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sinomenine
morphinan-6-one, 7,8-didehydro-4-hydroxy-3,7-dimethoxy-17-methyl-, (9a,13a,14a)-

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Name:(+)-4-hydroxy-3,7-dimethoxy-17-methylmorphin-7-en-6-one
CAS Number: 115-53-7Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:204-094-6
FDA UNII: 63LT81K70N
Beilstein Number:0095280
MDL:MFCD00134303
XlogP3-AA:2.20 (est)
Molecular Weight:329.39611000
Formula:C19 H23 N O4
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:natural substances and extractives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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Physical Properties:
Appearance:white powder (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 162.00 °C. @ 760.00 mm Hg
Boiling Point: 513.00 to 514.00 °C. @ 760.00 mm Hg (est)
Flash Point: 508.00 °F. TCC ( 264.40 °C. ) (est)
logP (o/w): 1.245 (est)
Soluble in:
 water, 1.071e+004 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
Alfa Biotechnology
For experimental / research use only.
Sinomenine 98%
AuNutra® Industries
Sinomenine P.E.
BOC Sciences
For experimental / research use only.
Sinomenine >98%
Odor: characteristic
Use: Sinomenine, a pure alkaloid extracted from the chinese medical plant Sinomenium acutum, is used for the treatment of rheumatism and arthritis.
Changsha Organic Herb
Sinomenium Extract
Coompo
For experimental / research use only.
Sinomenine from Plants ≥98%
Odor: characteristic
Use: Sinomenine is a morphinan derivative, related to opioids such as levorphanol and the non-opioid cough suppressant dextromethorphan. Its anti-rheumatic effects are thought to be primarily mediated via release of histamine, but other effects such as inhibition of prostaglandin, leukotriene and nitric oxide synthesis may also be involved. Sinomenine prevents oligomeric Aβ-induced microglial activation, and confers protection against indirect neurotoxicity to hippocampal cells. These results raise the possibility that sinomenine may have therapeutic potential for the treatment of Alzheimer's diseases as well as other diseases that involve neuroinflammation. Sinomenine shows a significant neuroprotective effects against both LPS- and MPP+-induced DA neurotoxicity, and that this protection is mediated through microglia. The finding that SN is acting to inhibit NADPH oxidase (PHOX) activity, which then results in the inhibition of a wide array of pro-inflammatory mediators produced by activated microglia, suggests that SN may be a potential novel and safe therapeutic agent for the treatment of inflammatory-mediated neurodegenerative diseases.
Sigma-Aldrich: Aldrich
For experimental / research use only.
Sinomenine 0.3 mol chloroform of crystallization
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-mouse LD50 580 mg/kg
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Yaoxue Xuebao. Acta Pharmaceutica Sinica. Pharmaceutical Journal. Vol. 10, Pg. 673, 1963.

intraperitoneal-mouse LD50 285 mg/kg
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Yaoxue Xuebao. Acta Pharmaceutica Sinica. Pharmaceutical Journal. Vol. 8, Pg. 177, 1960.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
natural substances and extractives
Recommendation for sinomenine usage levels up to:
 not for fragrance use.
 
Recommendation for sinomenine flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :5459308
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
(+)-4-hydroxy-3,7-dimethoxy-17-methylmorphin-7-en-6-one
Chemidplus:0000115537
RTECS:QD2170000 for cas# 115-53-7
 
References:
 (+)-4-hydroxy-3,7-dimethoxy-17-methylmorphin-7-en-6-one
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):5459308
Pubchem (sid):135047789
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
KEGG (GenomeNet):C09643
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2939.90.5000
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 sinomenium acutum root
Search Trop Picture
 
Synonyms:
 coculine
 cucoline
7,8-didehydro-4-hydroxy-3,7-dimethoxy-17-methyl-9-alpha,13-alpha,14-alpha-morphinan-6-one
(9a,13a,14a)-7,8-didehydro-4-hydroxy-3,7-dimethoxy-17-methylmorphinan-6-one
7,8-didehydro-4-hydroxy-3,7-dimethoxy-17-methylmorphinan-6-one
(9a,13a,14a)-4-hydroxy-3,7-dimethoxy-17-methyl-7,8-didehydromorphinan-6-one
(+)-4-hydroxy-3,7-dimethoxy-17-methylmorphin-7-en-6-one
 kukoline
 morphinan-6-one, 7,8-didehydro-4-hydroxy-3,7-dimethoxy-17-methyl-, (9a,13a,14a)-
 sabianine A
 

Articles:

PubMed:Ethnobotany, phytochemistry and pharmacology of Stephania rotunda Lour.
