progesterone, 57-83-0

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CODE127882 CODE127882
Product(s):
57-83-0 Progesterone ≥98%
Progesterone, synthesized from cholesterol by the sequential action of desmolase in the mitochondria, plays an important role in brain function as a endogenous progesterone receptor (PR) agonist (EC50 = 0.5 nM). Endogenous progesterone receptor (PR) agonist

Glentham Life Sciences Ltd

The Chemical, Biochemical & Research Essentials Supplier
Glentham Life Sciences is a supplier of fine chemicals and raw materials with warehousing, laboratories and packaging facilities in the UK.
With a Glentham Life Sciences account you can view more product details, request quotes and order products online.
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CODE127882 CODE127882
Product(s):
GP3663 Progesterone

Penta International Corporation

Chemistry innovation
At Penta, our products and services help businesses do business better.
For over 30 years, Penta Manufacturing Company has played a growing role in worldwide chemistry innovations and applications. As an industry leader, Penta continues to pioneer chemistry-based solutions for practically every area of commerce. Our products and expertise have helped fuel technical advances in dozens of commercial applications including flavoring, coloring, fragrances and chemical processes.
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CODE127882 CODE127882
Product(s):
16-65900 PROGESTERONE MICRONIZED POWDER USP
16-65910 PROGESTERONE WETTABLE POWDER USP

WholeChem, LLC

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CODE127882 CODE127882
Product(s):
Progesterone

CAS Number:	57-83-0	3D/inchi
Other(deleted CASRN):	257630-50-5
ECHA EINECS - REACH Pre-Reg:	200-350-6
FDA UNII:	4G7DS2Q64Y
Nikkaji Web:	J2.329I
Beilstein Number:	1915950
MDL:	MFCD00003658
XlogP3:	3.90 (est)
Molecular Weight:	314.46850000
Formula:	C21 H30 O2
BioActivity Summary:	listing
NMR Predictor:	Predict (works with chrome, Edge or firefox)

Category:pharmaceuticals / chemical synthisis

US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:

Google Scholar:	Search
Google Books:	Search
Google Scholar: with word "volatile"	Search
Google Scholar: with word "flavor"	Search
Google Scholar: with word "odor"	Search
Google Patents:	Search
US Patents:	Search
EU Patents:	Search
Pubchem Patents:	Search
PubMed:	Search
NCBI:	Search

Physical Properties:

Appearance:	white powder (est)
Assay:	95.00 to 100.00
Food Chemicals Codex Listed:	No
Melting Point:	121.00 °C. @ 760.00 mm Hg
Boiling Point:	447.15 °C. @ 760.00 mm Hg (est)
Vapor Pressure:	3.590000 mmHg @ 25.00 °C. (est)
Flash Point:	332.00 °F. TCC ( 166.70 °C. ) (est)
logP (o/w):	3.870
Soluble in:
	water, 8.81 mg/L @ 25 °C (exp)
	water, 5.003 mg/L @ 25 °C (est)

Organoleptic Properties:

Odor and/or flavor descriptions from others (if found).

Cosmetic Information:

None found

Suppliers:

Alfa Biotechnology

For experimental / research use only.

Progesterone 98%

BOC Sciences

For experimental / research use only.

Progesterone ≥98%

Odor: characteristic

Use: Progesterone, synthesized from cholesterol by the sequential action of desmolase in the mitochondria, plays an important role in brain function as a endogenous progesterone receptor (PR) agonist (EC50 = 0.5 nM). Endogenous progesterone receptor (PR) agonist

Glentham Life Sciences

Progesterone

Indis NV

For experimental / research use only.

For experimental / research use only.

Progesterone

Penta International

PROGESTERONE MICRONIZED POWDER USP

Penta International

PROGESTERONE WETTABLE POWDER USP

Sigma-Aldrich: Sigma

For experimental / research use only.

Safety Information:

Preferred SDS: View

Hazards identification

Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements

Pictogram

Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intravenous-mouse LDLo 100 mg/kg BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: ATAXIA Journal of Medicinal Chemistry. Vol. 11, Pg. 117, 1968. intraperitoneal-rat LD50 327 mg/kg Drugs in Japan Vol. -, Pg. 1183, 1995.
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined

Safety in Use Information:

Category:
pharmaceuticals / chemical synthisis
Recommendation for progesterone usage levels up to:
	not for fragrance use.

Recommendation for progesterone flavor usage levels up to:
	not for flavor use.

