EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

maleic anhydride
cis-butenedioic anhydride

Supplier Sponsors

CAS Number: 108-31-6Picture of molecule3D/inchi
Other(deleted CASRN):184288-31-1
ECHA EINECS - REACH Pre-Reg:203-571-6
FDA UNII: V5877ZJZ25
Nikkaji Web:J2.419H
Beilstein Number:0106909
MDL:MFCD00005518
XlogP3-AA:-0.10 (est)
Molecular Weight:98.05754000
Formula:C4 H2 O3
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:film forming agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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Google Patents:Search
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PubMed:Search
NCBI:Search
DG SANTE Food Contact Materials:maleic anhydride
FDA Mainterm (IAUFC):108-31-6 ; MALEIC ANHYDRIDE
 
Physical Properties:
Appearance:white solid (est)
Assay: 98.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 59.00 to 62.00 °C. @ 760.00 mm Hg
Boiling Point: 196.00 to 197.00 °C. @ 760.00 mm Hg
Boiling Point: 110.00 to 111.00 °C. @ 50.00 mm Hg
Vapor Pressure:0.299000 mmHg @ 25.00 °C. (est)
Flash Point: 218.00 °F. TCC ( 103.33 °C. )
logP (o/w): -0.648 (est)
Soluble in:
 water, 4912 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: film formers
 
Suppliers:
Bartek Ingredients
MALEIC ANHYDRIDE
Charkit Chemical
MALEIC ANHYDRIDE
Covalent Chemical
Maleic Anhydride, Briquette
EMD Millipore
For experimental / research use only.
Maleic Anhydride
sds
Glentham Life Sciences
Maleic anhydride
Krunal Group
Maleic Anhydride (MA)
Penta International
MALEIC ANHYDRIDE
Shiva Chemicals and Pharmaceuticals
Maleic Anhydride
Sigma-Aldrich: Aldrich
For experimental / research use only.
Maleic anhydride briquettes, 99%
sds
Silver Fern Chemical
Maleic Anhydride Briquettes
Odor: characteristic
Use: Maleic anhydride is used in polyester resins, the manufacture of fumaric and tartaric acid, pesticides and fungicides, preservative for oils and fats, and textiles.
SysKem Chemie
Maleic Anhydride
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50 400 mg/kg
Interagency Collaborative Group on Environmental Carcinogenesis, National Cancer Institute, Memorandum, June 17, 1974Vol. 17JUN1974

intraperitoneal-rat LD50 97 mg/kg
"Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 79, 1982.

oral-rabbit LD50 875 mg/kg
"Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 79, 1982.

oral-mouse LD50 465 mg/kg
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 13(4), Pg. 42, 1969.

oral-guinea pig LD50 390 mg/kg
"Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 79, 1982.

Dermal Toxicity:
skin-rabbit LD50 2620 mg/kg
Toxicology and Applied Pharmacology. Vol. 42, Pg. 417, 1977.

skin-guinea pig LD50 > 20000 mg/kg
Interagency Collaborative Group on Environmental Carcinogenesis, National Cancer Institute, Memorandum, June 17, 1974Vol. 17JUN1974

Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
film forming agents
Recommendation for maleic anhydride usage levels up to:
 not for fragrance use.
 
Recommendation for maleic anhydride flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
EPA-Iris:IRIS
NIOSH International Chemical Safety Cards:search
NIOSH Pocket Guide:search
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):108-31-6
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :7923
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:1
furan-2,5-dione
Chemidplus:0000108316
EPA/NOAA CAMEO:hazardous materials
RTECS:108-31-6
 
References:
 furan-2,5-dione
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:108-31-6
Pubchem (cid):7923
Pubchem (sid):134972904
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Indirect Additives used in Food Contact Substances:View
CHEBI:View
CHEMBL:View
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2917.14.5000
ChemSpider:View
Wikipedia:View
EFSA Update of results on the monitoring of furan levels in food:Read Report
EFSA Previous report: Results on the monitoring of furan levels in food:Read Report
EFSA Report of the CONTAM Panel on provisional findings on furan in food:Read Report
Formulations/Preparations:
•minimum assay of 99.5% •grade: technical; rods, flakes, lumps, briquettes and molten
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
cis-butene dioic anhydride
cis-butenedioic anhydride
 furan-2,5-dione
2,5-furandione
2,5-furanedione
 maleic acid anhydride
 maleic anhydride [UN2215] [Corrosive]
 maleicanhydride
 toxilic anhydride
 

Articles:

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PubMed:Interaction and release of catechin from anhydride maleic-grafted polypropylene films.
PubMed:Self-assembly and emulsification of poly{[styrene-alt-maleic acid]-co-[styrene-alt-(N-3,4-dihydroxyphenylethyl-maleamic acid)]}.
PubMed:Microwave-assisted hydrogel synthesis: a new method for crosslinking polymers in aqueous solutions.
PubMed:Preparation of lignopolyols from wheat straw soda lignin.
PubMed:Antioxidant activity of N-acyl chitosan oligosaccharide with same substituting degree.
PubMed:Promoting fertilizer use via controlled release of a bacteria-encapsulated film bag.
PubMed:Immobilization of tyrosinase in carboxylic and carbonyl group-modified MWNT electrode and its application for sensing phenolics in red wines.
PubMed:Design, synthesis, and bioactivity study of novel benzoylpyridazyl ureas.
PubMed:Maleimide and maleic anhydride derivatives from the mycelia of Antrodia cinnamomea and their nitric oxide inhibitory activities in macrophages.
PubMed:Controlled release of tebuconazole from a polymer matrix microparticle: release kinetics and length of efficacy.
PubMed:Identification of the major allergens in wheat flour responsible for baker's asthma.
PubMed:NTP Toxicology and Carcinogenesis Studies of Succinic Anhydride (CAS No. 108-30-5) in F344/N Rats and B6C3F1 Mice (Gavage Studies).
 
Notes:
used in copolymerization reactions, in the diels-alder(diene)synthesis, in the preparation of resins, pharmaceuticals and agricultural chemicals. it is a powerful irritant and causes burns.
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