PubMed:The pharmacokinetic study of sinomenine, paeoniflorin and paeonol in rats after oral administration of a herbal product Qingfu Guanjiesu capsule by HPLC.
PubMed:[Synthesis of 4-palmitoyl-sinomenine and its anti-inflammation activity].
PubMed:Sinomenine reverses multidrug resistance in bladder cancer cells via P-glycoprotein-dependent and independent manners.
PubMed:Cooperative inhibitory effect of sinomenine combined with 5-fluorouracil on esophageal carcinoma.
PubMed:Sinomenine induces apoptosis in RAW 264.7 cell-derived osteoclasts in vitro via caspase-3 activation.
PubMed:A combination of sinomenine and methotrexate reduces joint damage of collagen induced arthritis in rats by modulating osteoclast-related cytokines.
PubMed:Sinomenine sensitizes gastric cancer cells to 5-fluorouracil in vitro and in vivo.
PubMed:Analgesic effect of sinomenine in rodents after inflammation and nerve injury.
PubMed:Influence of sinomenine on protein profiles of peripheral blood mononuclear cells from ankylosing spondylitis patients: a pharmacoproteomics study.
PubMed:Sinomenine suppresses osteoclast formation and Mycobacterium tuberculosis H37Ra-induced bone loss by modulating RANKL signaling pathways.
PubMed:Effects of sinomenine on the expression of microRNA-155 in 2,4,6-trinitrobenzenesulfonic acid-induced colitis in mice.
PubMed:Sinomenine protects mice against ischemia reperfusion induced renal injury by attenuating inflammatory response and tubular cell apoptosis.
PubMed:Penetration effect of ostrich oil as a promising vehicle on transdermal delivery of sinomenine.
PubMed:Dynamic pH junction high-speed counter-current chromatography coupled with microwave-assisted extraction for online separation and purification of alkaloids from Stephania cepharantha.
PubMed:A novel perspective and approach to intestinal octreotide absorption: sinomenine-mediated reversible tight junction opening and its molecular mechanism.
PubMed:Preparation and evaluation of sinomenine hydrochloride in situ gel for uveitis treatment.
PubMed:[Analgesic effect of sinomenine on SSNI model rats and monoamine neurotransmitters in striatal extracellular fluid].
PubMed:[Akaloids from roots of Stephania dentifolia].
PubMed:[The role of sinomenine in treatment of allergic rhinitis mice model and its mechanism].
PubMed:Bioavailability enhancers of herbal origin: An overview.
PubMed:Sinomenine decreases MyD88 expression and improves inflammation-induced joint damage progression and symptoms in rat adjuvant-induced arthritis.
PubMed:Sinomenine protects against lipopolysaccharide-induced acute lung injury in mice via adenosine A(2A) receptor signaling.
PubMed:Sinomenine reduces iNOS expression via inhibiting the T-bet IFN-γ pathway in experimental autoimmune encephalomyelitis in rats.
PubMed:Pharmacological characteristics of Kampo medicine as a mixture of constituents and ingredients.
PubMed:Determination of alkaloids in Sinomenium acutum by field-amplified sample stacking in capillary electrophoresis with chemiluminescene detection.
PubMed:Sinomenine inhibits the expression of PD‑L1 in the peripheral blood mononuclear cells of mesangial proliferative nephritis patients.
PubMed:Microfluidics assisted synthesis and bioevaluation of sinomenine derivatives as antiinflammatory agents.
