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Category:food starch-modified, preservative
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Appearance: | colorless clear liquid (est) |
| Assay: | 99.00 to 100.00
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| Food Chemicals Codex Listed: | No |
| Specific Gravity: | 0.82500 to 0.83500 @ 20.00 °C.
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| Pounds per Gallon - (est).: | 6.873 to 6.956
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| Refractive Index: | 1.36500 to 1.36700 @ 20.00 °C.
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| Boiling Point: | 35.00 °C. @ 760.00 mm Hg
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| Vapor Pressure: | 572.478027 mmHg @ 25.00 °C. (est) |
| Flash Point: | -35.00 °F. TCC ( -37.22 °C. )
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| logP (o/w): | 0.030 |
| Soluble in: |
| | water, 590000 mg/L @ 25 °C (exp) |
Organoleptic Properties:
| Odor Description:at 100.00 %. ethereal sweet |
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
oral-rat LD50 380 mg/kg
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
BEHAVIORAL: ATAXIA
BEHAVIORAL: EXCITEMENT
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 14(11), Pg. 55, 1970.
oral-guinea pig LD50 660 mg/kg
KIDNEY, URETER, AND BLADDER: OTHER CHANGES
LIVER: OTHER CHANGES
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 46(7), Pg. 76, 1981.
oral-mammal (species unspecified) LD50 440 mg/kg
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 39(4), Pg. 86, 1974.
intraperitoneal-mouse LD50 175 mg/kg
"Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 103, 1982.
oral-mouse LD50 440 mg/kg
BEHAVIORAL: ATAXIA
BEHAVIORAL: EXCITEMENT
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 14(11), Pg. 55, 1970.
intraperitoneal-rat LD50 150 mg/kg
"Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 103, 1982.
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| Dermal Toxicity: |
skin-rabbit LD50 1500 ul/kg
American Industrial Hygiene Association Journal. Vol. 30, Pg. 470, 1969.
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| Inhalation Toxicity: |
inhalation-rat LC50 4000 ppm/4H
LUNGS, THORAX, OR RESPIRATION: DYSPNEA
SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE
SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION
AMA Archives of Industrial Health. Vol. 13, Pg. 237, 1956.
inhalation-dog LCLo 2005 ppm/4H
SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION
SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE
GASTROINTESTINAL: NAUSEA OR VOMITING
AMA Archives of Industrial Health. Vol. 13, Pg. 237, 1956.
inhalation-guinea pig LCLo 4000 ppm/4H
LUNGS, THORAX, OR RESPIRATION: DYSPNEA
BEHAVIORAL: MUSCLE WEAKNESS
SENSE ORGANS AND SPECIAL SENSES: IRITIS: EYE
AMA Archives of Industrial Health. Vol. 13, Pg. 228, 1956.
inhalation-man TCLo 1400000 mg/m3/10M
GASTROINTESTINAL: NAUSEA OR VOMITING
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
BEHAVIORAL: HEADACHE
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 15(2), Pg. 48, 1971.
inhalation-mouse LC50 1740 ppm/4H
SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION
LUNGS, THORAX, OR RESPIRATION: DYSPNEA
GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS
AMA Archives of Industrial Health. Vol. 13, Pg. 237, 1956.
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Safety in Use Information:
| Category: | | food starch-modified, preservative |
| Recommendation for propylene oxide usage levels up to: | | | not for fragrance use.
