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Category:cosmetic agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00
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| Food Chemicals Codex Listed: | No |
| Melting Point: | 330.00 °C. @ 760.00 mm Hg
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| Boiling Point: | 599.41 °C. @ 760.00 mm Hg (est)
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| Flash Point: | 451.00 °F. TCC ( 233.00 °C. ) (est)
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| logP (o/w): | 1.970 (est) |
| Soluble in: |
| | water, 5489 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
intravenous-mouse LD50 180 mg/kg
U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#01998
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | | cosmetic agents |
| Recommendation for fisetin usage levels up to: | | | not for fragrance use.
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| Recommendation for fisetin flavor usage levels up to: |
| | not for flavor use.
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Safety References:
| EPI System: View |
| Chemical Carcinogenesis Research Information System:Search |
| AIDS Citations:Search |
| Cancer Citations:Search |
| Toxicology Citations:Search |
| EPA Substance Registry Services (TSCA):528-48-3 |
| EPA ACToR:Toxicology Data |
| EPA Substance Registry Services (SRS):Registry |
| Laboratory Chemical Safety Summary :5281614 |
| National Institute of Allergy and Infectious Diseases:Data |
| 2-(3,4-dihydroxyphenyl)-3,7-dihydroxychromen-4-one |
| Chemidplus:0000528483 |
| RTECS:LK9250000 for cas# 528-48-3 |
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| 4H-1- | benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-3,7-dihydroxy- | | | C.I. natural brown 1 | | | cotinin | | 5- | deoxyquercetin | | 5- | desoxy-quercetin | | 5- | desoxyquercetin | | 3,7- | dihydroxy-2-(3,4-dihydroxyphenyl)-4H-1-benzopyran-4-one | | 2-(3,4- | dihydroxyphenyl)-3,7-dihydroxy-4H-1-benzopyran-4-one | | 2-(3,4- | dihydroxyphenyl)-3,7-dihydroxychromen-4-one | | | fiestin | | | fisidenolon 1521 | | | flavone, 3,3',4',7-tetrahydroxy- | | | fustel | | | fustet | | | superfustel K | | 3,3',4',7- | tetrahydroxy-flavone | | 3,3',4',7- | tetrahydroxyflavone | | 3,7,3',4'- | tetrahydroxyflavone | | 7,3',4'- | trihydroxyflavonol |
Articles:
| PubMed:Fisetin improves glucose homeostasis through the inhibition of gluconeogenic enzymes in hepatic tissues of streptozotocin induced diabetic rats. |
| PubMed:Effects of antioxidants of bamboo leaves and flavonoids on 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) formation in chemical model systems. |
| PubMed:Differences in the hydroxylation pattern of flavonoids alter their chemoprotective effect against direct- and indirect-acting mutagens. |
| PubMed:The flavonoid fisetin promotes osteoblasts differentiation through Runx2 transcriptional activity. |
| PubMed:Immunosuppressive effects of fisetin against dinitrofluorobenzene-induced atopic dermatitis-like symptoms in NC/Nga mice. |
| PubMed:Fisetin antagonizes cell fusion, cytoskeletal organization and bone resorption in RANKL-differentiated murine macrophages. |
| PubMed:Simultaneous determination of bioactive phenolic compounds in the stem extract of Rhus verniciflua stokes by high performance liquid chromatography. |
| PubMed:Protective effect of detoxified Rhus verniciflua stokes on human keratinocytes and dermal fibroblasts against oxidative stress and identification of the bioactive phenolics. |
| PubMed:Dietary flavonoids fisetin, luteolin and their derived compounds inhibit arginase, a central enzyme in Leishmania (Leishmania) amazonensis infection. |
| PubMed:The polyphenol fisetin protects bone by repressing NF-κB and MKP-1-dependent signaling pathways in osteoclasts. |
| PubMed:Fisetin protects against hepatosteatosis in mice by inhibiting miR-378. |
| PubMed:Fisetin, a tetra hydroxy flavone recuperates antioxidant status and protects hepatocellular ultrastructure from hyperglycemia mediated oxidative stress in streptozotocin induced experimental diabetes in rats. |
| PubMed:Extract of Rhus verniciflua Bark Suppresses 2,4-Dinitrofluorobenzene-Induced Allergic Contact Dermatitis. |
| PubMed:Cognitive-enhancing effects of Rhus verniciflua bark extract and its active flavonoids with neuroprotective and anti-inflammatory activities. |
| PubMed:Effects of fisetin supplementation on hepatic lipogenesis and glucose metabolism in Sprague-Dawley rats fed on a high fat diet. |
| PubMed:Hypocholesterolemic effect of daily fisetin supplementation in high fat fed Sprague-Dawley rats. |
| PubMed:Fisetin regulates obesity by targeting mTORC1 signaling. |
| PubMed:A diet low in animal fat and rich in N-hexacosanol and fisetin is effective in reducing symptoms of Parkinson's disease. |
| PubMed:Dietary flavonoid fisetin: a novel dual inhibitor of PI3K/Akt and mTOR for prostate cancer management. |
| PubMed:Preparative isolation and purification of neuroprotective compounds from Rhus verniciflua by high speed counter-current chromatography. |
| PubMed:Neuroprotective and anti-inflammatory effects of flavonoids isolated from Rhus verniciflua in neuronal HT22 and microglial BV2 cell lines. |
| PubMed:Fisetin prevents fluoride- and dexamethasone-induced oxidative damage in osteoblast and hippocampal cells. |
| PubMed:Immunosuppressive effects of fisetin in ovalbumin-induced asthma through inhibition of NF-κB activity. |
| PubMed:Dietary chromones as antioxidant agents--the structural variable. |
