EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

sesamol
phenol, 3,4-(methylenedioxy)-

Supplier Sponsors

Name:1,3-benzodioxol-5-ol
CAS Number: 533-31-3Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:208-561-5
FDA UNII: 94IEA0NV89
Nikkaji Web:J1.589J
Beilstein Number:0127405
MDL:MFCD00005827
XlogP3:1.20 (est)
Molecular Weight:138.12242000
Formula:C7 H6 O3
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:antioxidants and preservatives for fragrance and flavor
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
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Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Appearance:white crystalline solid (est)
Assay: 97.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 62.00 to 65.00 °C. @ 760.00 mm Hg
Boiling Point: 272.00 to 274.00 °C. @ 760.00 mm Hg
Boiling Point: 113.00 to 116.00 °C. @ 2.00 mm Hg
Vapor Pressure:0.003000 mmHg @ 25.00 °C. (est)
Flash Point: 247.00 °F. TCC ( 119.44 °C. )
logP (o/w): 1.253 (est)
Shelf Life: 12.00 month(s) or longer if stored properly.
Soluble in:
 alcohol
 water, slightly
 water, 1.465e+004 mg/L @ 25 °C (est)
Insoluble in:
 water
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: hair dyeing agents
not used anymore
 
Suppliers:
Alfa Biotechnology
For experimental / research use only.
Sesamol 98%
BOC Sciences
For experimental / research use only.
Sesamol >98%
Nacalai USA
For experimental / research use only.
Sesamol
Penta International
SESAMOL
Santa Cruz Biotechnology
For experimental / research use only.
Sesamol ≥97%
Sigma-Aldrich: Aldrich
For experimental / research use only.
Sesamol 98%
sds
TCI AMERICA
For experimental / research use only.
Sesamol >98.0%(GC)
sds
United International
Sesamol
 
Safety Information:
Preferred SDS: View
European information :
Most important hazard(s):
Xi - Irritant
R 36/38 - Irritating to skin and eyes.
S 02 - Keep out of the reach of children.
S 22 - Do not breath dust.
S 24/25 - Avoid contact with skin and eyes.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 37/39 - Wear suitable gloves and eye/face protection.
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
antioxidants and preservatives for fragrance and flavor
Recommendation for sesamol usage levels up to:
 not for fragrance use.
 
Maximised Survey-derived Daily Intakes (MSDI-EU): 1.70 (μg/capita/day)
Modified Theoretical Added Maximum Daily Intake (mTAMDI): 420 (μg/person/day)
Threshold of Concern:1800 (μg/person/day)
Structure Class: I
 
Food categories according to Commission Regulation EC No. 1565/2000 (EC, 2000) in FGE.06 (EFSA, 2002a). According to the Industry the "normal" use is defined as the average of reported usages and "maximum use" is defined as the 95th percentile of reported usages (EFSA, 2002i).
Note: mg/kg = 0.001/1000 = 0.000001 = 1/1000000 = ppm.
 average usage mg/kgmaximum usage mg/kg
Dairy products, excluding products of category 02.0 (01.0): 0.500002.50000
Fats and oils, and fat emulsions (type water-in-oil) (02.0): 0.200001.00000
Edible ices, including sherbet and sorbet (03.0): 0.500002.50000
Processed fruit (04.1): 0.400002.00000
Processed vegetables (incl. mushrooms & fungi, roots & tubers, pulses and legumes), and nuts & seeds (04.2): --
Confectionery (05.0): 1.000005.00000
Chewing gum (05.3): --
Cereals and cereal products, incl. flours & starches from roots & tubers, pulses & legumes, excluding bakery (06.0): 0.200001.00000
Bakery wares (07.0): 2.0000010.00000
Meat and meat products, including poultry and game (08.0): 0.200001.00000
Fish and fish products, including molluscs, crustaceans and echinoderms (MCE) (09.0): 0.200001.00000
Eggs and egg products (10.0): --
Sweeteners, including honey (11.0): --
Salts, spices, soups, sauces, salads, protein products, etc. (12.0): 0.300001.50000
Foodstuffs intended for particular nutritional uses (13.0): 0.500002.50000
Non-alcoholic ("soft") beverages, excl. dairy products (14.1): 0.200001.00000
Alcoholic beverages, incl. alcohol-free and low-alcoholic counterparts (14.2): 1.000005.00000
Ready-to-eat savouries (15.0): 2.0000010.00000
Composite foods (e.g. casseroles, meat pies, mincemeat) - foods that could not be placed in categories 01.0 - 15.0 (16.0): 0.400002.00000
 
