EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

laevo-carnitine hydrochloride
(R)-3-carboxy-2-hydroxy-N,N,N-trimethyl-1-propanaminium, inner salt, hydrochloride (1:1)

Supplier Sponsors

CAS Number: 6645-46-1Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:229-663-6
FDA UNII: J3Y5E6IKS3
Beilstein Number:0773748
MDL:MFCD00066100
Molecular Weight:197.66112000
Formula:C7 H16 Cl N O3
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:humectants, skin conditioning
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Flash Point: 32.00 °F. TCC ( 0.00 °C. ) (est)
logP (o/w): -4.518 (est)
Soluble in:
 water, 1e+006 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: humectants
skin conditioning
 
Suppliers:
BOC Sciences
For experimental / research use only.
L-Carnitine HCL 95%
Glentham Life Sciences
L-Carnitine hydrochloride
Indis NV
For experimental / research use only.
L-Carnitine (Base, HCl,
Penta International
L-CARNITINE HCL
Qingdao Dacon Trading
L-Carnitine HCL
Santa Cruz Biotechnology
For experimental / research use only.
L-Carnitine Hydrochloride
Sigma-Aldrich: Sigma
For experimental / research use only.
L-Carnitine hydrochloride synthetic, ≥98%
sds
TCI AMERICA
For experimental / research use only.
L-Carnitine Hydrochloride >98.0%(T)
sds
United International
L-Carnitine base hydrochloride
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intravenous-dog LD50 2272 mg/kg
SKIN AND APPENDAGES (SKIN): HAIR: OTHER GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" VASCULAR: OTHER CHANGES
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 19, Pg. 238, 1988.

oral-dog LD50 > 1600 mg/kg
Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 32, Pg. 1761, 1990.

intraperitoneal-mouse LD50 1690 mg/kg
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 19, Pg. 446, 1988.

intravenous-mouse LD50 3100 mg/kg
BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 19, Pg. 446, 1988.

oral-mouse LD50 8000 mg/kg
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 19, Pg. 446, 1988.

intravenous-rabbit LD50 1200 mg/kg
BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 19, Pg. 446, 1988.

oral-rabbit LD50 5400 mg/kg
BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 19, Pg. 446, 1988.

intraperitoneal-rat LD50 1920 mg/kg
GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" SKIN AND APPENDAGES (SKIN): HAIR: OTHER VASCULAR: OTHER CHANGES
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 19, Pg. 191, 1988.

intravenous-rat LD50 1440 mg/kg
SKIN AND APPENDAGES (SKIN): HAIR: OTHER VASCULAR: OTHER CHANGES GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 19, Pg. 191, 1988.

oral-rat LD50 6890 mg/kg
VASCULAR: OTHER CHANGES SKIN AND APPENDAGES (SKIN): HAIR: OTHER GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 19, Pg. 191, 1988.

Dermal Toxicity:
subcutaneous-mouse LD50 4320 mg/kg
BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 19, Pg. 446, 1988.

subcutaneous-rat LD50 > 5000 mg/kg
SKIN AND APPENDAGES (SKIN): HAIR: OTHER SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 19, Pg. 191, 1988.

Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
humectants, skin conditioning
Recommendation for laevo-carnitine hydrochloride usage levels up to:
 not for fragrance use.
 
Recommendation for laevo-carnitine hydrochloride flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :656657
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:2
[(2R)-3-carboxy-2-hydroxypropyl]-trimethylazanium;chloride
Chemidplus:0006645461
RTECS:BP2979100 for cas# 6645-46-1
 
