EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

thiourea
methanethiol, 1-amino-1-imino-

Supplier Sponsors

Name:thiourea
CAS Number: 62-56-6Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:200-543-5
FDA UNII: GYV9AM2QAG
Nikkaji Web:J2.351E
Beilstein Number:605327
MDL:MFCD00008067
XlogP3-AA:-0.80 (est)
Molecular Weight:76.12188000
Formula:C H4 N2 S
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:information only not used for fragrances or flavors
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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PubMed:Search
NCBI:Search
FDA Mainterm (SATF):62-56-6 ; THIOUREA--PROHIBITED
FDA Regulation:
FDA PART 189 -- SUBSTANCES PROHIBITED FROM USE IN HUMAN FOOD
Subpart C--Substances Generally Prohibited From Direct Addition or Use as Human Food
Sec. 189.190 Thiourea.
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 182.00 °C. @ 760.00 mm Hg
Boiling Point: 186.00 to 187.00 °C. @ 760.00 mm Hg (est)
Vapor Pressure:0.650000 mmHg @ 25.00 °C. (est)
Flash Point: 152.00 °F. TCC ( 66.80 °C. ) (est)
logP (o/w): -1.050 (est)
Soluble in:
 water, 142000 mg/L @ 25 °C (exp)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
Allan Chemical
Thiourea
Covalent Chemical
Thiourea
EMD Millipore
For experimental / research use only.
Thiourea
sds
Glentham Life Sciences
Thiourea
OQEMA
Thiourea
OQEMA
Thiourea
Penta International
THIOUREA
Sigma-Aldrich
For experimental / research use only.
Thiourea ACS reagent, ≥99.0%
Silver Fern Chemical
Thiourea
Odor: characteristic
Use: Thiourea is used in applications such as photography and photocopying papers, organic synthesis, rubber accelerators, analytical reagents, amino resins, mold inhibitors, and silver cleaning.
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50 125 mg/kg
"Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59Vol. 5, Pg. 177, 1959.

intraperitoneal-rat LD50 436 mg/kg
Food and Cosmetics Toxicology. Vol. 3, Pg. 597, 1965.

intraperitoneal-mouse LD50 100 mg/kg
National Technical Information Service. Vol. AD277-689

intraperitoneal-mammal (species unspecified) LD50 3500 mg/kg
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 30(3), Pg. 42, 1986.

oral-mammal (species unspecified) LDLo 1000 mg/kg
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 30(3), Pg. 42, 1986.

unreported-man LDLo 147 mg/kg
"Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970Vol. 2, Pg. 73, 1970.

oral-rabbit LDLo 6985 mg/kg
"Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59Vol. 5, Pg. 177, 1959.

Dermal Toxicity:
subcutaneous-frog LDLo 10000 mg/kg
"Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59Vol. 5, Pg. 177, 1959.

subcutaneous-guinea pig LDLo 4000 mg/kg
"Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59Vol. 5, Pg. 177, 1959.

Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
information only not used for fragrances or flavors
Recommendation for thiourea usage levels up to:
 not for fragrance use.
 
Recommendation for thiourea flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
NIOSH International Chemical Safety Cards:search
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
Carcinogenic Potency Database:Search
EPA GENetic TOXicology:Search
EPA Substance Registry Services (TSCA):62-56-6
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :2723790
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
thiourea
Chemidplus:0000062566
EPA/NOAA CAMEO:hazardous materials
RTECS:62-56-6
 
References:
 thiourea
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:62-56-6
Pubchem (cid):2723790
Pubchem (sid):134971518
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS):View
CHEBI:View
CHEMBL:View
KEGG (GenomeNet):C14415
HMDB (The Human Metabolome Database):HMDB34155
FooDB:FDB012439
Export Tariff Code:2930.90.5050
ChemSpider:View
Wikipedia:View
Formulations/Preparations:
•thiourea is available in the usa as a lab chemical containing 99% active ingredient. the specifications for a west german commercial product were as follows: 99% minimum active ingredient, 0.15% maximum water, 0.1% maximum ash, 0.4% maximum dicyanodiamide and traces of sulfate ion. •grades: technical; reagent
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
 carbamimidothioic acid
 methanethiol, 1-amino-1-imino-
 thiocarbamide
2-thiopseudourea
beta-thiopseudourea
2-thiourea
 urea, thio- (8CI)
 

