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Category:antifoaming, emollient agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Food Chemicals Codex Listed: | No |
| Specific Gravity: | 0.76400 @ 25.00 °C.
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| Flash Point: | 27.00 °F. TCC ( -2.78 °C. )
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| Soluble in: |
| | water, 0.93 mg/L @ 25 °C (exp) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
| |
| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
| |
| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
oral-guinea pig LDLo 50000 mg/kg
Journal of Industrial Hygiene and Toxicology. Vol. 30, Pg. 332, 1948.
intraperitoneal-mouse LD50 4500 mg/kg
Russian Chemical Reviws Vol. 38, Pg. 975, 1969.
intraperitoneal-rat LDLo 1825 mg/kg
National Technical Information Service. Vol. OTS0572636
oral-rat LDLo 8 mL/kg
BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Acute Toxicity Data. Journal of the American College of Toxicology, Part B. Vol. 12, Pg. 590, 1993.
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| Dermal Toxicity: |
skin-rabbit LD50 16 mL/kg
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITH APPROPRIATE ANESTHESIA
Acute Toxicity Data. Journal of the American College of Toxicology, Part B. Vol. 12, Pg. 590, 1993.
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| Inhalation Toxicity: |
inhalation-rat LC50 15956 ppm/4H
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
BEHAVIORAL: ATAXIA
National Technical Information Service. Vol. OTS0573658
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Safety in Use Information:
| Category: | | antifoaming, emollient agents |
| Recommendation for disiloxane usage levels up to: | | | not for fragrance use.
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| Recommendation for disiloxane flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
| | antifoaming agents |
| | emollients |
Occurrence (nature, food, other): note
Synonyms:
| | belsil DM 0.65 | | | hexamethyldisiloxane | | | silane, oxybis(trimethyl- | | | trimethyl(trimethylsilyloxy)silane | | bis( | trimethylsyl)oxide |
Articles:
| PubMed:Formation of unexpected silicon- and disiloxane-bridged multiferrocenyl derivatives bearing Si-O-CH[double bond, length as m-dash]CH2 and Si-(CH2)2C(CH3)3 substituents via cleavage of tetrahydrofuran and trapping of its ring fragments. |
| PubMed:Reactivity of the Sterically Demanding Siloxanediol Mes2Si(OH)(µ-O)Si(OH)Mes2 Towards Water and Ether Molecules. |
| PubMed:Neutral and cationic bismuth compounds supported by bis(amidodimethyl)disiloxane ligands. |
| PubMed:Cu3(BTC)2 catalyzed dehydrogenative coupling of dimethylphenylsilane with phenol and homocoupling of dimethylphenylsilane to disiloxane. |
| PubMed:Improving the Solubility of Artificial Ligands of Streptavidin to Enable More Practical Reversible Switching of Protein Localization in Cells. |
| PubMed:Catalytic Synthesis of Saturated Oxygen Heterocycles by Hydrofunctionalization of Unactivated Olefins: Unprotected and Protected Strategies. |
| PubMed:Co-Catalyzed Hydroarylation of Unactivated Olefins. |
| PubMed:Disiloxane Synthesis Based on Silicon-Hydrogen Bond Activation using Gold and Platinum on Carbon in Water or Heavy Water. |
| PubMed:In situ generated polysiloxanes stabilizing μ3-oxo bridged Sb3 triangles. |
| PubMed:Disiloxanes and Functionalized Silica Gels: One Route, Two Complementary Outcomes-Guanidinium and Pyridinium Ion-Exchangers. |
| PubMed:Dimer formation upon deprotonation: synthesis and structure of a m-terphenyl substituted (R,S)-dilithium disiloxanolate disilanol. |
| PubMed:Charge and Spin States in Schiff Base Metal Complexes with a Disiloxane Unit Exhibiting a Strong Noninnocent Ligand Character: Synthesis, Structure, Spectroelectrochemistry, and Theoretical Calculations. |
| PubMed:SILA-421 activity in vitro against rifampicin-susceptible and rifampicin-resistant Mycobacterium tuberculosis, and in vivo in a murine tuberculosis model. |
| PubMed:Silanetriols as Powerful Starting Materials for Selective Condensation to Bulky POSS Cages. |
| PubMed:Easily processable highly ordered Langmuir-Blodgett films of quaterthiophene disiloxane dimer for monolayer organic field-effect transistors. |
| PubMed:Catalytic hydroamination of unactivated olefins using a Co catalyst for complex molecule synthesis. |
| PubMed:Enhanced hydrolytic stability of siliceous surfaces modified with pendant dipodal silanes. |
| PubMed:A 3,4-trans-fused cyclic protecting group facilitates α-selective catalytic synthesis of 2-deoxyglycosides. |