Safety References:
European Food Safety Athority(EFSA):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...

European Food Safety Authority (EFSA) reference(s):

Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) related to Flavouring Group Evaluation 22 (FGE.22): Ring-substituted phenolic substances from chemical groups 21 and 25 (Commission Regulation (EC) No 1565/2000 of 18 July 2000)
View page or View pdf

Flavouring Group Evaluation 58 (FGE.58) Consideration of phenol derivatives evaluated by JECFA (55th meeting) structurally related to ring substituted phenolic substances evaluated by EFSA in FGE.22 (2006) (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC)
View page or View pdf

Flavouring Group Evaluation 60 (FGE.60): Consideration of eugenol and related hydroxyallylbenzene derivatives evaluated by JECFA (65th meeting) structurally related to ring- substituted phenolic substances evaluated by EFSA in FGE.22 (2006)
View page or View pdf

Scientific Opinion on Flavouring Group Evaluation 22, Revision 1 (FGE.22Rev1): Ring-substituted phenolic substances from chemical groups 21 and 25
View page or View pdf

EPI System: View
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
Carcinogenic Potency Database:Search
EPA Substance Registry Services (TSCA):533-31-3
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :68289
National Institute of Allergy and Infectious Diseases:Data
SCCNFP:opinion
WGK Germany:3
1,3-benzodioxol-5-ol
Chemidplus:0000533313
RTECS:533-31-3
 
References:
 1,3-benzodioxol-5-ol
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):68289
Pubchem (sid):135023654
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
KEGG (GenomeNet):C10832
HMDB (The Human Metabolome Database):HMDB33812
FooDB:FDB011975
Export Tariff Code:2932.99.9090
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
 hair dyeing agents
 
Occurrence (nature, food, other):note
 sesame seed oil
Search Trop Picture
 
Synonyms:
 benzo[1,3]dioxol-5-ol
2H-benzo[d]1,3-dioxolen-5-ol
1,3-benzodioxol-5-ol
2H-1,3-benzodioxol-5-ol
5-hydroxy-1,3-benzodioxole
3,4-methylendioxyphenol
3,4-(methylene dioxy) phenol
3,4-methylene dioxyphenol
 methylene ether of oxyhydroquinone
3,4-(methylenedioxy)phenol
3,4-methylenedioxyphenol
 phenol, 3,4-(methylenedioxy)-
 sesamol
 

Articles:

