EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

dimethyl fumarate
2-butenedioic acid (E)-, dimethyl ester

Supplier Sponsors

CAS Number: 624-49-7Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:210-849-0
FDA UNII: FO2303MNI2
Nikkaji Web:J45.019G
Beilstein Number:0774590
MDL:MFCD00064438
XlogP3:0.70 (est)
Molecular Weight:144.12656000
Formula:C6 H8 O4
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:information only not used for fragrances or flavors
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
FDA Mainterm (IAUFC):624-49-7 ; METHYL FUMARATE
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Soluble in:
 water, 1.877e+004 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
BOC Sciences
For experimental / research use only.
Dimethyl Fumarate >98%
Odor: characteristic
Use: Dimethyl fumarate is an anti-inflammatory, a promising novel oral therapeutic option shown to reduce disease activity and progression in patients with relapsing-remitting multiple sclerosis.
Glentham Life Sciences
Dimethyl fumarate
Qingdao Dacon Trading
Dimethyl Fumarate
Sigma-Aldrich
For experimental / research use only.
Dimethyl Fumarate certified reference material, TraceCERT®
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
information only not used for fragrances or flavors
Recommendation for dimethyl fumarate usage levels up to:
 not for fragrance use.
 
Recommendation for dimethyl fumarate flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
ClinicalTrials.gov:search
Daily Med:search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):624-49-7
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :637568
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:1
dimethyl (E)-but-2-enedioate
Chemidplus:0000624497
RTECS:EM6125000 for cas# 624-49-7
 
References:
 dimethyl (E)-but-2-enedioate
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:624-49-7
Pubchem (cid):637568
Pubchem (cas):624-49-7
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Indirect Additives used in Food Contact Substances:View
CHEBI:View
CHEMBL:View
KEGG (GenomeNet):D03846
HMDB (The Human Metabolome Database):HMDB31257
FooDB:FDB003290
Export Tariff Code:2917.19.2700
ChemSpider:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
trans-butene dioic acid dimethyl ester
2-butenedioic acid (E)-, dimethyl ester
 dimethyl (E)-but-2-enedioate
 dimethyl trans-butene dioate
 dimethylfumarate
 fumaric acid dimethyl ester
 fumaric acid, dimethyl ester
 

Articles:

PubMed:Treatment with disease-modifying drugs for people with a first clinical attack suggestive of multiple sclerosis.
PubMed:Dimethyl Fumarate Selectively Reduces Memory T Cells and Shifts the Balance between Th1/Th17 and Th2 in Multiple Sclerosis Patients.
PubMed:Update on disease-modifying therapies for multiple sclerosis.
PubMed:(1) H qNMR Quantification of Annonaceous Acetogenins in Crude Extracts of Annona muricata L. Fruit Pulp.
PubMed:Liver injury associated with dimethyl fumarate in multiple sclerosis patients.
PubMed:Efficacy and tolerability of dimethyl fumarate in White-, African- and Hispanic- Americans with multiple sclerosis.
PubMed:Dimethyl fumarate attenuates intracerebroventricular streptozotocin-induced spatial memory impairment and hippocampal neurodegeneration in rats.
PubMed:Teriflunomide for multiple sclerosis.
PubMed:Attenuation of 7-ketocholesterol-induced overproduction of reactive oxygen species, apoptosis, and autophagy by dimethyl fumarate on 158N murine oligodendrocytes.
PubMed:Gastrointestinal Tolerability of Delayed-Release Dimethyl Fumarate in a Multicenter, Open-Label Study of Patients with Relapsing Forms of Multiple Sclerosis (MANAGE).
PubMed:Currently approved and emerging oral therapies in multiple sclerosis: An update for the ophthalmologist.
PubMed:Consensus Management of Gastrointestinal Events Associated with Delayed-Release Dimethyl Fumarate: A Delphi Study.
PubMed:Novel Agents for Relapsing Forms of Multiple Sclerosis.
PubMed:Immunomodulators and immunosuppressants for relapsing-remitting multiple sclerosis: a network meta-analysis.
PubMed:[Determination of dimethyl fumarate in bakery food by d-SPE-HPLC-PDA].
PubMed:Dimethyl fumarate for multiple sclerosis.
PubMed:Managing flushing and gastrointestinal events associated with delayed-release dimethyl fumarate: Experiences of an international panel.
PubMed:New FDA-Approved Disease-Modifying Therapies for Multiple Sclerosis.
PubMed:Oral disease-modifying therapies for relapsing-remitting multiple sclerosis.
PubMed:Dimethyl fumarate induces apoptosis of hematopoietic tumor cells via inhibition of NF-κB nuclear translocation and down-regulation of Bcl-xL and XIAP.
PubMed:Multiple sclerosis: a primary care perspective.
PubMed:Dimethyl fumarate protection against collagen II degradation.
PubMed:Design of oral agents for the management of multiple sclerosis: benefit and risk assessment for dimethyl fumarate.
PubMed:Pharmacology and clinical efficacy of dimethyl fumarate (BG-12) for treatment of relapsing-remitting multiple sclerosis.
PubMed:Pathophysiological processes in multiple sclerosis: focus on nuclear factor erythroid-2-related factor 2 and emerging pathways.
PubMed:An update on new and emerging therapies for relapsing-remitting multiple sclerosis.
PubMed:Multiple sclerosis: current and emerging disease-modifying therapies and treatment strategies.
PubMed:Risk assessment of dimethylfumarate residues in dwellings following contamination by treated furniture.
PubMed:Multiple sclerosis: Five new things.
PubMed:The top 10 drug trends right now.
PubMed:Drugs: An injection of hope.
PubMed:Globalisation and allergy.
PubMed:Risks vs benefits of glatiramer acetate: a changing perspective as new therapies emerge for multiple sclerosis.
PubMed:Combination of dacarbazine and dimethylfumarate efficiently reduces melanoma lymph node metastasis.
PubMed:[Effects of chemical agents on the prevention of fungal contamination during household wheat storage in Cixian county].
PubMed:Inhibition of Escherichia coli by dimethyl fumarate.
PubMed:Elevation of serum phase II enzymes by anticarcinogenic enzyme inducers: markers for a chemoprotected state?
PubMed:Induction of glutathione transferases and NAD(P)H:quinone reductase by fumaric acid derivatives in rodent cells and tissues.
 
Notes:
Fungal growth inhibitor for tomato juice Dimethyl fumarate is an ester and an ?,?-unsaturated electrophilic compound, undergoing reactions typical to them. It is also a diene acceptor in the ordinary Diels-Alder reaction, where the reactivity of its vinylidenic bond is enchanced by the two electron-withdrawing ester groups. Due to the geometry of the starting ester, the Diels-Alder product will have a trans configuration.; Dimethyl fumarate is used to treat psoriasis.. It is a lipophilic, highly mobile molecule in human tissue. However, as an ?,?-unsaturated ester, dimethyl fumarate reacts rapidly with the detoxifying agent glutathione by Michael addition. When administered orally, it does not survive long enough to be absorbed into blood.
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