EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

pyridoxine
3,4-pyridinedimethanol, 5-hydroxy-6-methyl-

Supplier Sponsors

Name:4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol
CAS Number: 65-23-6Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:200-603-0
FDA UNII: KV2JZ1BI6Z
Nikkaji Web:J2.356F
Beilstein Number:139854
MDL:MFCD00006335
XlogP3:-0.80 (est)
Molecular Weight:169.18027000
Formula:C8 H11 N O3
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:special dietary and nutritional additives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 FDA/DG SANTE Petitions, Reviews, Notices:
1977 Pyridoxine View - review
FDA Mainterm (SATF):65-23-6 ; PYRIDOXINE
FDA Regulation:
FDA PART 101 -- FOOD LABELING
Subpart A--General Provisions
Sec. 101.9 Nutrition labeling of food.
 
Physical Properties:
Appearance:white crystalline powder (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 159.00 to 162.00 °C. @ 760.00 mm Hg
Boiling Point: 491.93 °C. @ 760.00 mm Hg (est)
Flash Point: 484.00 °F. TCC ( 251.30 °C. ) (est)
logP (o/w): -0.770
Soluble in:
 water, 2.82e+005 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: antistatic agents
hair conditioning
skin conditioning
 
Suppliers:
Alfa Biotechnology
For experimental / research use only.
Pyridoxine 98%
BOC Sciences
For experimental / research use only.
Pyridoxine >98%
DSM Nutritional
Vitamin B6
EMD Millipore
For experimental / research use only.
Pyridoxine
Farbest-Tallman Foods
Pyridoxine 97-98% for DC
Foodchem International
Vitamin B6
Graham Chemical
Vitamine B6
Jiangyin Healthway
Vitamin B6
New functional food ingredients
Kraft Chemical
Vitamin B6
OQEMA
Vitamin B6
Prinova
Vitamin B6 USP; FCC
Sigma-Aldrich: Sigma
For experimental / research use only.
Pyridoxine ≥98%
Silver Fern Chemical
Vitamin B 6
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50 4000 mg/kg
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Proceedings of the Society for Experimental Biology and Medicine. Vol. 43, Pg. 116, 1940.

intravenous-rat LD50 657 mg/kg
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Proceedings of the Society for Experimental Biology and Medicine. Vol. 44, Pg. 147, 1940.

oral-man TDLo 5143 mg/kg/17W
PERIPHERAL NERVE AND SENSATION: LOCAL ANESTHETIC
New England Journal of Medicine. Vol. 309, Pg. 445, 1983.

intraperitoneal-mouse LD50 966 mg/kg
Farmakologiya i Toksikologiya Vol. 40, Pg. 371, 1977.

intravenous-mouse LD50 545 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 10, Pg. 683, 1960.

intraperitoneal-rat LD50 1500 mg/kg
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Proceedings of the European Society for the Study of Drug Toxicity. Vol. 4, Pg. 179, 1964.

Dermal Toxicity:
subcutaneous-rat LD50 3100 mg/kg
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Proceedings of the Society for Experimental Biology and Medicine. Vol. 43, Pg. 116, 1940.

Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
special dietary and nutritional additives
Recommendation for pyridoxine usage levels up to:
 not for fragrance use.
 
Recommendation for pyridoxine flavor usage levels up to:
 not for flavor use.
 
Safety References:
European Food Safety Authority (EFSA) reference(s):

Scientific Opinion on the substantiation of a health claim related to a combination of thiamin, riboflavin, niacin, pantothenic acid, pyridoxine, D-biotin and pumpkin seed oil and maintenance of normal hair pursuant to Article 13(5) of Regulation (EC) No 1924/2006
View page or View pdf

Dietary Reference Values for vitamin B6
View page or View pdf

Outcome of a public consultation on the Draft Scientific Opinion of the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) on Dietary Reference Values for vitamin B6
View page or View pdf

EPI System: View
ClinicalTrials.gov:search
Daily Med:search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):65-23-6
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :1054
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol
Chemidplus:0000065236
RTECS:UV1300000 for cas# 65-23-6
 