PubMed:Anti-Atherosclerotic and Anti-Inflammatory Actions of Sesame Oil.
PubMed:The relationship of antioxidant components and antioxidant activity of Sesame seed oil.
PubMed:Neuroprotective potential of sesamol and its loaded solid lipid nanoparticles in ICV-STZ-induced cognitive deficits: Behavioral and biochemical evidence.
PubMed:Hepatoprotective effects of sesamol loaded solid lipid nanoparticles in carbon tetrachloride induced sub-chronic hepatotoxicity in rats.
PubMed:N,N'-Dioxide-Scandium(III)-Catalyzed Asymmetric Aza-Friedel-Crafts Reaction of Sesamol with Aldimines.
PubMed:Enhancing antioxidant activity of sesamol at frying temperature by addition of additives through reducing volatility.
PubMed:Sesamol-loaded solid lipid nanoparticles for treatment of skin cancer.
PubMed:Sesamol and sesame (Sesamum indicum) oil enhance macrophage cholesterol efflux via up-regulation of PPARγ1 and LXRα transcriptional activity in a MAPK-dependent manner.
PubMed:Antioxidant, antimelanogenic, and skin-protective effect of sesamol.
PubMed:The ameliorative effects of sesamol against seizures, cognitive impairment and oxidative stress in the experimental model of epilepsy.
PubMed:Crocin prevents sesamol-induced oxidative stress and apoptosis in human platelets.
PubMed:Sesamol suppresses cyclooxygenase-2 transcriptional activity in colon cancer cells and modifies intestinal polyp development in Apc (Min/+) mice.
PubMed:Investigation of sesamol on myeloperoxidase and colon morphology in acetic acid-induced inflammatory bowel disorder in albino rats.
PubMed:Organocatalytic asymmetric Friedel-Crafts reaction of sesamol with isatins: access to biologically relevant 3-aryl-3-hydroxy-2-oxindoles.
PubMed:Sesame oil attenuates nutritional fibrosing steatohepatitis by modulating matrix metalloproteinases-2, 9 and PPAR-γ.
PubMed:Sesamol ameliorates cyclophosphamide-induced hepatotoxicity by modulating oxidative stress and inflammatory mediators.
PubMed:Plants and phytochemicals for Huntington's disease.
PubMed:Application of FTIR microspectroscopy for characterization of biomolecular changes in human melanoma cells treated by sesamol and kojic acid.
PubMed:Antioxidant, lipid lowering, and membrane stabilization effect of sesamol against doxorubicin-induced cardiomyopathy in experimental rats.
PubMed:Sesamol and naringenin reverse the effect of rotenone-induced PD rat model.
PubMed:Protective effect of 3,4-methylenedioxyphenol (sesamol) on stress-related mucosal disease in rats.
PubMed:Modulatory effects of sesamol in dinitrochlorobenzene-induced inflammatory bowel disorder in albino rats.
PubMed:Lignans of sesame: purification methods, biological activities and biosynthesis--a review.
PubMed:Sesamol induces apoptosis in human platelets via reactive oxygen species-mediated mitochondrial damage.
PubMed:The interaction of sesamol with DNA and cytotoxicity, apoptosis, and localization in HepG2 cells.
PubMed:Beneficial effect of sesame oil on heavy metal toxicity.
PubMed:Sesamol prevents doxorubicin-induced oxidative damage and toxicity on H9c2 cardiomyoblasts.
PubMed:Implication of NGF and endocannabinoid signaling in the mechanism of action of sesamol: a multi-target natural compound with therapeutic potential.
PubMed:DPPH assay of vegetable oils and model antioxidants in protic and aprotic solvents.
PubMed:Modulatory effect of sesamol on DOCA-salt-induced oxidative stress in uninephrectomized hypertensive rats.
PubMed:Evaluation of sesamol and buspirone in stress induced anxiety in mice.
PubMed:Sesamol treatment reduces plasma cholesterol and triacylglycerol levels in mouse models of acute and chronic hyperlipidemia.
PubMed:Synthesis and characterization of polymerizable one-component photoinitiator based on sesamol.
PubMed:Determination of the degree of oxidation in highly-oxidised lipids using profile changes of fatty acids.