PubMed:[Investigation of articular cavity medicating for treatment of knee osteoarthritis].
PubMed:Analysis of active alkaloids in the Menispermaceae family by nonaqueous capillary electrophoresis-ion trap mass spectrometry.
PubMed:Can treatment with Cocculine improve the control of chemotherapy-induced emesis in early breast cancer patients? A randomized, multi-centered, double-blind, placebo-controlled Phase III trial.
PubMed:[Effects of sinomenine and methotrexate on fibroblast-like synoviocytes in rheumatoid arthritis].
PubMed:Sinomenine hydrochloride inhibits human hepatocellular carcinoma cell growth in vitro and in vivo: involvement of cell cycle arrest and apoptosis induction.
PubMed:Probing the influences of urea on the interaction of sinomenine with human serum albumin by steady-state fluorescence.
PubMed:Effect of sinomenine on vascular smooth muscle cell dedifferentiation and neointima formation after vascular injury in mice.
PubMed:Anti-inflammatory effect of sinomenine by inhibition of pro-inflammatory mediators in PMA plus A23187-stimulated HMC-1 Cells.
PubMed:Effects of alkaloid sinomenine on levels of IFN-γ, IL-1β, TNF-α and IL-6 in a rat renal allograft model.
PubMed:Sinomenine hydrochloride enhancement of the inhibitory effects of anti-transferrin receptor antibody-dependent on the COX-2 pathway in human hepatoma cells.
PubMed:Gastrodin inhibits cell proliferation in vascular smooth muscle cells and attenuates neointima formation in vivo.
PubMed:Design, synthesis and molecular docking studies of sinomenine derivatives.
PubMed:Therapeutic effect of an injectable sustained-release sinomenine hydrochloride and sodium hyaluronate compound in a rabbit model of osteoarthritis.
PubMed:Sinomenine inhibits proliferation of SGC-7901 gastric adenocarcinoma cells via suppression of cyclooxygenase-2 expression.
PubMed:Sinomenine can prolong high-risk corneal graft survival in a rat model.
PubMed:Sinomenium acutum: a review of chemistry, pharmacology, pharmacokinetics, and clinical use.
PubMed:Tissue-specific metabolite profiling of alkaloids in Sinomenii Caulis using laser microdissection and liquid chromatography-quadrupole/time of flight-mass spectrometry.
PubMed:Protective effects of sinomenine against doxorubicin-induced nephrosis in rats.
PubMed:Activation of PI3K/Akt and ERK signaling pathways antagonized sinomenine-induced lung cancer cell apoptosis.
PubMed:Determination of sinomenine sustained-release capsules in healthy Chinese volunteers by liquid chromatography-tandem mass spectrometry.
PubMed:Synthesis and biological evaluation of novel sinomenine derivatives as anti-inflammatory agents.
PubMed:Effect of the Japanese herbal medicine, Boiogito, on the osteoarthritis of the knee with joint effusion.
PubMed:(9S,13R,14S)-7,8-Didehydro-4-(4-fluoro-benz-yloxy)-3,7-dimeth-oxy-17-methyl-morphinan-6-one sesquihydrate.
PubMed:Six alkaloids inhibit secretion of IL-1α, TXB(2), ET-1 and E-selectin in LPS-induced endothelial cells.
PubMed:(7R,8S,9S,12S)-1-(4-Chloro-benz-yloxy)-13,14-didehydro-12-hy-droxy-2,13-dimeth-oxy-N-methyl-morphinane.
PubMed:(7R,8S,9S,12S)-1-Benz-yloxy-13,14-didehydro-12-hy-droxy-2,13-dimeth-oxy-N-methyl-morphinane.
PubMed:Sinomenine inhibits microglial activation by Aβ and confers neuroprotection.
PubMed:Network target for screening synergistic drug combinations with application to traditional Chinese medicine.
PubMed:Anti-inflammatory activities of Chinese herbal medicine sinomenine and Liang Miao San on tumor necrosis factor-α-activated human fibroblast-like synoviocytes in rheumatoid arthritis.
