EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes

sodium thiocyanate
thiocyanic acid, sodium salt (1:1)

Supplier Sponsors

CAS Number: 540-72-7Picture of molecule3D/inchi
Other(deleted CASRN):104345-12-2
ECHA EINECS - REACH Pre-Reg:208-754-4
FDA UNII: 5W0K9HKA05
Nikkaji Web:J44.071J
Beilstein Number:3594965
MDL:MFCD00011123
Molecular Weight:81.07276928
Formula:C N Na S
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:preservatives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 FDA/DG SANTE Petitions, Reviews, Notices:
GRN 688 Sodium thiocyanate View - notice PDF
GRN 753 Sodium thiocyanate View - notice PDF
JECFA Food Additive: Sodium Thiocyanate
FDA Mainterm (IAUFC):540-72-7 ; SODIUM THIOCYANATE
 
Physical Properties:
Appearance:colorless crystals (est)
Assay: 99.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 287.00 °C. @ 760.00 mm Hg
Boiling Point: 146.00 °C. @ 760.00 mm Hg (est)
Vapor Pressure:4.730000 mmHg @ 25.00 °C. (est)
Flash Point: 108.00 °F. TCC ( 42.10 °C. ) (est)
logP (o/w): 0.580 (est)
Soluble in:
 water, 580000 mg/L @ 25 °C (exp)
 alcohol
 acetone
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: hair conditioning
 
Suppliers:
American Elements
Sodium Thiocyanate 99%
Odor: characteristic
Use: Sodium Thiocyanate is generally immediately available in most volumes. High purity, submicron and nanopowder forms may be considered. We also produce Sodium Thiocyanate Solution. American Elements produces to many standard grades when applicable, including Mil Spec (military grade); ACS, Reagent and Technical Grade; Food, Agricultural and Pharmaceutical Grade; Optical Grade, USP and EP/BP (European Pharmacopoeia/British Pharmacopoeia) and follows applicable ASTM testing standards.
American International Chemical, LLC.
Sodium Thiocyanate
BOC Sciences
For experimental / research use only.
Sodium thiocyanate
Charkit Chemical
SODIUM THIOCYANATE CRYSTALS
Covalent Chemical
Sodium Thiocyanate
EMD Millipore
For experimental / research use only.
Sodium Thiocyanate
sds
Glentham Life Sciences
Sodium thiocyanate
Santa Cruz Biotechnology
For experimental / research use only.
Sodium Thiocyanate ≥99%
Sigma-Aldrich: Aldrich
For experimental / research use only.
Sodium thiocyanate ≥99.99% trace metals basis
sds
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50 764 mg/kg
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 29, Pg. 152, 1940.

intraperitoneal-rat LD50 540 mg/kg
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: TREMOR BEHAVIORAL: EXCITEMENT
Journal of Pharmacology and Experimental Therapeutics. Vol. 96, Pg. 416, 1949.

oral-mouse LD50 362 mg/kg
"Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 106, 1982.

intravenous-mouse LD50 484 mg/kg
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 29, Pg. 152, 1940.

intravenous-dog LDLo 100 mg/kg
GASTROINTESTINAL: NAUSEA OR VOMITING
Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 169, Pg. 429, 1933.

intraperitoneal-guinea pig LDLo 500 mg/kg
BEHAVIORAL: EXCITEMENT BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)
Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 169, Pg. 429, 1933.

oral-guinea pig LDLo 600 mg/kg
Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 29, Pg. 152, 1940.

intraperitoneal-mouse LD50 500 mg/kg
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE)
Japanese Journal of Pharmacology. Vol. 3, Pg. 99, 1954.

intravenous-rabbit LDLo 100 mg/kg
Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 169, Pg. 429, 1933.

oral-rabbit LDLo 750 mg/kg
Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 169, Pg. 429, 1933.

intratracheal-rat LD50 232 mg/kg
"Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 106, 1982.

Dermal Toxicity:
subcutaneous-guinea pig LDLo 500 mg/kg
Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 29, Pg. 152, 1940.

subcutaneous-mouse LDLo 400 mg/kg
Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 29, Pg. 152, 1940.

subcutaneous-rabbit LDLo 200 mg/kg
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD AUTONOMIC NERVOUS SYSTEM: OTHER (DIRECT) PARASYMPATHOMIMETIC BEHAVIORAL: FOOD INTAKE (ANIMAL)
Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 152, Pg. 250, 1930.

Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
preservatives
Recommendation for sodium thiocyanate usage levels up to:
 not for fragrance use.
 
Recommendation for sodium thiocyanate flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
NIOSH International Chemical Safety Cards:search
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
Carcinogenic Potency Database:Search
EPA Substance Registry Services (TSCA):540-72-7
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :516871
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:1
sodium thiocyanate
Chemidplus:0000540727
EPA/NOAA CAMEO:hazardous materials
RTECS:540-72-7
 
References:
 sodium thiocyanate
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:540-72-7
Pubchem (cid):516871
Pubchem (sid):134975740
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Indirect Additives used in Food Contact Substances:View
CHEBI:View
CHEMBL:View
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2838.00.0000
FDA Listing of Food Additive Status:View
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
 sodium isothiocyanate
 sodium sulfocyanide
 sodium sulphocyanate
 sodium sulphocyanide
 sodium thiocyanide
 thiocyanate sodium
 thiocyanate, sodium
 thiocyanic acid sodium salt
 thiocyanic acid sodium salt (1:1)
 thiocyanic acid, sodium salt
 thiocyanic acid, sodium salt (1:1)
 

Articles:

PubMed:Dissolution properties of silk cocoon shells and degummed fibers from African wild silkmoths.
PubMed:Effect of selected Hofmeister salts on textural and rheological properties of nonfat cheese.
PubMed:In vitro and in vivo effects of a composition containing lactoperoxidase on oral bacteria and breath odor.
PubMed:Effects of lactoperoxidase and hydrogen peroxide on rheological properties of yoghurt.
PubMed:Urinary thiocyanate levels as a biomarker for the generation of inorganic cyanide from benzyl cyanide in the rat.
PubMed:Effect of a lysine-enriched diet on L-lysine transport by the brush-border membrane of the chicken jejunum.
PubMed:Influence of a three-day feed and water deprivation period on gut fill, tissue weights, and tissue composition in mature wethers.
PubMed:Sodium nitroprusside-induced cyanide intoxication and prevention with sodium thiosulfate prophylaxis.
PubMed:Effect of the lactoperoxidase system on Listeria monocytogenes behavior in raw milk at refrigeration temperatures.
PubMed:Chronic toxicity tests of sodium thiocyanate with sodium nitrite in F344 rats.
PubMed:Effects of phenol and 2,6-dimethoxyphenol (syringol) on in vivo formation of N-nitrosomorpholine in rats.
PubMed:[Sodium thiocyanate as a protective agent in intensive calf fattening. Brief report].
 
Notes:
None found
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