EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

laevo-serine
propanoic acid, 2-amino-3-hydroxy-, (S)-

Supplier Sponsors

CAS Number: 56-45-1Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:200-274-3
FDA UNII: 452VLY9402
Nikkaji Web:J1.195I
Beilstein Number:1721404
MDL:MFCD00064224
XlogP3:-3.10 (est)
Molecular Weight:105.09339000
Formula:C3 H7 N O3
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:special dietary and nutritional additives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
FDA Mainterm (SATF):56-45-1 ; L-SERINE
FDA Regulation:
FDA PART 172 -- FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION
Subpart D--Special Dietary and Nutritional Additives
Sec. 172.320 Amino acids.
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 220.00 to 222.00 °C. @ 760.00 mm Hg
Boiling Point: 394.00 to 396.00 °C. @ 760.00 mm Hg
Flash Point: 378.00 °F. TCC ( 192.22 °C. )
logP (o/w): -1.580
Soluble in:
 water, 4.02e+005 mg/L @ 25 °C (est)
 water, 4.25E+05 mg/L @ 25 °C (exp)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: antistatic agents
fragrance
hair conditioning
skin conditioning
 
Suppliers:
Ajinomoto USA
AjiPure™ Serine
Flavor: characteristic
Manufactured under cGMP conditions using no materials of animal origin.
Ajinomoto USA
L-Serine
Flavor: characteristic
L-serine is classified as a non essential amino acid. The body can synthesize sufficient amounts of L-serine to meet its daily needs.
Alfa Biotechnology
For experimental / research use only.
L-Serine 98%
Anhui Haibei
L-Serine
AuNutra® Industries
L-Serine USP
BOC Sciences
For experimental / research use only.
L-Serine >98%
Charkit Chemical
SERINE, L-
EMD Millipore
For experimental / research use only.
L-serine
sds
ExtraSynthese
For experimental / research use only.
L-Serine
Glentham Life Sciences
L-Serine, GlenCell?, suitable for cell culture
Glentham Life Sciences
L-Serine
sds
Graham Chemical
L-Serine
Penta International
L-SERINE NATURAL
Penta International
L-SERINE SYNTHETIC
Prinova
L-Serine FCC
Qingdao Dacon Trading
L-Serine
Sigma-Aldrich: Sigma
For experimental / research use only.
L-Serine ReagentPlus®, ≥99% (TLC)
sds
United International
L-Serine
WEN International
L-SERINE Natural
Zhong Ya Chemical
L-Serine
 
Safety Information:
Preferred SDS: View
European information :
Most important hazard(s):
None - None found.
S 02 - Keep out of the reach of children.
S 22 - Do not breath dust.
S 24/25 - Avoid contact with skin and eyes.
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
special dietary and nutritional additives
Recommendation for laevo-serine usage levels up to:
 not for fragrance use.
 
Recommendation for laevo-serine flavor usage levels up to:
 not for flavor use.
 
Safety References:
European Food Safety Authority (EFSA) reference(s):

Scientific Report of EFSA on the risk assessment of salts of authorised acids, phenols or alcohols for use in food contact materials [1]
View page or View pdf

EPI System: View
ClinicalTrials.gov:search
Daily Med:search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):56-45-1
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :5951
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:1
(2S)-2-amino-3-hydroxypropanoic acid
Chemidplus:0000056451
RTECS:VT8100000 for cas# 56-45-1
 
References:
 (2S)-2-amino-3-hydroxypropanoic acid
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:56-45-1
Pubchem (cid):5951
Pubchem (sid):134972610
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS):View
CHEBI:View
CHEMBL:View
Golm Metabolome Database:Search
Metabolomics Database:Search
UM BBD:Search
KEGG (GenomeNet):C00065
HMDB (The Human Metabolome Database):HMDB00187
FooDB:FDB012739
YMDB (Yeast Metabolome Database):YMDB00112
Export Tariff Code:2922.50.5000
FDA Listing of Food Additive Status:View
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
Formulations/Preparations:
flavor, food and pharmaceutical grades; usp and fcc grades
 
Potential Blenders and core components note
None Found
 
Potential Uses:
 antistatic agents
 hair conditioning
 skin conditioning
 
Occurrence (nature, food, other):note
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Synonyms:
L-alanine, 3-hydroxy-
(S)-2-amino-3-hydroxy-propanoic acid
(2S)-2-amino-3-hydroxypropanoic acid
(S)-2-amino-3-hydroxypropanoic acid
2-amino-3-hydroxypropanoic acid, (S)-
(S)-2-amino-3-hydroxypropionic acid
L-2-amino-3-hydroxypropionic acid
alpha-amino-beta-hydroxypropionic acid
L-3-hydroxy-2-aminopropionic acid
beta-hydroxyalanine
 propanoic acid, 2-amino-3-hydroxy-, (S)
 propanoic acid, 2-amino-3-hydroxy-, (S)-
(S)-serine
(S)-(-)-serine
L-serine
 serine, L-
 

