EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

cytosine
6-aminopyrimidin-2(1H)-one

Supplier Sponsors

Name:6-amino-1H-pyrimidin-2-one
CAS Number: 71-30-7Picture of molecule3D/inchi
Other(deleted CASRN):118511-36-7
ECHA EINECS - REACH Pre-Reg:200-749-5
FDA UNII: 8J337D1HZY
Nikkaji Web:J9.343B
Beilstein Number:002637
MDL:MFCD00006034
XlogP3:-1.70 (est)
Molecular Weight:111.10405000
Formula:C4 H5 N3 O
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:cosmetic agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 322.50 °C. @ 760.00 mm Hg
Flash Point: 32.00 °F. TCC ( 0.00 °C. ) (est)
logP (o/w): -1.962 (est)
Soluble in:
 water, 8000 mg/L @ 25 °C (exp)
 water, 1.586e+005 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: skin conditioning
 
Suppliers:
Alfa Biotechnology
For experimental / research use only.
Cytosine 98%
BOC Sciences
For experimental / research use only.
Cytosine >98%
Changzhou Longo Chemical
Cytosine
George Uhe Company
Cytosine
Glentham Life Sciences
Cytosine
Sigma-Aldrich: Sigma
For experimental / research use only.
Cytosine ≥99%
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-mouse LD50 > 2222 mg/kg
BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Journal of Pharmacology and Experimental Therapeutics. Vol. 207, Pg. 504, 1978.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
cosmetic agents
Recommendation for cytosine usage levels up to:
 not for fragrance use.
 
Recommendation for cytosine flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA GENetic TOXicology:Search
EPA Substance Registry Services (TSCA):71-30-7
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :597
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:1
6-amino-1H-pyrimidin-2-one
Chemidplus:0000071307
RTECS:UW7350150 for cas# 71-30-7
 
References:
 6-amino-1H-pyrimidin-2-one
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:71-30-7
Pubchem (cid):597
Pubchem (sid):134972137
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
Golm Metabolome Database:Search
Metabolomics Database:Search
KEGG (GenomeNet):C00380
HMDB (The Human Metabolome Database):HMDB00630
FooDB:FDB022151
YMDB (Yeast Metabolome Database):YMDB00651
Export Tariff Code:2933.59.9000
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 found in nature
 
Synonyms:
2-oxy-4-amino pyrimidine
4-amino-1H-pyrimidin-2-one
6-amino-1H-pyrimidin-2-one
4-amino-2-hydroxypyrimidine
4-amino-2-oxo-1,2-dihydropyrimidine
6-amino-2(1H)-pyrimidinone
6-amino-3-hydropyrimidin-2-one
4-aminopyrimidin-2-ol
4-aminopyrimidin-2(1H)-one
6-aminopyrimidin-2(1H)-one
 cytosin
 cytosinimine
2(1H)-pyrimidinone, 4-amino-
2(1H)-pyrimidinone, 4-amino- (9CI)
2(1H)-pyrimidinone, 6-amino-
 zytosin
 

Articles:

