EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

uvaol
(3beta)-urs-12-ene-3,28-diol

Supplier Sponsors

Name:(3S,4aR,6aR,6bS,8aS,11R,12S,12aS,14aR,14bR)-8a-(hydroxymethyl)-4,4,6a,6b,11,12,14b-heptamethyl-2,3,4a,5,6,7,8,9,10,11,12,12a,14,14a-tetradecahydro-1H-picen-3-ol
CAS Number: 545-46-0Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:208-888-3
FDA UNII: W599R31ROT
Nikkaji Web:J14.120H
MDL:MFCD00009620
XlogP3-AA:7.40 (est)
Molecular Weight:442.72690000
Formula:C30 H50 O2
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:natural substances and extractives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 523.70 °C. @ 760.00 mm Hg (est)
Flash Point: 413.00 °F. TCC ( 211.60 °C. ) (est)
logP (o/w): 9.130 (est)
Soluble in:
 water, 0.0002014 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
BOC Sciences
For experimental / research use only.
Uvaol >98%
Odor: characteristic
Use: Uvaol, also called urs-12-ene-3b,28-diol is a natural triterpenoid found in the herbs of Callicarpa bodinieri Levl. Urs-12-ene-3b,28-diol exhibits the activity of anti-inflammatory. Urs-12-ene-3b,28-diol also has has anti-proliferative activity, anti-inflammatory; anti-proliferative
Coompo
For experimental / research use only.
Uvaol from Plants ≥96%
ExtraSynthese
For experimental / research use only.
Uvaol (HPLC) ≥98,5%
Santa Cruz Biotechnology
For experimental / research use only.
Uvaol
Sigma-Aldrich: Sigma
For experimental / research use only.
Uvaol ≥95%
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
natural substances and extractives
Recommendation for uvaol usage levels up to:
 not for fragrance use.
 
Recommendation for uvaol flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :92802
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
(3S,4aR,6aR,6bS,8aS,11R,12S,12aS,14aR,14bR)-8a-(hydroxymethyl)-4,4,6a,6b,11,12,14b-heptamethyl-2,3,4a,5,6,7,8,9,10,11,12,12a,14,14a-tetradecahydro-1H-picen-3-ol
Chemidplus:0000545460
 
References:
 (3S,4aR,6aR,6bS,8aS,11R,12S,12aS,14aR,14bR)-8a-(hydroxymethyl)-4,4,6a,6b,11,12,14b-heptamethyl-2,3,4a,5,6,7,8,9,10,11,12,12a,14,14a-tetradecahydro-1H-picen-3-ol
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):92802
Pubchem (sid):135050099
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
HMDB (The Human Metabolome Database):HMDB02391
FooDB:FDB013518
Export Tariff Code:2906.19.0000
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 cherry sweet cherry
Search Trop Picture
 olive oil
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 olive pericarp
Search Trop Picture
 osmanthus
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 persimmon
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 sage plant
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Synonyms:
(3S,4aR,6aR,6bS,8aS,11R,12S,12aS,14aR,14bR)-8a-(hydroxymethyl)-4,4,6a,6b,11,12,14b-heptamethyl-2,3,4a,5,6,7,8,9,10,11,12,12a,14,14a-tetradecahydro-1H-picen-3-ol
(3beta)-urs-12-ene-3,28-diol
 urs-12-ene-3beta,28-diol
 

Articles:

PubMed:Chemical of Vitex trifolia.
PubMed:[Chemical constituents from Euphorbia lunulata].
PubMed:Studies on cytotoxic constituents from the leaves of Elaeagnus oldhamii Maxim. in non-small cell lung cancer A549 cells.
PubMed:[Chemical constituents from the roots of Ilex pubescens].
PubMed:New cytotoxic cycloartane triterpene from Cassia italica aerial parts.
PubMed:A new antioxidant stilbene and other constituents from the stem bark of Morus nigra L.
PubMed:Bioactive properties of the main triterpenes found in olives, virgin olive oil, and leaves of Olea europaea.
PubMed:Time course of pentacyclic triterpenoids from fruits and leaves of olive tree (Olea europaea L.) cv. Picual and cv. Cornezuelo during ripening.
PubMed:[Chemical constituents of Gentiana rhodantha].
PubMed:[Chemical constituents and their antitumor cytotoxic activity in leaves of Ilex centrochinensis].
PubMed:A rapid method to determine sterol, erythrodiol, and uvaol concentrations in olive oil.
PubMed:Changes of the wax contents in mixtures of olive oils as determined by gas chromatography with a flame ionization detector.
PubMed:Triterpenoid content of berries and leaves of bilberry Vaccinium myrtillus from Finland and Poland.
PubMed:Triterpenoid profile of flower and leaf cuticular waxes of heather Calluna vulgaris.
PubMed:Fast separation of triterpenoids by supercritical fluid chromatography/evaporative light scattering detector.
PubMed:Sterols and triterpene diols in olive oil as indicators of variety and degree of ripening.
PubMed:Study of skin anti-ageing and anti-inflammatory effects of dihydroquercetin, natural triterpenoids, and their synthetic derivatives.
PubMed:Characterisation and phenolic profiles of two rare olive oils from southern Tunisia: Dhokar and Gemri-Dhokar cultivars.
PubMed:DIOL triterpenes block profibrotic effects of angiotensin II and protect from cardiac hypertrophy.
PubMed:Efficacy of bioactive compounds from extra virgin olive oil to modulate atherosclerosis development.
PubMed:Anti-Helicobacter pylori activity of the methanolic extract of Geum iranicum and its main compounds.
PubMed:Comparison of the triterpenoid content of berries and leaves of lingonberry Vaccinium vitis-idaea from Finland and Poland.
PubMed:Chemical constituents and allelopathic and antioxidant activities of Alchorneopsis floribunda Müll. Arg. (Euphorbiaceae).
PubMed:Cloning, expression, characterization and inhibition studies on trypanothione synthetase, a drug target enzyme, from Leishmania donovani.
PubMed:CYP716A subfamily members are multifunctional oxidases in triterpenoid biosynthesis.
PubMed:[Synthesis and antitumor activity of betulin, erythrodiol and uvaol aminopropoxy derivatives].
PubMed:[Studies on the chemical constituents of Coleus forskohlii transplanted in Tongcheng and their antitumor activity].
PubMed:Inhibitory effects of constituents from Morus alba var. multicaulis on differentiation of 3T3-L1 cells and nitric oxide production in RAW264.7 cells.
PubMed:Chemometric classification of the fat residues from the conditioning operations of table olive processing, based on their minor components.
PubMed:Antibacterial properties of compounds isolated from Carpobrotus edulis.
PubMed:Antioxidant, antiproliferative, and pro-apoptotic capacities of pentacyclic triterpenes found in the skin of olives on MCF-7 human breast cancer cells and their effects on DNA damage.
PubMed:Pentacyclic triterpenoids from olive fruit and leaf.
PubMed:Antioxidant and antiatherogenic activities of pentacyclic triterpenic diols and acids.
PubMed:Constituents of Carpobrotus edulis inhibit P-glycoprotein of MDR1-transfected mouse lymphoma cells.
PubMed:Fruit quality and olive leaf and stone addition affect Picual virgin olive oil triterpenic content.
PubMed:A new labdane diterpene from Vitex cauliflora Moldenke from the Madagascar rainforest.
PubMed:Natural triterpenic diols promote apoptosis in astrocytoma cells through ROS-mediated mitochondrial depolarization and JNK activation.
PubMed:In vitro antileishmanial, antiplasmodial and cytotoxic activities of phenolics and triterpenoids from Baccharis dracunculifolia D. C. (Asteraceae).
PubMed:Triterpenic content and chemometric analysis of virgin olive oils from forty olive cultivars.
PubMed:Fast and selective determination of triterpenic compounds in olive leaves by liquid chromatography-tandem mass spectrometry with multiple reaction monitoring after microwave-assisted extraction.
PubMed:Steroids, alkaloids, and coumarins from Gelsemium sempervirens.
PubMed:A new monoterpene alkaloid and other constituents of Plumeria acutifolia.
PubMed:[Studies on triterpenoid constituents in leaf of Ilex pernyi].
PubMed:[Studies on chemical constituents of in herb Pyrola calliatha].
PubMed:How heating affects extra virgin olive oil quality indexes and chemical composition.
PubMed:Ultrasound-assisted extraction and silylation prior to gas chromatography-mass spectrometry for the characterization of the triterpenic fraction in olive leaves.
