EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

N-acetyl glycine
aceturic acid

Supplier Sponsors

CAS Number: 543-24-8Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:208-839-6
FDA UNII: U2UT4677KR
Nikkaji Web:J2.645J
Beilstein Number:774114
MDL:MFCD00004275
XlogP3:-1.20 (est)
Molecular Weight:117.10439000
Formula:C4 H7 N O3
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:information only not used for fragrances or flavors
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Soluble in:
 water, 2.63E+04 mg/L @ 15 °C (exp)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
Alfa Biotechnology
For experimental / research use only.
N-Acetylglycine 98%
BOC Sciences
For experimental / research use only.
N-Acetylglycine 99%
Glentham Life Sciences
N-Acetylglycine
sds
Shiva Chemicals and Pharmaceuticals
N-Acetyl Glycine
Sigma-Aldrich: Aldrich
For experimental / research use only.
N-Acetylglycine ReagentPlus®, 99%
sds
TCI AMERICA
For experimental / research use only.
N-Acetylglycine >99.0%(T)
sds
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
information only not used for fragrances or flavors
Recommendation for N-acetyl glycine usage levels up to:
 not for fragrance use.
 
Recommendation for N-acetyl glycine flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):543-24-8
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :10972
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
2-acetamidoacetic acid
Chemidplus:0000543248
 
References:
 2-acetamidoacetic acid
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:543-24-8
Pubchem (cid):10972
Pubchem (cas):543-24-8
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
Golm Metabolome Database:Search
Metabolomics Database:Search
HMDB (The Human Metabolome Database):HMDB00532
FooDB:FDB022100
Export Tariff Code:2924.19.8000
ChemSpider:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
2-acetamidoacetic acid
 aceturic acid
 acetylaminoacetic acid
N-acetylglycine
 ethanoylaminoethanoic acid
 glycine, N-acetyl-
 

Articles:

PubMed:Biochemical phenotyping unravels novel metabolic abnormalities and potential biomarkers associated with treatment of GLUT1 deficiency with ketogenic diet.
PubMed:Metabolomic Determinants of Metabolic Risk in Mexican Adolescents.
PubMed:Organocatalyzed and mechanochemical solvent-free synthesis of novel and functionalized bis-biphenyl substituted thiazolidinones as potent tyrosinase inhibitors: SAR and molecular modeling studies.
PubMed:Pd-catalysed ligand-enabled carboxylate-directed highly regioselective arylation of aliphatic acids.
PubMed:Experimental conformational energy maps of proteins and peptides.
PubMed:Metabolomics-based approach for ranking the candidate structures of unidentified peaks in capillary electrophoresis time-of-flight mass spectrometry.
PubMed:Organocatalyzed Novel Synthetic Methodology for Highly Functionalized Piperidines as Potent α-Glucosidase Inhibitors.
PubMed:Pharmacometabonomic Prediction of Busulfan Clearance in Hematopoetic Cell Transplant Recipients.
PubMed:N-Acetylglycine Cation Tautomerization Enabled by the Peptide Bond.
PubMed:Effects of sodium benzoate, a widely used food preservative, on glucose homeostasis and metabolic profiles in humans.
PubMed:Liquid hot NAGMA cooled to 0.4 K: benchmark thermochemistry of a gas-phase peptide.
PubMed:Molecular structure and vibrational spectra of N-acetylglycine oligomers and polyglycine I using DFT approach.
PubMed:Identifying hypoxia in a newborn piglet model using urinary NMR metabolomic profiling.
PubMed:Comparison of the conformational behavior of amino acids and N-acetylated amino acids: a theoretical and matrix-isolation FT-IR study of N-acetylglycine.
PubMed:UPLC-MS-based urine metabolomics reveals indole-3-lactic acid and phenyllactic acid as conserved biomarkers for alcohol-induced liver disease in the Ppara-null mouse model.
PubMed:Toxicology studies with N-acetylglycine.
PubMed:Metabolomic profiling of a modified alcohol liquid diet model for liver injury in the mouse uncovers new markers of disease.
PubMed:Functionalizing glycine derivatives by direct C-C bond formation.
PubMed:Metabolite profiling of human amniotic fluid by hyphenated nuclear magnetic resonance spectroscopy.
PubMed:Syntheses of highly fluorescent GFP-chromophore analogues.
PubMed:Structure of alpha-glycerophosphate oxidase from Streptococcus sp.: a template for the mitochondrial alpha-glycerophosphate dehydrogenase.
PubMed:Reactions of 3-formylchromone with active methylene and methyl compounds and some subsequent reactions of the resulting condensation products.
PubMed:Gas-phase ionic syntheses of amino acids: beta versus alpha.
PubMed:Behavior of acetyl modified amino acids in reverse micelles: a non-invasive and physiochemical approach.
PubMed:Understanding the EPR parameters of glycine-derived radicals: the case of N-acetylglycyl in the N-acetylglycine single-crystal environment.
PubMed:Efficient synthesis of tyrosine-derived marine sponge metabolites via acylation of amines with a coumarin.
PubMed:Enantiomer separation of a powerful chiral auxiliary, 2-methoxy-2-(1-naphthyl)propionic acid by liquid chromatography using chiral anion exchanger-type stationary phases in polar-organic mode; investigation of molecular recognition aspects.
PubMed:NMR spectroscopic filtration of polypeptides and proteins in complex mixtures.
PubMed:Calculation of electrostatic interaction energies in molecular dimers from atomic multipole moments obtained by different methods of electron density partitioning.
PubMed:Additive transfer free energies of the peptide backbone unit that are independent of the model compound and the choice of concentration scale.
PubMed:The influence of methionine-containing peptides on the reaction of carboplatin with 5'-guanosine monophosphate: a comparison with cisplatin.
PubMed:Single-scan longitudinal relaxation measurements in high-resolution NMR spectroscopy.
PubMed:Temperature dependence of the kinetics of the acylase hydrolysis reaction by differential stopped flow microcalorimetry.
PubMed:Structural and mechanistic studies on ThiO, a glycine oxidase essential for thiamin biosynthesis in Bacillus subtilis.
PubMed:[Synthesis of new N3S pseudo-peptide complexes and biodistribution in mice].
PubMed:Recent developments in the electronic spectroscopy of amides and alpha-helical polypeptides.
PubMed:Importance of product inhibition in the kinetics of the acylase hydrolysis reaction by differential stopped flow microcalorimetry.
PubMed:Formation and stability of peptide enolates in aqueous solution.
PubMed:Synthesis of 2-[4'-(ethylcarbamoyl)phenyl]-N-acetylglycine, the proposed structure for giganticine.
PubMed:Synchronized adiabatic decoupling.
PubMed:Adiabatic decoupling sidebands.
PubMed:Vancomycin binding to low-affinity ligands: delineating a minimum set of interactions necessary for high-affinity binding.
PubMed:Two- and three-dimensional 1H/13C PISEMA experiments and their application to backbone and side chain sites of amino acids and peptides.
PubMed:"BEST" homonuclear adiabatic decoupling for 13C- and 15N-double-labeled proteins.
PubMed:Three-dimensional 13C shift/1H-15N coupling/15N shift solid-state NMR correlation spectroscopy.