PubMed:The role of cyclooxygenase-derived oxidative stress in surgically induced lymphedema in a mouse tail model.
PubMed:Attenuation of adjuvant-induced arthritis by dietary sesamol via modulation of inflammatory mediators, extracellular matrix degrading enzymes and antioxidant status.
PubMed:Cell-based screening identifies paroxetine as an inhibitor of diabetic endothelial dysfunction.
PubMed:DNA interaction studies of sesamol (3,4-methylenedioxyphenol) food additive.
PubMed:Synthesis and photopolymerization kinetics of benzophenone sesamol one-component photoinitiator.
PubMed:Effect of sesamol on the pathophysiological changes induced by surgical menopause in rodents.
PubMed:Efficacy of sesamol on plasma and tissue lipids in isoproterenol-induced cardiotoxicity in Wistar rats.
PubMed:Polyalkoxy substituted 4H-chromenes: synthesis by domino reaction and anticancer activity.
PubMed:Prophylactic sesame oil attenuates sinusoidal obstruction syndrome by inhibiting matrix metalloproteinase-9 and oxidative stress.
PubMed:Direct chemical method for preparing 2,3-epoxyamides using sodium chlorite.
PubMed:Comparison of the simple cyclic voltammetry (CV) and DPPH assays for the determination of antioxidant capacity of active principles.
PubMed:Therapeutic oral sesame oil is ineffectual against monocrotaline-induced sinusoidal obstruction syndrome in rats.
PubMed:Sesamol alleviates diet-induced cardiometabolic syndrome in rats via up-regulating PPARγ, PPARα and e-NOS.
PubMed:Patterns of carbohydrate and fatty acid changes under nitrogen starvation in the microalgae Haematococcus pluvialis and Nannochloropsis sp.
PubMed:A novel role of sesamol in inhibiting NF-κB-mediated signaling in platelet activation.
PubMed:Sesamol attenuates oxidative stress-mediated experimental acute pancreatitis in rats.
PubMed:Selective recognition of sesamol using molecularly imprinted polymers containing magnetic wollastonite.
PubMed:Delivery of sesamol-loaded solid lipid nanoparticles to the brain for menopause-related emotional and cognitive central nervous system derangements.
PubMed:Physicochemical insights on the free radical scavenging activity of sesamol: importance of the acid/base equilibrium.
PubMed:Sesamol as a potential radioprotective agent: in vitro studies.
PubMed:Effects of sesamol on apoptosis and steroidogenesis in MA-10 mouse Leydig tumor cells.
PubMed:Therapeutic sesamol attenuates monocrotaline-induced sinusoidal obstruction syndrome in rats by inhibiting matrix metalloproteinase-9.
PubMed:Experimental antithrombotic effects of sesame seed whole grains and extracts.
PubMed:Sesamol attenuates isoproterenol-induced acute myocardial infarction via inhibition of matrix metalloproteinase-2 and -9 expression in rats.
PubMed:Modulation of nitrergic pathway by sesamol prevents cognitive deficits and associated biochemical alterations in intracerebroventricular streptozotocin administered rats.
PubMed:Studies on chemical and sensory parameters of coconut oil and its olein blends with sesame oil and palmolein during wheat flour-based product frying.
PubMed:Chondroprotective role of sesamol by inhibiting MMPs expression via retaining NF-κB signaling in activated SW1353 cells.
PubMed:Identification of methanol-soluble compounds in sesame and evaluation of antioxidant potential of its lignans.
PubMed:Inhibitory activity of natural occurring antioxidants on Thiyl radical-induced trans-arachidonic acid formation.
PubMed:Anti-hepatotoxic effects of 3,4-methylenedioxyphenol and N-acetylcysteine in acutely acetaminophen-overdosed mice.
PubMed:Comments on Vennila and Pugalendi. Vennila L, Pugalendi KV. Protective effect of sesamol against myocardial infarction caused by isoproterenol in Wistar rats. Redox Rep 2010; 15: 36-42.
PubMed:Protection of cellular DNA and membrane from γ-radiation-induced damages and enhancement in DNA repair by sesamol.