PubMed:Comparative Analysis of the Base Compositions of the Pre-mRNA 3' Cleaved-Off Region and the mRNA 3' Untranslated Region Relative to the Genomic Base Composition in Animals and Plants.
PubMed:Transposable Element Insertion and Epigenetic Modification Cause the Multiallelic Variation in the Expression of FAE1 in Sinapis alba.
PubMed:Hypothalamic neurogenesis is not required for the improved insulin sensitivity following exercise training.
PubMed:A novel single-labeled fluorescent oligonucleotide probe for silver(i) ion detection in water, drugs, and food.
PubMed:Multilocus sequence typing of Lactococcus lactis from naturally fermented milk foods in ethnic minority areas of China.
PubMed:Safety, tolerability, and biomarkers of the treatment of mice with aerosolized Toll-like receptor ligands.
PubMed:NSUN4 is a dual function mitochondrial protein required for both methylation of 12S rRNA and coordination of mitoribosomal assembly.
PubMed:Characterization of a novel resistance-related deoxycytidine deaminase from Brassica oleracea var. capitata.
PubMed:Decitabine induces delayed reactive oxygen species (ROS) accumulation in leukemia cells and induces the expression of ROS generating enzymes.
PubMed:Hypermethylation of Sp1 binding site suppresses hypothalamic POMC in neonates and may contribute to metabolic disorders in adults: impact of maternal dietary CLAs.
PubMed:Effects of short chain fatty acid producing bacteria on epigenetic regulation of FFAR3 in type 2 diabetes and obesity.
PubMed:Impact of folic acid fortification on global DNA methylation and one-carbon biomarkers in the Women's Health Initiative Observational Study cohort.
PubMed:SERPINE1, PAI-1 protein coding gene, methylation levels and epigenetic relationships with adiposity changes in obese subjects with metabolic syndrome features under dietary restriction.
PubMed:Detection of DNA damage based on metal-mediated molecular beacon and DNA strands displacement reaction.
PubMed:Contingency nature of Helicobacter bizzozeronii oxygen-insensitive NAD(P)H-nitroreductase (HBZC1_00960) and its role in metronidazole resistance.
PubMed:Allele characterization of genes required for rpg4-mediated wheat stem rust resistance identifies Rpg5 as the R gene.
PubMed:Recognition of O6-benzyl-2'-deoxyguanosine by a perimidinone-derived synthetic nucleoside: a DNA interstrand stacking interaction.
PubMed:The NuRD complex cooperates with DNMTs to maintain silencing of key colorectal tumor suppressor genes.
PubMed:The AplI restriction-modification system in an edible cyanobacterium, Arthrospira (Spirulina) platensis NIES-39, recognizes the nucleotide sequence 5'-CTGCAG-3'.
PubMed:Protamine nanoparticles with CpG-oligodeoxynucleotide prevent an allergen-induced Th2-response in BALB/c mice.
PubMed:DNA methyltransferases in hematologic malignancies.
PubMed:Detection of 3-amino-1,2,4-triazine adulteration in milk using an oxidation product 3-amino-1,2,4-triazin-5(2H)-one.
PubMed:Mercury biomarkers and DNA methylation among Michigan dental professionals.
PubMed:Folic acid acts through DNA methyltransferases to induce the differentiation of neural stem cells into neurons.
PubMed:Base damage within single-strand DNA underlies in vivo hypermutability induced by a ubiquitous environmental agent.
PubMed:Folic acid enforces DNA methylation-mediated transcriptional silencing of PTEN, APC and RARbeta2 tumour suppressor genes in breast cancer.
PubMed:The interaction of nemorubicin metabolite PNU-159682 with DNA fragments d(CGTACG)(2), d(CGATCG)(2) and d(CGCGCG)(2) shows a strong but reversible binding to G:C base pairs.
PubMed:Theoretical study on the binding mechanism between N6-methyladenine and natural DNA bases.
PubMed:Differential DNA methylation in discrete developmental stages of the parasitic nematode Trichinella spiralis.
PubMed:Pharmacokinetics of low-dose cidofovir in kidney transplant recipients with BK virus infection.
PubMed:Combined effect of longevity-associated mitochondrial DNA 5178 c/a polymorphism and green tea consumption on risk of hypertension in middle-aged Japanese men.
