EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

ethylene glycol
ethyleneglycol

Supplier Sponsors

Name:ethane-1,2-diol
CAS Number: 107-21-1Picture of molecule3D/inchi
Other(deleted CASRN):37221-95-7
ECHA EINECS - REACH Pre-Reg:203-473-3
FDA UNII: FC72KVT52F
Nikkaji Web:J4.061D
Beilstein Number:505945
MDL:MFCD00002885
XlogP3:-1.40 (est)
Molecular Weight:62.06822000
Formula:C2 H6 O2
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:humectants, solvents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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DG SANTE Food Contact Materials:ethyleneglycol
FDA Mainterm (IAUFC):107-21-1 ; ETHYLENE GLYCOL
 
Physical Properties:
Appearance:colorless to pale yellow clear oily liquid (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Specific Gravity:1.11300 @ 25.00 °C.
Melting Point: -12.00 to -11.00 °C. @ 760.00 mm Hg
Boiling Point: 197.00 to 198.00 °C. @ 760.00 mm Hg
Boiling Point: 121.00 to 122.00 °C. @ 50.00 mm Hg
Vapor Pressure:0.096000 mmHg @ 25.00 °C. (est)
Flash Point:> 230.00 °F. TCC ( > 110.00 °C. )
logP (o/w): -1.688 (est)
Soluble in:
 water, 1e+006 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: humectants
solvents
viscosity controlling agents
 
Suppliers:
AquaChemie
For experimental / research use only.
Mono EthyleneGlycol - MEG
BASF
Ethylene Glycol
BOC Sciences
For experimental / research use only.
Ethylene glycol 99%
Covalent Chemical
Ethylene Glycol
ECSA Chemicals
ETHYLENE GLYCOL 30%
ECSA TRADE THE MOST UPDATED FINANCIAL PUBLICATION ON THE WORLD OF CHEMISTRY
ECSA Chemicals
ETHYLENE GLYCOL RE-PURE, ML 1000
ECSA Chemicals
ETHYLENE GLYCOL
EMD Millipore
For experimental / research use only.
Ethylene Glycol
Glentham Life Sciences
Ethylene glycol
Graham Chemical
Ethylene Glycol
Krunal Group
Mono Ethylene Glycol (MEG)
Lluch Essence
ETHYLENE GLYCOL
LyondellBasell Industries
Ethylene glycols
Sigma-Aldrich
For experimental / research use only.
Ethylene glycol anhydrous, 99.8%
Silver Fern Chemical
Ethylene Glycol, Inhibited – FernTherm
Odor: characteristic
Use: Applications for FernTherm-EG Inhibited include closed loop heating and cooling systems, solar heating, thermal energy storage, sidewalk subsurface heating, refrigeration warehouse floor heating, ice rinks, freeze and burst protection in semi-sedentary systems, various deicing functions, cold room dehumidifying, and more.
Wedor Corporation
ETHYLENE GLYCOL
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-cat LD50 1650 mg/kg
KIDNEY, URETER, AND BLADDER: OTHER CHANGES
Recueil de Medecine Veterinaire. Vol. 154, Pg. 137, 1978.

oral-child TDLo 5500 mg/kg
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION BEHAVIORAL: GENERAL ANESTHETIC KIDNEY, URETER, AND BLADDER: OTHER CHANGES
Postgraduate Medical Journal. Vol. 52, Pg. 598, 1976.

oral-dog LD50 5500 mg/kg
KIDNEY, URETER, AND BLADDER: OTHER CHANGES
Recueil de Medecine Veterinaire. Vol. 154, Pg. 137, 1978.

oral-guinea pig LD50 6610 mg/kg
GASTROINTESTINAL: OTHER CHANGES KIDNEY, URETER, AND BLADDER: OTHER CHANGES BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Journal of Industrial Hygiene and Toxicology. Vol. 23, Pg. 259, 1941.

unreported-guinea pig LD50 11150 mg/kg
BEHAVIORAL: EXCITEMENT BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) GASTROINTESTINAL: NAUSEA OR VOMITING
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 33(3), Pg. 16, 1968.

oral-human LDLo 398 mg/kg
GASTROINTESTINAL: NAUSEA OR VOMITING BEHAVIORAL: HEADACHE LIVER: OTHER CHANGES
Sudebno-Meditsinskaya Ekspertiza. Forensic Medical Examination. Vol. 26(2), Pg. 48, 1983.

oral-human LDLo 786 mg/kg
GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" BEHAVIORAL: COMA BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
European Journal of Toxicology and Environmental Hygiene. Vol. 9, Pg. 373, 1976.

