EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

suberic acid
hexamethylenedicarboxylic acid

Supplier Sponsors

Name:octanedioic acid
CAS Number: 505-48-6Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:208-010-9
FDA UNII: 6U7Y4M9C1H
Nikkaji Web:J6.225A
Beilstein Number:1210161
MDL:MFCD00004428
XlogP3:1.00 (est)
Molecular Weight:174.19638000
Formula:C8 H14 O4
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:pharmaceuticals / chemical synthisis
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Appearance:colorless crystalline solid (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 144.00 °C. @ 760.00 mm Hg
Boiling Point: 345.50 °C. @ 760.00 mm Hg
Flash Point: 368.00 °F. TCC ( 186.50 °C. ) (est)
logP (o/w): 0.687 (est)
Soluble in:
 water, 1.19E+04 mg/L @ 25 °C (exp)
 water, 1.35e+004 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
BOC Sciences
For experimental / research use only.
Suberic acid
EMD Millipore
For experimental / research use only.
Octanedioic acid
sds
Penta International
SUBERIC ACID
Santa Cruz Biotechnology
For experimental / research use only.
Suberic Acid 99%
Sigma-Aldrich: Aldrich
For experimental / research use only.
Suberic Acid 98%
sds
SysKem Chemie
Suberic Acid
TCI AMERICA
For experimental / research use only.
Suberic Acid >99.0%(GC)(T)
sds
Vistachem
Suberic Acid
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
pharmaceuticals / chemical synthisis
Recommendation for suberic acid usage levels up to:
 not for fragrance use.
 
Recommendation for suberic acid flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):505-48-6
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :10457
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:1
octanedioic acid
Chemidplus:0000505486
 
References:
 octanedioic acid
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:505-48-6
Pubchem (cid):10457
Pubchem (sid):134976295
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
Golm Metabolome Database:Search
Metabolomics Database:Search
KEGG (GenomeNet):C08278
HMDB (The Human Metabolome Database):HMDB00893
FooDB:FDB003340
Export Tariff Code:2917.19.1700
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 bean green bean root
Search Trop Picture
 
Synonyms:
 carboxylic acids, di-, C4-11
 cork acid
 hexamethylenedicarboxylic acid
 hexane-1,6-dicarboxylic acid
1,6-hexanedicarboxylic acid
 octane-1,8-dioic acid
 octanedioic acid
1,8-octanedioic acid
 octanedioicacid
 subericacid
 

Articles:

PubMed:Novel Synthesis of Anionic Gemini Surfactants from 1, 4-Diol as a Key Block Material.
PubMed:Investigation on the antidepressant effect of sea buckthorn seed oil through the GC-MS-based metabolomics approach coupled with multivariate analysis.
PubMed:Human sweat metabolomics for lung cancer screening.
PubMed:Integrated engineering of β-oxidation reversal and ω-oxidation pathways for the synthesis of medium chain ω-functionalized carboxylic acids.
PubMed:Optimized protocol for protein macrocomplexes stabilization using the EDC, 1-ethyl-3-(3-(dimethylamino)propyl)carbodiimide, zero-length cross-linker.
PubMed:Identification and antifungal activity of novel organic compounds found in cuticular and internal lipids of medically important flies.
PubMed:Synthesis and Biological Evaluation of 5'-O-Dicarboxylic Fatty Acyl Monoester Derivatives of Anti-HIV Nucleoside Reverse Transcriptase Inhibitors.
PubMed:Metabonomic analysis of quercetin against the toxicity of chronic exposure to low-level dichlorvos in rats via ultra-performance liquid chromatography-mass spectrometry.
PubMed:A histone deacetylase inhibitor YCW1 with antitumor and antimetastasis properties enhances cisplatin activity against non-small cell lung cancer in preclinical studies.
PubMed:Identification of unknown impurity of azelaic acid in liposomal formulation assessed by HPLC-ELSD, GC-FID, and GC-MS.
PubMed:Biochemical and structural studies of the oligomerization domain of the Nipah virus phosphoprotein: evidence for an elongated coiled-coil homotrimer.
PubMed:Functionalized nanospheres for targeted delivery of paclitaxel.
PubMed:Real time in situ chemical characterization of sub-micron organic aerosols using Direct Analysis in Real Time mass spectrometry (DART-MS): the effect of aerosol size and volatility.
PubMed:Application of ultraperformance liquid chromatography/mass spectrometry-based metabonomic techniques to analyze the joint toxic action of long-term low-level exposure to a mixture of organophosphate pesticides on rat urine profile.
PubMed:Metabonomics evaluation of urine from rats administered with phorate under long-term and low-level exposure by ultra-performance liquid chromatography-mass spectrometry.
PubMed:Metabonomics analysis of urine and plasma from rats given long-term and low-dose dimethoate by ultra-performance liquid chromatography-mass spectrometry.
PubMed:Peroxisomal L-bifunctional enzyme (Ehhadh) is essential for the production of medium-chain dicarboxylic acids.
PubMed:A comparative study on mechanical and biochemical properties of bovine pericardium after single or double crosslinking treatment.
PubMed:Bidirectional solid phase synthesis of a model oligoglycine bolaamphiphile and purification by rapid self-assembly.
PubMed:Development of controlled release formulations of imidacloprid employing novel nano-ranged amphiphilic polymers.
PubMed:Formation of octacalcium phosphates with co-incorporated succinate and suberate ions.
PubMed:Structure-based design, synthesis and structure-activity relationships of dibenzosuberyl- and benzoate-substituted tropines as ligands for acetylcholine-binding protein.
PubMed:Bioconjugation of protein-repellent zwitterionic polymer brushes grafted from silicon nitride.
PubMed:Metabolomic analysis of the toxic effects of chronic exposure to low-level dichlorvos on rats using ultra-performance liquid chromatography-mass spectrometry.
PubMed:B vitamin supplementation reduces excretion of urinary dicarboxylic acids in autistic children.
PubMed:Design, synthesis, docking, and biological evaluation of novel diazide-containing isoxazole- and pyrazole-based histone deacetylase probes.
PubMed:Study of the GC-MS determination of the palmitic-stearic acid ratio for the characterisation of drying oil in painting: La Encarnación by Alonso Cano as a case study.
PubMed:Synthesis, crystal structure and photoelectric property of two new coordination polymers constructed by longer-spanning suberic acid and 4,4'-bipyridine ligands.
PubMed:Synthesis and biological evaluation of triazol-4-ylphenyl-bearing histone deacetylase inhibitors as anticancer agents.
PubMed:Preparation of polycarboxylic acids by oxidative cleavage with oxygen / Co-Mn-Br system.
PubMed:2,2'-Hexamethyl-enedi-1,3-benzothia-zole.
PubMed:Chitosan salts coated with stearic acid as colon-specific delivery systems for vancomycin.
PubMed:A series of potent and selective, triazolylphenyl-based histone deacetylases inhibitors with activity against pancreatic cancer cells and Plasmodium falciparum.
PubMed:Effect of cross-linker length on the stability of hemoglobin.
PubMed:Immobilization of a bone and cartilage stimulating peptide to a synthetic bone graft.
PubMed:[Isolation and structure identification of chemical constituents from the skin of Bufo bufo gargarizans].
PubMed:Tyrosine-derived nanospheres for enhanced topical skin penetration.
PubMed:Squalene-derived flexible linkers for bioactive peptides.
PubMed:Ruthenium-catalyzed oxidation of alkenes, alkynes, and alcohols to organic acids with aqueous hydrogen peroxide.