PubMed:Gene-diet-interactions in folate-mediated one-carbon metabolism modify colon cancer risk.
PubMed:Impact of cadmium exposure during pregnancy on hepatic glucocorticoid receptor methylation and expression in rat fetus.
PubMed:Supramolecular polymeric chemosensor for biomedical applications: design and synthesis of a luminescent zinc metallopolymer as a chemosensor for adenine detection.
PubMed:Effect of high contents of dietary animal-derived protein or carbohydrates on canine faecal microbiota.
PubMed:Dietary supplementation with methyl donors reduces fatty liver and modifies the fatty acid synthase DNA methylation profile in rats fed an obesogenic diet.
PubMed:Epigenetics and breast cancers.
PubMed:Specific multiplex analysis of pathogens using a direct 16S rRNA hybridization in microarray system.
PubMed:Pregnancy and the methyltransferase genotype independently influence the arsenic methylation phenotype.
PubMed:Reversal of cocaine-conditioned place preference through methyl supplementation in mice: altering global DNA methylation in the prefrontal cortex.
PubMed:Low-level environmental cadmium exposure is associated with DNA hypomethylation in Argentinean women.
PubMed:Genetic variation in MMP20 contributes to higher caries experience.
PubMed:A nebulized gelatin nanoparticle-based CpG formulation is effective in immunotherapy of allergic horses.
PubMed:Cytarabine induced cerebellar neuronal damage in juvenile rat: correlating neurobehavioral performance with cellular and genetic alterations.
PubMed:Progressive, transgenerational changes in offspring phenotype and epigenotype following nutritional transition.
PubMed:Bovine DNA methylation imprints are established in an oocyte size-specific manner, which are coordinated with the expression of the DNMT3 family proteins.
PubMed:S-Adenosylhomocysteine enhances DNA damage through increased β-amyloid formation and inhibition of the DNA-repair enzyme OGG1b in microglial BV-2 cells.
PubMed:Anti-proliferative effect of curcumin on melanoma cells is mediated by PDE1A inhibition that regulates the epigenetic integrator UHRF1.
PubMed:Epigenetic events associated with breast cancer and their prevention by dietary components targeting the epigenome.
PubMed:Specific interactions between nucleolipid doped liposomes and DNA allow a more efficient polynucleotide condensation.
PubMed:Comparison of the quantitative performances and measurement uncertainty estimates obtained during method validation versus routine applications of a novel hydrophilic interaction chromatography method for the determination of cidofovir in human plasma.
PubMed:Tissue-specific alterations of methyl group metabolism with DNA hypermethylation in the Zucker (type 2) diabetic fatty rat.
PubMed:Ultraviolet irradiation and the mechanisms underlying its inactivation of infectious agents.
PubMed:HPLC-UV, MALDI-TOF-MS and ESI-MS/MS analysis of the mechlorethamine DNA crosslink at a cytosine-cytosine mismatch pair.
PubMed:Identification of novel Clostridium perfringens type E strains that carry an iota toxin plasmid with a functional enterotoxin gene.
PubMed:Comparison of DNA methylation levels of repetitive loci during bovine development.
PubMed:Phenylaminopropyl-functionalized stationary phase for open-tubular capillary electrochromatography of alkaloids and aromatic acids.
PubMed:Dual targeting of tumor angiogenesis and chemotherapy by endostatin-cytosine deaminase-uracil phosphoribosyltransferase.
PubMed:Homocysteine levels impact directly on epigenetic reprogramming in astrocytes.
PubMed:Naked eye sensing of melamine using rationally tailored gold nanoparticles: hydrogen-bonding and charge-transfer recognition.
PubMed:The implications of DNA methylation for toxicology: toward toxicomethylomics, the toxicology of DNA methylation.
PubMed:Epigenetic alterations in liver of C57BL/6J mice after short-term inhalational exposure to 1,3-butadiene.
PubMed:Postexposure prevention of progressive vaccinia in SCID mice treated with vaccinia immune globulin.
PubMed:Global DNA methylation measurement by HPLC using low amounts of DNA.