PubMed:Two new morphinane alkaloids from Sinomenium acutum.
PubMed:Sinomenine protects against ischaemic brain injury: involvement of co-inhibition of acid-sensing ion channel 1a and L-type calcium channels.
PubMed:Synthesis and biological evaluation of unique stereodimers of sinomenine analogues as potential inhibitors of NO production.
PubMed:[Study on the alkaloids in the stems and leaves of Stephania cepharantha (II)].
PubMed:Displacement of bilirubin from albumin in plasma from jaundiced newborns. An in vitro study of purified Chinese herbal constituents and sulfisoxazole.
PubMed:[Rat in vitro plasma-binding percentage determination of sinomenine hydrochloride by using microdialysis method and ultrafiltration].
PubMed:Immunosuppressive and anti-inflammatory activities of sinomenine.
PubMed:Anti-allergic effects of sinomenine by inhibition of prostaglandin D₂ and leukotriene C₄ in mouse bone marrow-derived mast cells.
PubMed:[The pharmacokinetics study on Sinomenine transdermal patch on anaesthetized Beagle dogs].
PubMed:HPLC and LC-MS analysis of sinomenine and its application in pharmacokinetic studies in rats.
PubMed:[Effect of sinomenine on tumor necrosis factor-alpha and nuclear factor-kappaB in the heterotopic tissue in rats with endometriosis].
PubMed:Protective effect of sinomenine on cartilage degradation and chondrocytes apoptosis.
PubMed:[Preparation of sinomenine hydrochloride delayed-onset sustained-release tablets].
PubMed:Sinomenine reduces invasion and migration ability in fibroblast-like synoviocytes cells co-cultured with activated human monocytic THP-1 cells by inhibiting the expression of MMP-2, MMP-9, CD147.
PubMed:[Research progress on immunosuppressive activity of monomers extracted from Chinese medicine].
PubMed:Sinomenine pretreatment attenuates cold ischemia/reperfusion injury in rats: the role of heme oxygenase-1.
PubMed:Genetic and chemical comparison of Boi (Sinomeni Caulis et Rhizoma) and Seifuto (Caulis Sinomenii).
PubMed:Sinomenine, theophylline, cysteine, and levamisole: Comparisons of their kinetic effects on mineral formation induced by matrix vesicles.
PubMed:Effects of sinomenine on proliferation and apoptosis in human lung cancer cell line NCI-H460 in vitro.
PubMed:[Study on the detoxification of alcohol extracts from orientvine and its effective component on withdrawal syndromes of morphine].
PubMed:Novel sinomenine derivative 1032 improves immune suppression in experimental autoimmune encephalomyelitis.
PubMed:Preparation and characterization of novel sinomenine microcapsules for oral controlled drug delivery.
PubMed:Development of patch and spray formulations for enhancing topical delivery of sinomenine hydrochloride.
PubMed:[Research advances of mechanism of sinomenine in treating rheumatoid arthritis].
PubMed:Effect of sinomenine on the in vitro intestinal epithelial transport of selected compounds.
PubMed:[Preparation of gastric retenting and chronopharmacologic drug delivery tablets of sinomenine hydrochloride].
PubMed:[Study on pharmacokinetics and absolute bioavailability of sinomenine in beagle dogs].
PubMed:[Study on optimization of formulation and preparation process of sinomenine liposomes].
PubMed:[Effect of sinomenine on the expression of chemokines and chemokine receptors in dendritic cells from patients with rheumatoid arthritis].
PubMed:[Effects of sinomenine on the cultured smooth muscle cell MAPK PKC activities and intracellular free Ca2+].
PubMed:Immunoregulatory effects of sinomenine on the T-bet/GATA-3 ratio and Th1/Th2 cytokine balance in the treatment of mesangial proliferative nephritis.
PubMed:Sinomenine influences capacity for invasion and migration in activated human monocytic THP-1 cells by inhibiting the expression of MMP-2, MMP-9, and CD147.