PubMed:A modified sesamol derivative inhibits progression of atherosclerosis.
PubMed:Interaction of sesamol (3,4-methylenedioxyphenol) with tyrosinase and its effect on melanin synthesis.
PubMed:Estrogenic activities of sesame lignans and their metabolites on human breast cancer cells.
PubMed:Neuropsychopharmacological effect of sesamol in unpredictable chronic mild stress model of depression: behavioral and biochemical evidences.
PubMed:Electrostatic spraying of antioxidants on the oxidative quality of ground beef.
PubMed:Normal and delayed wound healing is improved by sesamol, an active constituent of Sesamum indicum (L.) in albino rats.
PubMed:Identification of cytotoxic dimers in oxidation product from sesamol, a potent antioxidant of sesame oil.
PubMed:Sesamol inhibits UVB-induced ROS generation and subsequent oxidative damage in cultured human skin dermal fibroblasts.
PubMed:Apoptosis-inducing action of two products from oxidation of sesamol, an antioxidative constituent of sesame oil: a possible cytotoxicity of oxidized antioxidant.
PubMed:Comparing antioxidant effectiveness of natural and synthetic free radical scavengers in thermally-oxidized lard using DPPH method.
PubMed:Sesamol suppresses neuro-inflammatory cascade in experimental model of diabetic neuropathy.
PubMed:The effect of lutein, sesamol, ellagic acid and olive leaf extract on lipid oxidation and oxymyoglobin oxidation in bovine and porcine muscle model systems.
PubMed:Protective effect of sesamol on the pulmonary inflammatory response and lung injury in endotoxemic rats.
PubMed:Evaluation of the effects of selected phytochemicals on quality indices and sensorial properties of raw and cooked pork stored in different packaging systems.
PubMed:Effect of lutein, sesamol, ellagic acid and olive leaf extract on the quality and shelf-life stability of packaged raw minced beef patties.
PubMed:Sesamin attenuates intercellular cell adhesion molecule-1 expression in vitro in TNF-alpha-treated human aortic endothelial cells and in vivo in apolipoprotein-E-deficient mice.
PubMed:Protective effect of sesamol against myocardial infarction caused by isoproterenol in Wistar rats.
PubMed:Influence of chemical structures of benzodioxole-based coinitiators on the properties of the unfilled dental resin.
PubMed:Low-cost fluorimetric determination of radicals based on fluorogenic dimerization of the natural phenol sesamol.
PubMed:Protective effect of sesamol against 3-nitropropionic acid-induced cognitive dysfunction and altered glutathione redox balance in rats.
PubMed:Studies on natural p-terphenyls: total syntheses of vialinin A and terrestrin B.
PubMed:Potent antiplatelet activity of sesamol in an in vitro and in vivo model: pivotal roles of cyclic AMP and p38 mitogen-activated protein kinase.
PubMed:Sesamol down-regulates the lipopolysaccharide-induced inflammatory response by inhibiting nuclear factor-kappa B activation.
PubMed:Development of a novel fluorometric assay for nitric oxide utilizing sesamol and its application to analysis of nitric oxide-releasing drugs.
PubMed:Expeditious synthesis of vialinin B, an extremely potent inhibitor of TNF-alpha production.
PubMed:Sulfamic acid catalyzed solvent-free synthesis of 10-aryl-7,7-dimethyl-6,7,8,10-tetrahydro-9H-[1,3]-dioxolo [4,5- b]xanthen-9-ones and 12-aryl-9,9-dimethyl-8,9,10,12-tetrahydro-11H-benzo[a]xanthen-11-ones.
PubMed:A new cross-coupling-based synthesis of carpanone.
PubMed:Fat content influences the color, lipid oxidation, and volatiles of irradiated ground beef.
PubMed:Antioxidant potential of sesamol and its role on radiation-induced DNA damage in whole-body irradiated Swiss albino mice.
PubMed:The non-peptide chemical 3,4-methylenedioxyphenol blocked lipopolysaccharide (LPS) from binding to LPS-binding protein and inhibited pro-inflammatory cytokines.
