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diethyl hexyl phthalate
bis(2-ethylhexyl)phthalate

Supplier Sponsors

CAS Number: 117-81-7Picture of molecule3D/inchi
Other(deleted CASRN):109630-52-6
ECHA EINECS - REACH Pre-Reg:204-211-0
FDA UNII: C42K0PH13C
Nikkaji Web:J2.909B
Beilstein Number:1890696
MDL:MFCD00009493
XlogP3:7.40 (est)
Molecular Weight:390.56366000
Formula:C24 H38 O4
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:indirect food additives: adhesives and components of coatings
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 FDA/DG SANTE Petitions, Reviews, Notices:
FR DOC # 2012-5069 Draft Guidance for Industry on Limiting the Use of Certain Phthalates as Excipients in Center for Drug Evaluation and Research-Regulated Products; Availability View - petition PDF
FR DOC # 2012-10465 Small Entity Compliance Guide: Bottled Water: Quality Standard: Establishing an Allowable Level for di(2-ethylhexyl)phthalate; Availability View - petition PDF
DG SANTE Food Contact Materials:phthalic acid bis(2-ethylhexyl) ester
FDA Mainterm (IAUFC):117-81-7 ; DI(2-ETHYLHEXYL) PHTHALATE
FDA Regulation:
FDA PART 175 -- INDIRECT FOOD ADDITIVES: ADHESIVES AND COMPONENTS OF COATINGS
Subpart B--Substances for Use Only as Components of Adhesives
Sec. 175.105 Adhesives.
 
Physical Properties:
Appearance:colorless clear oily liquid (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Specific Gravity:0.98400 to 0.98700 @ 20.00 °C.
Pounds per Gallon - (est).: 8.197 to 8.222
Refractive Index:1.48500 to 1.48800 @ 20.00 °C.
Melting Point: -55.00 °C. @ 760.00 mm Hg
Boiling Point: 384.00 °C. @ 760.00 mm Hg
Flash Point: 405.00 °F. TCC ( 207.22 °C. )
logP (o/w): 7.600
Soluble in:
 water, 0.27 mg/L @ 25 °C (exp)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
Alfa Biotechnology
For experimental / research use only.
Bis(2-ethylhexyl) Phthalate 98%
BOC Sciences
For experimental / research use only.
Dioctyl phthalate 98.0%
Coompo
For experimental / research use only.
Bis(2-Ethylhexyl) Phthalate from Plants ≥96%
Penta International
DIOCTYL PHTHALATE
Santa Cruz Biotechnology
For experimental / research use only.
Bis(2-ethylhexyl) phthalate
Shiva Chemicals and Pharmaceuticals
Dioctyl Phthalate
Sigma-Aldrich: Aldrich
For experimental / research use only.
Dioctyl phthalate ≥99.5%
Silver Fern Chemical
Dioctyl Phthalate (DOP)
Odor: characteristic
Use: DOP has common applications in plastics, such as medical supplies, PVA and rubber manufacturing, wood coatings, and is sometimes used as a waxing agent.
TCI AMERICA
For experimental / research use only.
Bis(2-Ethylhexyl) Phthalate >98.0%(GC)
Universal Preserv-A-Chem Inc.
DIOCTYL PHTHALATE
Odor: characteristic
Use: DEHP is the most common of the class of phthalates which are used as plasticizers. Due to its suitable properties and the low cost, DEHP is widely used as a plasticizer in manufacturing of articles made of PVC. DEHP also finds use as a solvent in glowsticks.
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-guinea pig LD50 26000 mg/kg
IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. Vol. 29, Pg. 269, 1982.

unreported-guinea pig LD50 40500 mg/kg
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 32(7), Pg. 52, 1988.

oral-man TDLo 143 mg/kg
GASTROINTESTINAL: OTHER CHANGES
Journal of Industrial Hygiene and Toxicology. Vol. 27, Pg. 130, 1945.