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| Recommendation for propylene oxide flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | epoxypropane | | 1,2- | epoxypropane | | | methyl ethylene oxide | | | methyl oxirane | | | methyloxacyclopropane | | | methyloxirane | | (±)- | methyloxirane | | 2- | methyloxirane | | | oxirane, 2-methyl- | | | propylene epoxide | | (±)- | propylene oxide | | 1,2- | propylene oxide | | | propyleneoxide |
Articles:
| PubMed:Pluronic modified leptin with increased systemic circulation, brain uptake and efficacy for treatment of obesity. |
| PubMed:A novel aqueous two phase system composed of a thermo-separating polymer and an organic solvent for purification of thermo-acidic amylase enzyme from red pitaya (Hylocereus polyrhizus) peel. |
| PubMed:Effects of acid-hydrolysis and hydroxypropylation on functional properties of sago starch. |
| PubMed:Properties and characteristics of dual-modified rice starch based biodegradable films. |
| PubMed:Reversal of multidrug resistance by the inhibition of ATP-binding cassette pumps employing "Generally Recognized As Safe" (GRAS) nanopharmaceuticals: A review. |
| PubMed:Reaction patterns of wheat starch granules substituted with an anionic propylene oxide analog (POA) revealed by confocal microscopy and 3D anaglyph imaging. |
| PubMed:Engineering a cyanobacterium as the catalyst for the photosynthetic conversion of CO2 to 1,2-propanediol. |
| PubMed:Relationship of the channels of normal maize starch to the properties of its modified products. |
| PubMed:Extractive fermentation for improved production and recovery of lipase derived from Burkholderia cepacia using a thermoseparating polymer in aqueous two-phase systems. |
| PubMed:Preparation of lignopolyols from wheat straw soda lignin. |
| PubMed:Effects of hydroxypropylation on the functional properties of psyllium. |
| PubMed:Transport across the blood-brain barrier of pluronic leptin. |
| PubMed:Hydroxypropylated tapioca starch retards the development of insulin resistance in KKAy mice, a type 2 diabetes model, fed a high-fat diet. |
| PubMed:Hydroxypropylated starches of varying amylose contents as sustained release matrices in tablets. |
| PubMed:An isotope dilution headspace method with gas chromatography-mass spectrometry for determination of propylene oxide in food. |
| PubMed:High-hydroxypropylated tapioca starch improves insulin resistance in genetically diabetic KKAy mice. |
| PubMed:Supercritical carbon dioxide interpolymer complexes improve survival of B. longum Bb-46 in simulated gastrointestinal fluids. |
| PubMed:Dual modification of starch via partial enzymatic hydrolysis in the granular state and subsequent hydroxypropylation. |
| PubMed:Evaluation of microwave irradiation for analysis of carbonyl sulfide, carbon disulfide, cyanogen, ethyl formate, methyl bromide, sulfuryl fluoride, propylene oxide, and phosphine in hay. |
| PubMed:Monte Carlo simulations assessing the risk of salmonellosis from consumption of almonds. |
| PubMed:Survival of Salmonella enteritidis PT 30 on inoculated almonds after commercial fumigation with propylene oxide. |
| PubMed:Toxicity of propylene oxide at low pressure against life stages of four species of stored product insects. |
| PubMed:Solubilization of Hydrophilic Compounds in Copolymer Aggregates. |
| PubMed:Reactions of epoxide monomers in food simulants used to test plastics for migration. |
| PubMed:A novel type of pyridine nucleotide-disulfide oxidoreductase is essential for NAD+- and NADPH-dependent degradation of epoxyalkanes by Xanthobacter strain Py2. |
| PubMed:Neurophysiological and neuropathological evaluation of primates exposed to ethylene oxide and propylene oxide. |
| PubMed:Effects of propylene oxide on nasal epithelial cell proliferation in F344 rats. |
| PubMed:Complementation of Xanthobacter Py2 mutants defective in epoxyalkane degradation, and expression and nucleotide sequence of the complementing DNA fragment. |
| PubMed:Effect of surface sterilization, fumigation and gamma irradiation on the microflora and germination of barley seeds. |
| PubMed:Inhalation developmental toxicity study of propylene oxide in Fischer 344 rats. |
| PubMed:Gas chromatographic determination with electron capture detection of residual ethylene oxide in intraocular lenses. |
| PubMed:Chronic inhalation toxicity and carcinogenicity study of propylene oxide in Wistar rats. |
| PubMed:Biomonitoring of exposure to potential mutagens and carcinogens in industrial populations. |
| PubMed:Mutagenicity of ethylene oxide and propylene oxide and of the glycols and halohydrins formed from them during the fumigation of foodstuffs. |
| PubMed:Mutagenic activity of propylene oxide in bacterial and mammalian systems. |
| PubMed:Sterilization of dehydrated potato granules with propylene oxide. |
| PubMed:Propylene oxide. |
| PubMed:Direct addition of liquid propylene oxide to dried materials for destruction of Salmonellae. |
| PubMed:Effect of propylene oxide treatment on the microflora of pecans. |
| PubMed:Gaseous sterilization: methyl bromide, propylene oxide and ozone. |
| PubMed:Effect of relative humidity on the bactericidal activity of propylene oxide vapor. |
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3D/inchi