| PubMed:Computational study of structural properties of lithium cation complexes with carbamate-modified disiloxanes. |
| PubMed:Study of carbamate-modified disiloxane in porous PVDF-HFP membranes: new electrolytes/separators for lithium-ion batteries. |
| PubMed:Chain length selectivity during the polycondensation of siloxane-containing esters and alcohols by immobilized Candida antarctica lipase B. |
| PubMed:Electron transport characteristics in nanosegregated columnar phases of perylene tetracarboxylic bisimide derivatives bearing oligosiloxane chains. |
| PubMed:Convergent synthesis of 4-O-phosphorylated L-glycero-D-manno-heptosyl lipopolysaccharide core oligosaccharides based on regioselective cleavage of a 6,7-O-tetraisopropyldisiloxane-1,3-diyl protecting group. |
| PubMed:Synthesis of lipase-catalysed silicone-polyesters and silicone-polyamides at elevated temperatures. |
| PubMed:Preparation of vinyl silyl ethers and disiloxanes via the silyl-Heck reaction of silyl ditriflates. |
| PubMed:2-Acetyl-amino-1,3,4,6-tetra-O-(tri-methyl-silyl)-2-de-oxy-α-d-gluco-pyran-ose. |
| PubMed:Nucleophilic addition to silyl-protected five-membered ring oxocarbenium ions governed by stereoelectronic effects. |
| PubMed:Chemistry and structures of hexakis(halogenomethyl)-, hexakis(azidomethyl)-, and hexakis(nitratomethyl)disiloxanes. |
| PubMed:Effects of two disiloxanes ALIS-409 and ALIS-421 on chemoprevention in model experiments. |
| PubMed:Hyperconjugative interactions in permethylated siloxanes and ethers: the nature of the SiO bond. |
| PubMed:Activity of the efflux pump inhibitor SILA 421 against drug-resistant tuberculosis. |
| PubMed:Disiloxanes with cyclic or non-cyclic carbamate moieties as electrolytes for lithium-ion batteries. |
| PubMed:Disila-analogues of the synthetic retinoids EC23 and TTNN: synthesis, structure and biological evaluation. |
| PubMed:Tetraisopropyldisiloxane-1,3-diyl as a versatile protecting group for pentopyranosides. |
| PubMed:Chemical properties of 1,3-bis(3-methacryloxypropyl)-1,1,3,3-tetramethyldisiloxane-methyl methacrylate copolymer. |
| PubMed:Assembly, growth, and catalytic activity of gold nanoparticles in hollow carbon nanofibers. |
| PubMed:Tetra-carbon-yl[bis-(diphenyl-phosphan-yl)tetra-methyl-disiloxane-κP,P']chromium(0). |
| PubMed:Anticancer effects of the organosilicon multidrug resistance modulator SILA 421. |
| PubMed:Highly mass-sensitive thin film plate acoustic resonators (FPAR). |
| PubMed:Self-assembly of linear and cyclic siloxane-containing mesogens: investigation of layered structures in bulk and thin films. |
| PubMed:Dissociation of the disilatricyclic diallylic dianion [(C4Ph4SiMe)2]-2 to the silole anion [MeSiC4Ph4]- by halide ion coordination or halide ion nucleophilic substitution at the silicon atom. |
| PubMed:A disiloxane-functionalized phosphonium-based ionic liquid as electrolyte for lithium-ion batteries. |
| PubMed:Synthesis of octyl S-glycosides of tri- to pentasaccharide fragments related to the GPI anchor of Trypanosoma brucei. |
| PubMed:Role of positive ions in determining the deposition rate and film chemistry of continuous wave hexamethyl disiloxane plasmas. |
| PubMed:Brønsted acid-promoted azide-olefin [3 + 2] cycloadditions for the preparation of contiguous aminopolyols: The importance of disiloxane ring size to a diastereoselective, bidirectional approach to zwittermicin A. |
| PubMed:Novel hard-block polyurethanes with high strength and transparency for biomedical applications. |
| PubMed:Vinyldisiloxanes: their synthesis, cross coupling and applications. |
| PubMed:An isolable bis-silylene oxide ("disilylenoxane") and its metal coordination. |
| PubMed:Unexpected formation of complexes between protonated organic ligand and neutral salt molecule studied by electrospray ionization mass spectrometry. |
| PubMed:The catalytic role of N-heterocyclic carbene in a metal-free conversion of carbon dioxide into methanol: a computational mechanism study. |
| PubMed:Si-C bond activation in the reaction of first generation Grubbs' catalyst with alkynylsilanes - formation of [Cl(2){P(C(6)H(11))(3)}(2)Ru(=CHCH=CHPh)] anddisiloxanes. |
| PubMed:Magnesium-mediated intramolecular reductive coupling: a stereoselective synthesis of C(2)-symmetric 3,4-bis-silyl-substituted adipic acid derivatives. |
| PubMed:Formation of two- and three-dimensional hybrid mesostructures from branched siloxane molecules. |
| PubMed:Tellurasiloxane cages containing Te(6)Si(4)O(12) and Te(6)Si(6)O(15) frameworks. |
| PubMed:SILA 421, an inhibitor of efflux pumps of cancer cells, enhances the killing of intracellular extensively drug-resistant tuberculosis (XDR-TB). |