Articles:

PubMed:Production of Long-Chain α,ω-Dicarboxylic Acids by Engineered Escherichia coli from Renewable Fatty Acids and Plant Oils.
PubMed:Inhibitory effect of synthetic aromatic heterocycle thiosemicarbazone derivatives on mushroom tyrosinase: Insights from fluorescence, (1)H NMR titration and molecular docking studies.
PubMed:Adsorptive removal of patulin from aqueous solution using thiourea modified chitosan resin.
PubMed:Simultaneous Determination of Five Alkaloid Compounds in a Drug Based on a Hydrophilic Monolithic Column by Capillary Electrochromatography.
PubMed:Chiral ligand-exchange separation and determination of malic acid enantiomers in apple juice by open-tubular capillary electrochromatography.
PubMed:Characterization of a flavin-containing monooxygenase from Corynebacterium glutamicum and its application to production of indigo and indirubin.
PubMed:Synthesis, X-ray, NMR, FT-IR, UV/vis, DFT and TD-DFT studies of N-(4-chlorobutanoyl)-N'-(2-, 3- and 4-methylphenyl)thiourea derivatives.
PubMed:Application of "hydrogen bonding interaction" in new drug development: design, synthesis, antiviral activity, and SARs of thiourea derivatives.
PubMed:Incorporation of graphene oxide nanosheets into boronate-functionalized polymeric monolith to enhance the electrochromatographic separation of small molecules.
PubMed:Meat authentication: a new HPLC-MS/MS based method for the fast and sensitive detection of horse and pork in highly processed food.
PubMed:Oxygenated monoterpenes citral and carvacrol cause oxidative damage in Escherichia coli without the involvement of tricarboxylic acid cycle and Fenton reaction.
PubMed:Uptake and protective effects of ergothioneine in human endothelial cells.
PubMed:Identification of redox-regulated components of arsenate (As(V)) tolerance through thiourea supplementation in rice.
PubMed:Occurrence of the antidiabetic drug Metformin and its ultimate transformation product Guanylurea in several compartments of the aquatic cycle.
PubMed:The PERK-eIF2α signaling pathway is involved in TCDD-induced ER stress in PC12 cells.
PubMed:Differential mechanism of Escherichia coli Inactivation by (+)-limonene as a function of cell physiological state and drug's concentration.
PubMed:Solid phase extraction of trace amounts of silver, cadmium, copper, mercury, and lead in various food samples based on ethylene glycol bis-mercaptoacetate modified 3-(trimethoxysilyl)-1-propanethiol coated Fe3O4 nanoparticles.
PubMed:Combined determination and confirmation of ethylenethiourea and propylenethiourea residues in fruits at low levels of detection.
PubMed:Currently used pesticides and their mixtures affect the function of sex hormone receptors and aromatase enzyme activity.
PubMed:Dispersive liquid-liquid microextraction for the determination of copper in cereals and vegetable food samples using flame atomic absorption spectrometry.
PubMed:Synthesis, insecticidal activities, and SAR studies of novel pyridylpyrazole acid derivatives based on amide bridge modification of anthranilic diamide insecticides.
PubMed:Pleiotropic effect of histamine H4 receptor modulation in the central nervous system.
PubMed:Rapid detection of economic adulterants in fresh milk by liquid chromatography-tandem mass spectrometry.
PubMed:Organocatalytic domino reaction of cyanosulfones: access to complex cyclohexane systems with quaternary carbon centers.
PubMed:In vitro inhibition effect and structure-activity relationships of some saccharin derivatives on erythrocyte carbonic anhydrase I and II.
PubMed:Protein extraction and two-dimensional gel electrophoresis of proteins in the marine mussel Mytilus galloprovincialis: an important tool for protein expression studies, food quality and safety assessment.
PubMed:Human taste receptor-functionalized field effect transistor as a human-like nanobioelectronic tongue.
PubMed:Biosorption of heavy metal ions onto agricultural residues buckwheat hulls functionalized with 1-hydroxylethylidenediphosphonic acid.
PubMed:Determination of Cd (II), Cu (II), and Pb (II) in some foods by FAAS after preconcentration on modified silica gels with thiourea.
PubMed:Growth-inhibiting, bactericidal, and urease inhibitory effects of Paeonia lactiflora root constituents and related compounds on antibiotic-susceptible and -resistant strains of Helicobacter pylori.
PubMed:Hybrid molecules of carvacrol and benzoyl urea/thiourea with potential applications in agriculture and medicine.
PubMed:Metamorphosis inhibition: an alternative rearing protocol for the newt, Cynops pyrrhogaster.
PubMed:Proteomic profiling of the rat hypothalamus.