PubMed:In vitro tRNA methylation assay with the Entamoeba histolytica DNA and tRNA methyltransferase Dnmt2 (Ehmeth) enzyme.
PubMed:Effects of specific DNMT gene depletion on cancer cell transformation and breast cancer cell invasion; toward selective DNMT inhibitors.
PubMed:Coupling global methylation and gene expression profiles reveal key pathophysiological events in liver injury induced by a methyl-deficient diet.
PubMed:Gestational low protein diet in the rat mediates Igf2 gene expression in male offspring via altered hepatic DNA methylation.
PubMed:Olanzapine increases cell mitotic activity and oligodendrocyte-lineage cells in the hypothalamus.
PubMed:Conservation of genomic localization and sequence content of Sau3AI-like restriction-modification gene cassettes among Listeria monocytogenes epidemic clone I and selected strains of serotype 1/2a.
PubMed:Diverse morphologies of self-assemblies from homoditopic 1,18-nucleotide-appended bolaamphiphiles: effects of nucleobases and complementary oligonucleotides.
PubMed:Dietary vitamin E deficiency does not affect global and specific DNA methylation patterns in rat liver.
PubMed:Impact on DNA methylation in cancer prevention and therapy by bioactive dietary components.
PubMed:Folate, DNA damage and the aging brain.
PubMed:Fast evolving 18S rRNA sequences from Solenogastres (Mollusca) resist standard PCR amplification and give new insights into mollusk substitution rate heterogeneity.
PubMed:Identification of prophage gene z2389 in Escherichia coli EDL933 encoding a DNA cytosine methyltransferase for full protection of NotI sites.
PubMed:Assessment of in vivo genotoxicity of the rodent carcinogen furan: evaluation of DNA damage and induction of micronuclei in mouse splenocytes.
PubMed:TNF-alpha promoter methylation as a predictive biomarker for weight-loss response.
PubMed:Genetic and environmental risks for high blood pressure among African American mothers and daughters.
PubMed:Label-free quantitative proteomics of two Bifidobacterium longum strains.
PubMed:The MTHFR C677T and DeltaDNMT3B C-149T polymorphisms confer different risks for right- and left-sided colorectal cancer.
PubMed:Evolution of the mitochondrial genome in mammals living at high altitude: new insights from a study of the tribe Caprini (Bovidae, Antilopinae).
PubMed:Varenicline for smoking cessation: A review of the literature.
PubMed:Effects of insulin and glucose on cellular metabolic fluxes in homocysteine transsulfuration, remethylation, S-adenosylmethionine synthesis, and global deoxyribonucleic acid methylation.
PubMed:Effects of cultural conditions on high temperature tolerance of Lentinula edodes mycelia.
PubMed:Single-strand DNA breaks in Ig class switch recombination that depend on UNG but not AID.
PubMed:Effects of the myostatin F94L substitution on beef traits.
PubMed:Distribution of nucleosides and nucleobases in edible fungi.
PubMed:The MTHFR 677TT genotype and folate intake interact to lower global leukocyte DNA methylation in young Mexican American women.
PubMed:Mandatory fortification with folic acid in the United States is associated with increased expression of DNA methyltransferase-1 in the cervix.
PubMed:Epigenetic changes in cancer.
PubMed:Food restriction in pregnant mice can induce changes in histone modifications and suppress gene expression in fetus.
PubMed:Global leukocyte DNA methylation is similar in African American and Caucasian women under conditions of controlled folate intake.
PubMed:AtNUDX1, an 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate pyrophosphohydrolase, is responsible for eliminating oxidized nucleotides in Arabidopsis.
PubMed:Lack of effect of the ghrelin gene-derived peptide obestatin on cardiomyocyte viability and metabolism.
PubMed:DNA methyltransferases as targets for cancer therapy.
PubMed:Genotoxicity (mitotic recombination) of the cancer chemotherapeutic agents cisplatin and cytosine arabinoside in Aspergillus nidulans.
PubMed:Mandatory fortification with folic acid in the United States is not associated with changes in the degree or the pattern of global DNA methylation in cells involved in cervical carcinogenesis.
