EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

guanidinoacetic acid
glycine, N-(aminoiminomethyl)-

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Name:2-(diaminomethylideneamino)acetic acid
CAS Number: 352-97-6Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:206-529-5
FDA UNII: GO52O1A04E
Nikkaji Web:J4.504G
Beilstein Number:1759179
MDL:MFCD00004278
XlogP3-AA:-1.60 (est)
Molecular Weight:117.10819000
Formula:C3 H7 N3 O2
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:food additive
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
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Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Soluble in:
 water, 3600 mg/L @ 15 °C (exp)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
Alfa Biotechnology
For experimental / research use only.
Guanidineacetic acid 98%
BOC Sciences
For experimental / research use only.
Guanidineacetic acid 99%
Santa Cruz Biotechnology
For experimental / research use only.
Guanidinoacetic Acid 99%
Sigma-Aldrich: Aldrich
For experimental / research use only.
Guanidinoacetic Acid 99%
sds
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
food additive
Recommendation for guanidinoacetic acid usage levels up to:
 not for fragrance use.
 
Recommendation for guanidinoacetic acid flavor usage levels up to:
 not for flavor use.
 
Safety References:
European Food Safety Authority (EFSA) reference(s):

Safety and efficacy of guanidinoacetic acid for chickens for fattening, breeder hens and roosters, and pigs
View page or View pdf

EPI System: View
ClinicalTrials.gov:search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :763
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
2-(diaminomethylideneamino)acetic acid
Chemidplus:0000352976
 
References:
 2-(diaminomethylideneamino)acetic acid
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:352-97-6
Pubchem (cid):763
Pubchem (sid):134975464
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
Metabolomics Database:Search
KEGG (GenomeNet):C00581
HMDB (The Human Metabolome Database):HMDB00128
FooDB:FDB021898
Export Tariff Code:2925.20.5000
FDA Listing of Food Additive Status:View
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
N-amidino-glycine
2-[[amino(imino)methyl]amino]acetic acid
 carbamimidamidoacetic acid
2-(diaminomethylideneamino)acetic acid
 glycine, N-(aminoiminomethyl)-
 glycocyamine
 guanidine acetic acid
 

Articles:

PubMed:Advanced physiological roles of guanidinoacetic acid.
PubMed:Suppression effects of betaine-enriched spinach on hyperhomocysteinemia induced by guanidinoacetic acid and choline deficiency in rats.
PubMed:Short-term creatine supplementation does not reduce increased homocysteine concentration induced by acute exercise in humans.
PubMed:Co-administration of methyl donors along with guanidinoacetic acid reduces the incidence of hyperhomocysteinaemia compared with guanidinoacetic acid administration alone.
PubMed:Advances in protein-amino acid nutrition of poultry.
PubMed:Creatine transporter deficiency: prevalence among patients with mental retardation and pitfalls in metabolite screening.
PubMed:Effects of starvation on guanidino compound metabolism in mice.
PubMed:The occurrence of guanidinoacetic acid and other substituted guanidines in mammalian liver.
PubMed:Transmethylation of guanidoacetic acid in beef liver autolyzates.
 
Notes:
Guanidoacetic acid is a metabolite in the Urea cycle and metabolism of amino groups, and in the metabolic pathways of several amino acids. This includes glycine, serine, threonine, arginine and proline metabolism. Guanidinoacetic acid is also a precursor of creatine, an essential substrate for muscle energy metabolism. [HMDB]
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