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isatin
1H-benzo[d]azoline-2,3-dione

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Name:1H-indole-2,3-dione
CAS Number: 91-56-5Picture of molecule3D/inchi
Other(deleted CASRN):5815-00-9
ECHA EINECS - REACH Pre-Reg:202-077-8
FDA UNII: 82X95S7M06
Nikkaji Web:J4.342G
Beilstein Number:0383659
MDL:MFCD00005718
XlogP3:0.80 (est)
Molecular Weight:147.13325000
Formula:C8 H5 N O2
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:cosmetic agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 203.00 °C. @ 760.00 mm Hg
Boiling Point: 360.30 °C. @ 760.00 mm Hg (est)
Vapor Pressure:0.000001 mmHg @ 25.00 °C. (est)
Flash Point: 341.00 °F. TCC ( 171.70 °C. ) (est)
logP (o/w): 0.830
Soluble in:
 water, 1.527e+004 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: hair dyeing agents
 
Suppliers:
Alfa Biotechnology
For experimental / research use only.
Isatin 98%
BOC Sciences
For experimental / research use only.
Isatin MP 202-204deg
BST Tianjin Co.
Isatin/2,3-Indolinedione
Glentham Life Sciences
Isatin
Penta International
ISATIN, PHARMACEUTICAL GRADE
Penta International
ISATIN, TECHNICAL GRADE
Santa Cruz Biotechnology
For experimental / research use only.
Isatin ≥98%
Sigma-Aldrich: Aldrich
For experimental / research use only.
Isatin 98%
sds
TCI AMERICA
For experimental / research use only.
Isatin >98.0%(GC)(T)
sds
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-mouse LD50 330 mg/kg
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 55, Pg. 1514, 1959.

intravenous-rat LD > 800 mg/kg
PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Indian Journal of Physiology and Pharmacology. Vol. 6, Pg. 145, 1962.

intraperitoneal-rat LD50 7740 mg/kg
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 27(8), Pg. 54, 1983.

unreported-rat LD50 725 mg/kg
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Russian Pharmacology and Toxicology Vol. 41, Pg. 146, 1978.

oral-rat LDLo 5000 mg/kg
PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Indian Journal of Physiology and Pharmacology. Vol. 6, Pg. 145, 1962.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
cosmetic agents
Recommendation for isatin usage levels up to:
 not for fragrance use.
 
Recommendation for isatin flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):91-56-5
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :7054
National Institute of Allergy and Infectious Diseases:Data
SCCNFP:opinion
WGK Germany:1
1H-indole-2,3-dione
Chemidplus:0000091565
RTECS:NL7873000 for cas# 91-56-5
 
References:
 1H-indole-2,3-dione
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:91-56-5
Pubchem (cid):7054
Pubchem (sid):134971576
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
KEGG (GenomeNet):C11129
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2933.79.1500
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
1H-benzo[d]azoline-2,3-dione
2,3-diketoindoline
2,3-dioxo-2,3-dihydroindole
2,3-dioxoindoline
3-hydroxy-2-oxoindole
 indole-2,3-dione
1H-indole-2,3-dione
 indolequinone
 indoline-2,3-dione
2,3-indolinedione
 

Articles:

PubMed:Mediators involved in the hyperthermic action of neuromedin U in rats.
PubMed:5-(2-carboxyethenyl) isatin derivative induces G₂/M cell cycle arrest and apoptosis in human leukemia K562 cells.
PubMed:Synthesis and in vitro antioxidant activity of new 3-substituted-2-oxindole derivatives.
PubMed:Rapid method for proline determination in grape juice and wine.
PubMed:Chemical synthesis, in vitro acetohydroxyacid synthase (AHAS) inhibition, herbicidal activity, and computational studies of isatin derivatives.
PubMed:Organophosphorus derivatives containing isatin-3-hydrazones as chemotherapeutants against fungal pathogens of sugarcane.
PubMed:Stress-induced increase in urinary isatin excretion in rats: reversal by both dexamethasone and alpha-methyl-P-tyrosine.
PubMed:Isatin inhibits food intake in mice.
PubMed:On the functions of monoamine oxidase, the emotions, and adaptation to stress.
PubMed:The response of some intravascular and intracellular lipid parameters of the rat after treatment with isatin.
 
Notes:
an indole-dione that is obtained by oxidation of indigo blue. it is a monoamine oxidase inhibitor and high levels have been found in urine of parkinsonism patients.
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