|
Category:information only not used for fragrances or flavors
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00
|
| Food Chemicals Codex Listed: | No |
| Flash Point: | 32.00 °F. TCC ( 0.00 °C. ) (est)
|
| logP (o/w): | -3.760 (est) |
| Soluble in: |
| | water, 5 mg/L @ 20 °C (exp) | | | water, 7.736e+005 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
| |
| Hazards identification |
| |
| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
| |
| Pictogram | |
| |
| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
|
Not determined
|
| Dermal Toxicity: |
|
Not determined
|
| Inhalation Toxicity: |
|
Not determined
|
Safety in Use Information:
| Category: | | information only not used for fragrances or flavors |
| Recommendation for isoxanthopterin usage levels up to: | | | not for fragrance use.
|
| |
| Recommendation for isoxanthopterin flavor usage levels up to: |
| | not for flavor use.
|
Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| 2- | amino-1,8-dihydropteridine-4,7-dione | | 2- | amino-4,7-dihydroxypteridine | | 2- | amino-4,7(1H,8H)-pteridinedione | | 2- | amino-4,7(3H,8H)-pteridinedione | | 2- | aminopteridine-4,7-diol | | 4,7(1H,8H)- | pteridinedione, 2-amino- (9CI) | | | ranachrome 4
|
Articles:
| PubMed:HPLC determination of serum pteridine pattern as biomarkers. |
| PubMed:Normalization of urinary pteridines by urine specific gravity for early cancer detection. |
| PubMed:Roles of long-range tertiary interactions in limiting dynamics of the Tetrahymena group I ribozyme. |
| PubMed:Capillary electrophoresis of pterin derivatives responsible for the warning coloration of Heteroptera. |
| PubMed:Use of a Pteridine Moiety to Track DNA Uptake in Cells. |
| PubMed:Determination of pterins in urine by HPLC with UV and fluorescent detection using different types of chromatographic stationary phases (HILIC, RP C8, RP C18). |
| PubMed:Simultaneous determination of three potential cancer biomarkers in rat urine by synchronous fluorescence spectroscopy. |
| PubMed:Screening of xanthine oxidase inhibitors in complex mixtures using online HPLC coupled with postcolumn fluorescence-based biochemical detection. |
| PubMed:Simultaneous detection of six urinary pteridines and creatinine by high-performance liquid chromatography-tandem mass spectrometry for clinical breast cancer detection. |
| PubMed:Isothermal amplification of DNA using quadruplex primers with fluorescent pteridine base analogue 3-methyl isoxanthopterin. |
| PubMed:Vibrational spectroscopic (FT-IR and FT-Raman) studies, natural bond orbital analysis and molecular electrostatic potential surface of Isoxanthopterin. |
| PubMed:Hydrophilic interaction liquid chromatography with tandem mass spectrometric detection applied for analysis of pteridines in two Graphosoma species (Insecta: Heteroptera). |
| PubMed:Preparation of chitosan-graft-(β-cyclodextrin) based sol-gel stationary phase for open-tubular capillary electrochromatography. |
| PubMed:Assignment of pterin deaminase activity to an enzyme of unknown function guided by homology modeling and docking. |
| PubMed:Electronic transition moments of 6-methyl isoxanthopterin--a fluorescent analogue of the nucleic acid base guanine. |
| PubMed:Determination of six pterins in urine by LC-MS/MS. |
| PubMed:Characterization of the 6-methyl isoxanthopterin (6-MI) base analog dimer, a spectroscopic probe for monitoring guanine base conformations at specific sites in nucleic acids. |
| PubMed:Enhanced MCR-ALS modeling of HPLC with fast scan fluorimetric detection second-order data for quantitation of metabolic disorder marker pteridines in urine. |
| PubMed:Biochemical measurement of neonatal hypoxia. |
| PubMed:Pterin detection using surface-enhanced Raman spectroscopy incorporating a straightforward silver colloid-based synthesis technique. |
