EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

oxosuccinic acid
oxalacetic acid (8CI)

Supplier Sponsors

CAS Number: 328-42-7Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:206-329-8
FDA UNII: 2F399MM81J
Nikkaji Web:J5.675H
Beilstein Number:1705475
MDL:MFCD00002592
XlogP3-AA:-0.60 (est)
Molecular Weight:132.07188000
Formula:C4 H4 O5
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:cosmetic ingredient for skin conditioning
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 161.00 °C. @ 760.00 mm Hg
Boiling Point: 341.93 °C. @ 760.00 mm Hg (est)
Flash Point: 347.00 °F. TCC ( 174.80 °C. ) (est)
logP (o/w): -1.821 (est)
Soluble in:
 water, 1e+006 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: skin conditioning
 
Suppliers:
Alfa Biotechnology
For experimental / research use only.
2-Oxosuccinic acid 98%
BOC Sciences
For experimental / research use only.
Oxalacetic acid 98%
EMD Millipore
For experimental / research use only.
oxoSuccinic Acid
sds
Santa Cruz Biotechnology
For experimental / research use only.
Oxaloacetic Acid
Sigma-Aldrich: Sigma
For experimental / research use only.
Oxaloacetic acid powder, BioReagent, suitable for cell culture, suitable for insect cell culture, ≥97%
sds
TCI AMERICA
For experimental / research use only.
oxoSuccinic Acid >97.0%(T)
sds
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
cosmetic ingredient for skin conditioning
Recommendation for oxosuccinic acid usage levels up to:
 not for fragrance use.
 
Recommendation for oxosuccinic acid flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):328-42-7
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :970
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
2-oxobutanedioic acid
Chemidplus:0000328427
 
References:
 2-oxobutanedioic acid
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:328-42-7
Pubchem (cid):970
Pubchem (sid):134973454
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
Golm Metabolome Database:Search
UM BBD:Search
KEGG (GenomeNet):C00036
HMDB (The Human Metabolome Database):HMDB00223
FooDB:FDB001479
YMDB (Yeast Metabolome Database):YMDB00235
Export Tariff Code:2918.13.5000
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 apple plant
Search Trop Picture
 barley seed
Search Trop Picture
 tamarind flower
Search Trop Picture
 tamarind fruit
Search Trop Picture
 tamarind leaf
Search Trop Picture
 tamarind seed
Search Trop Picture
 
Synonyms:
2-oxobutanedioic acid
oxobutanedioic acid
 butanedioic acid, 2-oxo-
 butanedioic acid, oxo-
oxobutanedioicacid
3-carboxy-3-oxopropanoic acid
oxalacetic acid
oxalacetic acid (8CI)
oxalaceticacid
oxaloethanoic acid
2-oxosuccinic acid
a-ketosuccinic acid
 

Articles:

