 years of published T.R.U.E. test data. |
| PubMed:[Contact sensitization to pharmaceutic aids in dermatologic cosmetic and external use preparations]. |
| PubMed:Multiple patch-test reactions: a pilot evaluation of a combination approach to visualize patterns of multiple sensitivity in patch-test databases and a proposal for a multiple sensitivity index. |
| PubMed:Patch test results in 542 patients with suspected contact dermatitis in Turkey. |
| PubMed:Dermatitis in a particleboard manufacturing facility. |
| PubMed:Occupational allergic contact dermatitis from quaternium-15 in an electroencephalography skin preparation gel. |
| PubMed:Delayed readings of a standard screening patch test tray: frequency of "lost," "found," and "persistent" reactions. |
| PubMed:Allergic contact dermatitis from formaldehyde and quaternium-15 in photocopier toner. |
| PubMed:Simultaneous allergic reactions to quaternium-15 and methenamine. |
| PubMed:Concomitant positive reactions to allergens in a patch testing standard series from 1988-1997. |
| PubMed:Significance-prevalence index number: a reinterpretation and enhancement of data from the North American contact dermatitis group. |
| PubMed:Patch testing reactions to a standard series in 608 patients tested from 1990 to 1997 at Massachusetts General Hospital. |
| PubMed:Allergic contact dermatitis to preservatives in topical medicaments. |
| PubMed:North American Contact Dermatitis Group patch test results for the detection of delayed-type hypersensitivity to topical allergens. |
| PubMed:Postmarketing survey results of T.R.U.E. TEST, a new allergen patch test. |
| PubMed:Evaluation of previously patch-tested patients referred to a contact dermatitis clinic. |
| PubMed:Comparison of automated and traditional minimum inhibitory concentration procedures for microbiological cosmetic preservatives. |
| PubMed:Reactions to formaldehyde and formaldehyde releasers in a standard series. |
| PubMed:Allergic contact dermatitis from quaternium 15 in Oilatum cream. |
| PubMed:Methyldibromoglutaronitrile is an important contact allergen in The Netherlands. |
| PubMed:Technical and ethical problems associated with patch testing. |
| PubMed:Patch testing with preservatives at St John's from 1982 to 1993. |
| PubMed:Ability of laboratory methods to predict in-use efficacy of antimicrobial preservatives in an experimental cosmetic. |
| PubMed:Frequency of sensitization to 13 common preservatives in Switzerland. Swiss Contact Dermatitis Research Group. |
| PubMed:Diazolidinyl urea: incidence of sensitivity, patterns of cross-reactivity and clinical relevance. |
| PubMed:Transforming growth factor-alpha (TGF-alpha) in a semisolid dosage form: preservative and vehicle selection. |
| PubMed:Occupational contact dermatitis due to quaternium 15 presenting as nail dystrophy. |
| PubMed:Occupational contact dermatitis due to quaternium 15. |
| PubMed:Prevalence and relevance of allergic reactions in patients patch tested in North America--1984 to 1985. |
| PubMed:Preservatives in the European standard series for epicutaneous testing. |
| PubMed:Allergy to cosmetics. |
| PubMed:Contact allergy to preservatives--II. |
| PubMed:Reactions to Quaternium 15, Bronopol and Germall 115 in a standard series. |
| PubMed:A five-year study of cosmetic reactions. |
| PubMed:Patch tests with fragrance materials and preservatives. |
| PubMed:Iatrogenic dermatitis. |
| PubMed:Cosmetic dermatitis. Part II. Reactions to some commonly used preservatives. |
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3D/inchi
3D/inchi