dextro-glucurolactone, 32449-92-6

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CODE123389 CODE123389
Product(s):
32449-92-6 D-Glucurono-3,6-lactone

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about: Since 1982, Charkit has been committed to expanding the markets we serve as our roster of products and services continues to grow with us. Our substantial portfolio of personal care ingredients now include a wide array of luxury and exotic components to compliment the key products we have always offered. We have expanded our offerings to the nutraceutical, industrial, and resin markets with a growing roster of versatile and unique ingredients. We continue to lead the way in our traditional markets such as Metal and Water Treatment, Imaging, Flavor & Fragrance, Aroma and Food. Our Pharmaceutical offerings continue to expand, still anchored by the Boronic Derivatives that meet the demands of Suzuki coupling reactions. Please contact us to learn how we can help you reach your goals.
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CODE123389 CODE123389
Product(s):
GLUCURONOLACTONE, D-

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Product(s):
G0055 D-Glucurono-6,3-lactone >99.0%(T)
SDS

Name:	(2R)-2-[(2S,3R,4S)-3,4-dihydroxy-5-oxooxolan-2-yl]-2-hydroxyacetaldehyde
CAS Number:	32449-92-6	3D/inchi
ECHA EINECS - REACH Pre-Reg:	251-053-3
FDA UNII:	XE4Y3016M9
Nikkaji Web:	J3.805I
Beilstein Number:	0083595
MDL:	MFCD00135622
XlogP3-AA:	-1.80 (est)
Molecular Weight:	176.12496000
Formula:	C6 H8 O6
BioActivity Summary:	listing
NMR Predictor:	Predict (works with chrome, Edge or firefox)

Category:special dietary and nutritional additives

US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:

Google Scholar:	Search
Google Books:	Search
Google Scholar: with word "volatile"	Search
Google Scholar: with word "flavor"	Search
Google Scholar: with word "odor"	Search
Perfumer and Flavorist:	Search
Google Patents:	Search
US Patents:	Search
EU Patents:	Search
Pubchem Patents:	Search
PubMed:	Search
NCBI:	Search

Physical Properties:

Assay:	98.00 to 100.00
Food Chemicals Codex Listed:	No
Melting Point:	174.00 to 178.00 °C. @ 760.00 mm Hg
Boiling Point:	403.00 to 404.00 °C. @ 760.00 mm Hg
Flash Point:	346.00 °F. TCC ( 174.44 °C. )
logP (o/w):	-3.457 (est)
Soluble in:
	alcohol
	water, 257000 mg/L @ 21C (exp)

Organoleptic Properties:

Odor Type: mentholic

Odor Strength:low

mentholic

Odor Description:at 100.00 %. very mild mentholic

Odor and/or flavor descriptions from others (if found).

Cosmetic Information:

CosIng:	cosmetic data
Cosmetic Uses:	skin conditioning

Suppliers:

BOC Sciences

For experimental / research use only.

D-Glucurono-3,6-lactone

Carbosynth

For experimental / research use only.

For experimental / research use only.

D-(+)-Glucurolactone

sds

Foodchem International

D-Glucurolactone

Prinova

D-Glucurolactone 99% min. CP

Santa Cruz Biotechnology

For experimental / research use only.

D-Glucurono-3,6-lactone ≥98%

Sigma-Aldrich: Aldrich

For experimental / research use only.

D-(+)-Glucuronic acid gamma-lactone ≥99%

sds

TCI AMERICA

For experimental / research use only.

D-Glucurono-6,3-lactone >99.0%(T)

sds

Safety Information:

Preferred SDS: View
European information :
Most important hazard(s):
None - None found.
S 02 - Keep out of the reach of children. S 24/25 - Avoid contact with skin and eyes.

Hazards identification

Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements

Pictogram

Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50 10700 mg/kg Drugs in Japan Vol. 6, Pg. 225, 1982. intravenous-rat LD50 3200 mg/kg Drugs in Japan Vol. 6, Pg. 225, 1982. intravenous-rabbit LD50 940 mg/kg Drugs in Japan Vol. 6, Pg. 225, 1982. oral-mouse LD50 > 20000 mg/kg Drugs in Japan Vol. 6, Pg. 225, 1982. intravenous-mouse LD50 4568 mg/kg Drugs in Japan Vol. 6, Pg. 225, 1982. intraperitoneal-mouse LD50 5797 mg/kg Drugs in Japan Vol. 6, Pg. 225, 1982. intravenous-dog LD50 940 mg/kg Drugs in Japan Vol. 6, Pg. 225, 1982.
Dermal Toxicity:
subcutaneous-rat LD50 4700 mg/kg Drugs in Japan Vol. 6, Pg. 225, 1982. subcutaneous-rabbit LD50 4700 mg/kg Drugs in Japan Vol. 6, Pg. 225, 1982. subcutaneous-mouse LD50 8210 ul/kg Drugs in Japan Vol. 6, Pg. 225, 1982. subcutaneous-cat LD50 4700 mg/kg Drugs in Japan Vol. 6, Pg. 225, 1982. subcutaneous-dog LD50 4700 mg/kg Drugs in Japan Vol. 6, Pg. 225, 1982.
Inhalation Toxicity:
Not determined