Articles:

PubMed:Lowering Plasma 1-Deoxysphingolipids Improves Neuropathy in Diabetic Rats.
PubMed:New amino acid germinants for spores of the enterotoxigenic Clostridium perfringens type A isolates.
PubMed:High-yield phosphatidylserine production via yeast surface display of phospholipase D from Streptomyces chromofuscus on Pichia pastoris.
PubMed:Targeting cystalysin, a virulence factor of treponema denticola-supported periodontitis.
PubMed:Arginine vasopressin regulated ASCT1 expression in astrocytes from stroke-prone spontaneously hypertensive rats and congenic SHRpch1_18 rats.
PubMed:Gustatory responsiveness to the 20 proteinogenic amino acids in the spider monkey (Ateles geoffroyi).
PubMed:Cane molasses as a source of precursors in the bioproduction of tryptophan by Bacillus subtilis.
PubMed:Influence of nanoparticle-membrane electrostatic interactions on membrane fluidity and bending elasticity.
PubMed:Hydrolysis of wheat gluten by combining peptidases of Flammulina velutipes and electrodialysis.
PubMed:Enzymatic synthesis of phosphatidylserine using bile salt mixed micelles.
PubMed:One-step of tryptophan attenuator inactivation and promoter swapping to improve the production of L-tryptophan in Escherichia coli.
PubMed:Pathological alterations of astrocytes in stroke-prone spontaneously hypertensive rats under ischemic conditions.
PubMed:Olfactory sensitivity to amino acids in the blackspot sea bream (Pagellus bogaraveo): a comparison between olfactory receptor recording techniques in seawater.
PubMed:Soybean-derived phosphatidylserine improves memory function of the elderly Japanese subjects with memory complaints.
PubMed:Purification, biochemical characterization, and cloning of phospholipase D from Streptomyces racemochromogenes strain 10-3.
PubMed:Nutrient selection in the absence of taste receptor signaling.
PubMed:Toxicology studies with N-acetyl-L-serine.
PubMed:Feruloyl dioleoylglycerol antioxidant capacity in phospholipid vesicles.
PubMed:A 90-day Feeding Toxicity Study of l-Serine in Male and Female Fischer 344 Rats.
PubMed:Effect of acute copper sulfate exposure on olfactory responses to amino acids and pheromones in goldfish (Carassius auratus).
PubMed:A 13-week subchronic oral toxicity study of L-serine in rats.
PubMed:Two crystal structures of lysyl-tRNA synthetase from Bacillus stearothermophilus in complex with lysyladenylate-like compounds: insights into the irreversible formation of the enzyme-bound adenylate of L-lysine hydroxamate.
PubMed:Importance of tyrosine residues of Bacillus stearothermophilus serine hydroxymethyltransferase in cofactor binding and L-allo-Thr cleavage.
PubMed:Mechanism of the suppression against D-galactosamine-induced hepatic injury by dietary amino acids in rats.
PubMed:Adaptational modification of serine and threonine metabolism in the liver to essential amino acid deficiency in rats.
PubMed:Serine dehydratase and tyrosine aminotransferase activities increased by long-term starvation and recovery by refeeding in rainbow trout (Oncorhynchus mykiss).
PubMed:Respiratory deficiency mediates the regulation of CHO1-encoded phosphatidylserine synthase by mRNA stability in Saccharomyces cerevisiae.
PubMed:The influence of extrusion on loss and racemization of amino acids.
PubMed:Glutamate reduces secretion of l-serine in astrocytes isolated from stroke-prone spontaneously hypertensive rats.
PubMed:Enzymatic and mechanistic studies on the formation of N-phenylglycolohydroxamic acid from nitrosobenzene and pyruvate in spinach leaf homogenate.
PubMed:The neurotransmitters glycine and GABA stimulate glucagon-like peptide-1 release from the GLUTag cell line.
PubMed:Anticholesterolemic effect of 3,4-di(OH)-phenylpropionic amides in high-cholesterol fed rats.
PubMed:Molecular characterization of the CmbR activator-binding site in the metC-cysK promoter region in Lactococcus lactis.
PubMed:Application of stepwise discriminant analysis to classify commercial orange juices using chiral micellar electrokinetic chromatography-laser induced fluorescence data of amino acids.
PubMed:The relative affective potency of glycine, L-serine and sucrose as assessed by a brief-access taste test in inbred strains of mice.
PubMed:Inverse correlation between the nitrogen balance and induction of rat liver serine dehydratase (SDH) by dietary protein.