PubMed:Solid-state preparation of hybrid organometallic-organic macrocyclic adducts with long chain dicarboxylic acids.
PubMed:Controlled synthesis of (S,S)-2,7-diaminosuberic acid: a method for regioselective construction of dicarba analogues of multicystine-containing peptides.
PubMed:The comparative metabonomics of age-related changes in the urinary composition of male Wistar-derived and Zucker (fa/fa) obese rats.
PubMed:Antifungal and new metabolites of Myrothecium sp. Z16, a fungus associated with white croaker Argyrosomus argentatus.
PubMed:Investigation into the erosion mechanism of salicylate-based poly(anhydride-esters).
PubMed:Hydrophobic drug delivery by self-assembling triblock copolymer-derived nanospheres.
PubMed:Concerning the origin of 19F-19F NMR COSY and NOESY connections in the spectra of perfluorooctanoic acid, R(F)-palmitic acid-F13 and diethyl perfluorosuberate.
PubMed:Aliphatic amino diacid Asu functions as an effective mimic of Tyr(SO3H) in sulfakinins for myotropic and food intake-inhibition activity in insects.
PubMed:[Late-onset riboflavin-responsive multiple acyl-CoA dehydrogenase deficiency (glutaric aciduria type II)].
PubMed:Development of antibodies for the detection of N-acetyl-glufosinate.
PubMed:The histone deacetylase inhibitor suberic bishydroxamate: a potential sensitizer of melanoma to TNF-related apoptosis-inducing ligand (TRAIL) induced apoptosis.
PubMed:Protease inhibitors: synthesis of bacterial collagenase and matrix metalloproteinase inhibitors incorporating arylsulfonylureido and 5-dibenzo-suberenyl/suberyl moieties.
PubMed:Synthesis of D-mannitol and L-iditol derivatives as monomers for the preparation of new regioregular AABB-type polyamides.
PubMed:Average structure of the composite crystal urea/octanedioic acid at room temperature within the superspace formalism.
PubMed:The first case of 4-hydroxybutyric aciduria in Japan.
PubMed:Anti-malarial effect of histone deacetylation inhibitors and mammalian tumour cytodifferentiating agents.
PubMed:A new HPLC method for the direct analysis of triglycerides of dicarboxylic acids in biological samples.
PubMed:A GC/MS/MS screening method for multiple organic acidemias from urine specimens.
PubMed:Adsorption of small hydroxy acids on glass: a pitfall in quantitative urinary organic acid analysis by GC-MS.
PubMed:Prolyl endopeptidase inhibitors from the underground part of Rhodiola sacra S. H. Fu.
PubMed:Resolution of DL-2-aminosuberic acid via protease-catalyzed ester hydrolysis.
PubMed:Mechanisms of peroxisome proliferation by perfluorooctanoic acid and endogenous fatty acids.
PubMed:Analytical strategies in the structural characterization of elcatonin.
PubMed:Amide cross-linking: an alternative to glutaraldehyde fixation.
PubMed:Extraction of mono- and dicarboxylic acids from a curative water.
PubMed:Polymethylene spacer linked bis(Ala) peptides form modified beta-sheet structures. Crystal structure and self-assembly pattern of adipoyl and suberoyl analogues.
PubMed:Structure of suberic acid at 18.4, 75 and 123 K from neutron diffraction data.
PubMed:Measurements of urinary adipic acid and suberic acid using high-performance liquid chromatography.
PubMed:Bissulfosuccinimidyl esters of aliphatic dicarboxylic acids: a new class of 'affinity directed' beta beta crosslinkers of HbA.
PubMed:Excretion of 3,6-epoxydicarboxylic acids in peroxisomal disorders.
PubMed:Kinetics and thermogenesis of medium-chain monocarboxylic and dicarboxylic acids in man: sebacate and medium-chain triglycerides.
PubMed:[Chemical constituents from the bark of Hibiscus syriacus L].
PubMed:Isolation of the rhabdomeral microvillar cytoskeleton of the crayfish (Orconectes limosus) photoreceptor by a crosslinking reagent.
PubMed:Azelaic and pimelic acids: metabolic intermediates or artefacts?
PubMed:Potent cytodifferentiating agents related to hexamethylenebisacetamide.
PubMed:Tissue uptake and oxidation of disodium sebacate in man.
PubMed:International Standards for salmon calcitonin, eel calcitonin, and the Asu1-7 analogue of eel calcitonin: calibration by international collaborative study.
PubMed:Metabolism of dicarboxylic acids in rat hepatocytes.
PubMed:Organic acid and acylcarnitine profiles of glutaric aciduria type I.
PubMed:Biological activity of different calcitonins in men.
PubMed:Noncyclic vasopressin analogs are effective diuretics in conscious rats.
PubMed:A novel biosynthesis of medium chain length alpha-ketodicarboxylic acids in methanogenic archaebacteria.
PubMed:[Studies on the constituents of trichosanthes root. III. Constituents of roots of Trichosanthes bracteata Voigt].
PubMed:[Studies on the constituents of trichosanthes root. I. Constituents of roots of Trichosanthes kirilowii Maxim. var. japonicum Kitam].
PubMed:Interrelationships between the imprinting potential and biological activity of insulin derivatives: studies on Tetrahymena and Chang liver cells.
PubMed:[Chemical modification of ristomycin A with bifunctional reagents].
PubMed:Metabolism of dicarboxylic acids in vivo and in the perfused kidney of the rat.