| PubMed:Epigallocatechin-3-gallate does not affect the activity of enzymes involved in metabolic activation and cellular excretion of benzo[a]pyrene in human colon carcinoma cells. |
| PubMed:Fisetin, a novel flavonol attenuates benzo(a)pyrene-induced lung carcinogenesis in Swiss albino mice. |
| PubMed:Directly suspended droplet microextraction with in injection-port derivatization coupled to gas chromatography-mass spectrometry for the analysis of polyphenols in herbal infusions, fruits and functional foods. |
| PubMed:Fisetin inhibits lipopolysaccharide-induced macrophage activation and dendritic cell maturation. |
| PubMed:Regulation of survival, proliferation, invasion, angiogenesis, and metastasis of tumor cells through modulation of inflammatory pathways by nutraceuticals. |
| PubMed:Fisetin induces apoptosis in Huh-7 cells via downregulation of BIRC8 and Bcl2L2. |
| PubMed:Involvement of the ERK signaling pathway in fisetin reduces invasion and migration in the human lung cancer cell line A549. |
| PubMed:The hydroxyflavone, fisetin, suppresses mast cell activation induced by interaction with activated T cell membranes. |
| PubMed:Induction of p53 contributes to apoptosis of HCT-116 human colon cancer cells induced by the dietary compound fisetin. |
| PubMed:Metabolism and pharmacokinetics of 3,3',4',7-tetrahydroxyflavone (fisetin), 5-hydroxyflavone, and 7-hydroxyflavone and antihemolysis effects of fisetin and its serum metabolites. |
| PubMed:Cupric ion reducing antioxidant capacity assay for food antioxidants: vitamins, polyphenolics, and flavonoids in food extracts. |
| PubMed:Analysis of flavonoids in propolis and Ginkgo biloba by micellar electrokinetic capillary chromatography. |
| PubMed:[Effects of flavonoids with different structures on proliferation of leukemia cell line HL-60]. |
| PubMed:Dietary flavones and flavonoles are inhibitors of poly(ADP-ribose)polymerase-1 in pulmonary epithelial cells. |
| PubMed:Determination of flavonoid aglycones in several food samples by mixed micellar electrokinetic chromatography. |
| PubMed:Effects of various plant polyphenols on bladder carcinogen benzidine-induced mutagenicity. |
| PubMed:Distinctive antioxidant and antiinflammatory effects of flavonols. |
| PubMed:Inhibition of the intestinal glucose transporter GLUT2 by flavonoids. |
| PubMed:Flavonoids modulate monocarboxylate transporter-1-mediated transport of gamma-hydroxybutyrate in vitro and in vivo. |
| PubMed:Nutraceutical inhibitors of urokinase: potential applications in prostate cancer prevention and treatment. |
| PubMed:Fisetin inhibits the activities of cyclin-dependent kinases leading to cell cycle arrest in HT-29 human colon cancer cells. |
| PubMed:Effects of naturally occurring compounds on fibril formation and oxidative stress of beta-amyloid. |
| PubMed:Oral flavonoids delay recovery from experimental autoimmune encephalomyelitis in SJL mice. |
| PubMed:Genotoxicity of phytoestrogens. |
| PubMed:Novel total antioxidant capacity index for dietary polyphenols and vitamins C and E, using their cupric ion reducing capability in the presence of neocuproine: CUPRAC method. |
| PubMed:Extract from Rhus verniciflua Stokes is capable of inhibiting the growth of human lymphoma cells. |
| PubMed:Degradation of ethyl docosahexaenoate by gamma-ray irradiation and suppression of this degradation by antioxidants. |
| PubMed:Antimutagenic activity of flavonoids from the heartwood of Rhus verniciflua. |
| PubMed:Inhibitory effects of several flavonoids on E-selectin expression on human umbilical vein endothelial cells stimulated by tumor necrosis factor-alpha. |
| PubMed:Inhibitory effects of plant-derived flavonoids and phenolic acids on malonaldehyde formation from ethyl arachidonate. |
| PubMed:Kinetic and stoichiometric assessment of the antioxidant activity of flavonoids by electron spin resonance spectroscopy. |
| PubMed:Inhibition of thyroid type 1 deiodinase activity by flavonoids. |
| PubMed:High-performance liquid chromatographic analysis of polyhydroxyflavones using solid-phase borate-complex extraction. |
| PubMed:Food constituents attenuate monoamine oxidase activity and peroxide levels in C6 astrocyte cells. |
| PubMed:Japanese intake of flavonoids and isoflavonoids from foods. |
| PubMed:In vitro attenuation of nitric oxide production in C6 astrocyte cell culture by various dietary compounds. |
| PubMed:Column-switching high-performance liquid chromatographic assay for the determination of quercetin in human urine with ultraviolet absorbance detection. |
| PubMed:In vitro biotransformation of flavonoids by rat liver microsomes. |
| PubMed:The inhibition by flavonoids of 2-amino-3-methylimidazo[4,5-f]quinoline metabolic activation to a mutagen: a structure-activity relationship study. |
| PubMed:In vivo effect of dietary factors on the molecular action of aflatoxin B1: role of non-nutrient phenolic compounds on the catalytic activity of liver fractions. |
| PubMed:Lignans and flavonoids inhibit aromatase enzyme in human preadipocytes. |
| PubMed:Antimutagenic effect of plant flavonoids in the Salmonella assay system. |
| PubMed:Antimutagenic effects of flavonoids, chalcones and structurally related compounds on the activity of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) and other heterocyclic amine mutagens from cooked food. |
| PubMed:Protection by albumin against the pro-oxidant actions of phenolic dietary components. |
| PubMed:Modifying role of dietary factors on the mutagenicity of aflatoxin B1: in vitro effect of plant flavonoids. |
| PubMed:An overview of aflatoxicosis of poultry: its characteristics, prevention and reduction. |
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3D/inchi