| PubMed:Bis(η-penta-methyl-cyclo-penta-dien-yl)cobalt(II). |
| PubMed:Incorporation of Linear Spacer Molecules in Vapor Deposited Silicone Polymer Thin Films. |
| PubMed:Silanol-based pincer Pt(II) complexes: synthesis, structure, and unusual reactivity. |
| PubMed:Plasma treatments of PET meshes for fuel-water separation applications. |
| PubMed:Reduction of ribonucleosides to 2'-deoxyribonucleosides. |
| PubMed:Basic study of a new soft resin applied with bisfunctional siloxane oligomer. |
| PubMed:Elimination of plasmids by SILA compounds that inhibit efflux pumps of bacteria and cancer cells. |
| PubMed:Vascular activity of two silicon compounds, ALIS 409 and ALIS 421, novel multidrug-resistance reverting agents in cancer cells. |
| PubMed:From a stable silylene to a mixed-valent disiloxane and an isolable silaformamide-borane complex with considerable silicon-oxygen double-bond character. |
| PubMed:Shell-cross-linked cylindrical Polyisoprene-b-polyferrocenylsilane (PI-b-PFS) block copolymer micelles: one-dimensional (1D) organometallic nanocylinders. |
| PubMed:Computational Requirements for Simulating the Structures and Proton Activity of Silicaceous Materials. |
| PubMed:1-Hydr-oxy-1,1,3,3,3-penta-phenyl-disiloxane, [Si(2)O(OH)(Ph)(5)], at 150 K. |
| PubMed:1-Hydr-oxy-1,1,3,3,3-penta-phenyl-disiloxane, [Si(2)O(OH)(Ph)(5)], at 100 K. |
| PubMed:An ab initio and DFT study of structure and vibrational spectra of disiloxane H3SiOSiH3 conformers. Comparison to experimental data. |
| PubMed:Si-O bonded interactions in silicate crystals and molecules: a comparison. |
| PubMed:Naphthalene-1,8-diylbis(diphenylmethylium) as an organic two-electron oxidant: benzidine synthesis via oxidative self-coupling of N,N-dialkylanilines. |
| PubMed:Hydrolysis of fluorosilanes: a theoretical study. |
| PubMed:Synthesis of epothilones via a silicon-tethered RCM reaction. |
| PubMed:Fluoride-promoted cross-coupling reactions of alkenylsilanols. Elucidation of the mechanism through spectroscopic and kinetic analysis. |
| PubMed:Stereoselective dialkylation of the proximal hydroxy groups of calix- and thiacalix[4]arenes. |
| PubMed:Endgroup-assisted siloxane bond cleavage in the gas phase. |
| PubMed:Intramolecular syn and anti hydrosilylation and silicon-assisted cross-coupling: highly regio- and stereoselective synthesis of trisubstituted allylic alcohols. |
| PubMed:The influence of plasma proteins and platelets on oxygen radical production and F-actin distribution in neutrophils adhering to polymer surfaces. |
| PubMed:Palladium-catalyzed asymmetric diene cyclization/hydrosilylation employing functionalized silanes and disiloxanes. |
| PubMed:Tautomeric equilibrium between penta- and hexacoordinate silicon chelates. A chloride bridge between two pentacoordinate silicons. |
| PubMed:Syntheses and reactions of the fluorinated cyclic thionylphosphazene NSO(Ar)[NPF(2)]2(Ar = 4-t-BuC(6)H(4)-) with difunctional reagents. |
| PubMed:Permeation of substituted silanes and siloxanes through selected gloves and protective clothing. |
| PubMed:Synthesis of alpha-galactosylated fragments related to the core-structure of the GPI anchor of Trypanosoma brucei. |
| PubMed:Disiloxane-protected 2-deoxyribonolactone as an efficient precursor to 1,2-dideoxy-1-beta-aryl-D-ribofuranoses. |
| PubMed:NaY zeolite as host for the selective heterogeneous oxidation of silanes and olefins with hydrogen peroxide catalyzed by methyltrioxorhenium |
| PubMed:Surface modification using a commercial triple quadrupole mass spectrometer. |
| PubMed:Study of Bond Angles and Bond Lengths in Disiloxane and Related Molecules in Terms of the Topology of the Electron Density and Its Laplacian. |
| PubMed:Estimation of monomer content in polymethyl methacrylate contact lens materials by Raman spectroscopy. |
| PubMed:Synthesis of octyl O- and S-glycosides related to the GPI anchor of Trypanosoma brucei and their in vitro galactosylation by trypanosomal alpha-galactosyltransferases. |
| PubMed:The chemiluminescence response of neutrophils on polymer surfaces made by glow discharge plasma polymerization. |
| PubMed:RF-plasma-modified polystyrene surfaces for studying complement activation. |
| PubMed:Studies on contact lens materials. |
| PubMed:A theoretical study of the Si-O bond in disiloxane and related molecules. |
| PubMed:The siloxane bond in contact lens materials: the siloxanyl alkyl methacrylate copolymers. |
| PubMed:Gas-to-liquid permeation in silicon-containing, crosslinked, glassy copolymers of methyl methacrylate. |
| PubMed:Shear-induced hemolysis with commercial and glow discharge silicones. |
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3D/inchi