PubMed:Design, synthesis, synergistic antimicrobial activity and cytotoxicity of 4-aryl substituted 3,4-dihydropyrimidinones of curcumin.
PubMed:Genetic influences on oral fat perception and preference: Presented at the symposium "The Taste for Fat: New Discoveries on the Role of Fat in Sensory Perception, Metabolism, Sensory Pleasure and Beyond" held at the Institute of Food Technologists 2011 Annual Meeting, New Orleans, LA, June 12, 2011.
PubMed:Responsiveness to 6-n-propylthiouracil (PROP) is associated with salivary levels of two specific basic proline-rich proteins in humans.
PubMed:A novel ionic liquid monolithic column and its separation properties in capillary electrochromatography.
PubMed:Purification and characterisation of polyphenol oxidase from leaves of Cleome gynandra L.
PubMed:Ultrasensitive and selective colorimetric detection of thiourea using silver nanoprobes.
PubMed:Modification of norfloxacin by a Microbacterium sp. strain isolated from a wastewater treatment plant.
PubMed:A rapid and environmental friendly determination of the dithiocarbamate metabolites ethylenethiourea and propylenethiourea in fruit and vegetables by ultra high performance liquid chromatography tandem mass spectrometry.
PubMed:Ultra trace analysis of small molecule by label-free impedimetric immunosensor using multilayer modified electrode.
PubMed:Phenylaminopropyl-functionalized stationary phase for open-tubular capillary electrochromatography of alkaloids and aromatic acids.
PubMed:The chemopreventive effect of dimethylthiourea against carmustine-induced myelotoxicity in rats.
PubMed:A simple spectrophotometric method for the determination of phosphate in soil, detergents, water, bone and food samples through the formation of phosphomolybdate complex followed by its reduction with thiourea.
PubMed:Genetic variation in taste perception: does it have a role in healthy eating?
PubMed:Preparation of organic-inorganic hybrid silica monolith with octyl and sulfonic acid groups for capillary electrochromatograhpy and application in determination of theophylline and caffeine in beverage.
PubMed:Screening the bio-safety of wheat produced from pretreated grains to enhance tolerance against drought using physiological and spectroscopic methods.
PubMed:Variation in the gene TAS2R38 is associated with the eating behavior disinhibition in Old Order Amish women.
PubMed:Genetic variation in taste sensitivity to 6-n-propylthiouracil and its relationship to taste perception and food selection.
PubMed:Slurry sampling flow injection chemical vapor generation inductively coupled plasma mass spectrometry for the determination of As, Cd, and Hg in cereals.
PubMed:Cytotoxic activity of acridin-3,6-diyl dithiourea hydrochlorides in human leukemia line HL-60 and resistant subline HL-60/ADR.
PubMed:Short photoperiod-induced decrease of histamine H3 receptors facilitates activation of hypothalamic neurons in the Siberian hamster.
PubMed:The role of histamine 3 receptors in the control of food intake in a seasonal model of obesity: the Siberian hamster.
PubMed:Synthesis and antiviral activities of chiral thiourea derivatives containing an alpha-aminophosphonate moiety.
PubMed:The pharmacological properties of a novel MCH1 receptor antagonist isolated from combinatorial libraries.
PubMed:Mercury speciation in sea food by flow injection cold vapor atomic absorption spectrometry using selective solid phase extraction.
PubMed:Protein-protein interactions during high-moisture extrusion for fibrous meat analogues and comparison of protein solubility methods using different solvent systems.
PubMed:Comparison of the effect of an H(3)-inverse agonist on energy intake and hypothalamic histamine release in normal mice and leptin resistant mice with high fat diet-induced obesity.
PubMed:Online YPA4 resin microcolumn separation/preconcentration coupled with inductively coupled plasma optical emission spectrometry (ICP-OES) for the speciation analysis of mercury in seafood.
PubMed:Synthetic pyrazole derivatives as growth inhibitors of some phytopathogenic fungi.
PubMed:[Changes in H2O2 and salicylic acid contents as well as plasma membrane H+-ATPase activity and their relations in pea leaves during thermotolerance induction].
PubMed:A synchronized amphibian metamorphosis assay as an improved tool to detect thyroid hormone disturbance by endocrine disruptors and apolar sediment extracts.
PubMed:S-allylcysteine scavenges singlet oxygen and hypochlorous acid and protects LLC-PK(1) cells of potassium dichromate-induced toxicity.
