EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

polysorbate 85
tween 85

Supplier Sponsors

CAS Number: 9005-70-3
Other(deleted CASRN):111389-05-0
FDA UNII: A7F3N56197
MDL:MFCD01779641
Category:emulsifiers, surfactants
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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NCBI:Search
DG SANTE Food Contact Materials:polyethyleneglycol sorbitan trioleate
FDA Mainterm (IAUFC):9005-70-3 ; POLYSORBATE 85
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Specific Gravity:1.02800 @ 25.00 °C.
Refractive Index:1.46800 @ 20.00 °C.
Flash Point:> 230.00 °F. TCC ( > 110.00 °C. )
Soluble in:
 water, 2.718e-019 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: surfactants
surfactant - emulsifying
 
Suppliers:
BOC Sciences
For experimental / research use only.
Tween 85
Chemical-navi - Nikkol
NIKKOL TO-30V
Odor: characteristic
Use: Emulsifier for soluble oils; water dispersible; oil soluble; plant-derived
Covalent Chemical
Polysorbate 85
ECSA Chemicals
POLYSORBATE 85
ECSA TRADE THE MOST UPDATED FINANCIAL PUBLICATION ON THE WORLD OF CHEMISTRY
Kao Corporation
RHEODOL TW-O320V
Odor: characteristic
Use: Emulsifier for pharmaceuticals and cosmetics, Stabilizer for color materials, Stabilizer for emulsion polymerizations, Emulsifier for adjuvant of agrochemicals, Emulsifier for water based metal process cutting oils, Surface coating type antistatic agents.
Lonza Group
Lonzest™ STO-20
Mohini Organics
MONEBAT™ - 85
Odor: characteristic
Use: MONEBAT™ - 85 is used as a emulsifier, dispersant, solubilizer, lubricant, detergent, antistat, wetting agent for cosmetics and pharmaceuticals.
Sigma-Aldrich: Sigma
For experimental / research use only.
TWEEN® 85
sds
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
emulsifiers, surfactants
Recommendation for polysorbate 85 usage levels up to:
 not for fragrance use.
 
Recommendation for polysorbate 85 flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):9005-70-3
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:1
Chemidplus:0009005703
RTECS:WG2934500 for cas# 9005-70-3
 
References:
Canada Domestic Sub. List:9005-70-3
Pubchem (sid):135287157
 
Other Information:
FDA Indirect Additives used in Food Contact Substances:View
HMDB (The Human Metabolome Database):Search
FooDB:FDB016184
Export Tariff Code:3402.13.2020
 
Potential Blenders and core components note
None Found
 
Potential Uses:
 emulsifying agents
 surfactants
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
 glycosperse TO-20
 hetsorb TO-20
 liposorb TO-20
 lonzest STO-20
 monebat - 85
 nikkol TO-30V
 poe-20 sorbitan trioleate
 polyethyleneglycol sorbitan trioleate
 polyoxyethylene (20) sorbitan trioleate
 protasorb TO-20
 rheodol TW-O320V
 toximul see-340
 tween 85
 

Articles:

PubMed:On the behaviour of nanoparticles in oil-in-water emulsions with different surfactants.
PubMed:Effective delivery of p65 shRNA by optimized Tween 85-polyethyleneimine conjugate for inhibition of tumor growth and lymphatic metastasis.
PubMed:Characterization of polysorbate 85, a nonionic surfactant, by liquid chromatography vs. ion mobility separation coupled with tandem mass spectrometry.
PubMed:In vitro assessment of drug-free and fenofibrate-containing lipid formulations using dispersion and digestion testing gives detailed insights into the likely fate of formulations in the intestine.
PubMed:The inhibition of metastasis and growth of breast cancer by blocking the NF-κB signaling pathway using bioreducible PEI-based/p65 shRNA complex nanoparticles.
PubMed:Formulation and cytotoxicity evaluation of new self-emulsifying multiple W/O/W nanoemulsions.
PubMed:Enhanced chemiluminescence of cerium(IV)-Tween 85 system and the analytical application.
PubMed:Joint-action of antifouling substances in copper-free paints.
PubMed:Anti-inflammatory activity of novel ammonium glycyrrhizinate/niosomes delivery system: human and murine models.
PubMed:Low-energy formation of edible nanoemulsions: factors influencing droplet size produced by emulsion phase inversion.
PubMed:Biodegradation of a keratin waste and the concomitant production of detergent stable serine proteases from Paecilomyces lilacinus.
PubMed:The influence of the structure and the composition of water/AOT-Tween 85/IPM microemulsion system on transdermal delivery of 5-fluorouracil.
PubMed:Low molecular weight polyethylenimine-graft-Tween 85 for effective gene delivery: synthesis and in vitro characteristics.
PubMed:[Water in oil microemulsions containing NaCl for transdermal delivery of fluorouracil].
PubMed:A novel biocatalytic approach to acetylation of 1-β-D-arabinofuranosylcytosine by Aspergillus oryzae whole cell in organic solvents.
PubMed:[Microemulsion-based gel of fluorouracil for transdermal delivery].
PubMed:Formulation and physicochemical characterization of imwitor 308 based self microemulsifying drug delivery systems.
PubMed:Characterization of potent anticholinesterase plant oil based microemulsion.
PubMed:Preparation and the in vitro evaluation of nanoemulsion system for the transdermal delivery of granisetron hydrochloride.
PubMed:Extraction of monoclonal antibodies (IgG1) using anionic and anionic/nonionic reverse micelles.
PubMed:Direct and rapid determination of ultratrace heavy metals in solid plant materials by ET-AAS ultrasonic-assisted slurry sampling.
PubMed:Optimization of mono and diacylglycerols production from enzymatic glycerolysis in solvent-free systems.
PubMed:[Water in oil microemulsions for transdermal delivery of fluorouracil].
PubMed:Biotransformation of steriodal saponins in Dioscorea zingiberensis C. H. Wright to diosgenin by Trichoderma harzianum.
PubMed:Potential of nanoemulsions for intravenous delivery of rifampicin.
PubMed:Bicontinuous cyclosporin a loaded water-AOT/Tween 85-isopropylmyristate microemulsion: structural characterization and dermal pharmacokinetics in vivo.
PubMed:Immobilization of lipases on hydrophobilized zirconia nanoparticles: highly enantioselective and reusable biocatalysts.
PubMed:Investigation of microemulsion system for transdermal delivery of meloxicam.
PubMed:Influence of excipients on moisturizing effect of urea.
PubMed:Behavior of soybean oil-in-water emulsion stabilized by nonionic surfactant.
PubMed:[Comparison of non-protected fluid room temperature phosphorescence and micellar-stabilized room temperature phosphorescence properties of indole-3-butyric acid].
PubMed:Effect of surfactant HLB and different formulation variables on the properties of poly-D,L-lactide microspheres of naltrexone prepared by double emulsion technique.
PubMed:Simultaneous conductivity and viscosity measurements as a technique to track emulsion inversion by the phase-inversion-temperature method.
PubMed:Self-generation of tiered surfactant superstructures for one-pot synthesis of Co3O4 nanocubes and their close- and non-close-packed organizations.
PubMed:Polymyxin B enhances ISS-mediated immune responses across multiple species.