unreported-man LDLo 1637 mg/kg
"Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970Vol. 2, Pg. 73, 1970.

oral-man TDLo 1195 mg/kg
KIDNEY, URETER, AND BLADDER: RENAL FUNCTION TESTS DEPRESSED PERIPHERAL NERVE AND SENSATION: SENSORY CHANGE INVOLVING PERIPHERAL NERVE
Annals of Emergency Medicine. Vol. 20, Pg. 208, 1991.

oral-man TDLo 15000 mg/kg
KIDNEY, URETER, AND BLADDER: RENAL FUNCTION TESTS DEPRESSED PERIPHERAL NERVE AND SENSATION: SENSORY CHANGE INVOLVING PERIPHERAL NERVE GASTROINTESTINAL: ULCERATION OR BLEEDING FROM SMALL INTESTINE
Annals of Emergency Medicine. Vol. 20, Pg. 208, 1991.

oral-man TDLo 16000 mg/kg
KIDNEY, URETER, AND BLADDER: RENAL FUNCTION TESTS DEPRESSED BEHAVIORAL: COMA
Human & Experimental Toxicology. Vol. 9, Pg. 317, 1990.

oral-man TDLo 24000 mg/kg
BRAIN AND COVERINGS: RECORDINGS FROM SPECIFIC AREAS OF CNS SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Journal of Toxicology, Clinical Toxicology. Vol. 38, Pg. 445, 2000.

intraperitoneal-mouse LD50 5614 mg/kg
KIDNEY, URETER, AND BLADDER: CHANGES IN BOTH TUBULES AND GLOMERULI BLOOD: CHANGES IN SPLEEN LUNGS, THORAX, OR RESPIRATION: CHRONIC PULMONARY EDEMA
Federation Proceedings, Federation of American Societies for Experimental Biology. Vol. 6, Pg. 342, 1947.

intravenous-mouse LD50 3000 mg/kg
Journal of Pharmacology and Experimental Therapeutics. Vol. 65, Pg. 89, 1939.

oral-mouse LD50 5500 mg/kg
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 32(3), Pg. 31, 1967.

unreported-mouse LD50 8050 mg/kg
BEHAVIORAL: EXCITEMENT GASTROINTESTINAL: NAUSEA OR VOMITING BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 33(3), Pg. 16, 1968.

unreported-rabbit LD50 5017 mg/kg
BEHAVIORAL: EXCITEMENT GASTROINTESTINAL: NAUSEA OR VOMITING BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 33(3), Pg. 16, 1968.

intramuscular-rabbit LDLo 5500 mg/kg
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION BEHAVIORAL: COMA BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Journal of Pharmacology and Experimental Therapeutics. Vol. 41, Pg. 387, 1931.

intraperitoneal-rabbit LDLo 1000 mg/kg
Pesticide Chemicals Official Compendium, Association of the American Pesticide Control Officials, Inc., 1966. Vol. -, Pg. 502, 1966.

intravenous-rabbit LDLo 5000 mg/kg
BEHAVIORAL: TREMOR BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Journal of Pharmacology and Experimental Therapeutics. Vol. 41, Pg. 387, 1931.

intraperitoneal-rat LD50 5010 mg/kg
Kriobiologiya i Kriomeditsina. Cryobiology and Cryomedicine. Vol. 9, Pg. 36, 1981.

intravenous-rat LD50 3260 mg/kg
Kriobiologiya i Kriomeditsina. Cryobiology and Cryomedicine. Vol. 9, Pg. 36, 1981.

oral-rat LD50 4700 mg/kg
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 26(6), Pg. 28, 1982.

unreported-rat LD50 13000 mg/kg
BEHAVIORAL: EXCITEMENT GASTROINTESTINAL: NAUSEA OR VOMITING BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 33(3), Pg. 16, 1968.

intramuscular-rat LDLo 3300 mg/kg
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION BEHAVIORAL: COMA BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Journal of Pharmacology and Experimental Therapeutics. Vol. 41, Pg. 387, 1931.

Dermal Toxicity:
subcutaneous-cat LDLo 2000 mg/kg
BEHAVIORAL: MUSCLE WEAKNESS BLOOD: OTHER CHANGES BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Archiv fuer Gewerbepathologie und Gewerbehygiene. Vol. 5, Pg. 1, 1933.

subcutaneous-guinea pig LDLo 5000 mg/kg
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 51, Pg. 398, 1935.

subcutaneous-mouse LDLo 2700 mg/kg
British Journal of Industrial Medicine. Vol. 1, Pg. 207, 1944.

skin-rabbit LD50 9530 uL/kg
"Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 731, 1969.

subcutaneous-rat LD50 2800 mg/kg
Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. Vol. 1, Pg. 49, 1974.