PubMed:Sesamol: an efficient antioxidant with potential therapeutic benefits.
PubMed:Storage stability of sunflower oil with added natural antioxidant concentrate from sesame seed oil.
PubMed:Improving the stability and antioxidant properties of sesame oil: water-soluble spray-dried emulsions from new transesterified phenolic derivatives.
PubMed:Attenuation of renoinflammatory cascade in experimental model of diabetic nephropathy by sesamol.
PubMed:Administration of sesamol improved blood-brain barrier function in streptozotocin-induced diabetic rats.
PubMed:Sesamol attenuate 3-nitropropionic acid-induced Huntington-like behavioral, biochemical, and cellular alterations in rats.
PubMed:Effect of infrared heating on the formation of sesamol and quality of defatted flours from Sesamum indicum L.
PubMed:Cytometric analysis of cytotoxicity of polyphenols and related phenolics to rat thymocytes: potent cytotoxicity of resveratrol to normal cells.
PubMed:A previously uncultured, paper mill Propionibacterium is able to degrade O-aryl alkyl ethers and various aromatic hydrocarbons.
PubMed:Effects of a diet rich in sesame ( Sesamum indicum) pericarp on the expression of oestrogen receptor alpha and oestrogen receptor beta in rat prostate and uterus.
PubMed:Renoprotective effects of sesamol in ferric nitrilotriacetate-induced oxidative renal injury in rats.
PubMed:Effect of antioxidant application methods on the color, lipid oxidation, and volatiles of irradiated ground beef.
PubMed:Elimination and metabolism of sesamol, a bioactive compound in sesame oil, in rats.
PubMed:Glycosylation of sesamol by cultured plant cells.
PubMed:Effects of germination on chemical composition and functional properties of sesame (Sesamum indicum L.) seeds.
PubMed:Effects of aging time and natural antioxidants on the color, lipid oxidation and volatiles of irradiated ground beef.
PubMed:The protective effect of sesamol against mitochondrial oxidative stress and hepatic injury in acetaminophen-overdosed rats.
PubMed:Metabolic transformation of sesamol and ex vivo effect on 2,2'-azo-bis(2-amidinopropane)dihydrochloride-induced hemolysis.
PubMed:Bioavailability and tissue distribution of sesamol in rat.
PubMed:The prophylactic protective effect of sesamol against ferric-nitrilotriacetate-induced acute renal injury in mice.
PubMed:Evaluation of coumarin derivatives as anti-fungal agents against soil-borne fungal pathogens.
PubMed:Sesamol attenuates diclofenac-induced acute gastric mucosal injury via its cyclooxygenase-independent antioxidative effect in rats.
PubMed:Effect of sesamol on diabetes-associated cognitive decline in rats.
PubMed:First total synthesis of vialinin A, a novel and extremely potent inhibitor of TNF-alpha production.
PubMed:The effect of sesamol on systemic oxidative stress and hepatic dysfunction in acutely iron-intoxicated mice.
PubMed:Practical and convenient synthesis of coumarins from phenols and propiolic acid esters.
PubMed:Scavenging effects of phenolic compounds on reactive oxygen species.
PubMed:Synergistic antimicrobial activities of phytoestrogens in crude extracts of two sesame species against some common pathogenic microorganisms.
PubMed:Effect of sesamol on radiation-induced cytotoxicity in Swiss albino mice.
PubMed:Characteristics of structured lipid prepared by lipase-catalyzed acidolysis of roasted sesame oil and caprylic acid in a bench-scale continuous packed bed reactor.
PubMed:Sesamol delays mortality and attenuates hepatic injury after cecal ligation and puncture in rats: role of oxidative stress.
PubMed:Effects of methyl parathion on Chasmagnathus granulatus hepatopancreas: protective role of sesamol.
PubMed:Attenuation of endotoxin-induced oxidative stress and multiple organ injury by 3,4-Methylenedioxyphenol in rats.
PubMed:Development and evaluation of sesamol as an antiaging agent.
