EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

lipase
enzyme that hydrolyzes triglycerides

Supplier Sponsors

CAS Number: 9001-62-1
ECHA EC Number:232-619-9
FDA UNII: OCG8G5QG5K
MDL:MFCD00217536
Formula:unspecified
Category:special dietary and nutritional additives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
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Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
PubMed:Search
NCBI:Search
 FDA/DG SANTE Petitions, Reviews, Notices:
GRN 708 Triacylglycerol lipase from Rhizopus oryzae produced in Aspergillus niger View - notice PDF
GRN 631 Triacylglycerol lipase from Fusarium oxysporum produced in Trichoderma reesei View - notice PDF
GRN 783 Triacylglycerol lipase from Rhizopus oryzae produced in Aspergillus niger View - notice PDF
GRN 866 Lipase from Penicillium camemberti View - notice PDF
GRN 908 Lipase from Penicillium camemberti View - notice PDF
FDA Mainterm (SATF):9001-62-1 ; LIPASE

555-43-1 ; GLYCERYL TRISTEARATE
FDA Regulation:
FDA PART 172 -- FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION
Subpart I--Multipurpose Additives
Sec. 172.811 Glyceryl tristearate
 
Physical Properties:
Food Chemicals Codex Listed: No
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: skin conditioning
 
Suppliers:
Amano Enzyme
CheeseMax
Flavor: characteristic
Application: Enzyme Modified Cheese (E.M.C.)
Amano Enzyme
Lipase A "Amano" 12
Flavor: characteristic
Application: Enzyme Modified Cheese (E.M.C.)
Amano Enzyme
Lipase AY "Amano" 30G
Flavor: characteristic
Application: Enzyme Modified Cheese (E.M.C.)
Amano Enzyme
Lipase AY "Amano" 30SD
Flavor: characteristic
Application: Enzyme Modified Cheese (E.M.C.)
Amano Enzyme
Lipase DF "Amano" 15
Flavor: characteristic
Application: Fats & Oils Processing.
Amano Enzyme
Lipase DF-DS, Kosher
Amano Enzyme
Lipase DS, Kosher
Amano Enzyme
Lipase G "Amano" 50
Flavor: characteristic
Application: Fats & Oils Processing.
Amano Enzyme
Lipase R "Amano"
Flavor: characteristic
Application: Enzyme Modified Cheese (E.M.C.)
BOC Sciences
For experimental / research use only.
Lipase pancreatic
Indis NV
For experimental / research use only.
Lipase
Sigma-Aldrich: Sigma
For experimental / research use only.
Lipase from Candida rugosa Type VII, =700 unit/mg solid
sds
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intravenous-rat LD50 104 mg/kg
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) KIDNEY, URETER, AND BLADDER: OTHER CHANGES
Pharmaceutical Chemistry Journal Vol. 13, Pg. 906, 1979.

intraperitoneal-rat LD50 634 mg/kg
SKIN AND APPENDAGES (SKIN): HAIR: OTHER BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 69, Pg. 191, 1973.

intraperitoneal-rat LD50 630 mg/kg
BLOOD: HEMORRHAGE LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Pharmaceutical Chemistry Journal Vol. 13, Pg. 906, 1979.

intravenous-guinea pig LD50 135 mg/kg
KIDNEY, URETER, AND BLADDER: OTHER CHANGES LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Pharmaceutical Chemistry Journal Vol. 13, Pg. 906, 1979.

oral-mouse LD > 10400 mg/kg
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 69, Pg. 191, 1973.

intraperitoneal-mouse LD50 395 mg/kg
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE SKIN AND APPENDAGES (SKIN): HAIR: OTHER
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 69, Pg. 191, 1973.

intraperitoneal-mouse LD50 833 mg/kg
BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) BLOOD: HEMORRHAGE LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
Pharmaceutical Chemistry Journal Vol. 13, Pg. 906, 1979.

intravenous-mouse LD50 127 mg/kg
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) KIDNEY, URETER, AND BLADDER: OTHER CHANGES
Pharmaceutical Chemistry Journal Vol. 13, Pg. 906, 1979.

oral-rabbit LD > 5000 mg/kg
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE SKIN AND APPENDAGES (SKIN): HAIR: OTHER
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 69, Pg. 191, 1973.

oral-rat LD > 10400 mg/kg
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 69, Pg. 191, 1973.

