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Category:natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 94.00 to 100.00
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| Food Chemicals Codex Listed: | No |
| Melting Point: | 163.00 to 164.00 °C. @ 760.00 mm Hg
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| Boiling Point: | 362.00 to 363.00 °C. @ 760.00 mm Hg
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| Vapor Pressure: | 0.000019 mmHg @ 25.00 °C. (est) |
| Flash Point: | 344.00 °F. TCC ( 173.33 °C. )
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| logP (o/w): | 1.670 |
| Soluble in: |
| | alcohol | | | water, 1925 mg/L @ 25 °C (est) |
| Insoluble in: |
| | water |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
| Alfa Biotechnology |
| For experimental / research use only. |
| Psoralen 98%
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| BOC Sciences |
| For experimental / research use only. |
| Psoralen >98%
Odor: characteristic Use: Psoralen is an active ingredient from Fructus Psoraleae and has anticancer activity. |
| Coompo |
| For experimental / research use only. |
| Psoralen from Plants ≥96%
Odor: characteristic Use: Psoralen (also called psoralene) is the parent compound in a family of natural products known as furocoumarins. It is widely used in PUVA (= psoralen + UVA) treatment for psoriasis, eczema, vitiligo, and cutaneous T-cell lymphoma.
An important use of psoralen is in PUVA treatment for skin problems such as psoriasis and (to a lesser extent) eczema and vitiligo. This takes advantage of the high UV absorbance of psoralen. The psoralen is applied first to sensitise the skin, then UVA light is applied to clean up the skin problem. Psoralen has also been recommended for treating alopecia.
Psoralen is a mutagen, and is used for this purpose in molecular biology research. Psoralen intercalates into the DNA and, on exposure to ultraviolet (UVA) radiation, can form covalent interstrand cross-links (ICL) with thymines preferentially at 5'-TpA sites in the genome. Psoralen plus UVA (PUVA) therapy has shown considerable clinical efficacy. Unfortunately, a side effect of PUVA treatment is a higher risk of skin cancer.
Recent reports indicate psoralens, activated by long wavelength ultraviolet light (black light), inhibit DNA synthesis in various cell types. This suggested to us a possible new therapeutic use for psoralens in proliferative epidermal diseases such as psoriasis. |
| ExtraSynthese |
| For experimental / research use only. |
| Psoralen (HPLC) ≥99%
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| Indo World Trading |
| Psoralen
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| Sigma-Aldrich: Sigma |
| For experimental / research use only. |
| Psoralen ≥99%
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Safety Information:
| Preferred SDS: View |
| European information : |
| Most important hazard(s): | | Xn - Harmful. |
R 22 - Harmful if swallowed.
R 36/37/38 - Irritating to eyes, respiratory system, and skin.
S 02 - Keep out of the reach of children.
S 20/21 - When using do not eat, drink or smoke.
S 22 - Do not breath dust.
S 24/25 - Avoid contact with skin and eyes.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 36/37/39 - Wear suitable clothing, gloves and eye/face protection.
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
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Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | | natural substances and extractives |
| Recommendation for psoralen usage levels up to: | | | not for fragrance use.
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| Recommendation for psoralen flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | ficusin | | | furano[3,2-g]chromen-2-one | | 6,7- | furanocoumarin | | | furo(2',3',7,6)coumarin | | | furo(3,2-g)-coumarin | | 7H- | furo(3,2-g)(1)benzopyran-7-one | | | furo(4',5',6,7)coumarin | | | furo[2',3':7,6]coumarin | | | furo[2'.3':7.6]coumarin | | 7H- | furo[3,2-g][1]benzopyran-7-one | | 7H- | furo[3,2-g]benzopyran-7-one | | | furo[3,2-g]chromen-7-one | | 7H- | furo[3,2-g]chromen-7-one | | | furo[3,2-g]coumarin | | | furo[4',5':6,7]coumarin | | | furocoumarin | | 6- | hydroxy-5-benzofuranacrylic acid beta-lactone | | 3-(6- | hydroxy-5-benzofuranyl)-2-propenoic acid d-lactone | | 2- | propenoic acid, 3-(6-hydroxy-5-benzofuranyl)-, d-lactone | | | psoralen | | | psoralene |
Articles:
| PubMed:Psoralen reverses docetaxel-induced multidrug resistance in A549/D16 human lung cancer cells lines. |
| PubMed:Probing the binding mode of psoralen to calf thymus DNA. |
| PubMed:Bioassay guided isolation and identification of anti-inflammatory active compounds from the root of Ficus formosana. |
| PubMed:Chemical quantification and antioxidant assay of four active components in Ficus hirta root using UPLC-PAD-MS fingerprinting combined with cluster analysis. |
| PubMed:Plasma components: properties, differences, and uses. |
| PubMed:Furanocoumarins in celeriac from different farming systems: a 3-year study. |
| PubMed:Furocoumarins affect hepatic cytochrome P450 and renal organic ion transporters in mice. |
| PubMed:Vitiligo in adults and children. |
| PubMed:Estrogenic activities of Psoralea corylifolia L. seed extracts and main constituents. |