| PubMed:Non-conventional hydrogen bonds: pterins-metal anions. |
| PubMed:Investigation of urinary pteridine levels as potential biomarkers for noninvasive diagnosis of cancer. |
| PubMed:[Determination of isoxanthopterin in human urine by solid phase extraction-high performance anion-exchange chromatography coupled with integrated pulsed amperometric detection]. |
| PubMed:Determination of marker pteridines in urine by HPLC with fluorimetric detection and second-order multivariate calibration using MCR-ALS. |
| PubMed:Simultaneous determination of xanthopterin and isoxanthopterin in human urine by synchronous fluorescence spectroscopy. |
| PubMed:Discovery and structure determination of the orphan enzyme isoxanthopterin deaminase . |
| PubMed:Conformational heterogeneity and quasi-static self-quenching in DNA containing a fluorescent guanine analogue, 3MI or 6MI. |
| PubMed:Effect of methyl substitution in a ligand on the selectivity and binding affinity for a nucleobase: a case study with isoxanthopterin and its derivatives. |
| PubMed:Improvement of base selectivity and binding affinity by controlling hydrogen bonding motifs between nucleobases and isoxanthopterin: application to the detection of T/C mutation. |
| PubMed:Guanines are a quartet's best friend: impact of base substitutions on the kinetics and stability of tetramolecular quadruplexes. |
| PubMed:Cytotoxicity of xanthopterin and isoxanthopterin in MCF-7 cells. |
| PubMed:Cytokine-mediated xanthine oxidase upregulation in chronic obstructive pulmonary disease's airways. |
| PubMed:Use of pteridine nucleoside analogs as hybridization probes. |
| PubMed:Nucleosides. LXV. Synthesis of new pteridine-N8-nucleosides. |
| PubMed:The pteridine pathway in zebrafish: regulation and specification during the determination of neural crest cell-fate. |
| PubMed:Pteridine concentrations differ between insectary-reared and field-collected Anopheles albimanus mosquitoes of the same physiological age. |
| PubMed:HU binding to DNA: evidence for multiple complex formation and DNA bending. |
| PubMed:A sensitive method to assay the xanthine oxidase activity in primary cultures of cerebellar granule cells. |
| PubMed:Development of the pteridine pathway in the zebrafish, Danio rerio. |
| PubMed:Ultrastructural and biochemical analysis of epidermal xanthophores and dermal chromatophores of the teleost Sparus aurata. |
| PubMed:Pteridine analysis in urine by capillary electrophoresis using laser-induced fluorescence detection. |
| PubMed:Simultaneous determination of pteridines in multicomponent mixtures using derivative spectrophotometry and partial least-squares calibration. |
| PubMed:Fluorescence properties of a new guanosine analog incorporated into small oligonucleotides. |
| PubMed:Inhalation of the nitric oxide synthase cofactor tetrahydrobiopterin in healthy volunteers. |
| PubMed:Photoinduced hydroxylation of deoxyguanosine in DNA by pterins: sequence specificity and mechanism. |
| PubMed:Tetrahydrobiopterin loading test in xanthine dehydrogenase and molybdenum cofactor deficiencies. |
| PubMed:Determination of human plasma xanthine oxidase activity by high-performance liquid chromatography. |
| PubMed:Yellow marking and pteridine contents in the integument of albino Armadillidium vulgare. |
| PubMed:Incorporation of a fluorescent guanosine analog into oligonucleotides and its application to a real time assay for the HIV-1 integrase 3'-processing reaction. |
| PubMed:Pteridine biosynthesis and nitric oxide synthase in Physarum polycephalum. |
| PubMed:Antenatal diagnosis of tetrahydrobiopterin deficiency by quantification of pterins in amniotic fluid and enzyme activity in fetal and extrafetal tissue. |
| PubMed:Pteridines in the yellow-colored chromatophores of the isopod, Armadillidium vulgare. |
| PubMed:Purification and partial characterization of xanthine oxidase from human milk. |