intraperitoneal-mouse LD50 14000 mg/kg
BEHAVIORAL: EXCITEMENT VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION
Journal of Pharmaceutical Sciences. Vol. 55, Pg. 158, 1966.

intravenous-mouse LD50 1060 mg/kg
National Technical Information Service. Vol. PB250-102

oral-mouse LD50 1500 mg/kg
GASTROINTESTINAL: NECROTIC GHANGES LUNGS, THORAX, OR RESPIRATION: STRUCTURAL OR FUNCTIONAL CHANGE IN TRACHEA OR BRONCHI BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. Vol. 2, Pg. 59, 1961.

unreported-mouse LD50 7000 mg/kg
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 32(7), Pg. 52, 1988.

intraperitoneal-rabbit LD > 31 mL/kg
AMA Archives of Industrial Health. Vol. 13, Pg. 259, 1956.

oral-rabbit LD50 34000 mg/kg
EHP, Environmental Health Perspectives. Vol. 4, Pg. 3, 1973.

intraperitoneal-rat LD50 30700 mg/kg
Journal of Industrial Hygiene and Toxicology. Vol. 27, Pg. 130, 1945.

intravenous-rat LD50 250 mg/kg
LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Toxicology and Applied Pharmacology. Vol. 45, Pg. 230, 1978.

oral-rat LD50 30000 mg/kg
Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. Vol. 2, Pg. 32, 1975.

unreported-rat LD50 47000 mg/kg
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 32(7), Pg. 52, 1988.

intratracheal-rat LDLo 30 mg/kg
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: STRUCTURAL OR FUNCTIONAL CHANGE IN TRACHEA OR BRONCHI BLOOD: HEMORRHAGE
Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. Vol. 2, Pg. 59, 1961.

Dermal Toxicity:
skin-guinea pig LD50 10000 mg/kg
EHP, Environmental Health Perspectives. Vol. 4, Pg. 3, 1973.

skin-mouse LDLo 4000 mg/kg
SKIN AND APPENDAGES (SKIN): OTHER GLANDS: OTHER
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 45(6), Pg. 35, 1980.

skin-rabbit LD50 25000 mg/kg
Journal of Industrial Hygiene and Toxicology. Vol. 27, Pg. 130, 1945.

skin-rat LDLo 4000 mg/kg
SKIN AND APPENDAGES (SKIN): OTHER GLANDS: OTHER
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 45(6), Pg. 35, 1980.

Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
indirect food additives: adhesives and components of coatings
Recommendation for diethyl hexyl phthalate usage levels up to:
 not for fragrance use.
 
Recommendation for diethyl hexyl phthalate flavor usage levels up to:
 not for flavor use.
 
Safety References:
European Food Safety Authority (EFSA) reference(s):

Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) related to Bis(2-ethylhexyl)phthalate (DEHP) for use in food contact materials
View page or View pdf

Technical report of the public consultation on the ‘Draft update of the risk assessment of di-butylphthalate (DBP), butyl-benzyl-phthalate (BBP), bis(2-ethylhexyl)phthalate (DEHP), di-isononylphthalate (DINP) and di-isodecylphthalate (DIDP) for use in food contact materials’
View page or View pdf

Update of the risk assessment of di-butylphthalate (DBP), butyl-benzyl-phthalate (BBP), bis(2-ethylhexyl)phthalate (DEHP), di-isononylphthalate (DINP) and di-isodecylphthalate (DIDP) for use in food contact materials
View page or View pdf

EPI System: View
EPA-Iris:IRIS
NIOSH International Chemical Safety Cards:search
NIOSH Pocket Guide:search
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
Carcinogenic Potency Database:Search
EPA GENetic TOXicology:Search
EPA Substance Registry Services (TSCA):117-81-7
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :8343
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:1
bis(2-ethylhexyl) benzene-1,2-dicarboxylate
Chemidplus:0000117817
EPA/NOAA CAMEO:hazardous materials
RTECS:117-81-7
 
