EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

glycofurol
ethylene oxide homopolymer 2-tetrahydrofuranylmethyl ether

Supplier Sponsors

CAS Number: 31692-85-0Picture of molecule3D/inchi
Other(deleted CASRN):121182-07-8
FDA UNII: YZC5LZ8BUB
Nikkaji Web:J218.084G
MDL:MFCD00801146
XlogP3-AA:-0.20 (est)
Molecular Weight:146.18618000
Formula:C7 H14 O3
NMR Predictor:Predict (works with chrome, Edge or firefox)
CAS Number: 9004-76-6Picture of molecule3D/inchi
FDA UNII: Search
Molecular Weight:1692.00000000
Category:viscosity controlling agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Specific Gravity:1.06900 @ 25.00 °C.
Refractive Index:1.46200 @ 20.00 °C.
Boiling Point: 256.00 to 257.00 °C. @ 760.00 mm Hg (est)
Vapor Pressure:0.002000 mmHg @ 25.00 °C. (est)
Flash Point:> 230.00 °F. TCC ( > 110.00 °C. )
logP (o/w): 5.997 (est)
Soluble in:
 water, 5.436e+005 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: solvents
viscosity controlling agents
 
Suppliers:
BOC Sciences
For experimental / research use only.
Glycofurol
Carbosynth
For experimental / research use only.
Glycofurol
EMD Millipore
For experimental / research use only.
Tetrahydrofurfuryl alcohol polyethylene glycol ether
sds
Santa Cruz Biotechnology
For experimental / research use only.
Tetraglycol
Sigma-Aldrich: Aldrich
For experimental / research use only.
Poly(ethylene glycol) tetrahydrofurfuryl ether average Mn 200
sds
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intravenous-mouse LD50 3500 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 6, Pg. 75, 1956.

intraperitoneal-mouse LD50 7800 mg/kg
BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) CARDIAC: OTHER CHANGES
Arzneimittel-Forschung. Drug Research. Vol. 28, Pg. 1586, 1978.

intravenous-rat LDLo 1000 mg/kg
CARDIAC: OTHER CHANGES BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Arzneimittel-Forschung. Drug Research. Vol. 28, Pg. 1586, 1978.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
viscosity controlling agents
Recommendation for glycofurol usage levels up to:
 not for fragrance use.
 
Recommendation for glycofurol flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :110717
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
2-(oxolan-2-ylmethoxy)ethanol
Chemidplus:0031692850
RTECS:MD0907500 for cas# 31692-85-0
Chemidplus:0009004766
RTECS:MD0907500 for cas# 9004-76-6
 
References:
 2-(oxolan-2-ylmethoxy)ethanol
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):110717
Pubchem (sid):135066885
Pubchem (sid):135072637
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
HMDB (The Human Metabolome Database):Search
Export Tariff Code:3907.20.0000
ChemSpider:View
EFSA Update of results on the monitoring of furan levels in food:Read Report
EFSA Previous report: Results on the monitoring of furan levels in food:Read Report
EFSA Report of the CONTAM Panel on provisional findings on furan in food:Read Report
 
Potential Blenders and core components note
None Found
 
Potential Uses:
 solvents
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
 ethanol, 2-[(tetrahydro-2-furanyl)methoxy]-
 ethylene oxide homopolymer 2-tetrahydrofuranylmethyl ether
 glycofural
 glycofurol 75
 glycofurolum 75
 glycols, polyethylene, mono(tetrahydrofurfuryl) ether
2-(oxolan-2-ylmethoxy)ethanol
 poly(ethylene glycol) tetrahydrofurfuryl ether
 polyethylene glycol tetrahydrofurfuryl ether
2-(tetrahydro-2-furanylmethoxy)-1-ethanol
2-(tetrahydrofuran-2-ylmethoxy)ethanol
 tetrahydrofurfuryl alcohol polyethylene glycol ether
 tetrahydrofurfuryl ethoxylate
2-((tetrahydrofurfuryl)oxy)ethanol
2-[(tetrahydrofurfuryl)oxy]ethanol
 THFP
 

Articles:

PubMed:Pharmacokinetics of a self-microemulsifying drug delivery system of tacrolimus.
PubMed:Optimized formulation of solid self-microemulsifying sirolimus delivery systems.
PubMed:Oral insulin delivery in rats by nanoparticles prepared with non-toxic solvents.
PubMed:Preparation of polymeric particles in CO(2) medium using non-toxic solvents: formulation and comparisons with a phase separation method.
PubMed:Preparation and biocompatibility study of in situ forming polymer implants in rat brains.
PubMed:Application of hydroxyapatite nanoparticles in development of an enhanced formulation for delivering sustained release of triamcinolone acetonide.
PubMed:Biocompatibility study of glycofurol in rat brains.
PubMed:Microsphere preparation using the untoxic solvent glycofurol.
PubMed:Evaluation of glycofurol-based gel as a new vehicle for topical application of naproxen.
PubMed:Solubility enhancement of hydrophobic compounds by cosolvents: role of solute hydrophobicity on the solubilization effect.
PubMed:Inhibition of acetylcholinesterase by chromophore-linked fluorophosphonates.
PubMed:Green fluorescent protein: structure, folding and chromophore maturation.
PubMed:Bioavailability and tolerability of intranasal diazepam in healthy adult volunteers.
PubMed:Photoregulation of ion permeation through a polyelectrolyte multilayer membrane by manipulating the chromophore orientation.
PubMed:Development and characterization of self-microemulsifying drug delivery system of tacrolimus for intravenous administration.
PubMed:Physicochemical studies of a newly synthesized molecule, 6-methyl-3-phenethyl-3,4-dihydro-1H-quinazoline-2-thione (JSH18) for topical formulations.
PubMed:The tachykinin NK3 receptor agonist senktide induces locomotor activity in male Mongolian gerbils.
PubMed:Mutant screen distinguishes between residues necessary for light-signal perception and signal transfer by phytochrome B.
PubMed:Reversible protein precipitation to ensure stability during encapsulation within PLGA microspheres.
PubMed:Cardiovascular effects of selected water-miscible solvents for pharmaceutical injections and embolization materials: a comparative hemodynamic study using a sheep model.
PubMed:Organic solvents as vehicles for precipitating liquid embolics: a comparative angiotoxicity study with superselective injections of swine rete mirabile.
PubMed:The effect of commonly used vehicles on canine hematology and clinical chemistry values.
PubMed:Enhanced permeation of diazepam through artificial membranes from supersaturated solutions.
PubMed:Acrylic polymers as thickening agents for tetraglycol cosolvent.
PubMed:Peripheral neuropathy: a persisting challenge in paclitaxel-based regimes.
PubMed:A green light-absorbing phycoerythrin is present in the high-light-adapted marine cyanobacterium Prochlorococcus sp. MED4.
PubMed:Crystal structures and mutational analysis of amFP486, a cyan fluorescent protein from Anemonia majano.
PubMed:Preparation of PLGA microparticles by an emulsion-extraction process using glycofurol as polymer solvent.
PubMed:Bioavailabilities of rectal and oral methadone in healthy subjects.
PubMed:[Study on the auxochrome of the electronic spectrum of organic compounds and its effect mechanism (II)].
PubMed:Solubilization of the lichen metabolite (+)-usnic acid for testing in tissue culture.
PubMed:Nasal bioavailability of peptide T in rabbits: absorption enhancement by sodium glycocholate and glycofurol.
PubMed:Solubilization and stability of bumetanide in vehicles for intranasal administration, a pilot study.
PubMed:Comparative hemolytic activity of undiluted organic water-miscible solvents for intravenous and intra-arterial injection.
PubMed:Organic solvents for pharmaceutical parenterals and embolic liquids: a review of toxicity data.
PubMed:Intranasal administration of different liquid formulations of bumetanide to rabbits.
PubMed:Characterization of a polymeric PLGA-injectable implant delivery system for the controlled release of proteins.
PubMed:Development and evaluation of microbicidal hydrogels containing monoglyceride as the active ingredient.
PubMed:Single- and repeated-dose local toxicity in the nasal cavity of rabbits after intranasal administration of different glycols for formulations containing benzodiazepines.
PubMed:Solubilization of various benzodiazepines for intranasal administration, a pilot study.
PubMed:Pharmacokinetic and pharmacodynamic response after intranasal administration of diazepam to rabbits.
PubMed:Intravenous carbamazepine: comparison of different parenteral formulations in a mouse model of convulsive status epilepticus.
PubMed:Evaluation of local toxicity after repeated intranasal vaccination of guinea-pigs.
PubMed:New injectable aqueous carbamazepine solution through complexing with 2-hydroxypropyl-beta-cyclodextrin: tolerability and pharmacokinetics after intravenous injection in comparison to a glycofurol-based formulation.
PubMed:The effect of progesterone and its metabolite 5 alpha-pregnan-3 alpha-ol-20-one on focal epileptic seizures in the cat's visual cortex in vivo.
PubMed:Selective 5-lipoxygenase inhibitor BW A4C does not influence progression of tissue injury in a canine model of regional myocardial ischaemia and reperfusion.
PubMed:The role of technical, biological and pharmacological factors in the laboratory evaluation of anticonvulsant drugs. I. The influence of administration vehicles.
PubMed:A new injectable carbamazepine solution--antiepileptic effects and pharmaceutical properties.
PubMed:Advances in the use of computerized gas chromatography-mass spectrometry and high-performance liquid chromatography with rapid scanning detection for clinical diagnosis.
PubMed:Topical application of penetration enhancers to the skin of nude mice: a histopathological study.
PubMed:Plasma and tissue concentrations of coenzyme Q10 in the rat after intravenous administration by a microsphere delivery system or in a new type of solution.
PubMed:Disposition of intravenous glycofurol: effect of hepatic cirrhosis.
PubMed:[Local tolerance for co-trimoxazole i. m.. Comparison with an intramuscularly administered penicillin combination].
PubMed:The induction of immunologic tolerance in guinea pigs infused with dimethylbenz(a)anthracene.
PubMed:Mechanisms in the potentiation and inhibition of pharmacological actions of hexobarbital and zoxazolamine by glycofurol.
PubMed:[A new injectable solvent (glycofurol)].
 
Notes:
None found
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