PubMed:Chitosan-graft poly(p-dioxanone) copolymers: preparation, characterization, and properties.
PubMed:Separation and detection of isoquinoline alkaloids using MEEKC coupled with field-amplified sample injection induced by ACN.
PubMed:[Bioequivalence study of sinomenine patch by microdialysis].
PubMed:(9S,13R,14R)-7,8-Didehydro-3,4,7-trimeth-oxy-17-methyl-morphinan-6-one.
PubMed:[Role of alkaloid sinomenine in chronic rejection in the rat heart transplantation model].
PubMed:[Effects of sinomenine on synovial fluid and serum content of interleukin-1beta in rabbits with osteoarthritis].
PubMed:Fast screening and structural elucidation of G-quadruplex ligands from a mixture via G-quadruplex recognition and NMR methods.
PubMed:[Dynamic determination of sinomenine in skin by microdialysis].
PubMed:Development and evaluation of the Sinomenine transdermal patch.
PubMed:Sinomenine ameliorates arthritis via MMPs, TIMPs, and cytokines in rats.
PubMed:Activation of opioid mu-receptor by sinomenine in cell and mice.
PubMed:Sinomenine versus NSAIDs for the treatment of rheumatoid arthritis: a systematic review and meta-analysis.
PubMed:pH-dependent, stereoselective dimerization of sinomenine.
PubMed:[Inhibitory effect of sinomenine on H2O2-induced apoptosis in neonatal rat cardiomyocytes].
PubMed:[Studies on preparation of sinomenine hydrochloride-loaded bovine serum albumin microspheres].
PubMed:Biocatalyzed cross-coupling of sinomenine and guaiacol by Antrodiella semisupina.
PubMed:Inhibition of the antigen-induced activation of RBL-2H3 cells by sinomenine.
PubMed:[Preparation of sinomenine microemulsion and its transdermal absorption].
PubMed:Morphinane alkaloid dimers from Sinomenium acutum.
PubMed:Voltammetric determination of sinomenine in biological fluid using a glassy carbon electrode modified by a composite film of polycysteic acid and carbon nanotubes.
PubMed:Effect of sinomenine on collagen-induced arthritis in mice.
PubMed:Vascular pharmacology of mokuboito (mu-fang-yi-tang) and its constituents on the smooth muscle and the endothelium in rat aorta.
PubMed:Sinomenine inhibits activation of rat retinal microglia induced by advanced glycation end products.
PubMed:Sinomenine, a natural dextrorotatory morphinan analog, is anti-inflammatory and neuroprotective through inhibition of microglial NADPH oxidase.
PubMed:Sinomenine suppresses TNF-alpha-induced VCAM-1 expression in human umbilical vein endothelial cells.
PubMed:Vasodilatation induced by sinomenine lowers blood pressure in spontaneously hypertensive rats.
PubMed:Sinomenine, an antirheumatic alkaloid, ameliorates clinical signs of disease in the Lewis rat model of acute experimental autoimmune encephalolmyelitis.
PubMed:[The effect of sinomenine on nNOS activity of brain tissues in morphine dependent and withdrawal mice].
PubMed:Preparative isolation and purification of sinomenine from Sinomenium acutum by centrifugal partition chromatography.
PubMed:Retraction: Pharmacokinetic interaction of paeoniflorin and sinomenine: pharmacokinetic parameters and tissue distribution characteristics in rats and protein binding ability in vitro.
PubMed:Assessment of in vitro and in vivo recovery of sinomenine using microdialysis.
PubMed:[Effects of sinomenine on NO/nNOS system in cerebellum and spinal cord of morphine-dependent and withdrawal mice].
PubMed:Sinomenine promotes differentiation but impedes maturation and co-stimulatory molecule expression of human monocyte-derived dendritic cells.
PubMed:[Effects of sinomenine on intracellular free calcium concentration and the activity of protein kinase in cultured rabbit aortic smooth muscle cells].