Safety in Use Information:

Category:
special dietary and nutritional additives
Recommendation for dextro-glucurolactone usage levels up to:
	not for fragrance use.

Recommendation for dextro-glucurolactone flavor usage levels up to:
	not for flavor use.

Safety References:

European Food Safety Authority (EFSA) reference(s):

The use of taurine and D-glucurono-gamma-lactone as constituents of the so-called �energy� drinks
View page or View pdf

Gathering consumption data on specific consumer groups of energy drinks
View page or View pdf

Scientific Opinion on the safety of caffeine
View page or View pdf

EPI System: View

AIDS Citations:Search

Cancer Citations:Search

Toxicology Citations:Search

EPA Substance Registry Services (TSCA):32449-92-6

EPA ACToR:Toxicology Data

EPA Substance Registry Services (SRS):Registry

Laboratory Chemical Safety Summary :92283

National Institute of Allergy and Infectious Diseases:Data

WGK Germany:2

(2R)-2-[(2S,3R,4S)-3,4-dihydroxy-5-oxooxolan-2-yl]-2-hydroxyacetaldehyde

Chemidplus:0032449926

RTECS:LZ8930000 for cas# 32449-92-6

References:

	(2R)-2-[(2S,3R,4S)-3,4-dihydroxy-5-oxooxolan-2-yl]-2-hydroxyacetaldehyde
NIST Chemistry WebBook:	Search Inchi
Canada Domestic Sub. List:	32449-92-6
Pubchem (cid):	92283
Pubchem (sid):	135048564

Other Information:

(IUPAC):	Atomic Weights of the Elements 2011 (pdf)
Videos:	The Periodic Table of Videos
tgsc:	Atomic Weights use for this web site
(IUPAC):	Periodic Table of the Elements
CHEBI:	View
Golm Metabolome Database:	Search
KEGG (GenomeNet):	C02670
HMDB (The Human Metabolome Database):	HMDB06355
FooDB:	FDB023903
Export Tariff Code:	2932.29.5050
FDA Listing of Food Additive Status:	View
VCF-Online:	VCF Volatile Compounds in Food
ChemSpider:	View
Wikipedia:	View
EFSA Update of results on the monitoring of furan levels in food:	Read Report
EFSA Previous report: Results on the monitoring of furan levels in food:	Read Report
EFSA Report of the CONTAM Panel on provisional findings on furan in food:	Read Report

Potential Blenders and core components note

None Found

Potential Uses:

skin conditioning

Occurrence (nature, food, other):note

found in nature

Synonyms:

beta-D-	anhydroglucuronate
beta-dextro-	anhydroglucuronate
	dicurone
(2R)-2-[(2S,3R,4S)-3,4-	dihydroxy-5-oxooxolan-2-yl]-2-hydroxyacetaldehyde
(2R)-[(2S,3R,4S)-3,4-	dihydroxy-5-oxotetrahydrofuran-2-yl](hydroxy)acetaldehyde
	glucofuranurono-6,3-lactone
D-	glucurolactone
D-	glucuronic acid lactone
D-	glucurono-3,6-lactone
D-	glucurono-6,3-lactone
dextro-	glucurono-6,3-lactone
D-	glucurono-gamma-lactone
dextro-	glucurono-gamma-lactone
D-	glucuronolactone

Articles:

PubMed:[Observation on therapeutic effect of acupuncture combined with Chinese herbal decoction on compensated liver cirrhosis].

PubMed:[Immunosuppressive treatment about the patient operated facial allotransplantation in perioperative period].

PubMed:Metabolism of glucurolactone to glucarate in Parkinson's disease.

Notes:

D-glucurono-6,3-lactone participates in ascorbate and aldarate metabolism. D-glucurono-6,3-lactone is produced by the reaction between D-glucaric acid and the enzyme, aldehyde dehydrogenase (NAD+) [EC: 1.2.1.3]. [HMDB]

dextro-glucurolactone beta-D-anhydroglucuronate

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Articles:

dextro-glucurolactone
beta-D-anhydroglucuronate