PubMed:Development of a new high performance low pressure chromatographic system using a multisyringe burette coupled to a chromatographic monolithic column.
PubMed:Endogenous thyroid hormone synthesis in facultative planktotrophic larvae of the sand dollar Clypeaster rosaceus: implications for the evolutionary loss of larval feeding.
PubMed:Determination of trace hydroxyl radicals by flow injection spectrofluorometry and its analytical application.
PubMed:Effect of storage, processing and cooking on glucosinolate content of Brassica vegetables.
PubMed:Felinine stability in the presence of selected urine compounds.
PubMed:Radical scavenging activities of alpha-alanine C60 adduct.
PubMed:Comparison of DNA fingerprinting methods for use in investigation of type E botulism outbreaks in the Canadian Arctic.
PubMed:Efficient solubilization buffers for two-dimensional gel electrophoresis of acidic and basic proteins extracted from wheat seeds.
PubMed:Development of time-resolved chemiluminescence for the determination of antu in river water, wheat, barley, and oat grain samples.
PubMed:Biochemical and biophysical changes induced by fungicide sodium diethyl dithiocarbamate (SDD), in phytocystatin purified from Phaseolus mungo (Urd): a commonly used Indian legume.
PubMed:Determination of ethylenethiourea (ETU) and propylenethiourea (PTU) in foods by high performance liquid chromatography-atmospheric pressure chemical ionisation-medium-resolution mass spectrometry.
PubMed:Polyphenols: factors influencing their sensory properties and their effects on food and beverage preferences.
PubMed:Evaluation of a new biosensor-based mushroom (Agaricus bisporus) tissue homogenate: investigation of certain phenolic compounds and some inhibitor effects.
PubMed:Effects of long-term inhibition of neuronal nitric oxide synthase (NOS1) in uninephrectomized diabetic rats.
PubMed:Elicitor-induced nitric oxide burst is essential for triggering catharanthine synthesis in Catharanthus roseus suspension cells.
PubMed:Sodium channels are required during in vivo sodium chloride hyperosmolarity to stimulate increase in intestinal endothelial nitric oxide production.
PubMed:Heterochronic developmental shift caused by thyroid hormone in larval sand dollars and its implications for phenotypic plasticity and the evolution of nonfeeding development.
PubMed:Antioxidant activity of thioureidic derivatives I.
PubMed:Plasma vitamin A and C status of in-school adolescents and associated factors in Enugu State, Nigeria.
PubMed:Accelerated degradation of methyl iodide by agrochemicals.
PubMed:Ameliorative role of nitric oxide on H2O2 toxicity to a chlorophycean alga Scenedesmus obliquus.
PubMed:Oxidative stress response of rat testis to model prooxidants in vitro and its modulation.
PubMed:Decontamination of aflatoxin-forming fungus and elimination of aflatoxin mutagenicity with electrolyzed NaCl anode solution.
PubMed:Iron-induced oxidative stress up-regulates calreticulin levels in intestinal epithelial (Caco-2) cells.
PubMed:Resveratrol and a novel tyrosinase in Carignan grape juice.
PubMed:Analytical and Sensory Characterization of gamma- and delta-Thiolactones.
PubMed:Degradation of ethylene thiourea (ETU) with three fenton treatment processes.
PubMed:Evidence for the involvement of N-methylthiourea, a ring cleavage metabolite, in the hepatotoxicity of methimazole in glutathione-depleted mice: structure-toxicity and metabolic studies.
PubMed:Thermal degradation of sulforaphane in aqueous solution.
PubMed:Comparison of yeast cell protein solubilization procedures for two-dimensional electrophoresis.
PubMed:Toxicity study of a rubber antioxidant, 2-mercaptobenzimidazole, by repeated oral administration to rats.
PubMed:The protective role of some antioxidants and scavengers on the free radicals-induced inhibition of the liver iodothyronine 5'-monodeiodinase activity and thiols content.
PubMed:Headspace gas-liquid chromatographic determination of dithiocarbamate residues in fruits and vegetables with confirmation by conversion to ethylenethiourea.
PubMed:Lethality induced by stannous chloride on Escherichia coli AB1157: participation of reactive oxygen species.
PubMed:Cisplatin- and carboplatin-DNA adducts: is PT-AG the cytotoxic lesion?
PubMed:Effects of thiourea and ammonium bicarbonate on the formation and stability of bifunctional cisplatin-DNA adducts: consequences for the accurate quantification of adducts in (cellular) DNA.
PubMed:Does the histaminergic system mediate bombesin/GRP-induced suppression of food intake?
PubMed:Assessment of contact sensitivity of four thiourea rubber accelerators: comparison of two mouse lymph node assays with the guinea pig maximization test.