PubMed:Determination of sinomenine in Sinomenium acutum by capillary electrophoresis with electrochemiluminescence detection.
PubMed:Sinomenine inhibits maturation of monocyte-derived dendritic cells through blocking activation of NF-kappa B.
PubMed:Sinomenine attenuates 2, 4, 6-trinitrobenzene sulfonic acid-induced colitis in mice.
PubMed:Sinomenine inhibits primary CD4+ T-cell proliferation via apoptosis.
PubMed:Three major urinary metabolites of sinomenine in rats.
PubMed:[The effects of sinomenine on the expresssion of ICAM-1 and IL-2 during the rejection of rat cardiac allograft].
PubMed:In vivo analysis and spatial profiling of phytochemicals in herbal tissue by matrix-assisted laser desorption/ionization mass spectrometry.
PubMed:Effect of sinomenine on human cytochrome P450 activity.
PubMed:A spectroscopic and molecular modeling study of sinomenine binding to transferrin.
PubMed:[Effects of Caulis Sinomenii and sinomenine on morphine-induced place preference and brain histamine level in mice].
PubMed:Cardiovascular pharmacology of sinomenine: the mechanical and electropharmacological actions.
PubMed:Pharmacokinetic study of free-form sinomenine in rat skin by microdialysis coupled with liquid chromatography-electrospray mass spectrometry.
PubMed:[Determination in vitro of rat plasma protein binding rate of sinomenine by using microdialysis method].
PubMed:Suppression of Th1 and Th2 immune responses in mice by Sinomenine, an alkaloid extracted from the chinese medicinal plant Sinomenium acutum.
PubMed:Mechanisms responsible for poor oral bioavailability of paeoniflorin: Role of intestinal disposition and interactions with sinomenine.
PubMed:Synthesis and anti-inflammatory activities investigation of sinomenine derivatives on ring C.
PubMed:[Study on determination of entrapment efficiency of sinomenine liposomes].
PubMed:Aporphine alkaloids and their reversal activity of multidrug resistance (MDR) from the stems and rhizomes of Sinomenium acutum.
PubMed:Combinative method using HPLC quantitative and qualitative analyses for quality consistency assessment of a herbal medicinal preparation.
PubMed:[Effects of the alkaloid sinomenine on COX-2 activity and acute rejection in heart allografts: an experiment with rats].
PubMed:In vitro pharmacological actions of sinomenine on the smooth muscle and the endothelial cell activity in rat aorta.
PubMed:[Study of the relative recovery of sinomenine microdialysis system and it's influential factor].
PubMed:Effect of sinomenine on gene expression of the IL-1 beta-activated human synovial sarcoma.
PubMed:[New study progress of sinomenine].
PubMed:Electropharmacological actions of the constituents of Sinomeni Caulis et Rhizome and Mokuboi-to in guinea pig heart.
PubMed:Pharmacokinetic interaction of paeoniflorin and sinomenine: pharmacokinetic parameters and tissue distribution characteristics in rats and protein binding ability in vitro.
PubMed:[Effect of sinomenine on adjuvant arthritis and its mechanisms].
PubMed:[Effect of penetration enhancers on the transdermal penetration of sinomenine liposome patch].
PubMed:[Research on extracting process for Fengshitongbi capsules].
PubMed:[Changes in cAMP and cGMP levels in neonatal rat histaminergic neurons of tuberomammillary nucleus following 48-hour morphine exposure and effects of sinomenine intervention].
PubMed:The effects of sinomenine on intestinal absorption of paeoniflorin by the everted rat gut sac model.
PubMed:The anti-angiogenic effect of sinomenine.
PubMed:Behavioral effects of sinomenine in murine models of anxiety.
PubMed:Impact of release characteristics of sinomenine hydrochloride dosage forms on its pharmacokinetics in beagle dogs.
PubMed:Morphinane alkaloids with cell protective effects from Sinomenium acutum.
PubMed:The pharmacokinetics and tissue distribution of sinomenine in rats and its protein binding ability in vitro.
