EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

tosylamide
benzenesulfonamide, 4-methyl-

Supplier Sponsors

CAS Number: 70-55-3Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:200-741-1
FDA UNII: I8266RI90M
Nikkaji Web:J4.878J
Beilstein Number:0472689
MDL:MFCD00011692
XlogP3-AA:0.80 (est)
Molecular Weight:171.21913000
Formula:C7 H9 N O2 S
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:plasticizers
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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US Patents:Search
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Pubchem Patents:Search
PubMed:Search
NCBI:Search
FDA Mainterm (IAUFC):70-55-3 ; TOLUENESULFONAMIDE, P-
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 138.50 °C. @ 760.00 mm Hg
logP (o/w): 0.820
Soluble in:
 water, 3160 mg/L @ 25 °C (exp)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: plasticisers
 
Suppliers:
BOC Sciences
For experimental / research use only.
p-Toluenesulfonamide
Carbosynth
For experimental / research use only.
p-Toluenesulfonamide
Glentham Life Sciences
p-Toluenesulfonamide
Sigma-Aldrich: Aldrich
For experimental / research use only.
p-Toluenesulfonamide ReagentPlus®, ≥99%
sds
TCI AMERICA
For experimental / research use only.
p-Toluenesulfonamide >98.0%(HPLC)(N)
sds
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-bird - wild LD50 75 mg/kg
Toxicology and Applied Pharmacology. Vol. 21, Pg. 315, 1972.

intraperitoneal-mouse LD50 250 mg/kg
National Technical Information Service. Vol. AD691-490

Dermal Toxicity:
subcutaneous-guinea pig LDLo 2000 mg/kg
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: EXCITEMENT BEHAVIORAL: MUSCLE WEAKNESS
Journal of Pharmacology and Experimental Therapeutics. Vol. 14, Pg. 259, 1920.

Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
plasticizers
Recommendation for tosylamide usage levels up to:
 not for fragrance use.
 
Recommendation for tosylamide flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
NIOSH International Chemical Safety Cards:search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA GENetic TOXicology:Search
EPA Substance Registry Services (TSCA):70-55-3
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :6269
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:1
4-methylbenzenesulfonamide
Chemidplus:0000070553
RTECS:70-55-3
 
References:
 4-methylbenzenesulfonamide
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:70-55-3
Pubchem (cid):6269
Pubchem (sid):134971979
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Indirect Additives used in Food Contact Substances:View
CHEBI:View
CHEMBL:View
KEGG (GenomeNet):C14412
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2935.00.9500
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
 benzenesulfonamide, 4-methyl-
4-methylbenzenesulfonamide
p-methylbenzenesulfonamide
para-toluene sulfonamide
 toluene-4-sulfonamide
 toluene-p-sulphonamide
p-toluenesulfamide
4-toluenesulfanamide
4-toluenesulfonamide
p-toluenesulfonamide
para-toluenesulfonamide
4-toluenesulfonic acid, amide
p-toluenesulfonylamide
 tolylsulfonamide
p-tolylsulfonamide
 tosyl amide
p-tosylamide
 

Articles:

PubMed:N-Substituted Derivatives of the Azadithiolate Cofactor from the [FeFe] Hydrogenases: Stability and Complexation.
PubMed:Ruthenium catalysts bearing a benzimidazolylidene ligand for the metathetical ring-closure of tetrasubstituted cycloolefins.
PubMed:An efficient approach to gem-difluorocyclopropylstannanes via highly regio- and stereoselective hydrostannylation of gem-difluorocyclopropenes and their unique ring-opening reaction to afford β-fluoroallylic alcohols.
PubMed:Unusual reaction behavior of gem-difluorocyclopropane derivatives: stereoselective synthesis of β-monofluoroallylic alcohols, ethers, esters, and amide.
PubMed:Gold(I)-promoted heterocyclization of internal alkynes: a comparative study of direct metallate 5-endo-dig cyclization versus a stepwise cyclization.
PubMed:Asymmetric synthesis of (-)-aurantioclavine via palladium-catalyzed intramolecular allylic amination.
PubMed:Dynamics of Solvent Controlled ESIPT of π-Expanded Imidazole Derivatives - pH Effect.
PubMed:Anti-influenza A virus activity of uridine derivatives of 2-deoxy sugars.
PubMed:In vitro antiviral activity of hypothiocyanite against A/H1N1/2009 pandemic influenza virus.
PubMed:North American Contact Dermatitis Group patch test results for 2007-2008.
PubMed:Results of patch-tests from Santa Casa de Belo Horizonte Dermatology Clinic, Belo Horizonte, Brazil, from 2003 to 2010.
PubMed:CuCl-K2CO3-catalyzed highly selective borylcupration of internal alkynes--ligand effect.
PubMed:Furanyl cyclic amines: a diastereoselective synthesis of 2,6-syn-disubstituted piperidines under thermodynamic control.
PubMed:Allylic C-H bond activation and functionalization mediated by tris(oxazolinyl)borato rhodium(I) and iridium(I) compounds.
PubMed:Synthesis of mono- and 1,3-diaminocalix[4]arenes via Ullmann-type amination and amidation of 1,3-bistriflate esters of calix[4]arenes.
PubMed:Nonradiative inter- and intramolecular energy transfer from the aromatic donor anisole to a synthesized photoswitchable acceptor system.
PubMed:Preparation, X-ray structure, and oxidative reactivity of N-(2-iodylphenyl)tosylamides and 2-iodylphenyl tosylate: iodylarenes stabilized by ortho-substitution with a sulfonyl group.
PubMed:Platinum(II) catalysts for highly enantioselective 1,6-enyne cycloisomerizations. synthetic, structural, and catalytic studies.
PubMed:Tosylamide/formaldehyde resin allergy in a young boy: exposure from bitter nail varnish used against nail biting.
PubMed:Tosylamide formaldehyde resin.
PubMed:Tosylamide/formaldehyde resin allergy--a consideration in the atopic toddler.
PubMed:Three-component coupling reaction and cyclization of N-tosylimines and TMS-substituted propiolate mediated by DABCO.
PubMed:Allergic contact dermatitis caused by tosylamide formaldehyde resin in nail varnish: an old allergen that has not disappeared.
PubMed:The aetiology of eyelid dermatitis: a 10-year retrospective analysis.
PubMed:Hydroamination and hydroalkoxylation catalyzed by triflic acid. Parallels to reactions initiated with metal triflates.
PubMed:Lewis base catalyzed Mannich-type reactions between trimethylsilyl enol ethers and aldimines.
PubMed:Detection of enzymes dehydrogenases and proteases inBrugia malayi filarial parasites.
PubMed:Cosmetic allergy: incidence, diagnosis, and management.
PubMed:Identification of tumor markers using two-dimensional electrophoresis in gastric carcinoma.
PubMed:Enantioselective synthesis of DIANANE, a novel C2-symmetric chiral diamine for asymmetric catalysis.
PubMed:Synthetic methodology utilized to prepare substituted imidazole p38 MAP kinase inhibitors.
PubMed:Contact dermatitis in adolescents.
PubMed:Imino ene reaction catalyzed by ytterbium(III) triflate and TMSCl or TMSOTf.
PubMed:Alkynyliodonium salts in organic synthesis. Application to the total synthesis of the tropoloisoquinoline alkaloid pareitropone.
PubMed:Cross-reactivity among epoxy acrylates and bisphenol F epoxy resins in patients with bisphenol A epoxy resin sensitivity.
PubMed:Palladium-catalyzed cyclization of allylsilanes with nucleophilic displacement of the silyl group.
PubMed:Aziridine-Allylsilane-Mediated Total Synthesis of (-)-Yohimbane.
PubMed:Palladium-Catalyzed Cross-Coupling of 2,5-Cyclohexadienyl-Substituted Aryl or Vinylic Iodides and Carbon or Heteroatom Nucleophiles.
PubMed:Palladium(II)-Catalyzed 1,4-Oxidation of 2-Aryl-1,3-cyclohexadienes. Application to the Synthesis of (+/-)-Epibatidine and Analogues.
PubMed:Synthesis of Medium-Ring Nitrogen Heterocycles via Palladium-Catalyzed Heteroannulation of 1,2-Dienes.
PubMed:Pyrrolo-annelated tetrathiafulvalenes: the parent systems