PubMed:DNA breakage by tannic acid and Cu(II): sequence specificity of the reaction and involvement of active oxygen species.
PubMed:[Determination of total arsenic in food by borohydride reduction colorimetric method].
PubMed:Delayed onset and decreased incidence of diabetes in BB rats fed free radical scavengers.
PubMed:Confirmation of domoic acid in shellfish using butyl isothiocyanate and reversed-phase liquid chromatography.
PubMed:Comparative studies on the effect of noxythiolin and other thioureas on the thyroid using in vitro and in vivo models of thyroid function.
PubMed:Effects of dimethylthiourea on chronic hypoxia-induced pulmonary arterial remodelling and ventricular hypertrophy in rats.
PubMed:Effect of diet particle size and feeding of H2-receptor antagonists on gastric ulcers in swine.
PubMed:Gastric antisecretory properties of SCH 32651.
PubMed:[Problems in the determination of small ethylenethiourea residue concentrations in plant crops].
PubMed:The effect of histamine, H1 and H2 agonists, and H1 and H2 antagonists on postprandial pancreatic polypeptide release in dogs.
PubMed:Apparent irreversible H2-receptor blocking and prolonged gastric antisecretory activities of 3-N-(3-[3-(1-piperidinomethyl)phenoxy]propyl) amino-4-amino-1,2,5-thiadiazole-1-oxide (L-643, 441).
PubMed:A capillary gas-liquid chromatographic method for determination of ethylenethiourea and prophylenethiourea in hops, beer, and grapes.
PubMed:Gastric lesions and feeding: effects of food and water deprivation and metiamide.
PubMed:[Comparative studies of food product contamination with carcinogenic aromatic polycyclic hydrocarbons (APH) in the USSR and the GDR (defining the problem)].
PubMed:Residues of four ethylenebis(dithiocarbamates) and their decomposition products on field-sprayed tomatoes.
PubMed:Uptake of ethylenebis(dithiocarbamate) fungicides and ethylenethiourea by soybeans.
PubMed:Behavior and fate of ethylenethiourea in plants.
PubMed:Potential carcinogenicity of food additives and contaminants.
PubMed:Metiamide: an antagonist of histamine-stimulated gastric acid secretion.
PubMed:The effects of metiamide on the "activity-stress" ulcer in rats.
PubMed:Effects of prolonged ethylene thiourea ingestion on the thyroid of the rat.
PubMed:Preliminary survey of ethylenethiourea residues in the Canadian food supply, 1972.
PubMed:The effect of histamine H2-receptor blockade with metiamide on serum gastrin levels in man.
PubMed:The effect of an H2-receptor antagonist on food-stimulated acid secretion, serum gastrin, and gastric emptying in patients with duodenal ulcers. Comparison with an anticholinergic drug.
PubMed:Analysis of residues of degradation products of ethylene-bis-dithiocarbamates.
PubMed:The search for positive goitrogenic agents.
PubMed:Effect of H2 receptor antagonists on histidine decarboxylase activity in rat gastric mucosa.
PubMed:Effect of metiamide, a histamine H2-receptor antagonist, on mucosal blood flow and serum gastrin level.
PubMed:[Morphometry of endocrine organs. 1. Karyometry of the chicken thyroid gland following administration of zinc and bismuth complexes of substituted bisthiourea].
PubMed:[Creation of a stress-free laying pause in turkeys with TURISYNCHRON].
PubMed:[Pharmacologic-endocrinological findings in animal experiments with TURISYNCHRON and SUISYNCHRON. 4. Analysis of residuals in pig carcasses].
PubMed:[Paper chromatographic and polarographic determination of ethylene thiourea residues in food].
PubMed:H2-receptor blockade and stimulation of histidine decarboxylase.
PubMed:The formation of carcinogenic nitroso compounds from nitrite and some types of agricultural chemicals.
PubMed:Determination of ethylenethiourea residues in apples.
PubMed:[Examination of foodstuffs for health-endangering residues].
PubMed:The insecticidal and the anticholinesterase activity of meta-acylamidophenyl and meta-thioureidophenyl N-methylcarbamates.
PubMed:Determination of ethylene thiourea residues in foods, using thin layer and gas chromatography.
PubMed:[Identification and quantitative determination of certain dialkyldithiocarbamates and products of their metabolism in various substances of plant and animal origin].
PubMed:Effect of prolonged individual caging on toxicity parameters in rats.
PubMed:NATURAL, METALLIC AND OTHER SUBSTANCES, AS CARCINOGENS.
PubMed:[EFFECTIVENESS OF ZIRAM (ZINC DIMETHYDITHIOCARBAMATE) ON THE BEDS OF RIVER MOLLUSCA AND TOXICITY FOR FISH].
PubMed:The effect of methylthiouracyl on food intake and selection.
PubMed:Influence of thiourea on organ weights of rats as related to food intake.
 