PubMed:Poly-epsilon-caprolactone nanocapsules containing octyl methoxycinnamate: preparation and characterization.
PubMed:Influence of surfactant hydrophobicity on the detachment of Escherichia coli O157:H7 from lettuce.
PubMed:Microemulsion formulation of clonixic acid: solubility enhancement and pain reduction.
PubMed:Effect of surface active agents on the production of biopesticides using wastewater sludge as a raw material.
PubMed:Biodegradable polymer nanocapsules containing a sunscreen agent: preparation and photoprotection.
PubMed:Development of a novel dosage form for intramuscular injection of titrated extract of Centella asiatica in a mixed micellar system.
PubMed:Preparation and in vitro characterization of gelatin microspheres containing Levodopa for nasal administration.
PubMed:Chiral epoxide production using mycobacterium solubilized in a water-in-oil microemulsion.
PubMed:Effects of some non-ionic surfactants on transepithelial permeability in Caco-2 cells.
PubMed:Lipase activity from strains of Pasteurella multocida.
PubMed:Long-term stability of PBCA nanoparticle suspensions.
PubMed:Enhanced absorption of indomethacin after oral or rectal administration of a self-emulsifying system containing indomethacin to rats.
PubMed:Gelatin-stabilised microemulsion-based organogels: rheology and application in iontophoretic transdermal drug delivery.
PubMed:Protein separation using affinity-based reversed micelles
PubMed:Nanoparticle technology for delivery of drugs across the blood-brain barrier.
PubMed:Efficacy of oral dalargin-loaded nanoparticle delivery across the blood-brain barrier.
PubMed:Protection against haemorrhagic septicaemia induced by vaccination of buffalo calves with an improved oil adjuvant vaccine.
PubMed:Effect of dosing vehicle on the hepatotoxicity of CCl4 and nephrotoxicity of CHCl3 in rats.
PubMed:Contribution of hydrophobicity of nonionic detergents to membrane lipid fluidity and disopyramide uptake by rat intestinal brush-border membrane vesicles.
PubMed:[Catalytic properties of catalase in microemulsions of surface-active agents in octane].
PubMed:Renaturation and ligand blotting of the major subunit of the rat asialoglycoprotein receptor after denaturing polyacrylamide gel electrophoresis.
PubMed:Degradation of pesticides in a continuous-flow two-phase microemulsion reactor.
PubMed:Biodegradation of pesticides in nonionic water-in-oil microemulsions of tween 85: Relationship between micelle structure and activity.
PubMed:High pressure EPR studies of protein mobility in reversed micelles.
PubMed:Surfactant-Induced hydrogen production in cyanobacteria.
PubMed:Solubilization and activity of proteins in compressible-fluid based microemulsions.
PubMed:Polarographic measurement of oxygen uptake using lipoxygenase in reverse micelles.
PubMed:The irritancy and allergenicity of 2-n-octyl-4-isothiazolin-3-one (Skane M-8), with recommendations for patch test concentration.
PubMed:Cytochemical and biochemical localization of lipase and sphingomyelinase activity in mammalian epidermis.
PubMed:Solubilization of bacterial cells in organic solvents via reverse micelles.
PubMed:[Effect of polyoxyethylene (20) sorbitan trioleate (tween 85) on E-rosette formation (in vitro) in blastomatosis patients].
PubMed:The triggering effect of surfaces and surfactants on heat output, oxygen consumption and size reduction of a starving marine Vibrio.
PubMed:[Complex effect of surface-active substances on the process of microbiological hydrocarbon oxidation].
PubMed:Hydrolytic enzymes of Moraxella bovis.
PubMed:Properties of a membrane-bound triglyceride lipase of rapeseed (Brassica napus L.) cotyledons.
PubMed:Studies on 2', 3'-cyclic AMP 3'-phosphohydrolase in rabbit skin.
PubMed:In vivo method for monitoring polysorbate 85 effect on epidermal permeability.
PubMed:Effect of polysorbate 85 on human skin.
 
Notes:
Emulsifier, wetting agent, dispersant, stabiliser, solubiliser Polysorbates are a class of emulsifiers used in some pharmaceuticals and food preparation. They are often used in cosmetics to solubilize essential oils into water-based products. Polysorbates are oily liquids derived from PEG-ylated sorbitan (a derivative of sorbitol) esterified with fatty acids. (Wikipedia)
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