PubMed:Supercritical fluid extraction of sinomenine from Sinomenium acutum (Thumb) Rehd et Wils.
PubMed:Sinomenine inhibits B7-H1 and B7-DC expression on human renal tubular epithelial cells.
PubMed:Determination of sinomenine in human plasma by HPLC/ESI/ion trap mass spectrum.
PubMed:[Immunopharmacological action of sinomenine, an alkaloid isolated from Sinomenium acutum, and its mechanism of action in treating rheumatoid arthritis].
PubMed:Influence of co-administrated sinomenine on pharmacokinetic fate of paeoniflorin in unrestrained conscious rats.
PubMed:Requirement for ERK activation in sinomenine-induced apoptosis of macrophages.
PubMed:Effect of sinomenine on cytokine expression of macrophages and synoviocytes in adjuvant arthritis rats.
PubMed:Quantification of sinomenine in caulis sinomenii collected from different growing regions and wholesale herbal markets by a modified HPLC method.
PubMed:[Inhibitory effect of sinomenine on expression of cyclooxygenase-2 in lipopolysaccharide-induced PC-12 cells].
PubMed:N-inversion-associated conformational dynamics is unusually rapid in morphine alkaloids.
PubMed:[Synthesis and anti-inflammatory analgesic activities of sinomenine derivatives].
PubMed:[The effect of sinomenine on cyclooxygenase activity and the expression of COX-1 and COX-2 mRNA in human peripheral monocytes].
PubMed:Inhibition of MAO A and B by some plant-derived alkaloids, phenols and anthraquinones.
PubMed:[Advances in the study on transdermal permeation of active elements of natural drugs in vitro].
PubMed:Effect of Sinomenine on IL-8, IL-6, IL-2 produced by peripheral blood mononuclear cells.
PubMed:Sinomenine blocks tissue remodeling in a rat model of chronic cardiac allograft rejection.
PubMed:Effect of sinomenine on morphine dependence in isolated guinea pig ileum.
PubMed:Regulation of hepatobiliary excretion of sinomenine by P-glycoprotein in Sprague-Dawley rats.
PubMed:[Study on the permeability of 125I-sinomenine via the transdermal delivery way in rats].
PubMed:[Effect of sinamine on withdrawal symptom and neurotransmitter of morphine-dependent rats].
PubMed:[Study progress in Sinomenium acutum (Thunb.) Rehd. et Wils].
PubMed:[Effect of different animal skin on the transdermal speed constant of sinomenine].
PubMed:[Study on 102 cases of anorectal post-operational pain treated by long-acting analgesic].
PubMed:The alkaloid sinomenine in rat transplant models: and yet it does move.
PubMed:The alkaloid sinomenine lacks efficacy in rat heart transplantation.
PubMed:Synergistic effects of the alkaloid sinomenine in combination with the immunosuppressive drugs tacrolimus and mycophenolic acid.
PubMed:Study on baths with crude drug. III. The effect of ligustici chuanxiong rhizoma extract on the percutaneous absorption of some natural compounds.
PubMed:[Determination of sinomenine HCl in serum and urine by HPLC and its pharmacokinetics in normal volunteers].
PubMed:Immunomodulatory effects of the alkaloid sinomenine in the high responder ACI-to-Lewis cardiac allograft model.
PubMed:Amelioration of rat experimental arthritides by treatment with the alkaloid sinomenine.
PubMed:A case of drug eruption caused by the crude drug Boi (Sinomenium stem/Sinomeni caulis et Rhizoma).
PubMed:Impairment of macrophage eicosanoid and nitric oxide production by an alkaloid from Sinomenium acutum.
PubMed:Protection by sinomenine against endotoxin-induced fulminant hepatitis in galactosamine-sensitized mice.
PubMed:Inhibition of lymphocyte proliferation by the anti-arthritic drug sinomenine.
PubMed:Inhibitory effects of phenolics on xanthine oxidase.
PubMed:[Prevention of sinomenine on isolated rat myocardial reperfusion injury].