| PubMed:[High-performance liquid chromatography for determination of psoralene, bergapten and apigenin in Ficus hirta Vahl]. |
| PubMed:Application of the concept of relative photomutagenic potencies to selected furocoumarins in V79 cells. |
| PubMed:Ficus carica L.: Metabolic and biological screening. |
| PubMed:Psoriasis (chronic plaque). |
| PubMed:Growth inhibition of mammalian cells by synthetic and natural photosensitising agents. |
| PubMed:Chemical composition and antioxidant potential of Ruta montana L. essential oil from Algeria. |
| PubMed:Pathogen reduction: a precautionary principle paradigm. |
| PubMed:Vitiligo. |
| PubMed:[Use of psoralen plus UV-A therapy in the autonomous community of Valencia, Spain]. |
| PubMed:Fluorescent DNA probes: study of mechanisms of changes in spectral properties and features of practical application. |
| PubMed:Treatment of mycosis fungoides using a 308-nm excimer laser: two case studies. |
| PubMed:Can dietary furanocoumarin ingestion enhance the erythemal response during high-dose UVA1 therapy? |
| PubMed:Evaluation of inactivation methods for severe acute respiratory syndrome coronavirus in noncellular blood products. |
| PubMed:Apiaceous vegetable constituents inhibit human cytochrome P-450 1A2 (hCYP1A2) activity and hCYP1A2-mediated mutagenicity of aflatoxin B1. |
| PubMed:Distribution of furanocoumarins in grapefruit juice fractions. |
| PubMed:Inhibition of P-glycoprotein transport function and reversion of MDR1 multidrug resistance by cnidiadin. |
| PubMed:Advancements in the treatment of psoriasis: role of biologic agents. |
| PubMed:Comparative tolerability of systemic treatments for plaque-type psoriasis. |
| PubMed:Atopic dermatitis and fungi. |
| PubMed:Effects of storage conditions on furocoumarin levels in intact, chopped, or homogenized parsnips. |
| PubMed:Simultaneous determination of furanocoumarins in infusions and decoctions from "Carapiá" (dorstenia species) by high-performance liquid chromatography. |
| PubMed:Prevention of transfusion-associated graft-versus-host disease by inactivation of T cells in platelet components. |
| PubMed:Furanocoumarins in celery and parsnips: method and multiyear Canadian survey. |
| PubMed:Anti-oxidant, pro-oxidant properties of tannic acid and its binding to DNA. |
| PubMed:Effect of selected coumarins on spinach chloroplast photosynthesis. |
| PubMed:Identification of coumarins from the fruit of Citrus hystrix DC as inhibitors of nitric oxide generation in mouse macrophage RAW 264.7 cells. |
| PubMed:The profile of atopic dermatitis in a tertiary dermatology outpatient clinic in Singapore. |
| PubMed:Cellular immune response to adenoviral vector infected cells does not require de novo viral gene expression: implications for gene therapy. |
| PubMed:Drug interactions with grapefruit juice. Extent, probable mechanism and clinical relevance. |
| PubMed:Psoralen photochemotherapy. |
| PubMed:Inhibition of the mutagenicity of 2-nitrofluorene, 3-nitrofluoranthene and 1-nitropyrene by flavonoids, coumarins, quinones and other phenolic compounds. |
| PubMed:Isolation and identification of antimicrobial furocoumarins from parsley. |
| PubMed:Medical UV exposures and HIV activation. |
| PubMed:Furocoumarin-photosensitized hydroxylation of guanosine in RNA and DNA. |
| PubMed:Treatment of psoriasis with psoralens and ultraviolet A. A double-blind comparison of 8-methoxypsoralen and 5-methoxypsoralen. |
| PubMed:Cellular and molecular mechanisms in photochemical sensitization: studies on the mechanism of action of psoralens. |
| PubMed:Phototoxic coumarins in limes. |
| PubMed:Psoralen photosensitization and plasma and cutaneous beta-carotene concentrations in hairless mice. |
| PubMed:Fate of [(14)C]xanthotoxin (8-methoxypsoralen) in laying hens and a lactating goat. |
| PubMed:Phototoxicity testing in guinea-pigs. |
| PubMed:Dietary intake and risk assessment of phototoxic furocoumarins in humans. |
| PubMed:[Influence of retinoids on the bioavailability of methoxy-8-psoralen]. |
| PubMed:Photosensitizing potential of benzanthrone. |
| PubMed:Analysis of spontaneous and psoralen-induced Salmonella typhimurium hisG46 revertants by oligodeoxyribonucleotide colony hybridization: use of psoralens to cross-link probes to target sequences. |
| PubMed:Natural pesticides and bioactive components in foods. |
| PubMed:Psoralen photochemotherapy. |
| PubMed:Phytophotodermatitis from celery among grocery store workers. |
| PubMed:Clinical pharmacokinetics of methoxsalen and other psoralens. |
| PubMed:Quantitative tests for psoralens in the blood: methods and uses in monitoring psoralen and longwave radiation therapy. |
| PubMed:Clinical pharmacology of oral psoralen drugs. |
| PubMed:Long-term risks of psoralen and UV-A therapy for psoriasis. |
| PubMed:HPLC analysis of linear furocoumarins (psoralens) in healthy celery (Apium graveolens). |
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a naturally occurring furocoumarin, found in psoralea. after photoactivation with uv radiation, it binds dna via single and double-stranded cross-linking. Found in common vegetables, e.g. parsnip, celery esp. if diseased or `spoiled'
Psoralen is a significant mutagen and is used for this purpose in molecular biology research.
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3D/inchi