Inhalation Toxicity:
inhalation-human TCLo 10000 mg/m3
LUNGS, THORAX, OR RESPIRATION: COUGH SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Archiv fuer Gewerbepathologie und Gewerbehygiene. Vol. 5, Pg. 1, 1933.

inhalation-mouse LC > 200 mg/m3/2H
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 25(11), Pg. 57, 1981.

inhalation-rat LC > 200 mg/m3/4H
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 25(11), Pg. 57, 1981.

 
Safety in Use Information:
Category:
humectants, solvents
Recommendation for ethylene glycol usage levels up to:
 not for fragrance use.
 
Recommendation for ethylene glycol flavor usage levels up to:
 not for flavor use.
 
Safety References:
European Food Safety Authority (EFSA) reference(s):

Safety of the proposed amendment of the specifications for the food additive polyvinyl alcohol-polyethylene glycol-graft-co-polymer (E 1209)
View page or View pdf

EPI System: View
EPA-Iris:IRIS
ClinicalTrials.gov:search
Daily Med:search
NIOSH International Chemical Safety Cards:search
NIOSH Pocket Guide:search
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA GENetic TOXicology:Search
EPA Substance Registry Services (TSCA):107-21-1
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :174
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:1
ethane-1,2-diol
Chemidplus:0000107211
EPA/NOAA CAMEO:hazardous materials
RTECS:107-21-1
 
References:
 ethane-1,2-diol
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:107-21-1
Pubchem (cid):174
Pubchem (sid):134972261
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Indirect Additives used in Food Contact Substances:View
CHEBI:View
CHEMBL:View
Golm Metabolome Database:Search
UM BBD:Search
KEGG (GenomeNet):C01380
HMDB (The Human Metabolome Database):Search
YMDB (Yeast Metabolome Database):YMDB01564
Export Tariff Code:2905.31.0000
MedlinePlusSupp:View
ChemSpider:View
Wikipedia:View
Formulations/Preparations:
•emulsifiable glycol ointment base (base g): polyethylene glycol 400 monostearate- 26 g, polyethylene glycol 400- 37 g, polyethylene glycol 4000- 37 g. •carbowax polyethylene glycol bases- base a: polyethylene glycol 1000- 96%, polyethylene glycol 4000- 4%; base b: polyethylene glycol 1000- 75%, polyethylene glycol 4000- 25%; base c: polyethylene glycol 1540- 70%, polyethylene glycol 6000- 50%. suppository preparation, from table •carbowax polyethylene glycol bases- base d: polyethylene glycol 6000- 50%, polyethylene glycol 1540- 30%, water and medication- 20%. suppository preparation, from table •ointment, with cetyl alcohol: polyethylene glycol 4000- 47.5 g, polyethylene glycol 400- 47.5 g, cetyl alcohol, to make 100 g; polyethylene glycol ointment, with sorbitan monopalmitate: polyethylene glycol 4000- 50 g, polyethylene glycol 400- 40 g, sorbitan monopalmitate- 1 g, purified water to make 100 g. •polyethylene glycol 300 nf; polyethylene glycol 400 usp; polyethylene glycol 1500; polyethylene glycol 1540 nf; polyethylene glycol 4000 usp; polyethylene glycol ointment usp: polyethylene glycol 4000- 40 g, polyethylene glycol, to make 100 g. •official ointment base is mixture of polyethylene glycol 4000 and 400. this base is water-soluble and non-staining. when a firmer preparation is desired not more than 10% of polyethylene glycol 400 may be replaced by an equal amount of polyethylene glycol 4000. •available in a broad range of molecular weight grades, i.e., as low as 100,000 to over 5x10+6
 
Potential Blenders and core components note
None Found
 
Potential Uses:
 solvents
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
1,2-dihydroxyethane
1,2-ethandiol
 ethane-1,2-diol
1,2-ethanediol
 ethylene alcohol
monoethylene glycol
 ethyleneglycol
 
 
Notes:
a colorless, odorless, viscous dihydroxy alcohol. it has a sweet taste, but is poisonous if ingested. ethylene glycol is the most important glycol commercially available and is manufactured on a large scale in the united states. it is used as an antifreeze and coolant, in hydraulic fluids, and in the manufacture of low-freezing dynamites and resins.
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