PubMed:Pseudoalteromonas sagamiensis sp. nov., a marine bacterium that produces protease inhibitors.
PubMed:Serine metabolism in Lactobacillus plantarum.
PubMed:Control of oxalate formation from L-hydroxyproline in liver mitochondria.
PubMed:[Effect of hypoproteic diets enriched with essential and non-essential amino acids on the uninephrectomized rat ].
PubMed:Use of a novel method to characterize the response of spores of non-proteolytic Clostridium botulinum types B, E and F to a wide range of germinants and conditions.
PubMed:Regulation of the metC-cysK operon, involved in sulfur metabolism in Lactococcus lactis.
PubMed:Chlorosis-inducing products from Pseudomonas syringae pathovars: new N-coronafacoyl compounds.
PubMed:Accelerative effect of olive oil on liver glycogen synthesis in rats subjected to water-immersion restraint stress.
PubMed:Oxalate synthesis in mammals: properties and subcellular distribution of serine:pyruvate/alanine:glyoxylate aminotransferase in the liver.
PubMed:Conversion to docosahexaenoic acid-containing phosphatidylserine from squid skin lecithin by phospholipase D-mediated transphosphatidylation.
PubMed:Formation of sugar-specific reactive intermediates from (13)C-labeled L-serines.
PubMed:Pyrazine formation from serine and threonine.
PubMed:Fumonisin B1 induces protein kinase C translocation via direct interaction with diacylglycerol binding site.
PubMed:Efficient L-serine production from methanol and glycine by resting cells of Methylobacterium sp. strain MN43.
PubMed:[Regulation of gene expression by nutrients].
PubMed:Lack of attenuation of valproic acid-induced embryotoxicity by compounds involved in one-carbon transfer reactions.
PubMed:Consumption of carbohydrate or medium- or long-chain triglycerides by unfed rats exerts different protein-sparing effects.
PubMed:Periportal expression of the serine dehydratase gene in rat liver.
PubMed:2-Methyl-L-tryptophan is a substrate of tryptophanase.
PubMed:Nutritional profile and antimicrobial spectrum of the spice Aframomum danielli K. Schum.
PubMed:Enzymatic assay for L-serine and glyoxylate involving the enzymes in the serine pathway of a methylotroph.
PubMed:Regulation of yeast phosphatidylserine synthase and phosphatidylinositol synthase activities by phospholipids in Triton X-100/phospholipid mixed micelles.
PubMed:Phosphorylation of yeast phosphatidylserine synthase in vivo and in vitro by cyclic AMP-dependent protein kinase.
PubMed:Chemotactic behavior of Campylobacter jejuni.
PubMed:Behavior of L-threonine-degrading enzymes during liver regeneration.
PubMed:Fasting and refeeding modulate neutral amino acid transport activity in the basolateral membrane of the rat exocrine pancreatic epithelium: fasting-induced insulin insensitivity.
PubMed:Effects of chronic uraemia on the formation of glucose and urea plus ammonia from L-alanine, L-glutamine and L-serine in isolated rat hepatocytes.
PubMed:Adaptation of rats to diets containing different levels of protein: effects on food intake, plasma and brain amino acid concentrations and brain neurotransmitter metabolism.
PubMed:Mutagenicity studies on N-nitrosated products of the Maillard browning reaction: N-nitroso-fructose-amino acids.
PubMed:Threonine imbalance and the threonine requirement of the chicken.
PubMed:Genetic control of serine dehydratase and phosphoenolpyruvate carboxykinase in mice.
PubMed:The effect of o,p'-DDT feeding and food deprivation on plasma and liver amino acids and liver serine dehydratase in rats.
PubMed:Induction of pyridoxal phosphate-dependent enzymes in vitamin B-6 deficient rats.
PubMed:The structure of two alanine containing ferrichromes: sequence determination by proton magnetic resonance.
PubMed:Neonatal rise of rat liver tyrosine aminotransferase and serine dehydratase activity associated with lack of food.
PubMed:Effect of cold exposure on the response of rats to a dietary amino acid imbalance.
PubMed:Associations among food and protein intake, serine dehydratase, and plasma amino acids.
PubMed:Serine Transhydroxymethylase of Cauliflower (Brassica oleracea var. botrytis L.): Partial Purification and Properties.
 
Notes:
a non-essential amino acid occurring in natural form as the l-isomer. it is synthesized from glycine or threonine. it is involved in the biosynthesis of purines; pyrimidines; and other amino acids. Dietary supplement
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