PubMed:VO2+ complexation by bioligands showing keto-enol tautomerism: a potentiometric, spectroscopic, and computational study.
PubMed:Isolation and characterization of an apple cytosolic malate dehydrogenase gene reveal its function in malate synthesis.
PubMed:Hepatoprotective activity of leaves of Zanthoxylum armatum DC in CCl4 induced hepatotoxicity in rats.
PubMed:[Study of metabonomics on pharmacological action appraisal Rhizoma coptidis in rats].
PubMed:Metabolic discrimination of Catharanthus roseus calli according to their relative locations using (1)H-NMR and principal component analysis.
PubMed:Molecular cloning and characterization of a novel lactate dehydrogenase gene from Clonorchis sinensis.
PubMed:Synthesis and NMR spectroscopy of nine stereoisomeric 5,7-diacetamido-3,5,7,9-tetradeoxynon-2-ulosonic acids.
PubMed:Synthesis and identification in bacterial lipopolysaccharides of 5,7-diacetamido-3,5,7,9-tetradeoxy-D-glycero-D-galacto- and -D-glycero-D-talo-non-2-ulosonic acids.
PubMed:Activities of superoxide dismutase and catalase in erythrocytes and transaminases in the plasma of carps (Cyprinus carpio L.) exposed to cadmium.
PubMed:Biosynthesis of pseudoisoeugenols in tissue cultures of Pimpinella anisum. Phenylalanine ammonia lyase and cinnamic acid 4-hydroxylase activities.
PubMed:Escherichia coli fumarase A catalyzes the isomerization of enol and keto oxalacetic acid.
PubMed:High molecular weight protein aggregates formed in the liver of the rat following large doses of paracetamol.
PubMed:Hydrolysis of phosphoenolpyruvate catalyzed by phosphoenolpyruvate carboxylase from Zea mays.
PubMed:Biosynthesis of Phytosiderophores : In Vitro Biosynthesis of 2'-Deoxymugineic Acid from l-Methionine and Nicotianamine.
PubMed:Repression of phenylacetic acid transport system in Penicillium chrysogenum Wis 54-1255 by free amino acids and ammonium salts.
PubMed:Studies on the biosynthesis of bialaphos (SF-1293). 8. Purification and characterization of 2-phosphinomethylmalic acid synthase from Streptomyces hygroscopicus SF-1293.
PubMed:The phosphoenolpyruvate carboxykinase of Trypanosoma (Schizotrypanum) cruzi epimastigotes: molecular, kinetic, and regulatory properties.
PubMed:Selective inactivation of heterokaryons of Candida albicans by anaerobiosis.
PubMed:[Effect of oxaloacetic acid on hydrogen-calcium metabolism in mitochondria].
PubMed:Effect of phloridzin on lipid biosynthesis by Cladosporium tenuissimum Cooke.
PubMed:Aspartate glucan, glycine glucan, and serine glucan for the removal of cobalt and copper from solutions and brines.
PubMed:Malic acid production by an electrochemical reduction system combined with the use of diaphorase and methylviologen.
PubMed:Testosterone stimulation of mitochondrial aspartate aminotransferase in organ cultures of rat ventral prostate.
PubMed:[Mechanism of auto-oscillations in mitochondria based on modulations of succinate dehydrogenase activity].
PubMed:[Regulation of glyoxylate cycle enzymes in Saccharomycopsis lipolytica. I. Effect of the carbon source on isocitrate lyase and malate synthase activity].
PubMed:Morphological and biochemical studies on liver, kidney and gill of fishes affected by pesticides.
PubMed:Inhibition of phosphoenolpyruvate carboxykinase by streptonigrin.
PubMed:The vitamin status of Viennese school children aged 11-12 years.
PubMed:[Functional characteristics of phosphoenolpyruvate carboxylase in bacteria producing lysine].
PubMed:Localization of adenylate cyclase and 5'-nucleotidase activities in human thyroid follicular cells.
PubMed:[Role of protonophore activity of oxalacetic acid in inducing Ca2+ yield from mitochondria].
PubMed:Oxidation of meso-diaminosuccinic acid, a possible natural substrate for D-aspartate oxidase.
PubMed:Distribution of glucose incorporated into macromolecular material by treponema pallidum.
PubMed:Production of methanol from aromatic acids by Pseudomonas putida.
PubMed:Cellular content of the Krebs cycle keto acids in yeasts grown on different nitrogen sources, including hydroxylamine.
PubMed:[Energy metabolism disorders in the myocardium due to alcoholic intoxication].
PubMed:Effect of ischaemia on the enzyme activity of the hepatic tissue.
PubMed:Enzymatic activity of pig heart mitochondrial malate dehydrogenase monomolecular films by surface exchange technique.