References:
 bis(2-ethylhexyl) benzene-1,2-dicarboxylate
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:117-81-7
Pubchem (cid):8343
Pubchem (sid):134973533
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Indirect Additives used in Food Contact Substances:View
CHEBI:View
CHEMBL:View
KEGG (GenomeNet):C03690
HMDB (The Human Metabolome Database):Search
FooDB:FDB004316
Export Tariff Code:2917.32.0000
ChemSpider:View
Wikipedia:View
Formulations/Preparations:
•trade names: flexol plasticizer dop, essochem dop palatinol ah-l (med., 99.5%), genomoll 100 (99.7%), vestinol ah (99.5%) •usepaopp pesticide code 295200; trade names: bisoflex dop, celluflex dop, compound 889, eviplast 80, fleximel, flexol dop, hercoflex 260, kodaflex dop, nci-c52733, octoil, palatinol ah, pittsburgh px-138, polycizer 162, px-138, rc plasticizer dop, sicol 150, staflex dop, truflex dop, union carbide flexol 380, vestinol ah, vinicizer 80, witcizer 312. •jayflex dehp •di(2-ethylhexyl) phthalate is available in a variety of technical grades (including a special grade for capacitor applications and a low residuals grade). typical specifications are: minimal ester content, 99.0-99.6%; maximal moisture content, 0.1%; and acidity (as acetic acid or phthalic acid), 0.007-0.01% . •trade names for di(2-ethylhexyl) phthalate include: bisoflex; compound 889; diacizer dop; dop; eastman dop plasticizer; ergoplast; etalon; eviplast; fleximel; flexol dop; good-rite gp 264; hatco-dop; kodaflex dop; monocizer dop; octoil; palatinol ah; pittsburgh px 138; plasthall dop; platinol ah; reomol d 79p; sicol 150; staflex dop; truflex dop; vestinol ah; vinycizer; witcizer 312
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
1,2-benzene dicarboxylic acid bis(2-ethyl hexyl) ester
1,2-benzenedicarboxylic acid bis(2-ethylhexyl) ester
1,2-benzenedicarboxylic acid, 1,2-bis(2-ethylhexyl) ester
1,2-benzenedicarboxylic acid, bis(2-ethylhexyl) ester
 bisoflex 81
 caswell no. 392k
 DEHP
 di-(2-ethyl-hexyl) phthalate
 di-(2-ethylhexyl) phthalate
 di-2-ethylhexyl phthalate
 di-sec-octyl phthalate
 di(2-ethyl hexyl) phthalate
 di(2-ethyl-hexyl) phthalate
 di(2-ethylhexyl phthalate)
 di(2-ethylhexyl) phthalate
 di(2-ethylhexyl)phthalate
 diethylhexyl phthalate
 diethylhexylphthalate
 dioctyl phthalate (so called)
sec-dioctyl phthalate
 dioctylpftalat
 ergoplast fdo
 ethyl hexyl phthalate
bis(2-ethyl hexyl) 1,2-benzene dicarboxylate
bis(2-ethyl hexyl) phthalate
2-ethylhexyl 2-[(2-ethylhexyl)oxycarbonyl]benzoate
bis(2-ethylhexyl) benzene-1,2-dicarboxylate
bis(2-ethylhexyl) phthalate
bis-(2-ethylhexyl)phthalate
bis(2-ethylhexyl)phthalate
2-ethylhexylphthalate
 fleximel
 hercoflex 260
sec-octyl phthalate
 phthalic acid bis(2-ethyl hexyl) ester
 phthalic acid bis(2-ethylhexyl ester)
 phthalic acid bis(2-ethylhexyl) ester
 phthalic acid bis(2-ethylhexyl)ester
 
 
Notes:
an ester of phthalic acid. it appears as a light-colored, odorless liquid and is used as a plasticizer for many resins and elastomers.
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