| PubMed:Quantification and excretion profiles of pteridines in primate urine. |
| PubMed:2,6-Dichlorophenolindophenol is a competitive inhibitor for xanthine oxidase and is therefore not usable as an electron acceptor in the fluorometric assay. |
| PubMed:Pigments and ultrastructures of pigment cells in xanthic sailfin mollies (Poecilia latipinna). |
| PubMed:Genetic and biochemical characterization of little isoxanthopterin (lix), a gene controlling dihydropterin oxidase activity in Drosophila melanogaster. |
| PubMed:[Pteridine pattern in the urine of swine of different breeds and halothane genotypes in relation to nutrition and stress]. |
| PubMed:Concentrations and patterns of released pterins of various animal cell cultures. |
| PubMed:Protection by deferoxamine from endothelial injury: a possible link with inhibition of intracellular xanthine oxidase. |
| PubMed:Regulation of pteridine biosynthesis and aromatic amino acid hydroxylation in Drosophila melanogaster. |
| PubMed:A sensitive fluorometric assay for measuring xanthine dehydrogenase and oxidase in tissues. |
| PubMed:Determination of pterins in urine by high-performance liquid chromatography on C18 columns conditioned with cetyltrimethylammonium bromide. |
| PubMed:The pigments in the dorsal skin of frogs. |
| PubMed:Effect of pteridines on normal and neoplastic cell lines of Xiphophorus. |
| PubMed:Inhibition of GTP cyclohydrolase I by pterins. |
| PubMed:Highly sensitive assay for xanthine oxidase activity by high-performance liquid chromatography with fluorescence detection. |
| PubMed:Presence of pterin pigments in wings of libytheidae butterflies. |
| PubMed:Evaluation of pteridines in patients with different tumors. |
| PubMed:Pigment cell differentiation: the relationship between pterin content, allopurinol treatment, and the melanoid gene in axolotls. |
| PubMed:Pigment patterns in mutants affecting the biosynthesis of pteridines and xanthommatin in Drosophila melanogaster. |
| PubMed:Two indirect methods for detecting ureide synthesis by nodulated legumes. |
| PubMed:Pterins in patients with Rett syndrome. |
| PubMed:Pteridine formation during lectin-induced lymphocyte activation. |
| PubMed:Pterins and the regulation of lymphocyte activation on the mode of xanthopterin action. |
| PubMed:GTP cyclohydrolase I deficiency, a new enzyme defect causing hyperphenylalaninemia with neopterin, biopterin, dopamine, and serotonin deficiencies and muscular hypotonia. |
| PubMed:Participation of pterins in the control of lymphocyte stimulation and lymphoblast proliferation. |
| PubMed:Separation of pteridines from blood cells and plasma by reverse-phase high-performance liquid chromatography. |
| PubMed:Determination of biopterin and other pterins in tissues and body fluids by high-performance liquid chromatography. |
| PubMed:Urinary excretion levels of unconjugated pterins in cancer patients and normal individuals. |
| PubMed:Isolation of six unconjugated pteridines from soybean (Glycin max L. Tsurunoko) seeds. |
| PubMed:Permanent cell lines from erythrophoromas in goldfish (Carassius auratus). |
| PubMed:Quantitative determination of pterins in biological fluids by high-performance liquid chromatography. |
| PubMed:Enzymatic inhibition assay for fluorometric determination of allopurinol and oxipurinol in serum and urine. |
| PubMed:The influence of some pterins on the circadian rhythmicity of hydroxyindole-O-methyl transferase in the pineal gland of 42-day old male Wistar rats. |
| PubMed:Pterin deaminase from Bacillus megaterium. Purification and properties. |
| PubMed:Separation of unconjugated pteridines by high-pressure cation-exchange liquid chromatography. |
| PubMed:A long-term study of the excretion of folate and pterins in a human subject after ingestion of 14C folic acid, with observations on the effect of diphenylhydantoin administration. |