PubMed:Regulation of aerobic fermentation in protozoans. VI Comparative biochemistry of pathogenic and nonpathogenic protozoans.
PubMed:Two omega-amino acid transaminases from Bacillus cereus.
PubMed:Inhibitory effect of fumaric acid and dicarboxylic acids on gastric ulceration in rats.
PubMed:[Correlation between the 'active' and 'passive' mechanisms of chlortetracycline penetration in the cells of a sensitive and resistant strains of mycobacteria].
PubMed:[Decarboxylation reaction of oxalacetic acid by metal chelates. III. Metal-peptide (author's transl)].
PubMed:[Decarboxylation reaction of oxalacetic acid by metal chelates. II. Metal-amino acid (author's transl)].
PubMed:Catalysis of decarboxylation of oxalacetic acid by modified poly(ethylenimines).
PubMed:[Mechanism of bacterial resistance to tetracyclines and the importance of structural elements of tetracycline molecule for induction of resistance].
PubMed:Photofragmentation of alpha-oxocarboxylic acids in aqueous solution. An EPR study. Formation of semidione radicals by decarboxylative substitution of alpha-oxocarboxylic acids by acyl radicals--II. Oxaloacetic acid (oxosuccinic acid).
PubMed:[Canges in nucleoprotein metabolism in the rat brain. III. Effect of a single concentration or of a mixture of oxalacetic acid, alpha-ketoglutarate and pyridoxal-5-phosphate in animals subjected to muscular exercise].
PubMed:[Changes in nucleoprotein metabolism in the rat brain. II. Effect of the administration of a combination of oxalacetic acid, alpha-ketoglutaric acid and pyridoxal-5-phosphate in normal and fatigued animalsA1].
PubMed:[Changes of the alkaline phosphatase, glutamine oxalacetic acid transaminase and lipid fraction, respectively, of the serum and of the liver in rats after local irradiation of the liver with 8000 R].
PubMed:Biotin deficiency in Arthrobactger globiformis: comparative cell ultrastructure and nonreplacement of the vitamin by structurally unrelated compounds.
PubMed:Non-enzymic β-decarboxylation of aspartic acid.
PubMed:Considerations of oxalacetic acid keto--enol equilibria in various solvents.
PubMed:[Multiplication of primary and permanent animal cells in oxalacetic acid media].
PubMed:[Effect of oxalacetic acid, malic acid and pyruvate on the adjustment of abnormal fatty acid metabolism in diabetes mellitus].
PubMed:Carbon dioxide effects on fruits : III. The fixation of C(14)O 2 in lemon in an atmosphere enriched with carbon dioxide.
PubMed:[Metalioncatalytic decarboxylation of oxalacetic acid(OAA)].
PubMed:[On the keto-enol-balance and decarboxylation of oxalacetic acid (OAA) ].
PubMed:[Experiments on the synthesis of agaricic acid. 2. On the accumulation of alpha-bromstearic acid ethyl ester on oxalacetic acid diethylester].
PubMed:Enzymatic enolization of oxalacetic acid.
PubMed:[Glutamic-oxalacetic acid transaminase activity in cerebrospinal fluid].
PubMed:REACTIONS OF OXALACETIC ACID AND THE FERRIC AND AMMONIUM COMPLEXES OF OXALACETIC ACID. REP NO. 571.
PubMed:Glutamic acid-oxalacetic acid transaminase in the spinal fluid in infectious diseases of the central nervous system.
PubMed:Daily changes in serum glutamic oxalacetic acid transaminase, with reference to the clinical aspects.
PubMed:Non-enzymatic reaction of fluoro-oxalacetic acid with pyridine nucleotides.
PubMed:[The determination of alcohol dehydrogenase and glutamic acid oxalacetic acid transaminase activity in the human liver after death].
PubMed:[The diagnostic value of serum leucine aminopeptidase, alkaline phosphatase and glutamine oxalacetic acid transaminase activity. Comparative studies].
PubMed:[Studies on the effect of sonic and ultrasonic fields on biochemical processes. VI. Effect on the level of pyruvic acid, oxalacetic acid, citric acid and alpha-ketoglutaric acid in the blood of guinea pigs].
PubMed:[Biological processes of oxalacetic acid decarboxylation].
PubMed:Growth studies on a tissue culture medium containing oxalacetic acid as a source of CO2.
PubMed:Differences in the distribution of glutamic acid-oxalacetic acid transaminase- and aldolase-activity among serum protein fractions in patients with acute myocardial infarct and hepatocellular damage.
