EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

dextro-(+)-neopterin
neopterin D-erythro-form

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Name:2-amino-6-[(1S,2R)-1,2,3-trihydroxypropyl]-1H-pteridin-4-one
CAS Number: 2009-64-5Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:217-924-7
FDA UNII: 9PLD60N7SO
Nikkaji Web:J82.093H
Beilstein Number:089070
MDL:MFCD00042801
XlogP3-AA:-3.50 (est)
Molecular Weight:253.21847000
Formula:C9 H11 N5 O4
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:natural substances and extractives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
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Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Soluble in:
 water, 1e+006 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
BOC Sciences
For experimental / research use only.
D-(+)-NEOPTERIN
Odor: characteristic
Use: Precursor in the biosynthesis of Biopterin. First isolated from the pupae of bees.
Santa Cruz Biotechnology
For experimental / research use only.
dextro-(+)-neoPterin ≥98%
Sigma-Aldrich: Aldrich
For experimental / research use only.
dextro-(+)-neoPterin ≥97.5% (sum of enantiomers, HPLC)
sds
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
natural substances and extractives
Recommendation for dextro-(+)-neopterin usage levels up to:
 not for fragrance use.
 
Recommendation for dextro-(+)-neopterin flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :448839
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
2-amino-6-[(1S,2R)-1,2,3-trihydroxypropyl]-1H-pteridin-4-one
Chemidplus:0002009645
 
References:
 2-amino-6-[(1S,2R)-1,2,3-trihydroxypropyl]-1H-pteridin-4-one
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):448839
Pubchem (cas):2009-64-5
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
KEGG (GenomeNet):C05926
HMDB (The Human Metabolome Database):HMDB00845
FooDB:FDB005562
Export Tariff Code:2933.90.8000
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 soybean seed
Search Trop Picture
 
Synonyms:
(S-(R*,S*))-2-amino-6-(1,2,3-trihydroxypropyl)-1H-pteridin-4-one
2-amino-6-[(1S,2R)-1,2,3-trihydroxypropyl]-1H-pteridin-4-one
6-(D-erythro-1,2,3-Trihydroxypropyl)pterin
1,2,3-proanetriol
D-(+)-neopterin
neopterin D-erythro-form
 

Articles:

PubMed:Capillary electrophoresis of pterin derivatives responsible for the warning coloration of Heteroptera.
PubMed:Simultaneous detection of six urinary pteridines and creatinine by high-performance liquid chromatography-tandem mass spectrometry for clinical breast cancer detection.
PubMed:Assignment of pterin deaminase activity to an enzyme of unknown function guided by homology modeling and docking.
PubMed:Investigation of urinary pteridine levels as potential biomarkers for noninvasive diagnosis of cancer.
PubMed:Optimization of urinary pteridine analysis conditions by CE-LIF for clinical use in early cancer detection.
PubMed:An Fe2+-dependent cyclic phosphodiesterase catalyzes the hydrolysis of 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate in methanopterin biosynthesis.
PubMed:Characterization of an Fe(2+)-dependent archaeal-specific GTP cyclohydrolase, MptA, from Methanocaldococcus jannaschii.
PubMed:(6R)-5,6,7,8-tetrahydro-L-biopterin and its stereoisomer prevent ischemia reperfusion injury in human forearm.
PubMed:Mechanism of dihydroneopterin aldolase. NMR, equilibrium and transient kinetic studies of the Staphylococcus aureus and Escherichia coli enzymes.
PubMed:Suppression of ischemia-reperfusion injury in murine models by neopterins.
PubMed:Analysis of 6R- and 6S-tetrahydrobiopterin and other pterins by reversed-phase ion-pair liquid-chromatography with fluorimetric detection by post-column sodium nitrite oxidation.
PubMed:Analysis for fully oxidized neopterin in serum by high-performance liquid chromatography.
PubMed:Synthesis of enzymatically active D-7,8-dihydroneopterin-3'-triphosphate.
PubMed:Inhibition of GTP cyclohydrolase I by pterins.
PubMed:Lethal mutations induced in Drosophila melanogaster by direct or indirect action of pteridines.
PubMed:Neopterin retards loss of serotonin N-acetyltransferase activity from cultured chick pineal glands.
PubMed:[Pterin chemistry. 43. Synthesis of D-neopterin-3'-phosphate and D-neopterin-2',3'-cyclophosphate. Considerations on the biogenesis of biopterin].
 
Notes:
Neopterin is a catabolic product of guanosine triphosphate (GTP), a purine nucleotide. Neopterin belongs to the chemical group known as pteridines. It is synthesised by macrophages upon stimulation with the cytokine interferon-gamma and is indicative of a pro-inflammatory immune status. Neopterin serves as a marker of cellular immune system activation. [Wikipedia]
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