EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

meglumine
N-methyl-D-glucamine

Supplier Sponsors

CAS Number: 6284-40-8Picture of molecule3D/inchi
Other(deleted CASRN):131133-75-0
ECHA EINECS - REACH Pre-Reg:228-506-9
FDA UNII: 6HG8UB2MUY
Nikkaji Web:J8.375E
Beilstein Number:385906
MDL:MFCD00004707
XlogP3:-2.80 (est)
Molecular Weight:195.21549000
Formula:C7 H17 N O5
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:cosmetic agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 128.50 °C. @ 760.00 mm Hg
Boiling Point: 490.40 °C. @ 760.00 mm Hg (est)
Flash Point: 485.00 °F. TCC ( 251.60 °C. ) (est)
logP (o/w): -3.370 (est)
Soluble in:
 water, 5.00E+05 mg/L @ 25 °C (exp)
 water, 1e+006 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: hair conditioning
 
Suppliers:
Aston Chemical
For experimental / research use only.
D-Glucamine
BOC Sciences
For experimental / research use only.
Meglumine
EMD Millipore
For experimental / research use only.
Meglumine
Glentham Life Sciences
N-Methyl-D-glucamine, USP grade
Glentham Life Sciences
N-Methyl-D-glucamine
Santa Cruz Biotechnology
For experimental / research use only.
Meglumine 99%
Sigma-Aldrich: Sigma
For experimental / research use only.
N-Methyl-D-glucamine 99.0-100.5% (titration)
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
cosmetic agents
Recommendation for meglumine usage levels up to:
 not for fragrance use.
 
Recommendation for meglumine flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
Daily Med:search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):6284-40-8
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :8567
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
(2R,3R,4R,5S)-6-(methylamino)hexane-1,2,3,4,5-pentol
Chemidplus:0006284408
 
References:
 (2R,3R,4R,5S)-6-(methylamino)hexane-1,2,3,4,5-pentol
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:6284-40-8
Pubchem (cid):8567
Pubchem (sid):134986908
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
KEGG (GenomeNet):D01796
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2922.19.5000
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
1-deoxy-1-(methylamino)-D-glucitol
1-deoxy-1-methylaminosorbitol
D-glucitol, 1-deoxy-1-(methylamino)-
 glucitol, 1-deoxy-1-(methylamino)-, D- (8CI)
 iosulamide
 meglumin
 meglumina
 megluminum
 methyl glucamine
N-methyl-D-glucamine
N-methyl-D(-)-glucamine
N-methyl-dextro-glucamine
(2R,3R,4R,5S)-6-(methylamino)hexane-1,2,3,4,5-pentol
 methylglucamine
D-(-)-N-methylglucamine
N-methylglucamine
N-methylglucamine solution
N-methylsorbitylamine
 sorbitol, 1-deoxy-1-methylamino-
 

Articles:

PubMed:Pain sensitivity and healing of hot-iron cattle brands.
PubMed:Healing of surgical castration wounds: a description and an evaluation of flunixin.
PubMed:The effect of breed and sex on sulfamethazine, enrofloxacin, fenbendazole and flunixin meglumine pharmacokinetic parameters in swine.
PubMed:Silibinin meglumine, a water-soluble form of milk thistle silymarin, is an orally active anti-cancer agent that impedes the epithelial-to-mesenchymal transition (EMT) in EGFR-mutant non-small-cell lung carcinoma cells.
PubMed:Gd(3+)-DTPA-Meglumine-Anionic Linear Globular Dendrimer G1: Novel Nanosized Low Toxic Tumor Molecular MR Imaging Agent.
PubMed:The CCKB antagonist CI988 reduces food intake in fasted rats via a dopamine mediated pathway.
PubMed:Examining the occurrence of residues of flunixin meglumine in cull dairy cows by use of the flunixin cull cow survey.
PubMed:Tafamidis for transthyretin amyloidosis.
PubMed:Roux-en-Y gastric bypass in mice--surgical technique and characterisation.
PubMed:Taeniasis and cysticercosis due to Taenia solium in Japan.
PubMed:Associations among behavioral and acute physiologic responses to lipopolysaccharide-induced clinical mastitis in lactating dairy cows.
PubMed:Effects of buprenorphine, meloxicam, and flunixin meglumine as postoperative analgesia in mice.
PubMed:[Simultaneous analysis of 4 non-steroidal anti-inflammatory drug residues in mutton muscle using high performance liquid chromatography assisted by ultrasonic-microwave extraction].
PubMed:Signal quality of single dose gadobenate dimeglumine pulmonary MRA examinations exceeds quality of MRA performed with double dose gadopentetate dimeglumine.
PubMed:Incidence of immediate gadolinium contrast media reactions.
PubMed:Biomarkers of inflammation in cattle determining the effectiveness of anti-inflammatory drugs.
PubMed:Phosphine intoxication following oral exposure of horses to aluminum phosphide-treated feed.
PubMed:Pain mitigation after band castration of beef calves and its effects on performance, behavior, Escherichia coli, and salivary cortisol.
PubMed:Treatment of calf diarrhea: antimicrobial and ancillary treatments.
PubMed:A physiologically based pharmacokinetic model linking plasma protein binding interactions with drug disposition.
PubMed:Extralabel use of nonsteroidal anti-inflammatory drugs in cattle.
PubMed:[The Grenelle of MR contrast agents?].
PubMed:Response to the FDA's May 23, 2007, nephrogenic systemic fibrosis update.
PubMed:FDA issues reminder on correct use of flunixin meglumine.
PubMed:Surveillance for selected bacterial and toxicologic contaminants in donated carcass meat fed to carnivores.
PubMed:Pharmacokinetics of flunixin meglumine in swine after intravenous dosing.
PubMed:A woman who excreted a tape-like substance. Diphyllobothriasis.
PubMed:Evaluating postoperative analgesics in mice using telemetry.
PubMed:Residue depletion study and withdrawal period for flunixin-N-methyl glucamine in bovine milk following intravenous administration.
PubMed:Flunixin residues in milk after intravenous treatment of dairy cattle with (14)C-flunixin.
PubMed:Transcervical catheterization and cervical patency during the oestrous cycle in domestic cats.
PubMed:Successful treatment of drug-resistant cutaneous leishmaniasis in humans by use of imiquimod, an immunomodulator.
PubMed:A simple method for the identification and assay of iopamidol and iothalamate meglumine in pharmaceutical samples based on proton nuclear magnetic resonance spectroscopy.
PubMed:Review of studies establishing the aging male spontaneously hypertensive rat as a detector and quantifier of the kidney toxicity of radiocontrast media and other chemicals.
PubMed:[Reproductive and developmental toxicity study of gadobenate dimeglumine formulation (E7155) (3)--Study of embryo-fetal toxicity in rabbits by intravenous administration].
PubMed:[Reproductive and developmental toxicity study of gadobenate dimeglumine formulation (E7155) (2)--Combined study of effects on fertility and embryo-fetal toxicity in female rats by intravenous administration].
PubMed:[Reproductive and developmental toxicity study of gadobenate dimeglumine formulation (E7155) (1)--Fertility study in male rats by intravenous administration].
PubMed:[General toxicity study of gadobenate dimeglumine formulation (E7155) (4)--4-week repeated dose intravenous toxicity study followed by 4-week recovery period in dogs].
PubMed:[General toxicity study of gadobenate dimeglumine formulation (E7155) (2)--Single dose intravenous toxicity study in dogs].
PubMed:Clinical follow-up examination after treatment of canine leishmaniasis.
PubMed:Drug disposition and dosage determination of once daily administration of gentamicin sulfate in horses after abdominal surgery.
PubMed:Effects of radiocontrast, mannitol, and endothelin on blood pressure and renal damage in the aging male spontaneously hypertensive rat.
PubMed:Inhibition of gastrin-stimulated cell proliferation by the CCK-B/gastrin receptor ligand CI-988.
PubMed:CholecystokininB receptor antagonist increases food intake in rats.
PubMed:Fatal adverse event secondary to high osmolality contrast agent.
PubMed:Effects of radiocontrast and endothelin administration on systolic blood pressure and renal damage in male spontaneously hypertensive and Wistar Kyoto rats with phentolamine-induced adrenergic blockade.
PubMed:Gastric effects of the CCK-B/gastrin receptor ligand CI-988 in cynomolgus monkeys.
PubMed:The SHR as a small animal model for radiocontrast renal failure. Relation of nephrotoxicity to animal's age, gender, strain, and dose of radiocontrast.
PubMed:Ancillary therapy of bovine respiratory disease.
PubMed:Extralabel use of nonsteroidal anti-inflammatory drugs.
PubMed:Failure of dietary bentonite clay, Silent Herder mineral supplement, or parenteral Banamine to alleviate locoweed toxicosis in rats.
PubMed:Effect of portal venous flow augmentation on liver enhancement with CT.
PubMed:Effects of a liquid meal on contrast-enhanced CT of the liver.
PubMed:Cholecystokinin A receptor antagonist inhibits feed memory in Japanese quail.
PubMed:Simple 1H NMR spectroscopic method for assay of salts of the contrast agent diatrizoate in commercial solutions.
PubMed:PD-135158, a CCKB receptor antagonist, microinjected into the nucleus accumbens and the expression of conditioned rewarded behavior.
PubMed:Determination of flunixin in milk by liquid chromatography with confirmation by gas chromatography/mass spectrometry and selected ion monitoring.
PubMed:Approval from the Food and Drug Administration for unapproved use of an approved drug or device.
PubMed:[Relationship between oral food intake and nausea caused by intravenous injection of iodinated contrast material].
PubMed:Esophageal perforation in recessive dystrophic epidermolysis bullosa.
PubMed:Effects of cholecystokinin antagonists on the discriminative stimulus effects of cocaine in rats and monkeys.
PubMed:Use of nonsteroidal anti-inflammatory drugs in food animal practice.
PubMed:Inhibition of food intake by omeprazole in the chicken.
PubMed:Treatment of diarrhea of neonatal calves.
PubMed:Evaluation of the effects of PD 134308 (CI-988), a CCK-B antagonist, on the punished responding of squirrel monkeys.
PubMed:The influence of anti-inflammatory therapy on bacterial clearance following intramammary Escherichia coli challenge in goats.
PubMed:Pharmacokinetics of flunixin meglumine in lactating cattle after single and multiple intramuscular and intravenous administrations.
PubMed:Gadopentetate dimeglumine: observations on the clinical research process.
PubMed:Opening of the blood-brain barrier by intravenous contrast media in euvolemic and dehydrated rabbits.
PubMed:Castor-oil induced diarrhoea in ponies: a model for acute colitis.
PubMed:Anti-inflammatory therapy in acute endotoxin-induced bovine mastitis.
PubMed:Experimental uses of flunixin meglumine and phenylbutazone in food-producing animals.
PubMed:Cardiovascular responses to the intravertebral artery injection of hypertonic contrast media in the dog.
PubMed:Avoidance reaction of painful stimulation of another rat: effect of methylglucamine orotate.
 
Notes:
1-deoxy-1-(methylamino)-d-glucitol. a derivative of sorbitol in which the hydroxyl group in position 1 is replaced by a methylamino group. often used in conjunction with iodinated organic compounds as contrast medium.
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