Dermal Toxicity:
subcutaneous-mouse LD50 2050 mg/kg
SKIN AND APPENDAGES (SKIN): HAIR: OTHER BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 69, Pg. 191, 1973.

subcutaneous-rat LD > 5000 mg/kg
SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE SKIN AND APPENDAGES (SKIN): HAIR: OTHER BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 69, Pg. 191, 1973.

Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
special dietary and nutritional additives
Recommendation for lipase usage levels up to:
 not for fragrance use.
 
Recommendation for lipase flavor usage levels up to:
 not for flavor use.
 
Safety References:
European Food Safety Authority (EFSA) reference(s):

Safety evaluation of the food enzyme triacylglycerol lipase from Aspergillus niger (strain LFS)
View page or View pdf

Safety evaluation of the food enzyme triacylglycerol lipase from the genetically modified Ogataea polymorpha strain DP-Jzk33
View page or View pdf

Safety evaluation of the food enzyme triacylglycerol lipase from the genetically modified Aspergillus niger strain NZYM-DB
View page or View pdf

Safety evaluation of the food enzyme triacylglycerol lipase from the genetically modified Aspergillus luchuensis strain FL100SC
View page or View pdf

ClinicalTrials.gov:search
Daily Med:search
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):9001-62-1
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:1
Chemidplus:0009001621
RTECS:TO9776500 for cas# 9001-62-1
 
References:
Pubchem (sid):135287466
 
Other Information:
FDA Substances Added to Food (formerly EAFUS):View
HMDB (The Human Metabolome Database):Search
FooDB:FDB001106
Export Tariff Code:3507.90.0000
FDA Listing of Food Additive Status:View
VCF-Online:VCF Volatile Compounds in Food
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 lipase
Search PMC Picture
 
Synonyms:
 accelerase
 allzyme lipase
 butyrinase
 cotazym
 entolase
 enzyme that hydrolyzes triglycerides
 fetipase
 fungal lipase
 ilozyme
 lipase of pancreas
 lipase, fungal
 pancrease
 pancrelipase
 pancrelipase lipase
 rizolipase
 rizolipasum
 steapsin
 triacetinase
 triacylglycerol lipase
 triacylglycerol lipase from aspergillus niger
 triacylglycerol lipase from rhizopus oryzae produced in aspergillus niger
 tributyrase
 tributyrin esterase
 tributyrinase
 triglyceride lipase
 triolein hydrolase
 tween esterase
 tween hydrolase
 tweenase
 viokase
 zymase
 

Articles:

Google Patents:Flavor enhancer
PubMed:Covalent attachment of lipases on glyoxyl-agarose beads: Application in fruit flavor and biodiesel synthesis.
PubMed:Catalyzed ester synthesis using Candida rugosa lipase entrapped by poly(N-isopropylacrylamide-co-itaconic acid) hydrogel.
PubMed:Short-chain flavor ester synthesis in organic media by an E. coli whole-cell biocatalyst expressing a newly characterized heterologous lipase.
PubMed:Application of a statistically enhanced, novel, organic solvent stable lipase from Bacillus safensis DVL-43.
PubMed:Homogenization and lipase treatment of milk and resulting methyl ketone generation in blue cheese.
PubMed:Isolation of a novel alkaline-stable lipase from a metagenomic library and its specific application for milkfat flavor production.
PubMed:Optimized butyl butyrate synthesis catalyzed by Thermomyces lanuginosus lipase.
PubMed:Robust nanobioconjugates of Candida antarctica lipase B--multiwalled carbon nanotubes: characterization and application for multiple usages in non-aqueous biocatalysis.
PubMed:Effect of psychrotrophic growth on the milk fat fraction at different temperatures of storage.
PubMed:Ultrasound-assisted butyl acetate synthesis catalyzed by Novozym 435: enhanced activity and operational stability.
PubMed:Discovery of aromatic components with excellent fragrance properties and biological activities: β-ionols with antimelanogenetic effects and their asymmetric syntheses.
PubMed:Identification of novel single nucleotide polymorphisms (SNPs) of the lipoprotein lipase (LPL) gene associated with fatty acid composition in Korean cattle.
PubMed:Penicillium species present in Uruguayan salami.
PubMed:Production of flavor esters catalyzed by CALB-displaying Pichia pastoris whole-cells in a batch reactor.
PubMed:Effects of cyclodextrins on the flavor of goat milk and its yogurt.
PubMed:Antiobesity effect of oil extract of ginseng.
PubMed:Influence of partial replacement of NaCl with KCl, CaCl2 and MgCl2 on lipolysis and lipid oxidation in dry-cured ham.
PubMed:Wheat bran stabilization and its use in the preparation of high-fiber pasta.
PubMed:Influence of milk pretreatment on production of free fatty acids and volatile compounds in hard cheeses: heat treatment and mechanical agitation.
PubMed:Effects of lipase, lipoxygenase, peroxidase and free fatty acids on volatile compound found in boiled buckwheat noodles.
PubMed:[Synthesis of flavor esters catalyzed by CALB-displaying Pichia pastoris whole-cells in non-aqueous phase].
PubMed:An alkaline lipase from organic solvent tolerant Acinetobacter sp. EH28: Application for ethyl caprylate synthesis.
PubMed:Display of Candida antarctica lipase B on Pichia pastoris and its application to flavor ester synthesis.
PubMed:Microbial formation of esters.
PubMed:Lipase-catalyzed ethanolysis of milk fat with a focus on short-chain fatty acid selectivity.
PubMed:[Expression of Candida antarctica lipase B on yeast surface and synthesis of ethyl hexanoate catalyzed by CALB].
PubMed:Production of butyl acetate ester by lipase from novel strain of Rhizopus oryzae.
PubMed:Optimal formation of hexyl laurate by Lipozyme IM-77 in solvent-free system.
PubMed:Lipoxygenase from banana leaf: purification and characterization of an enzyme that catalyzes linoleic acid oxygenation at the 9-position.
PubMed:Influence of raw milk quality on fluid milk shelf life.
PubMed:Synthesis of the four stereoisomers of 7-acetoxy-15-methylnonacosane, a component of the female sex pheromone of the screwworm fly, Cochliomyia hominivorax.
PubMed:Lipase-catalyzed production of short-chain acids terpenyl esters of interest to the food industry.
PubMed:Purification and characterization of a pregastric esterase from a hygienized kid rennet paste.
PubMed:Synthesis of flavor and fragrance esters using Candida antarctica lipase.
PubMed:Determination of esterolytic and lipolytic activities of lactic acid bacteria.
PubMed:Ester synthesis catalyzed by Mucor miehei lipase immobilized on magnetic polysiloxane-polyvinyl alcohol particles.
PubMed:Hard ewe's milk cheese manufactured from milk of three different groups of somatic cell counts.
PubMed:Lipase catalyzed modification of milkfat.
PubMed:A review of nutritional and physiological factors affecting goat milk lipid synthesis and lipolysis.
PubMed:Sensory threshold of off-flavors caused by proteolysis and lipolysis in milk.
PubMed:Purification and partial characterization of psychrotrophic Serratia marcescens lipase.
PubMed:The impact of fortification with conjugated linoleic acid (CLA) on the quality of fluid milk.
PubMed:Synthesis of fatty acid esters by recombinant Staphylococcus epidermidis lipases in aqueous environment.
PubMed:Optimized synthesis of lipase-catalyzed hexyl acetate in n-hexane by response surface methodology.
PubMed:Orosensory factors in the ingestion of corn oil/sucrose mixtures by the rat.
PubMed:Determination of short-chain free fatty acids in lipolyzed milk fat by capillary electrophoresis.
PubMed:Molecular and phenotypic characterization of Pseudomonas spp. isolated from milk.
PubMed:Enantiomeric synthesis of (S)-2-methylbutanoic acid methyl ester, apple flavor, using lipases in organic solvent.
PubMed:Chemoenzymatic synthesis of homochiral (R)- and (S)-karahanaenol from (R)-limonene.
PubMed:Synthesis and estimation of calorific value of a structured lipid-potential reduced calorie fat.
PubMed:The role of muscle proteases and lipases in flavor development during the processing of dry-cured ham.
PubMed:Formation of flavor compounds in cheese.
PubMed:Effects of the lipase inhibitor orlistat on intake and preference for dietary fat in rats.
PubMed:Genome structure and nucleotide sequence of a lipolytic enzyme gene of Aspergillus oryzae.
PubMed:Pregastric esterase and other oral lipases--a review.
PubMed:Enzymes of Penicillium roqueforti involved in the biosynthesis of cheese flavor.
PubMed:Lactones in foods.
PubMed:Photoinactivation of Milk Fat Lipase and the Origin of Bitter Flavor in Milk.
 
Notes:
an enzyme of the hydrolase class that catalyzes the reaction of triacylglycerol and water to yield diacylglycerol and a fatty acid anion. it is produced by glands on the tongue and by the pancreas and initiates the digestion of dietary fats. (from dorland, 27th ed) ec 3.1.1.3.
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