Safety References:

EPI System: View

ClinicalTrials.gov:search

Daily Med:search

Chemical Carcinogenesis Research Information System:Search

AIDS Citations:Search

Cancer Citations:Search

Toxicology Citations:Search

EPA GENetic TOXicology:Search

EPA Substance Registry Services (TSCA):57-83-0

EPA ACToR:Toxicology Data

EPA Substance Registry Services (SRS):Registry

Laboratory Chemical Safety Summary :5994

National Institute of Allergy and Infectious Diseases:Data

WGK Germany:3

(8S,9S,10R,13S,14S,17S)-17-acetyl-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one

Chemidplus:0000057830

EPA/NOAA CAMEO:hazardous materials

RTECS:TW0175000 for cas# 57-83-0

References:

	(8S,9S,10R,13S,14S,17S)-17-acetyl-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one
NIST Chemistry WebBook:	Search Inchi
Pubchem (cid):	5994
Pubchem (sid):	134971194

Other Information:

(IUPAC):	Atomic Weights of the Elements 2011 (pdf)
Videos:	The Periodic Table of Videos
tgsc:	Atomic Weights use for this web site
(IUPAC):	Periodic Table of the Elements
CHEBI:	View
CHEMBL:	View
Golm Metabolome Database:	Search
Metabolomics Database:	Search
KEGG (GenomeNet):	C00410
HMDB (The Human Metabolome Database):	HMDB01830
FooDB:	FDB001871
Export Tariff Code:	2937.92.8020
MedlinePlusSupp:	View
VCF-Online:	VCF Volatile Compounds in Food
ChemSpider:	View
Wikipedia:	View
Formulations/Preparations: •progesterone is available in an oily solution for injection, as pessaries or suppositories and as an intrauterine device. •prochieve is available in two strengths: 4% gel (45 mg of progesterone) and 8% gel (90 mg of progesterone). •progesterone injection, (projestaject, others) contains 25 to 100 mg progesterone per ml of vegetable oil. aqueous suspensions of progesterone are particularly painful & are seldom used. progesterone is also available in a t-shaped intrauterine contraceptive device that provides continuous delivery of progesterone in the uterine cavity for 1 yr. this is marketed under the name of progestasert and contains 38 mg of progesterone. •vials (aqueous solution and in oil), 25 mgml, 50 mgml, and 100 mgml. intrauterine system, 38 mg, provides contraceptive effectiveness for a period of one year. •grade: national formulary •progesterone exists in two crystalline forms (alpha- and beta-) of equal physiological activity. •alza corp...developed and intrauterine device, progestasert, designed to release progesterone by diffusion through a rate-controlling membrane for up to one year.

Potential Blenders and core components note

None Found

Potential Uses:

None Found

Occurrence (nature, food, other):note

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	not found in nature
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Synonyms:

(8S,9S,10R,13S,14S,17S)-17-	acetyl-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one
	agolutin
	akrolutin
	bio-luton
	colprosterone
	corlutin
	corluvite
	corporin
	crinone
	cyclogest
	duraprogen
	endometrin
	estima
	flavolutan
	fologenon
	gesterol 100
	gesterol 50
	gestiron
	gestone
	gestormone
	gestron
	glanducorpin
	gynlutin
	gynoluton
	hormoflaveine
	hormoluton
	lingusorbs
	lipolutin
	lucorteum
	lugesteron
	luteodyn
	luteol
	luteosan
	luteostab
	luteovis
	luteum
	lutociclina
	lutocuclin M
	lutocyclin
	nalutron
	percutacrine
	piaponon
	pregn-4-en-3,20-dione
(S)-	pregn-4-en-3,20-dione
	pregn-4-ene-3,20-dione
4-	pregnen-3,20-dione
(S)-4-	pregnene-3,20-dione
	progeffik
	progestan
	progestasert
(S)-	progesterone
	progestogel
	progestol
	prontogest
	syngesterone
	synovex S
	utrogest
	vitarrine

Articles:

PubMed:Effects of ractopamine hydrochloride and zilpaterol hydrochloride supplementation on longissimus muscle shear force and sensory attributes of calf-fed Holstein steers.

PubMed:Transcript profiling of candidate genes in testis of pigs exhibiting large differences in androstenone levels.

PubMed:Effects of growth implants on consumer perceptions of meat tenderness in beef steers.

PubMed:Persistence of flavor neophobia as an indicator of state-dependent retention induced by pentobarbital, stress, and estrus.

Notes:

the major progestational steroid that is secreted primarily by the corpus luteum and the placenta. progesterone acts on the uterus, the mammary glands and the brain. it is required in embryo implantation; pregnancy maintenance, and the development of mammary tissue for milk production. progesterone, converted from pregnenolone, also serves as an intermediate in the biosynthesis of gonadal steroid hormones and adrenal corticosteroids. Progestational hormone secreted by corpus luteum during menstrual cycle. Also found in the gonads and haemolymph of crustaceans, e.g. Artemia, Euphosia, Homarus, Pandalus and Penaeus spp (CCD)

progesterone 4-pregnen-3,20-dione

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Articles:

progesterone
4-pregnen-3,20-dione