PubMed:The influence of i.v. MCT and carnitine on the excretion of dicarboxylic acids.
PubMed:The influence of intravenous medium- and long-chain triglycerides and carnitine on the excretion of dicarboxylic acids.
PubMed:In vitro studies on the oxidation of medium-chain dicarboxylic acids in rat liver.
PubMed:Development of specific and non-specific somatostatin analogs.
PubMed:Structure-activity relationship of bufotoxins and related compounds for the inhibition of Na+, K+ -adenosine triphosphatase.
PubMed:Composition and peptide maps of cross-linked human choriogonadotropin-receptor complexes on porcine granulosa cells.
PubMed:Urinary excretion of dicarboxylic acids from patients with the Zellweger syndrome. Importance of peroxisomes in beta-oxidation of dicarboxylic acids.
PubMed:Prenatal diagnosis of glutaric aciduria type II by direct chemical analysis of dicarboxylic acids in amniotic fluid.
PubMed:A new patient with dicarboxylic aciduria suggestive of medium-chain Acyl-CoA dehydrogenase deficiency presenting as Reye's syndrome.
PubMed:On the effect of aliphatic saturated dicarboxylic acids on anaerobic glycolysis in chicken embryo.
PubMed:Organic acids or urine in multiple sclerosis.
PubMed:On the biologic origin of C6-C10-dicarboxylic and C6-C10-omega-1-hydroxy monocarboxylic acids in human and rat with acyl-CoA dehydrogenation deficiencies: in vitro studies on the omega- and omega-1-oxidation of medium-chain (C6-C12) fatty acids in human and rat liver.
PubMed:Abnormal metabolism of valproic acid in fatal hepatic failure.
PubMed:General (medium-chain) acyl-CoA dehydrogenase deficiency (non-ketotic dicarboxylic aciduria): quantitative urinary excretion pattern of 23 biologically significant organic acids in three cases.
PubMed:Acute valproate intoxication: biochemical investigations and hemodialysis treatment.
PubMed:Microbial transformation of bile acids. A unified scheme for bile acid degradation, and hydroxylation of bile acids.
PubMed:C6--C10-dicarboxylic aciduria in starved, fat-fed and diabetic rats receiving decanoic acid or medium-chain triacylglycerol. An in vivo measure of the rate of beta-oxidation of fatty acids.
PubMed:Urinary excretion of C4--C10-dicarboxylic acids and antiketogenic properties of adipic acid in ketogenic-stimulated rats due to diabetes, long-chain and short-chain monocarboxylic acids.
PubMed:Adenylate cyclase activation and competitive binding with renal tissue using synthetic eel calcitonin analog and its fragments.
PubMed:Dicarboxylic aciduria during ketotic phases in various types of glycogen storage disease.
PubMed:The occurrence of C6--C10-dicarboxylic acids in urine from patients and rats treated with dipropylacetate.
PubMed:Excretion of short-chain N-acylglycines in the urine of a patient with D-glyceric acidemia.
PubMed:Non-ketotic C6-C10-dicarboxylic aciduria: biochemical investigations of two cases.
PubMed:The excretion of C6-C10-dicarboxylic acids in the urine of newborn infants during starvation. Evidence for omega-oxidation of fatty acids in the newborn.
PubMed:Dicarboxylic aciduria: the response to fasting.
PubMed:Urinary metabolites of cis-9,10-methylene octadecanoic acid. cis-3,4-Methylene hexanedioic acid and related compounds.
PubMed:Rat urinary metabolites of [9,10-methylene-14C] sterculic acid.
PubMed:[Effect of cholinesterase inhibition on nicotinic effects of dicholine and monocholine esters of suberic acid in experiments on cats].
PubMed:[Kinetics of enzymatic hydrolysis of quaternary aminoalkyl esters of aromatic mono- and dicarboxylic acids by butyrylcholinesterase from horse serum].
PubMed:[Enzymatic hydrolysis and reversible binding of suberyldicholine by cholinesterases].
PubMed:Urinary excretion of n-hexanedioic and n-octanedioic acid in juvenile diabetics with ketonuria.
PubMed:The occurrence of adipic and suberic acid in urine from ketotic patients.
PubMed:[Reflex stimulation on respiration with dicholine ester of suberic acid].
PubMed:Investigation of some complexes formed in solution by caffeine. V. Interactions between caffeine and p-aminobenzoic acid, m-hydroxybenzoic acid, picric acid, o-phthalic acid, suberic acid, and valeric acid.
PubMed:The 'turn over' transition of suberic acid.
PubMed:A convenient preparation of suberic acid; concerning the homogeneity and use in synthesis of polymethylene chlorobromide preparations.
PubMed:SEROLOGICAL REACTIONS WITH SIMPLE CHEMICAL COMPOUNDS (PRECIPITIN REACTIONS).
 
Notes:
used in plastics industry; inhibits activity of some enzymes. Isol. from the roots of Phaseolus vulgaris (kidney bean) Suberic acid, also octanedioic acid, is a dicarboxylic acid, with formula C6H12(COOH)2. It is present in the urine of patients with Fatty Acid Oxidation Disorders (PMID 10404733); ; A metabolic breakdown product derived from oleic acid. Elevated levels of this unstaruated dicarboxylic acid are found in individuals with dicarboxylic acid and medium-chain acyl-CoA dehydrogenase deficiency (MCAD)
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