levodopa
L-tyrosine, 3-hydroxy-

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  CODE125353 CODE125353
  Product(s):
  59-92-7 Levodopa >98%
  Levodopa (Sinemet) is an amino acid precursor of dopamine with antiparkinsonian properties.

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  Product(s):
  GM9724 3,4-Dihydroxy-L-phenylalanine

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  Jiangyin Healthway International Trade Co., Ltd

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  Jiangyin Healthway International Trade Co., Ltd is a professional company, main engaged in manufacturing and exporting aroma chemicals ,food additives , cosmetic ingredient ,pharmaceutical intermediates & other fine chemicals; especially on aroma chemicals , as the major manufacturer of heterocyclic and sulphur aroma compounds , we are the leading independent ingredients supplier to the flavour and fragrance industries in China, can offer hundreds of different high quality aroma chemicals.
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  HLG0320 Levodopa

CAS Number: 59-92-7 3D/inchi Other(deleted CASRN): 23734-74-9 ECHA EINECS - REACH Pre-Reg: 200-445-2 FDA UNII: 46627O600J Nikkaji Web: J9.225H Beilstein Number: 2215169 MDL: MFCD00002598 XlogP3: -2.70 (est) Molecular Weight: 197.19047000 Formula: C9 H11 N O4 BioActivity Summary: listing NMR Predictor: Predict (works with chrome, Edge or firefox) Category:information only not used for fragrances or flavors   US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information: Google Scholar: Search Google Books: Search Google Scholar: with word "volatile" Search Google Scholar: with word "flavor" Search Google Scholar: with word "odor" Search Google Patents: Search US Patents: Search EU Patents: Search Pubchem Patents: Search PubMed: Search NCBI: Search   Physical Properties: Appearance: white powder (est) Assay: 95.00 to 100.00 Food Chemicals Codex Listed: No Melting Point: 281.00 to 285.00 °C. @ 760.00 mm Hg Boiling Point: 447.00 to 449.00 °C. @ 760.00 mm Hg Flash Point: 437.00 °F. TCC ( 225.00 °C. ) logP (o/w): -1.154 (est) Soluble in:   water, 5000 mg/L @ 20 °C (exp)   Organoleptic Properties: Odor Type: odorless Odor Strength:none Odor Description:at 100.00 %. odorless Flavor Type: sweet sweet Taste Description: sweet Odor and/or flavor descriptions from others (if found).   Cosmetic Information: None found   Suppliers: Ajinomoto USA L-Dopa Flavor: characteristic L-dopa is not a core amino acid in terms of a building block for proteins. L-dopa is a synthetic protein for medical use. Alfa Biotechnology For experimental / research use only. Levodopa 98% BOC Sciences For experimental / research use only. Levodopa >98% Odor: characteristic Use: Levodopa (Sinemet) is an amino acid precursor of dopamine with antiparkinsonian properties. Glentham Life Sciences 3,4-Dihydroxy-L-phenylalanine Jiangyin Healthway Levodopa New functional food ingredients Qingdao Dacon Trading Levodopa Shaanxi Y-Herb Biotechnology Levodopa Weight Loss Supplement Powder 10%-98% L- Dopa Seed Mucuna Pruriens Extract Shiva Chemicals and Pharmaceuticals Levodopa Sigma-Aldrich: Sigma For experimental / research use only. 3,4-Dihydroxy-L-phenylalanine ≥98% (TLC) sds   Safety Information: Preferred SDS: View European information : Most important hazard(s): Xn - Harmful. R 22 - Harmful if swallowed. R 36/37/38 - Irritating to eyes, respiratory system, and skin. S 02 - Keep out of the reach of children. S 20/21 - When using do not eat, drink or smoke. S 24/25 - Avoid contact with skin and eyes. S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 36/37/39 - Wear suitable clothing, gloves and eye/face protection.   Hazards identification   Classification of the substance or mixture GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) None found. GHS Label elements, including precautionary statements   Pictogram   Hazard statement(s) None found. Precautionary statement(s) None found. Oral/Parenteral Toxicity: intravenous-mouse LD50 450 mg/kg Toxicology and Applied Pharmacology. Vol. 28, Pg. 1, 1974. oral-mouse LD50 2363 mg/kg BEHAVIORAL: EXCITEMENT Toxicology and Applied Pharmacology. Vol. 28, Pg. 1, 1974. oral-rabbit LD50 609 mg/kg Toxicology and Applied Pharmacology. Vol. 28, Pg. 1, 1974. intraperitoneal-rat LD50 624 mg/kg SKIN AND APPENDAGES (SKIN): HAIR: OTHER BEHAVIORAL: EXCITEMENT SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE Toxicology and Applied Pharmacology. Vol. 28, Pg. 1, 1974. intravenous-rat LD50 > 100 mg/kg Drugs in Japan Vol. 6, Pg. 905, 1982. oral-bird - wild LD50 100 mg/kg Archives of Environmental Contamination and Toxicology. Vol. 12, Pg. 355, 1983. oral-human TDLo 13000 mg/kg/1Y BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) Journal of Neurology, Neurosurgery and Psychiatry. Vol. 34, Pg. 668, 1971. oral-human TDLo 156000 mg/kg/10Y BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: TOXIC PSYCHOSIS BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS" Journal of Neurology, Neurosurgery and Psychiatry. Vol. 34, Pg. 502, 1971. intraperitoneal-mouse LD50 588 mg/kg BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE Toxicology and Applied Pharmacology. Vol. 28, Pg. 1, 1974. unreported-mouse LDLo 3500 mg/kg AUTONOMIC NERVOUS SYSTEM: SYMPATHOMIMETIC Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 153, Pg. 161, 1930. oral-rat LD50 1780 mg/kg BEHAVIORAL: AGGRESSION BEHAVIORAL: ATAXIA BEHAVIORAL: EXCITEMENT Toxicology and Applied Pharmacology. Vol. 28, Pg. 1, 1974. Dermal Toxicity: subcutaneous-mouse LD50 4449 mg/kg BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS PERIPHERAL NERVE AND SENSATION: LOCAL ANESTHETIC Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 3, Pg. 186, 1972. subcutaneous-rat LD50 2000 mg/kg GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 3, Pg. 186, 1972. Inhalation Toxicity: Not determined   Safety in Use Information: Category: information only not used for fragrances or flavors Recommendation for levodopa usage levels up to:   not for fragrance use.   Recommendation for levodopa flavor usage levels up to:   not for flavor use.   Safety References: EPI System: View ClinicalTrials.gov:search Daily Med:search Chemical Carcinogenesis Research Information System:Search AIDS Citations:Search Cancer Citations:Search Toxicology Citations:Search EPA Substance Registry Services (TSCA):59-92-7 EPA ACToR:Toxicology Data EPA Substance Registry Services (SRS):Registry Laboratory Chemical Safety Summary :6047 National Institute of Allergy and Infectious Diseases:Data WGK Germany:3 (2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoic acid Chemidplus:0000059927 RTECS:AY5600000 for cas# 59-92-7   References:   (2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoic acid NIST Chemistry WebBook: Search Inchi Pubchem (cid): 6047 Pubchem (sid): 134972617   Other Information: (IUPAC): Atomic Weights of the Elements 2011 (pdf) Videos: The Periodic Table of Videos tgsc: Atomic Weights use for this web site (IUPAC): Periodic Table of the Elements CHEBI: View CHEMBL: View Golm Metabolome Database: Search Metabolomics Database: Search KEGG (GenomeNet): C00355 HMDB (The Human Metabolome Database): HMDB00181 FooDB: FDB000567 Export Tariff Code: 2922.50.4000 VCF-Online: VCF Volatile Compounds in Food ChemSpider: View Wikipedia: View Formulations/Preparations: •capsules usp: 100, 250, & 500 mg; tablets usp: 100, 250, & 500 mg. •levodopa is one of the main ingredients along with carbidopa in the drug sinemet (tablets) •levodopa is one of the main ingredients along with carbidopa in the drug atamet (tablets)   Potential Blenders and core components note None Found   Potential Uses: None Found   Occurrence (nature, food, other):note   banana fruit Search Trop Picture   bean fava bean Search Trop Picture   bean fava bean flower Search Trop Picture   bean fava bean fruit Search Trop Picture   bean fava bean leaf Search Trop Picture   bean fava bean seed Search Trop Picture   bean fava bean sprout Search Trop Picture   bean fava bean stem Search Trop Picture   lupinus spp. Search Trop Picture   purslane plant Search Trop Picture   Synonyms: (2S)-2- amino-3-(3,4-dihydroxyphenyl)propanoic acid (S)-2- amino-3-(3,4-dihydroxyphenyl)propanoic acid 2- amino-3-(3,4-dihydroxyphenyl)propanoic acid 3,4- dihydroxy-L-phenylalanine 3,4- dihydroxy-laevo-phenyl alanine L-3,4- dihydroxyphenyl alanine laevo-3,4- dihydroxyphenyl alanine 3,4- dihydroxyphenyl-laevo-alanine L-3-(3,4- dihydroxyphenyl) alanine laevo-3-(3,4- dihydroxyphenyl) alanine L-beta-(3,4- dihydroxyphenyl)-alpha-alanine laevo-beta-(3,4- dihydroxyphenyl)-alpha-alanine 3-(3,4- dihydroxyphenyl)-L-alanine beta-(3,4- dihydroxyphenyl)-laevo-alanine 3,4-L- dihydroxyphenylalanine L-3,4- dihydroxyphenylalanine L- dopa laevo- dopa 3- hydroxy-L-tyrosine 3- hydroxy-laevo-tyrosine L- tyrosine, 3-hydroxy-   Articles:   None found yet. 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Notes: the naturally occurring form of dihydroxyphenylalanine and the immediate precursor of dopamine. unlike dopamine itself, it can be taken orally and crosses the blood-brain barrier. it is rapidly taken up by dopaminergic neurons and converted to dopamine. it is used for the treatment of parkinsonian disorders and is usually given with agents that inhibit its conversion to dopamine outside of the central nervous system. Occurs in seedlings and pods of Vicia faba L-DOPA (L-3,4-dihydroxyphenylalanine; INN levodopa; trade names Sinemet, Parcopa, Atamet, Stalevo, Madopar, Prolopa, etc.) is a naturally-occurring dietary supplement and psychoactive drug found in certain kinds of food and herbs (e.g., Mucuna pruriens, or velvet bean), and is synthesized from the amino acid L-tyrosine in the mammalian body and brain. (Wikipedia)