PubMed:Sesamol induces nitric oxide release from human umbilical vein endothelial cells.
PubMed:Protective effect of 1,2,4-benzenetriol on LPS-induced NO production by BV2 microglial cells.
PubMed:Synthesis and HIV-1 integrase inhibitory activities of caffeic acid dimers derived from Salvia officinalis.
PubMed:Photoprotective effect of sesamol on UVB-radiation induced oxidative stress in human blood lymphocytes in vitro.
PubMed:Improved malonaldehyde assay using headspace solid-phase microextraction and its application to the measurement of the antioxidant activity of phytochemicals.
PubMed:Free radical reactions and antioxidant activities of sesamol: pulse radiolytic and biochemical studies.
PubMed:Radioprotective effect of sesamol on gamma-radiation induced DNA damage, lipid peroxidation and antioxidants levels in cultured human lymphocytes.
PubMed:Sesamol regulates plasminogen activator gene expression in cultured endothelial cells: a potential effect on the fibrinolytic system.
PubMed:Sesame lignans enhance antioxidant activity of vitamin E in lipid peroxidation systems.
PubMed:Comprehensive study on vitamin C equivalent antioxidant capacity (VCEAC) of various polyphenolics in scavenging a free radical and its structural relationship.
PubMed:Inhibitory actions of several natural products on proliferation of rat vascular smooth muscle cells induced by Hsp60 from Chlamydia pneumoniae J138.
PubMed:The sesame seed oil constituent, sesamol, induces growth arrest and apoptosis of cancer and cardiovascular cells.
PubMed:Thermodynamic study of sesamol, piperonyl alcohol, piperonylic acid and homopiperonylic acid: a combined experimental and theoretical investigation.
PubMed:Free radical scavenging behavior of antioxidant compounds of sesame (sesamum indicum L.) in DPPH(*) system.
PubMed:Far-infrared radiation increases the antioxidant properties of rice hull extract in cooked turkey meat.
PubMed:Use of double packaging and antioxidant combinations to improve color, lipid oxidation, and volatiles of irradiated raw and cooked turkey breast patties.
PubMed:Antiphoto-oxidative activity of sesamol in methylene blue- and chlorophyll-sensitized photo-oxidation of oil.
PubMed:Action of pyrethrum-based formulations against grain weevils.
PubMed:Use of antioxidants to reduce lipid oxidation and off-odor volatiles of irradiated pork homogenates and patties.
PubMed:Effect of antioxidants on the quality of irradiated sausages prepared with turkey thigh meat.
PubMed:Chemopreventive effect of resveratrol, sesamol, sesame oil and sunflower oil in the Epstein-Barr virus early antigen activation assay and the mouse skin two-stage carcinogenesis.
PubMed:Palladium-catalyzed intramolecular C-O bond formation.
PubMed:Cytotoxicity effects of di- and tri-hydroxybenzaldehydes as a chemopreventive potential agent on tumor cells.
PubMed:Increased survival after cecal ligation and puncture in mice consuming diets enriched with sesame seed oil.
PubMed:Field assessment of plant derivative compounds for managing fungal soybean diseases.
PubMed:Sesamol exhibits antimutagenic activity against oxygen species mediated mutagenicity.
PubMed:Decreased production of interleukin-6 and prostaglandin E2 associated with inhibition of delta-5 desaturation of omega6 fatty acids in mice fed safflower oil diets supplemented with sesamol.
PubMed:Increased band 3 protein aggregation and anti-band 3 binding of erythrocyte membranes on treatment with sesamol.
PubMed:Synthesis, binding affinity and selectivity of new beta 1- and beta 2-adrenoceptor blockers.
PubMed:Medium-term bioassays for carcinogenicity of chemical mixtures.
PubMed:Food constituents attenuate monoamine oxidase activity and peroxide levels in C6 astrocyte cells.
PubMed:In vitro attenuation of nitric oxide production in C6 astrocyte cell culture by various dietary compounds.