PubMed:Contact dermatitis from tosylamide/formaldehyde resin with photosensitivity.
PubMed:Desquamative gingivitis, sole manifestation of tosylamide/formaldehyde resin allergy.
PubMed:Palladium(II)-Catalyzed Intramolecular Aminocarbonylation of endo-Carbamates under Wacker-Type Conditions.
PubMed:Purification of a 24-kD protease from apoptotic tumor cells that activates DNA fragmentation.
PubMed:Purification and characterization of a novel acrosin-like enzyme from boar cauda epididymal sperm.
PubMed:Direct peptide mapping of sickle-cell hemoglobin using electrospray mass spectrometry.
PubMed:Mass spectrometry and characterization of Aedes aegypti trypsin modulating oostatic factor (TMOF) and its analogs.
PubMed:Inhibition of neutrophil superoxide production by human plasma alpha 1-antitrypsin.
PubMed:Granulocyte-macrophage colony-stimulating factor is a stimulant of platelet-activating factor and superoxide anion generation by human neutrophils.
PubMed:Reduction in cell entry of Eimeria tenella (Coccidia) sporozoites by protease inhibitors, and partial characterization of proteolytic activity associated with intact sporozoites and merozoites.
PubMed:Macrocyclic chelates of radiometals for diagnosis and therapy.
PubMed:The measurement of dimethylamine, trimethylamine, and trimethylamine N-oxide using capillary gas chromatography-mass spectrometry.
PubMed:Identification of a highly reactive sulphydryl group in human placental glutathione transferase by a site-directed fluorescent reagent.
PubMed:Serum protease inhibitor abrogation of Newcastle disease virus enhancement of cytolysis by recombinant tumor necrosis factors alpha and beta.
PubMed:Stable bifunctional chelates of metals used in radiotherapy.
PubMed:Cell surface-associated proteinases in NK cell-mediated cytotoxicity: enhancement of enzyme expression is unique to activation with interferon-alpha.
PubMed:Trichomonas vaginalis surface proteinase activity is necessary for parasite adherence to epithelial cells.
PubMed:Xenopus laevis skin Arg-Xaa-Val-Arg-Gly-endoprotease. A highly specific protease cleaving after a single arginine of a consensus sequence of peptide hormone precursors.
PubMed:Activation of Ca2+ channels during the acrosome reaction of sea urchin sperm is inhibited by inhibitors of chymotrypsin-like proteases.
PubMed:Factors influencing lethality of Bacillus thuringiensis kurstaki toxin for eggs and larvae of Trichostrongylus colubriformis (Nematoda).
PubMed:Detachment of oral bacteria from saliva-coated hydroxyapatite by human polymorphonuclear leukocytes.
PubMed:Giardia lamblia: characterization of proteinase activity in trophozoites.
PubMed:Isolation of a chymotrypsinlike enzyme from Treponema denticola.
PubMed:Palmitoylcarnitine reverses 12-O-tetradecanoylphorbol-13-acetate-induced refractory state for the TPA-caused ornithine decarboxylase induction in mouse epidermis.
PubMed:Influence of proteinase inhibitors and substrates on 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-binding capacity of the rat hepatic Ah receptor.
PubMed:Characterization of the reactivity of sulphydryl groups in tryptophanase by a dual-monitoring high-performance liquid chromatographic system with a site-directed fluorescent reagent.
PubMed:Evidence for involvement of serine proteases in the late stages of the natural killer cell lytic reaction.
PubMed:Requirement for cell-bound proteases in the mechanism of human neutrophil activation with various stimuli.
PubMed:Extracellular fluid proteins of goldfish brain: evidence for the presence of proteases and esterases.
PubMed:Electrophoretic analysis of membrane proteases in the luteinized rat ovary.
PubMed:Purification and characterization of an enzyme produced by Treponema denticola capable of hydrolyzing synthetic trypsin substrates.
PubMed:Reducing conditions induce a total degradation of the major zymogen granule membrane protein in both its membranous and its soluble form. Immunochemical quantitation of the two forms.
PubMed:Lectin binding sites related with rat ascites hepatoma cell adhesion.
PubMed:Trichostrongylus colubriformis: egg lethality due to Bacillus thuringiensis crystal toxin.
PubMed:Decrease of metastatogenic potential by pregraft treatment of Lewis lung carcinoma cells with proteinase and protein kinase affinity labels.
PubMed:Characterization of certain proteinase isoenzymes produced by benign and virulent strains of Bacteroides nodosus.
PubMed:Properties of interleukin-1 as a complete secretagogue for human neutrophils.
PubMed:A membrane-bound protease in microsomes of spinach callus.