References:
 4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:65-23-6
Pubchem (cid):1054
Pubchem (sid):134972472
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS):View
CHEBI:View
CHEMBL:View
Golm Metabolome Database:Search
Metabolomics Database:Search
UM BBD:Search
KEGG (GenomeNet):C00314
HMDB (The Human Metabolome Database):HMDB00239
FooDB:FDB000574
YMDB (Yeast Metabolome Database):YMDB00037
Export Tariff Code:2936.25.0000
FDA Listing of Food Additive Status:View
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
Formulations/Preparations:
•bonadoxin an anti-emetic; antispasmodic is mixture of meclizine & pyridoxine hcl. from table •dosage forms: injection usp: 50 & 100 mgml, 500 mg & 1 g10 ml, 3 g30 ml; tablets usp: 10, 25, 50, & 100 mg. •oral capsules, 500 mg, vitamin b-6 capsules, solgar; capsules, extended release, 100 mg, vitamin b-6 t.r. capsules, scherer; 150 mg, rodex(r) t.d., legere; tablets, 10 mg, 25 mg, 50 mg, 100 mg, 200 mg, 250 mg, 500 mg, and tablets extended release, vitamin b-6 timed tablets, interstate. •parenteral injection, 100 mgml, beesix (r) (with benzyl alcohol), forest; hexa-betalin (r) (with chlorobutanol), lilly; rodex (r), legere. •pyridoxine hydrochloride is also commercially available in combination with other vitamins, minerals, amino acids, antihistamines, cerebral stimulants, enzymes, infant formulas, hormones, laxatives, protein supplements, sedatives, unsaturated fatty acids, and antituberculars. for iv infusion, pyridoxine hydrochloride is also commercially available in combination with other vitamins in caloric and electrolyte solutions.
 
Potential Blenders and core components note
None Found
 
Potential Uses:
 antistatic agents
 
Occurrence (nature, food, other):note
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 barley seed
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 bean asparagus bean seed
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 gooseberry fruit
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 gourd calabash gourd fruit
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 lettuce leaf
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 mallow jew's mallow leaf
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 mandarin fruit
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 mango fruit
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 marango fruit
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 marango shoot
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 oat plant
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 oat seed
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 okra fruit
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 onion bulb
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 orange fruit
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 papaya fruit
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 parsley plant
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 parsnip root
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 pea black-eyed pea seed
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 pea fruit
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 pea pigeon pea seed
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 pea seed
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 peach fruit
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 peanut seed
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 pear fruit
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 pepper bell pepper fruit
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 peppermint leaf
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 pineapple fruit
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 plum fruit
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 pomegranate fruit
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 poppy opium poppy seed
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 potato sweet potato root
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 potato tuber
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 purslane plant
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 radish root
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 raspberry red raspberry fruit
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 rice seed
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 rosemary leaf
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 rye seed
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 sesame seed
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 soursop fruit
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 soybean seed
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 spearmint leaf
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 spinach plant
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 squash summer squash fruit
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 tamarind fruit
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 tomato fruit
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 walnut english walnut nut
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 watercress herb
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 wheat seed
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Synonyms:
 adermine
3-hydroxy-2-picoline-4,5-dimethanol
3-hydroxy-4,5-bis(hydroxymethyl)-2-methylpyridine
3-hydroxy-4,5-dimethylol-a-picoline
3-hydroxy-4,5-dimethylol-alpha-picoline
5-hydroxy-6-methyl-3,4-pyridine dimethanol
5-hydroxy-6-methyl-3,4-pyridinedimethanol
(5-hydroxy-6-methylpyridine-3,4-diyl)dimethanol
4,5-bis-hydroxymethyl-2-methyl-pyridin-3-ol
4,5-bis(hydroxymethyl)-2-methyl-3-pyridinol
4,5-bis(hydroxymethyl)-2-methyl-pyridin-3-ol
4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol
2-methyl-3-hydroxy-4,5-bis(hydroxy-methyl) pyridine
2-methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine
2-methyl-3-hydroxy-4,5-di(hydroxymethyl)pyridine
2-methyl-3-hydroxy-4,5-dihydroxymethylpyridine
2-methyl-4,5-bis(hydroxymethyl)-3-hydroxypyridine
2-picoline-4,5-dimethanol, 3-hydroxy-
3,4-pyridinedimethanol, 5-hydroxy-6-methyl-
 vitamin B6
 
 
Notes:
the 4-methanol form of vitamin b 6 which is converted to pyridoxal phosphate which is a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. although pyridoxine and vitamin b 6 are still frequently used as synonyms, especially by medical researchers, this practice is erroneous and sometimes misleading (ee snell; ann ny acad sci, vol 585 pg 1, 1990). Found in rice husks, cane molasses, yeast, wheat germ and cod liver oils. Vitamin, dietary supplement, nutrient Pyridoxine is one of the compounds that can be called vitamin B6, along with pyridoxal and pyridoxamine. It differs from pyridoxamine by the substituent at the '4' position. It is often used as 'pyridoxine hydrochloride'. (Wikipedia)
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