PubMed:Sesamolin inhibits lipid peroxidation in rat liver and kidney.
PubMed:Carcinogenicity of antioxidants BHA, caffeic acid, sesamol, 4-methoxyphenol and catechol at low doses, either alone or in combination, and modulation of their effects in a rat medium-term multi-organ carcinogenesis model.
PubMed:The prevention of ferric nitrilotriacetate-induced nephro- and hepatotoxicity by methylenedioxybenzene antioxidants.
PubMed:Malic enzyme: a lipogenic enzyme in fungi.
PubMed:Comparative evaluation of some antioxidants in salame Milano and mortadella production.
PubMed:Sesamol as an inhibitor of growth and lipid metabolism in Mucor circinelloides via its action on malic enzyme.
PubMed:Formation of the mutagenic/carcinogenic imidazoquinoxaline-type heterocyclic amines through the unstable free radical Maillard intermediates and its inhibition by phenolic antioxidants.
PubMed:The prevention of CCl4-induced liver necrosis in mice by naturally occurring methylenedioxybenzenes.
PubMed:Antioxidative effect of sesamol and related compounds on lipid peroxidation.
PubMed:Effect of plant phenolics on the formation of the spin-adduct of hydroxyl radical and the DNA strand breaking by hydroxyl radical.
PubMed:Inhibitory effects of phenolic compounds on development of naturally occurring preneoplastic hepatocytic foci in long-term feeding studies using male F344 rats.
PubMed:[Protective effects of sesamol and its related compounds on carbon tetrachloride induced liver injury in rats].
PubMed:EPR and TREPR spectroscopic studies of antioxidant sesamolyl and related phenoxyl radicals.
PubMed:Cell proliferation and forestomach carcinogenesis.
PubMed:Comparison of reversibility of rat forestomach lesions induced by genotoxic and non-genotoxic carcinogens.
PubMed:Organ-specific modification of carcinogenesis by antioxidants in rats.
PubMed:Forestomach neoplasm induction in F344/DuCrj rats and B6C3F1 mice exposed to sesamol.
PubMed:Regiochemical differences in cytochrome P450 isozymes responsible for the oxidation of methylenedioxyphenyl groups by rabbit liver.
PubMed:Suppression of diethylnitrosamine-initiated preneoplastic foci development in the rat liver by combined administration of four antioxidants at low doses.
PubMed:Aromatic hydroxylation of methylenedioxybenzene (MDB) and methylenedioxymethamphetamine (MDMA) by rabbit liver microsomes.
PubMed:Changes of ingredients in the process of cooking of sesame oil.
PubMed:In vitro assessment of the structure-activity relationship of tyrosinase-dependent cytotoxicity of a series of substituted phenols.
PubMed:[Studies on chemical protectors against radiation. XXXIII. Protective mechanisms of various compounds against skin injury induced by radiation].
PubMed:[Protective effects of antioxidants on experimental liver injuries].
PubMed:Stomach carcinogenicity of caffeic acid, sesamol and catechol in rats and mice.
PubMed:Antioxidants--carcinogenic and chemopreventive properties.
PubMed:Is sesamol present in sesame oil?
PubMed:Induction of forestomach lesions in rats by oral administrations of naturally occurring antioxidants for 4 weeks.
PubMed:Inhibition of rabbit nasal and hepatic cytochrome P-450-dependent hexamethylphosphoramide (HMPA) N-demethylase by methylenedioxyphenyl compounds.
PubMed:Interaction of hemoglobin A with sesamol and polyphenolics.
PubMed:Transformation of hemoglobin A into methemoglobin by sesamol.
PubMed:Coupling between oxidative metabolism and active transport in the midgut of tobacco hornworm.
PubMed:Autoxidation in milk rich in linoleic acid. I. An objective method of measuring autoxidation and evaluating antioxidants.
PubMed:Allergens in sesame oil contact dermatitis.
PubMed:Sesamol transport by human blood.
 
Notes:
constituent of sesame oil. Isol. from sesame oil
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