PubMed:[Glutamic acid--pyruvic acid and glutamic acid-oxalacetic acid transaminase in maternal and embryonal organs, placenta, maternal serum and amniotic fluid of gravid rats in normal and pathological conditions].
PubMed:Serum glutamic oxalacetic acid transaminase activity following hypothermia.
PubMed:[Condensation of glyoxylic acid with oxalacetic acid].
PubMed:[Serum glutamic acid oxalacetic acid transaminase and aldolase in acute pancreatitis].
PubMed:[A method for determination of calibration curves for colorimetric studies demonstrated by an example of determination of serum glutamic acid-oxalacetic acid-transaminase with the Havemann electrocolorimeter].
PubMed:Cerebrospinal fluid-glutamic oxalacetic acid transaminase in patients receiving electroconvulsive therapy and in neurologic diseases.
PubMed:[Glutamic acid-oxalacetic acid transaminase determinations in infancy and childhood II. Studies in connection with hydrocephalus].
PubMed:[Glutamic-oxalacetic acid transaminase determinations in infancy and childhood. II. Studies on premature and newborn infants].
PubMed:[Glutamic-acid oxalacetic acid transaminase determinations in infancy and childhood. I. Studies in relation to hydrocephalus].
PubMed:[Effect of glyoxylic acid and oxalacetic acid on fumarase].
PubMed:[Glutamic acid-oxalacetic acid transaminase determinations in human liver tissue].
PubMed:[On the influence of prednisone on the activity of the serum glutamic-oxalacetic acid transaminase (SGOT) in acute viral hepatitis].
PubMed:[Diagnostic significance of glutamic acid-oxalacetic acid transaminase determination in serum; technical errors and statistical dispersion of normal values].
PubMed:[On the influence of roentgen total body irradiations on the activity of lactic acid dehydrogenase as well as glutamic acid-oxalacetic acid and glutamic acid-pyruvic acid transaminase in blood serum of rats].
PubMed:Lactic dehydrogenase versus glutamic oxalacetic acid transaminase as a diagnostic test for myocardial infarction.
PubMed:[Glutamic acid-oxalacetic acid transaminase in pathological changes of the horny layer of the epidermis].
PubMed:[The behavior of serum glutamic acid-oxalacetic acid transaminase in myopathies and neurogenic muscle atrophies].
PubMed:[Enzymatic determination of oxalacetic acid in blood].
PubMed:The enzymatic formation of oxalacetic acid by nonpyridine nucleotide malic dehydrogenase of Micrococcus lysodeikticus.
PubMed:Chemoautotrophic carbon dioxide fixation by extracts of Thiobacillus thiooxidans. I. Formation of oxalacetic acid.
PubMed:[Diagnostic significance of the serum glutamic acid-oxalacetic acid-transaminase].
PubMed:[A simple method of determination of serum glutamic acid-oxalacetic acid-transaminase].
PubMed:[Diagnostic value of glutamic oxalacetic acid transaminase].
PubMed:The effect of oxalacetic acid and pyruvic acid on hypoglycemia and ketonemia in pregnant ewes.
PubMed:Oxalacetic acid as amino group acceptor in transamination.
PubMed:The influence of pH on the enzymatic decarboxylation of oxalacetic acid.
PubMed:Interrelationships of oxalacetic and l-malic acids in carbon dioxide fixation.
PubMed:Enzymatic synthesis of citrate from pyruvate and oxalacetate.
PubMed:Studies on the intracellular composition of livers from rats fed various aminoazo dyes; effects on succinoxidase and oxalacetic acid oxidase.
PubMed:Decomposition of oxalacetic acid by metal compounds.
PubMed:The effect of cations on the decarboxylation of oxalacetic acid.
PubMed:Anaerobic phosphorylation due to a coupled oxidation-reduction between alpha-ketoglutaric acid and oxalacetic acid.
PubMed:The assay of animal tissues for respiratory enzymes; oxalacetic acid oxidation and the coupled phosphorylations in isotonic homogenates.
PubMed:Phosphorylation of glucose due to a coupled oxidation-reduction between alpha-keto-glutaric acid and oxalacetic acid.
PubMed:The action of metmyoglobin, oxygen, and manganese on oxalacetic acid.
 
Notes:
a dicarboxylic acid ketone that is an important metabolic intermediate of the citric acid cycle. it can be converted to aspartic acid by aspartate transaminase. Oxaloacetic acid, also known as oxosuccinic acid or oxalacetic acid, is a four-carbon dicarboxylic acid appearing as an intermediate of the citric acid cycle. (Wikipedia)
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