Notes:
a photographic fixative used also in the manufacture of resins. according to the fourth annual report on carcinogens (ntp 85-002, 1985), this substance may reasonably be anticipated to be a carcinogen (merck index, 9th ed). many of its derivatives are antithyroid agents and/or free radical scavengers. Prohibited from use in food Another common application for use of thiourea is a common sulfur source for making semiconductor cadmium sulfide nanoparticle. A slurry of 1 g cadmium sulfate (1.3 mmol), 0.5 g thiourea (6.6 mmol), and 0.1 g SiO2 (1.7 mmol) were sonicated for 3 hours under ambient air at room temperature. The colorless slurry solution changes to yellow indicating the generation of CdS.; Thiourea is a planar molecule. The C=S bond distance is 1.60±0.1 Å for a wide range of derivatives. This narrow range indicates that the C=S bond is insensitive to the nature of the substitutent. Thus, the thioamide, which is similar to an amide group, is difficult to perturb.; Thiourea is an organic compound of carbon, nitrogen, sulfur and hydrogen, with the formula CSN2H4 or (NH2)2CS. It is similar to urea, except that the oxygen atom is replaced by a sulfur atom. The properties of urea and thiourea differ significantly because of the relative electronegativities of sulfur and oxygen. Thiourea is a versatile reagent in organic synthesis. "Thioureas" refers to a broad class of compounds with the general structure (R1R2N)(R3R4N)C=S. Thioureas are related to thioamides, e.g. RC(S)NR2, where R is methyl, ethyl, etc.; Thiourea reduces peroxides to the corresponding diols. The intermediate of the reaction is an unstable epidioxide which can only be identified at -100 °C. Epidioxide is similar to epoxide except with two oxygen atoms. This intermediate reduces to diol by thiourea.
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