PubMed:Enzymatic characterization of arginine esterase from dog seminal plasma.
PubMed:Involvement of cell surface macromolecules sensitive to alkylating ketones in lysis by human peripheral blood NK cells.
PubMed:Isolation and initial characterization of tumoricidal monokine(s) from the human monocytic leukemia cell line THP-1.
PubMed:Protease inhibition of natural killer (NK) and antibody-dependent cell-mediated cytoxicity (ADCC) activities.
PubMed:Phorbol ester-induced adhesion of murine erythroleukemia cells: possible involvement of cellular proteases.
PubMed:Characterization of tumor cell membrane serine proteases by polyacrylamide gel electrophoresis.
PubMed:Inhibition of 12-O-tetradecanoylphorbol-13-acetate induction of epidermal transglutaminase activity by protease inhibitors.
PubMed:Plasmodium knowlesi: studies on invasion of rhesus erythrocytes by merozoites in the presence of protease inhibitors.
PubMed:Effects of proteolytic enzymes and protease inhibitors on bovine thyroid adenylate cyclase activity.
PubMed:Characterization of proopiocortin converting activity in rat anterior pituitary secretory granules.
PubMed:Anti-inflammatory effect of proteinase inhibitors on carrageenin-induced inflammation in rats.
PubMed:In vitro production of corticosteroid binder IB in the presence of proteolytic inhibitors.
PubMed:Effect of phorbol myristate acetate, a tumor-promoting agent, on the growth of Mycobacterium lepraemurium in the mouse footpad.
PubMed:The formylpeptide chemotactic receptor on rabbit peritoneal neutrophils: change of receptor affinity and number by L-1-tosylamide-2-phenylethyl chloromethyl ketone (TPCK).
PubMed:Increased lability of triosephosphate isomerase in progeria and Werner's syndrome fibroblasts.
PubMed:Effect of proteinase inhibitors having anti-inflammatory activity on gelatinase, elastase and cathepsin G isolated from rat polymorphonuclear leukocytes.
PubMed:Regression line analysis of neutrophil chemotaxis.
PubMed:Characteristics of two trypsin type isozymes isolated from the arctic fish capelin (Mallotus villosus).
PubMed:[Thermitase, a thermostable serine protease of Thermoactinomyces vulgaris: interaction of the active center and the SH-group of the enzyme].
PubMed:Role of tumor cell membrane-bound serine proteases in tumor-induced target cytolysis.
PubMed:Induction of human malignant T-lymphoblastic cell lines MOLT-3 and jurkat by 12-O-tetradecanoylphorbol-13-acetate: biochemical, physical, and morphological characterization.
PubMed:A two-fold effect of L-1-tosylamide-2-phenylethyl chloromethyl ketone on the oxidative metabolism of guinea pig phagocytes.
PubMed:Proteinase inhibitors suppress the formation of granulation tissue in the carrageenin-induced inflammation in rats.
PubMed:Some properties of neutral proteinases from lysosomes of rabbit polymorphonuclear leucocytes.
PubMed:A dual effect of L-1-tosylamide-2-phenylethyl chloromethyl ketone on the respiratory metabolism of guinea pig phagocytes.
PubMed:Asparaginase II of Saccharomyces cerevisiae: inactivation during the transition to stationary phase.
PubMed:Protease of adenovirus type 2. Subcellular localization.
PubMed:Evidence for translational control of the binding of 7, 12-dimethylbenz[a]anthracene to DNA of murine epidermal cell in culture.
PubMed:Boar malpha-acrosin. Purification and characterization of the inital active enzyme resulting from the conversion of boar proacrosin to acrosin.
PubMed:Role of ions and extracellular protein in leukocyte motility and membrane ruffling.
PubMed:Degradation of serum amyloid A protein by surface-associated enzymes of human blood monocytes.
PubMed:Inhibition by protease inhibitors of binding of adrenal and sex steroid hormones.
PubMed:[Breakdown of luliberin, somatostatin and substance P as an effect of hypothalamic endopeptidases].
PubMed:Human leukocyte migration inhibitory factor (LIF) III. Further investigations on the serine protease nature of this lymphokine and its preference for arginine amides.
PubMed:Monomer molecular weight of T antigen from simian virus 40-infected and transformed cells.
PubMed:Pregrowth hormone: product of the translation in vitro of messenger RNA coding for growth hormone.
PubMed:Modulation of human neutrophil polymorphonuclear leucocyte migration by human plasma alpha-globulin inhibitors and synthetic esterase inhibitors.
PubMed:Mechanism of histamine release by alpha-chymotrypsin from isolated rat mast cells.
PubMed:Purification and properties of a serine protease from Pseudomonas matophilia.
 
Notes:
None found
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