References:
 [(2R)-3-carboxy-2-hydroxypropyl]-trimethylazanium;chloride
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):656657
Pubchem (sid):134970538
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEMBL:View
KEGG (GenomeNet):D02030
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2922.49.4050
ChemSpider:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
 ammonium, (3-carboxy-2-hydroxypropyl)trimethyl-, chloride
(R)-3-carboxy-2-hydroxy-N,N,N-trimethyl-1-propanaminium, inner salt, hydrochloride (1:1)
(R)-3-carboxy-2-hydroxy-N,N,N-trimethylpropan-1-aminium chloride
[(2R)-3-carboxy-2-hydroxypropyl)-trimethylazanium;chloride
(±)-(3-carboxy-2-hydroxypropyl)trimethyl-ammonium chloride
 carnitine chloride
L-carnitine hydrochloirde (bovine)
laevo-carnitine hydrochloride from equine muscle
L-carnitinehydrochloride
 entomin
(R)-3-hydroxy-4-(trimethylamino)butanoic acid, chloride
(R)-3-hydroxy-4-(trimethylammonio)butanoate hydrochloride
(R)-3-hydroxy-4-(trimethylammonio)butyrate hydrochloride
 levocarnitine hydrochloride
1-propanaminium, 3-carboxy-2-hydroxy-N,N,N-trimethyl-, chloride, (R)-
1-propanaminium, 3-carboxy-2-hydroxy-N,N,N-trimethyl-, chloride, (R)- (1:1)
1-propanaminium, 3-carboxy-2-hydroxy-N,N,N-trimethyl-, inner salt, hydrochloride, (R)- (1:1)
 

Articles:

PubMed:[Experience with levocarnitine chloride supplementation for the treatment of fatigue in cancer patients undergoing chemotherapy].
PubMed:L-carnitine exposure and mitochondrial function in human neuronal cells.
PubMed:2,4-dichlorophenol induces apoptosis in primary hepatocytes of grass carp (Ctenopharyngodon idella) through mitochondrial pathway.
PubMed:Novel c.2216T > C (p.I739T) mutation in exon 13 and c.1481T > A (p.L494X) mutation in exon 8 of MUT gene in a female with methylmalonic acidemia.
PubMed:Propionyl-L-carnitine hydrochloride for treatment of mild to moderate colonic inflammatory bowel diseases.
PubMed:Roles of reactive oxygen species and mitochondria in cadmium-induced injury of liver cells.
PubMed:[Optimum preparation of levocarnitine chloride solution in the hospital pharmacy].
PubMed:Protective effect of L-carnitine on renal ischaemia-reperfusion injury in the rat.
PubMed:Effects of L-carnitine-hydrochloride in the cold ischemic preservation of fatty liver grafts.
PubMed:Effect of acetyl-L-carnitine on leukemia L1210 resistant to mitoxantrone.
PubMed:Pharmacokinetics of propionyl-L-carnitine in humans: evidence for saturable tubular reabsorption.
PubMed:[Influence of multiple-dose administration of cefetamet pivoxil on blood and urinary concentrations of carnitine and effects of simultaneous administration of carnitine with cefetamet pivoxil].
PubMed:A 1-year multicenter placebo-controlled study of acetyl-L-carnitine in patients with Alzheimer's disease.
PubMed:Propionyl-L-carnitine: labelling in the N-methyl position with carbon-11 and pharmacokinetic studies in rats.
PubMed:[Effects of levocarnitine chloride, a new mitochondrial function reactivating agent, on fatty acid and glucose oxidation under hypoxic condition in homogenates from rat heart].
PubMed:[Studies on the beneficial effect of levocarnitine chloride (LC-80) on organic acidemias, especially propionic acidemia and methylmalonic acidemia].
PubMed:[Effects of levocarnitine chloride (LC-80) on the cardiovascular system].
PubMed:[Effects of levocarnitine chloride (LC-80) on hemodynamics and myocardial metabolism in anesthetized open-chest dogs under normoxic or hypoxic conditions].
PubMed:Metabolism and disposition of intravenously administered acetyl-L-carnitine in healthy volunteers.
PubMed:[Induction of fetal lung-maturity. Part III: surfactant-parameters in amniotic-fluid and fetal lung].
 
Notes:
None found
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