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N-phenyl-2-naphthyl amine
neozone

Supplier Sponsors

CAS Number: 135-88-6Picture of molecule3D/inchi
Other(deleted CASRN):52907-17-2
ECHA EINECS - REACH Pre-Reg:205-223-9
FDA UNII: 456KT854AJ
Nikkaji Web:J3.627G
Beilstein Number:2211188
MDL:MFCD00004052
XlogP3:5.10 (est)
Molecular Weight:219.28661000
Formula:C16 H13 N
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:natural substances and extractives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
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EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
FDA Mainterm (IAUFC):135-88-6 ; PHENYL-BETA-NAPHTHYLAMINE (FREE OF BETA-NAPHTHYLAMINE)
 
Physical Properties:
Appearance:light gray to gray powder (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Soluble in:
 water, 6.311 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
OQEMA
Phenyl-a-tert-butyl nitrone (PBN)
Sigma-Aldrich: Aldrich
For experimental / research use only.
N-Phenyl-2-naphthylamine 97%
sds
TCI AMERICA
For experimental / research use only.
N-Phenyl-2-naphthylamine >97.0%(N)
sds
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-mouse LD50 1450 mg/kg
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Hygiene and Sanitation Vol. 31(1-3), Pg. 183, 1966.

oral-rat LD50 8730 mg/kg
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Hygiene and Sanitation Vol. 31(1-3), Pg. 183, 1966.

unreported-rat LD50 8700 mg/kg
LIVER: OTHER CHANGES BRAIN AND COVERINGS: OTHER DEGENERATIVE CHANGES LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA
Tijdschrift Voor Sociale Geneeskunde. Vol. 53, Pg. 415, 1975.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
natural substances and extractives
Recommendation for N-phenyl-2-naphthyl amine usage levels up to:
 not for fragrance use.
 
Recommendation for N-phenyl-2-naphthyl amine flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
NIOSH International Chemical Safety Cards:search
NIOSH Pocket Guide:search
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
Carcinogenic Potency Database:Search
EPA Substance Registry Services (TSCA):135-88-6
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :8679
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:2
N-phenylnaphthalen-2-amine
Chemidplus:0000135886
EPA/NOAA CAMEO:hazardous materials
RTECS:135-88-6
 
References:
 N-phenylnaphthalen-2-amine
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:135-88-6
Pubchem (cid):8679
Pubchem (cas):135-88-6
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Indirect Additives used in Food Contact Substances:View
CHEBI:View
CHEMBL:View
KEGG (GenomeNet):C14694
HMDB (The Human Metabolome Database):HMDB32865
FooDB:FDB010843
Export Tariff Code:2921.45.1000
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 carrot
Search Trop Picture
 
Synonyms:
2-anilinonaphthalene
2-naphthylamine, N-phenyl-
beta-naphthylphenylamine
 neozone
 neozone D
 phenyl-2-naphthylamine
N-phenyl-2-naphthylamine
 phenyl-beta-naphtilamine
2-phenylaminonaphthalene
N-phenylnaphthalen-2-amine
 

Articles:

PubMed:Quantification of N-phenyl-2-naphthylamine by gas chromatography and isotope-dilution mass spectrometry and its percutaneous absorption ex vivo under workplace conditions.
PubMed:Comparative biotoxicity of N-Phenyl-1-naphthylamine and N-Phenyl-2-naphthylamine on cyanobacteria Microcystis aeruginosa.
PubMed:Induction of Strong Long-Lived Room-Temperature Phosphorescence of N-Phenyl-2-naphthylamine Molecules by Confinement in a Crystalline Dibromobiphenyl Matrix.
PubMed:[Secretion of Phenolic Compounds into Root Exudates of Pea Seedlings upon Inoculation with Rhizobium leguminosarum bv. viceae or Pseudomonas siringae pv. Pisi].
PubMed:Pollution-Induced Community Tolerance To Diagnose Hazardous Chemicals in Multiple Contaminated Aquatic Systems.
PubMed:A toxicokinetic study of specifically acting and reactive organic chemicals for the prediction of internal effect concentrations in Scenedesmus vacuolatus.
PubMed:Metabolic dephenylation of the rubber antioxidant N-phenyl-2-naphthylamine to carcinogenic 2-naphthylamine in rats.
PubMed:Effect propagation in a toxicokinetic/toxicodynamic model explains delayed effects on the growth of unicellular green algae Scenedesmus vacuolatus.
PubMed:[Role of allelopathic compositions in the regulation and development of legume-rhizobial symbiosis].
PubMed:Identification of mutagens in freshwater sediments by the Ames-fluctuation assay using nitroreductase and acetyltransferase overproducing test strains.
PubMed:Effects of copper sulfate, hydrogen peroxide and N-phenyl-2-naphthylamine on oxidative stress and the expression of genes involved photosynthesis and microcystin disposition in Microcystis aeruginosa.
PubMed:Anchoring metabolic changes to phenotypic effects in the chlorophyte Scenedesmus vacuolatus under chemical exposure.
PubMed:Effect-directed analysis of sediment-associated algal toxicants at selected hot spots in the river Elbe basin with a special focus on bioaccessibility.
PubMed:Phenyl-naphthyl amine effect of new phenothiazine derivatives with high T(g) for hole injection and hole transporting materials.
PubMed:Allelochemical stress causes oxidative damage and inhibition of photosynthesis in Chlorella vulgaris.
PubMed:Percutaneous absorption of aromatic amines - a contribution for human health risk assessment.
PubMed:Julichrome Q6 glucuronide, a monomeric subunit of the julimycin B-I complex from a terrestrial Streptomyces sp.
PubMed:Flow cytometry as a tool to study phytotoxic modes of action.
PubMed:Dephenylation of the rubber chemical N-phenyl-2-naphthylamine to carcinogenic 2-naphthylamine: a classical problem revisited.
PubMed:Effect-directed analysis of key toxicants in European river basins a review.
PubMed:On the mode of action of N-phenyl-2-naphthylamine in plants.
PubMed:Mechanism study of N-dephenylation mediated through a N-para-hydroxy metabolite.
PubMed:A novel alkaloid from Mitrephora maingayi.
PubMed:What contributes to the combined effect of a complex mixture?
PubMed:Effects of solvent on the fluorescence of 2-anilinonaphthalene.
PubMed:Oils and cancer.
PubMed:[The carcinogenic and anticarcinogenic properties of neozon D].
PubMed:[PBNA induce malignant transformation in Syrian hamster lung cell culture].
PubMed:NTP Toxicology and Carcinogenesis Studies of N-Phenyl-2-naphthylamine (CAS No. 135-88-6) in F344/N Rats and B6C3F1 Mice (Feed Studies).
PubMed:[Mutagenic action of latex polymerization stabilizers in various test systems].
PubMed:Unusual allergic contact dermatitis to aromatic amines.
PubMed:[Epidemiology of occupational cancer of the upper respiratory tract in Poland 1971-1985].
PubMed:[Carcinogenic activity of components of polymeric materials].
PubMed:Quantitative analysis of aromatic amines in human urine by gas chromatography-mass spectrometry-selected-ion monitoring.
PubMed:Three new contaminants detected in postmortem blood samples.
PubMed:Investigation of cancer epidemiology and study of carcinogenic agents in the Shanghai Rubber Industry.
PubMed:Carcinogenicity of N-phenyl-1-naphthylamine and N-phenyl-2-naphthylamine in mice.
PubMed:[Industrial toxicologic evaluation of vulcanizing vapors with special reference to nitrogen-containing aging-preventive agents].
PubMed:[Analysis of nitrogen containing aging-preventive agents in vulcanizing vapors].
PubMed:Low sensitization rate of naphthyl mix.
PubMed:Biological conversion of N-phenyl-2-naphthylamine to 2-naphthylamine in the Sprague-Dawley rat.
PubMed:[Carcinogenic risk of Neozone D (N-phenyl-2-naphthylamine)].
PubMed:The chronic effects of magenta, paramagenta and phenyl-beta-naphthylamine in rats after intragastric administration.
PubMed:[Method of determining the stabilizer N, N'-diphenyl-p-phenylene-diamine].
PubMed:Hepatic microsomal metabolism and macromolecular binding of the antioxidant, N-phenyl-2-naphthylamine.
PubMed:[Mutagenic, embryotropic and blastomogenic action of Neozone D].
PubMed:[Examination of N-phenyl-2-naphthylamine in cooling lubrication fluids used in the metal industry].
PubMed:N-phenyl-2-naphthylamine.
PubMed:Dephenylation of N-phenyl-2-naphthylamine in dogs and its possible oncogenic implications.
PubMed:[Spectrophotometric determination of isoprene and neozone-D in the water].
PubMed:Booby trap for biochemists: N-phenyl-2-naphthylamine.
PubMed:[Cutaneous changes caused by phenyl-beta-naphthylamine].
 
Notes:
Constit. of Daucus carota (carrot)
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