| PubMed:Oxidation of selected pteridine derivatives by mamalian liver xanthine oxidase and aldehyde oxidase. |
| PubMed:Correlation of guanosine triphosphate cyclohydrolase activity and the synthesis of pterins in Drosophila melanogaster. |
| PubMed:Characterization of an isoxanthopterin binding protein from Oncopeltus fasciatus. |
| PubMed:Pteridines. XXXVI. Syntheses of xanthopterin and isoxanthopterin. Application of N-oxide chemistry to highly functionalized pyrazines and pteridines. |
| PubMed:Inhibition of RNA synthesis in Drosophila embryos by isoxanthopterin. |
| PubMed:Pteridine and riboflavin in tumor tissue and the effect of chloramphenicol and isoxanthopterin. |
| PubMed:Pteridine and riboflavin patterns during tail regeneration in Triturus species and the effects of chloramphenicol, isoxanthopterin and reserpine. |
| PubMed:[Pterins from Pieridae (lepidoptera) and their biosynthesis. II. Synthesis and transport of isoxanthopterin during nymphal and adult life in Pieris brassicae]. |
| PubMed:[Identification of the isoxanthopterin in the tegument of Palomena prasina L. I]. |
| PubMed:Morphological and biochemical characterization of goldfish erythrophores and their pterinosomes. |
| PubMed:Interaction in vitro between isoxanthopterin and DNA. |
| PubMed:Studies on fine structure and cytochemical properties of erythrophores in swordtail, Xiphophorus helleri, with special reference to their pigment granules (Pterinosomes). |
| PubMed:Genetic control of cytodifferentiation. |
| PubMed:The metabolism of isoxanthopterin by Alcaligenes faecalis. |
| PubMed:Convenient assay of xanthine dehydrogenase in single Drosophila melanogaster. |
| PubMed:Cytodifferentiation in the rosy mutant of Drosophila melanogaster. |
| PubMed:Conversion of 2-14C-pteroyl-L-monoglutamic acid into isoxanthopterin in Drosophila melanogaster. |
| PubMed:Isolation of isoxanthopterin from human urine. |
| PubMed:Conversion of 2-amino-4-hydroxypteridine to isoxanthopterin in D. Melanogaster. |
| PubMed:[A mutant (rosy2) of Drosophila melanogaster without isoxanthopterin which is non-autonomous for the red eye pigments]. |
| PubMed:[Ontogenetic changes of isoxanthopterin content in various genotypes of Drosophila melanogaster]. |
| PubMed:Isoxanthopterin. |
| PubMed:[Research on the fluorescence of the hemolymph of Orthoptera; spectrographic identification of isoxanthopterin]. |
|
Isoxanthopterin is a pteridine normally present in plasma, urine, and other bodily fluids also vary from normal concentrations in some disease states and also have diagnostic value. Pteridines' urinary concentrations seem to vary independently from each other and from normal values to yield a pattern of excreted pteridines that is diagnostic for different species, tissues, and tumor types. Intravenous or intramuscular administration of isoxanthopterin inhibits the growth rates of animal tumor models. ; Pteridin derivatives are a family of organic compound with very similar chemical structures which play an important biochemistry role. Pteridines metabolism and its regulation in normal and pathological conditions have not been extensively investigated due to the difficulty of their quantification. A significant decrease of isoxanthopterin has been determined in cancer patients. (PMID 15837549, 9800651); Xanthine dehydrogenase (XDH) is the enzymes responsible for the conversion of xanthine to uric acid. It requires the presence of the molybdenum cofactor for its proper functioning. XDH is reported to have additional functions, i.e., the conversion of pterin to isoxanthopterin, one of the steps the degradation pathway of 5,6,7,8-tetrahydrobiopterin (BH4). Isoxanthopterin is very low in some cases of hereditary xanthinuria (OMIM 278300) and molybdenum cofactor deficiency (OMIM 252150). (PMID: 8812740)
|
3D/inchi