EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

visnagin
desmethoxykhellin

Supplier Sponsors

Name:4-methoxy-7-methylfuro[3,2-g]chromen-5-one
CAS Number: 82-57-5Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:201-430-3
FDA UNII: P64438MLBW
Nikkaji Web:J4.613B
Beilstein Number:0234955
MDL:MFCD00005008
XlogP3-AA:2.30 (est)
Molecular Weight:230.21950000
Formula:C13 H10 O4
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:natural substances and extractives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 144.50 °C. @ 760.00 mm Hg
Boiling Point: 378.20 °C. @ 760.00 mm Hg (est)
Flash Point: 361.00 °F. TCC ( 182.50 °C. ) (est)
logP (o/w): 2.260 (est)
Soluble in:
 water, 97.76 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
BOC Sciences
For experimental / research use only.
Visnagin 0.98
Odor: characteristic
Use: Visnagin isolated form the herbs of Ammi visnaga. It has anti-inflammatory effect, might own to the inhibition of transcription factors, such as AP-1. anti-inflammatory effect
Carbosynth
For experimental / research use only.
Visnagin
ExtraSynthese
For experimental / research use only.
Visnagin (HPLC) ≥95%
Sigma-Aldrich: Aldrich
For experimental / research use only.
Visnagin
sds
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intramuscular-mouse LD50 123 mg/kg
Journal of Drug Research. Vol. 7(2), Pg. 1, 1975.

oral-rat LD50 832 mg/kg
Journal of Drug Research. Vol. 7(2), Pg. 1, 1975.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
natural substances and extractives
Recommendation for visnagin usage levels up to:
 not for fragrance use.
 
Recommendation for visnagin flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :6716
National Institute of Allergy and Infectious Diseases:Data
4-methoxy-7-methylfuro[3,2-g]chromen-5-one
Chemidplus:0000082575
RTECS:LV1420000 for cas# 82-57-5
 
References:
 4-methoxy-7-methylfuro[3,2-g]chromen-5-one
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):6716
Pubchem (sid):134970929
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
KEGG (GenomeNet):C09049
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2932.90.4100
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
EFSA Update of results on the monitoring of furan levels in food:Read Report
EFSA Previous report: Results on the monitoring of furan levels in food:Read Report
EFSA Report of the CONTAM Panel on provisional findings on furan in food:Read Report
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 found in nature
 
Synonyms:
 desmethoxykhellin
5H-furo(3,2-g)(1)benzopyran-5-one, 4-methoxy-7-methyl-
5-methoxy-2-methylfuranochromone
4-methoxy-7-methyl furo(3,2-g)chromen-5-one
4-methoxy-7-methyl-5H-furo(3,2-g)(1)-benzopyran-5-one
4-methoxy-7-methylfuro[3,2-g]chromen-5-one
 visnagidin
 visnagine
 

Articles:

Google Patents:Method for the preparation of visnagin from chellol and new compositions of matter
PubMed:Validated HPLC method for simultaneous estimation of khellol glucoside, khellin and visnagin in Ammi visnaga L. fruits and pharmaceutical preparations.
PubMed:Khellin and visnagin differentially modulate AHR signaling and downstream CYP1A activity in human liver cells.
PubMed:Aflatoxin B1: toxicity, bioactivation and detoxification in the polyphagous caterpillar Trichoplusia ni.
PubMed:Pharmacokinetic evaluation of visnagin and Ammi visnaga aqueous extract after oral administration in rats.
PubMed:Antitumor and antimicrobial activities of some hetero aromatic benzofurans derived from naturally occurring visnagin.
PubMed:Nonlinear pharmacokinetics of visnagin in rats after intravenous bolus administration.
PubMed:DNA binding, antiviral activities and cytotoxicity of new furochromone and benzofuran derivatives.
PubMed:Synthesis of new visnagen and khellin furochromone pyrimidine derivatives and their anti-inflammatory and analgesic activity.
PubMed:Neuroprotective Effect of Visnagin on Kainic Acid-induced Neuronal Cell Death in the Mice Hippocampus.
PubMed:Anti-inflammatory effect of visnagin in lipopolysaccharide-stimulated BV-2 microglial cells.
PubMed:Prevention of renal crystal deposition by an extract of Ammi visnaga L. and its constituents khellin and visnagin in hyperoxaluric rats.
PubMed:An aqueous extract of Ammi visnaga fruits and its constituents khellin and visnagin prevent cell damage caused by oxalate in renal epithelial cells.
PubMed:Determination of visnagin in rat plasma by liquid chromatography with tandem mass spectrometry and its application to in vivo pharmacokinetic studies.
PubMed:A new steroid glycoside and furochromones from Cyperus rotundus L.
PubMed:Synthesis of 6- and 9-alkylaminomethyl furoflavones as gastroprotective agents.
PubMed:Nanosecond time-resolved infrared studies of visnagin and khellin triplets and radical ions.
PubMed:Ultraviolet photoionization of the photosensitizers khellin and visnagin in aqueous solution and in micelles: one-photon ionization is a minor process.
PubMed:The chemical investigations on the ripe fruits of Ammi visnaga (Lam.) Lamarck growing in Turkey.
PubMed:Stimulation of furanochromone accumulation in callus cultures of Ammi visnaga L. by addition of elicitors.
PubMed:Fluorometric determination of khellin in human urine and serum by high-performance liquid chromatography using postcolumn photoirradiation.
PubMed:Photosynthesis of furocoumarin- and furochromone-types potential intercalative alkylating and oxidizing agents of DNA through photooxidations using gamma-ray.
PubMed:Effect of psoralens on Fenton-like reaction generating reactive oxygen species.
PubMed:A new synthesis of oxadiazole, thiazolidinone, N-phthalimidoamino carbonyl and arylidene derivatives with potential antimicrobial activity.
PubMed:Epoxidation of some natural furocoumarins and furochromones using gamma-ray.
PubMed:Determination of khellin and visnagin in Ammi visnaga fruits by capillary electrophoresis.
PubMed:Furanochromone radical cations: generation, characterization and interaction with DNA.
PubMed:Cardiovascular effects of visnagin on rats.
PubMed:Effects of visnagin on cyclic nucleotide phosphodiesterases and their role in its inhibitory effects on vascular smooth muscle contraction.
PubMed:Inhibition of metabolic activation of the promutagens, benzo[a]pyrene, 2-aminofluorene and 2-aminoanthracene by furanochromones in Salmonella typhimurium.
PubMed:Determination of furanochromones and pyranocoumarins in drugs and Ammi visnaga fruits by combined solid-phase extraction-high-performance liquid chromatography and thin-layer chromatography-high-performance liquid chromatography.
PubMed:Photophysical properties and photobiological activity of the furanochromones visnagin and khellin.
PubMed:Studies on the photobiological activity of two naturally occurring furochromones, visnagin and khellin, in Chlamydomonas reinhardtii.
PubMed:Inhibition of the mutagenicity of 2-nitrofluorene, 3-nitrofluoranthene and 1-nitropyrene by flavonoids, coumarins, quinones and other phenolic compounds.
PubMed:Synthesis and biological activities of flavonoid derivatives as A3 adenosine receptor antagonists.
PubMed:Vasodilator effects of visnagin in isolated rat vascular smooth muscle.
PubMed:The involvement of a Ca2+ channel blocking mode of action in the pharmacology of Ammi visnaga fruits.
PubMed:Photosensitized cleavage and cross-linking of pBR322 DNA with khellin and visnagin.
PubMed:Improved high-performance liquid chromatographic determination of khellin and visnagin in Ammi visnaga fruits and pharmaceutical formulations.
PubMed:Inhibition of aflatoxin production inAspergillus flavus by natural coumarins and chromones.
PubMed:Photosensitization of DNA of defined sequence by furochromones, khellin and visnagin.
PubMed:High performance liquid chromatographic determinations of khellin, phenobarbitone and dipyrone combination in tablets.
PubMed:Ammi visnaga: Somatic Embryo Induction and Furanochromone Production in Embryos, Seedlings, and Plants.
PubMed:Plant photosensitizers with antiviral properties.
PubMed:The mechanism of antiviral phototoxicity of the furanochromones visnagin and khellin.
PubMed:The mechanisms of interaction between furanochromones and DNA. A heteronuclear Overhauser effect study on the khellin-thymidine model system.
PubMed:[Production of oxygen radicals and the UV spectrum of furanocoumarins].
PubMed:High performance liquid chromatography analysis of the furanochromones khellin and visnagin in various organs of Ammi visnaga (L.) Lam. at different developmental stages.
PubMed:Differential effects of photoactive furanyl compounds on virus functions.
PubMed:Active oxygen forms in photoreaction between DNA and furanochromones khellin and visnagin.
PubMed:Native American food and medicinal plants, 5. Isolation of the lipid altering visnagin from Musineon divaricatum.
PubMed:Rapid separation and quantitative determination of khellin and visnagin in Ammi visnaga (L.) Lam. fruits by high-performance liquid chromatography.
PubMed:Genotoxicity of the natural furochromones, khellin and visnagin and the identification of a khellin-thymine photoadduct.
PubMed:Simultaneous TLC separation of khellin and visnagin and their assay in Ammi visnaga fruits, extracts, and formulations.
PubMed:The biosynthesis of radioactive khellin and visnagin from C14-acetate by Ammi visnaga plants.
PubMed:The biosynthesis of visnagin from 2-14C-acetate by Ammi visnaga suspension cultures and the metabolism of 14C-visnagin and 14C-khellin by A. visnaga and A. majus.
PubMed:Visnagin: biosynthesis and isolation from Ammi visnagi suspension cultures.
PubMed:[A COLOR REACTION FOR THE IDENTIFICATION OF 2-METHYLCHROMONE AND FOR THE DETECTION OF VISNAGIN].
PubMed:[Bronchodilatory effects of visnagin].
PubMed:[Treatment of angina pectoris with visnagin].
PubMed:[Treatment of angina pectoris with a new principle of ammi visnaga: or visnagin; chemical, pharmacological and clinical study].
PubMed:New tests for the identification of khellin, visnagin and khellol-glucoside.
 
Notes:
from musineon divaricatum.
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