PubMed:[Pharmacokinetics of sinomenine by HPLC].
PubMed:[Immunosuppressive effects of sinomenine].
PubMed:[Effects of sinomenine on slow response action potential in guinea pig papillary muscle].
PubMed:[Effects of sinomenine on action potential and force of contraction in guinea pig heart muscle].
PubMed:[Quantitative determination of sinomenine in qingfengteng (Sinomenium acutum and s. acutum var. cinereum) by TLC densitometry and the relation between the content and the seasons].
PubMed:[Antiarrhythmic effects of sinomenine hydrochloride].
PubMed:Effect of sinomenine on antibody responses in mice.
PubMed:[Metabolism of quaternary salt of 14C-sinomenine A bismethyliodide in mice (author's transl)].
PubMed:Inhibition of adjuvant arthritis by histamine.
PubMed:Pharmacology of sinomenine, an anti-rheumatic alkaloid from Sinomenium acutum.
PubMed:Inhibition of granulation tissue growth by histamine.
PubMed:The effects of morphine, etorphine and sinomenine on the chemical sensitivity and synaptic responses of Renshaw cells and other spinal neurones in the rat.
PubMed:Studies on the syntheses of heterocyclic compounds. CCC. Syntheses of salutaridine, sinoacutine, and thebaine. Formal total syntheses of morphine and sinomenine.
PubMed:Dogs refractory to compound 48/80 and sinomenine.
PubMed:[Reinvestigations on the Hofman degradation products of sinomenine homologs].
PubMed:Phenol oxidation and biosynthesis. XVII. Investigations on the biosynthesis of sinomenine.
PubMed:Studies on the alkaloids of menispermaceous plants. CCXXXIX. Synthesis of hasubanan derivative from sinomenine.
PubMed:Coexistence of energy-dependent and non-dependent processes in the histamine release mechanism of compound 48-80 and sinomenine: experiments on skin from various animal species.
PubMed:[The pharmacology of sinomenine. VII. Effect of sinomenine on the gastro-intestinal movement and its mechanism].
PubMed:[The pharmacology of sinomenine. VI. The mode of antiphlogistic action in rats].
PubMed:[EFFECT OF SINOMENINE ON THE DEFENSE CONDITIONED REFLEX ACTIVITY].
PubMed:[THE MECHANISM OF HYPOTENSIVE ACTION OF SINOMENINE].
PubMed:[PHARMACOLOGICAL ACTION OF SINOMENINE ON THE CENTRAL NERVOUS SYSTEM].
PubMed:[ON THE MECHANISM OF SINOMENINE "ANALGESIA"].
PubMed:[THE TOXICITY AND GENERAL PHARMACOLOGICAL ACTIONS OF SINOMENINE].
PubMed:[Comparative effect of papaverine, sinomenine, tifen, and dibazol on the bioelectric activity and contraction range of the heart].
PubMed:[Studies on the reduction products of sinomenine. II. On reduction products of sinomenine].
PubMed:[Studies on the reduction products of sinomenine. VI. Configuration of dihydrosinomenine derivatives].
PubMed:[Studies on the reduction products of sinomenine. IV. Configuration of sinomeninol and dihydrosinomeninol].
PubMed:[Studies on the reduction products of sinomenine. V. Hydrolysis of methylsinomeninol].
PubMed:[Studies on the reduction products of sinomenine. III. Configuration of hydroxyl group at C6-position of dihydrothebainol].
PubMed:[On changes in bio-electrical activities of the cerebral cortex and optic thalamus under the influence of papaverine, sinomenine, tiphen and dibazol].
PubMed:[Trypsin inhibition of histamine depletion caused by sinomenine in rat].
PubMed:[Discharge of heparin in the dog treated by sinomenine].
PubMed:[Comparative effects of sinomenine chloride and a methylamine derivatives on rat labrocytes].
PubMed:The site of histamine release by sinomenine.
PubMed:The release of histamine by sinomenine.
 
Notes:
isolated from root of sinomenium acutum; antirheumatic, antineuralgic.
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