PubMed:N-acylglycine amidation: implications for the biosynthesis of fatty acid primary amides.
PubMed:Pharmacokinetic analysis and anticonvulsant activity of glycine and glycinamide derivatives.
PubMed:Toward understanding tryptophan fluorescence in proteins.
PubMed:Bloch-Siegert shift compensated and cyclic irradiation sidebands eliminated, double-adiabatic homonuclear decoupling for 13C- and 15N-double-labeled proteins.
PubMed:[Pharmacological treatment of memory disorders caused by hypoxia and cerebral ischemia in rats].
PubMed:Liquid chromatographic-atmospheric pressure chemical ionization mass spectrometric analysis of glycine conjugates and urinary isovalerylglycine in isovaleric acidemia.
PubMed:Mechanism-based catalytic antibody inactivation.
PubMed:Decompositions of cationized heterodimers of amino acids in relation to charge location in peptide ions.
PubMed:Determination of N-acetylneuraminic acid and N-glycolylneuraminic acid in glycoproteins by high-performance liquid chromatography without derivatization.
PubMed:Mechanistic studies of a tyrosine-dependent catalytic antibody.
PubMed:Protection against 2-methoxyethanol-induced teratogenesis by serine enantiomers: studies of potential alteration of 2-methoxyethanol pharmacokinetics.
PubMed:Deuterium quadrupole coupling in N-acetylglycine and librational dynamics in solid poly(gamma-benzyl-L-glutamate).
PubMed:Substrate specificity of an acylaminopeptidase that catalyzes the cleavage of the blocked amino termini of peptides.
PubMed:Hydrophilicity of polar amino acid side-chains is markedly reduced by flanking peptide bonds.
PubMed:Delineation and conformational analysis of two synthetic peptide models of antigenic sites on rodent cytochrome c.
PubMed:The amino terminal acetylation of cat globin chains and their tryptic peptides.
PubMed:Adenylosuccinate synthetase from Dictyostelium discoideum: effects of hadacidin analogs and binding of [14C]hadacidin.
PubMed:Nitrosamide carcinogenesis: nitrosation of amide linkages and facile decomposition of resulting nitrosamides.
PubMed:Specificity of anti-Mg antibody--a study with synthetic peptides and glycopeptides.
PubMed:Computer simulation of the conformational properties of retro-inverso peptides. I. Empirical force field calculations of rigid and flexible geometries of N-acetylglycine-N'-methylamide, bis(acetamido) methane, and N,N'-dimethylmalonamide and their corresponding C alpha-methylated analogs.
PubMed:Properties and localization of N-acetylglutamate deacetylase from Pseudomonas aeruginosa.
PubMed:E.s.r. of spin-trapped radicals in gamma-irradiated polycrystalline amino acids, N-acetyl amino acids and dipeptides.
PubMed:Deacetylation of PS-5, a new beta-lactam compound. III. Enzymological characterization of L-amino acid acylase and D-amino acid acylase from Pseudomonas sp. 1158.
PubMed:The effect of selenium on the biliary excretion and organ distribution of mercury in the rat after exposure to methyl mercuric chloride.
PubMed:Oxidation of sarcosine and N-alkyl derivatives of glycine by D-amino-acid oxidase.
PubMed:The identification of N-acetylglycine as a contaminant of glacial acetic acid.
PubMed:Structure-activity relationship in the urokinase hydrolysis of alpha-N-acetyl-L-lysine anilides.
PubMed:An e.s.r. study of free-radical conversions in irradiated single crystals of N-acetylglycine in the temperature range 77-300 K.
PubMed:Electron spin resonance studies of electron irradiated peptides. A single crystal of N-acetylglycine at 77 K.
PubMed:Nuclear magnetic resonance determination of the angle psi in peptides.
PubMed:Electron spin resonance studies and INDO MO-calculations of electron irradiated peptides. A single crystal of N-acetylglycine.
PubMed:Formation of N-acetyl-L-alanine and N-acetylglycine from glucose by Candida tropicalis OH 23 .
PubMed:Effect of ionizing radiation and U.V. light on N-acetylglycine in the presence of ammonia.
PubMed:Nuclear magnetic resonance studies of proton-exchange kinetics of N-methylacetamide and N-acetylglycine N-methylamide.
PubMed:Specificity and stereospecificity of alpha-chymotrypsin.
PubMed:The alpha-chymotryptic ydrolysis of glycine esters.
PubMed:[p-ethoxy-phenyl]-N-acetylglycine dimethylamide) with special reference to comparative studies with acetanilid and phenacetin].
PubMed:THE AMPHOTERIC PROPERTIES OF SOME AMINO-ACIDS AND PEPTIDES.
 
Notes:
N-Acetylglycine is used is in biological research of peptidomimetics. It is used as the blocking agent of the N-terminus to prepare unnatural and unusual amino acids and amino acid analogs as well as to modify peptides. N-Substituted glycine analogs are widely used in peptidomimetics and drug research. Excessive amounts N-acetyl amino acids including N-acetylglycine (as well as N-acetylserine, N-acetylglutamine, N-acetylglutamate, N-acetylalanine, Nacetylmethionine and smaller amounts of N-acetylthreonine, N-acetylleucine, N-acetylvaline and N-acetylisoleucine) can be detected in the urine with individuals with Acylase I defiency. This enzyme is involved in the degradation of N-acylated proteins. Individuals with this disorder will experience convulsions, hearing loss ond difficulty feeding. [HMDB]
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