PubMed:Triterpenes in the hexane extract of leaves of Olea europaea L.: analysis using 13C-NMR spectroscopy.
PubMed:Antimicrobial activity of oleanolic acid from Salvia officinalis and related compounds on vancomycin-resistant enterococci (VRE).
PubMed:Formation of triterpenoids throughout Olea europaea fruit ontogeny.
PubMed:Modulation of cytokine secretion by pentacyclic triterpenes from olive pomace oil in human mononuclear cells.
PubMed:Analysis of unsaponifiable compounds of edible oils by automated on-line coupling reversed-phase liquid chromatography-gas chromatography using the through oven transfer adsorption desorption interface.
PubMed:Triterpenic compounds from "orujo" olive oil elicit vasorelaxation in aorta from spontaneously hypertensive rats.
PubMed:Triterpenoids from Brazilian Ilex species and their in vitro antitrypanosomal activity.
PubMed:Cardiotonic and antidysrhythmic effects of oleanolic and ursolic acids, methyl maslinate and uvaol.
PubMed:Four new triterpenoids from Maytenus ilicifolia.
PubMed:Chemical constituents from the leaves of Psidium guajava.
PubMed:[Studies on chemical components of Gentiana tizuensis Franch. (I)].
PubMed:Inhibitory activity of minor polyphenolic and nonpolyphenolic constituents of olive oil against in vitro low-density lipoprotein oxidation.
PubMed:Antimicrobial triterpenes from Debregeasia salicifolia.
PubMed:Effect of five triterpenoid compounds isolated from leaves of Diospyros kaki on stimulus-induced superoxide generation and tyrosyl phosphorylation in human polymorphonuclear leukocytes.
PubMed:Microbial transformation of cadina-4,10(15)-dien-3-one, aromadendr-1(10)-en-9-one and methyl ursolate by Mucor plumbeus ATCC 4740.
PubMed:Constituents of Compositae plants III. Anti-tumor promoting effects and cytotoxic activity against human cancer cell lines of triterpene diols and triols from edible chrysanthemum flowers.
PubMed:[Nonpolar components of the leaves of Philadelphus coronarius L].
PubMed:Cytotoxic triterpenes from Crataegus pinnatifida.
PubMed:Protective effects of triterpene compounds against the cytotoxicity of cadmium in HepG2 cells.
PubMed:Inhibitory effect of triterpenes from Crataegus pinatifida on HIV-I protease.
PubMed:Chitin synthase II inhibitory activity of ursolic acid, isolated from Crataegus pinnatifida.
PubMed:Terpenoids of Syzygium formosanum.
PubMed:Synthesis and anti-ulcer activity of new derivatives of glycyrrhetic, oleanolic and ursolic acids.
PubMed:Validated method for quantitation and identification of 4,4-desmethylsterols and triterpene diols in plant oils by thin-layer chromatography-high resolution gas chromatography-mass spectrometry.
PubMed:Inhibitory effect of Di- and trihydroxy triterpenes from the flowers of compositae on 12-O-tetradecanoylphorbol-13-acetate-induced inflammation in mice.
PubMed:Synthesis and antiulcer activity of uvaol hemiphthalate derivatives.
PubMed:Effects of Ursolic Acid and its Analogues on Soybean 15-Lipoxygenase Activity and the Proliferation Rate of A human Gastric Tumour Cell Line.
PubMed:The effects of 10 triterpenoid compounds on experimental liver injury in mice.
PubMed:Effects of xanthone glycoside on ephedrine-induced biting behavior and motor activity.
PubMed:Determination of sterols, erythrodiol, uvaol and alkanols in olive oils using combined solid-phase extraction, high-performance liquid chromatographic and high-resolution gas chromatographic techniques.
PubMed:Inhibition of human leucocyte elastase by ursolic acid. Evidence for a binding site for pentacyclic triterpenes.
PubMed:[Plant from New-Caledonia. Alkaloids of Melodinus reticulatus].
PubMed:Tumor inhibitory agents from Vauquelinia corymbosa (Rosaceae).
PubMed:A new triterpenoid lactone, alpha-amyrin and uvaol from Helichrysum italicum.
PubMed:[Ursolic acid and uvaol as contents of Rhododendron ponticum].
PubMed:[A new natural triterpenic lactone, alpha-amyrin and uvaol from Helichrysum italicum (G. Don)].
 
Notes:
from vauquelinia corymbosa (rosaceae). Constit. of olive oil and Osmanthus fragrans (sweet osmanthus) Uvaol is a pentacyclic triterpene, found in the non-glyceride fraction of olive pomace oil (Olive pomace oil, also known as "orujo" olive oil, is a blend of refined-pomace oil and virgin olive oil, fit for human consumption). Pentacyclic triterpenes are natural compounds which are widely distributed in plants. These natural products have been demonstrated to possess anti-inflammatory properties. Triterpenoids have been reported to possess antioxidant properties, since they prevent lipid peroxidation and suppress superoxide anion generation. The triterpenes have a history of medicinal use in many Asian countries. Uvaol exhibits both pro- and anti-inflammatory properties depending on chemical structure and dose and may be useful in modulating the immune response; further studies are required to confirm the immunomodulatory behaviour of this triterpenoid, and characterise the mechanisms underlying the biphasic nature of some aspects of the inflammatory response. (PMID: 17292619)
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