PubMed:Evidence for degradation of abnormal prion protein in tissues from sheep with scrapie during composting.
PubMed:16S ribosomal RNA tools identify an unexpected predominance of Paenibacillus-like bacteria in an industrial activated sludge system suffering from poor biosolids separation.
PubMed:Base-displaced intercalated structure of the food mutagen 2-amino-3-methylimidazo[4,5-f]quinoline in the recognition sequence of the NarI restriction enzyme, a hotspot for -2 bp deletions.
PubMed:Viral mRNA expression but not DNA replication is required for lipogenic effect of human adenovirus Ad-36 in preadipocytes.
PubMed:Characterization of lysine decarboxylase-negative strains of Salmonella enterica serovar Enteritidis disseminated in Japan.
PubMed:Case of progressive dysplasia concomitant with intralesional cidofovir administration for recurrent respiratory papillomatosis.
PubMed:Cidofovir for recurrent respiratory papillomatosis (RRP): a re-assessment of risks.
PubMed:Molecular dynamics of a food carcinogen-DNA adduct in a replicative DNA polymerase suggest hindered nucleotide incorporation and extension.
PubMed:Transcriptome analysis of human colon Caco-2 cells exposed to sulforaphane.
PubMed:Are effects of MTHFR (C677T) genotype on BMD confined to women with low folate and riboflavin intake? Analysis of food records from the Danish osteoporosis prevention study.
PubMed:CpG RNA: identification of novel single-stranded RNA that stimulates human CD14+CD11c+ monocytes.
PubMed:Adenomatous polyposis coli influences micronuclei induction by PhIP and acrylamide in mouse erythrocytes.
PubMed:CpG stimulation of precursor B-lineage acute lymphoblastic leukemia induces a distinct change in costimulatory molecule expression and shifts allogeneic T cells toward a Th1 response.
PubMed:Current state of immunotherapy for bladder cancer.
PubMed:Polymorphisms in the bovine leptin promoter associated with serum leptin concentration, growth, feed intake, feeding behavior, and measures of carcass merit.
PubMed:Chemotherapy for the brain: the antitumor antibiotic mithramycin prolongs survival in a mouse model of Huntington's disease.
PubMed:Methylenetetrahydrofolate reductase 677C-->T polymorphism affects DNA methylation in response to controlled folate intake in young women.
PubMed:Use of DNA from human stools to detect aberrant CpG island methylation of genes implicated in colorectal cancer.
PubMed:Single-stranded DNA breaks adjacent to cytosines occur during Ig gene class switch recombination.
PubMed:Combination of polydextrose and lactitol affects microbial ecosystem and immune responses in rat gastrointestinal tract.
PubMed:Immunomodulation: the future of allergy and asthma treatment.
PubMed:The management of oral human papillomavirus with topical cidofovir: a case report.
PubMed:Relationship between antiviral activity and host toxicity: comparison of the incorporation efficiencies of 2',3'-dideoxy-5-fluoro-3'-thiacytidine-triphosphate analogs by human immunodeficiency virus type 1 reverse transcriptase and human mitochondrial DNA polymerase.
PubMed:Separation of purine and pyrimidine bases by capillary electrophoresis using beta-cyclodextrin as an additive.
PubMed:Involvement of gene-diet/drug interaction in DNA methylation and its contribution to complex diseases: from cancer to schizophrenia.
PubMed:Applications of the ninhydrin reaction for analysis of amino acids, peptides, and proteins to agricultural and biomedical sciences.
PubMed:New agents in the treatment of small-cell lung cancer: focus on gemcitabine.
PubMed:Folate status response to controlled folate intake is affected by the methylenetetrahydrofolate reductase 677C-->T polymorphism in young women.
PubMed:Theoretical study of substitution effect of the hydrogen bond stability of 9-methylguanine derivatives and 1-methylcytosine.
PubMed:Rapid genomic changes in interspecific and intergeneric hybrids and allopolyploids of Triticeae.
PubMed:The -159 C-->T polymorphism of CD14 is associated with nonatopic asthma and food allergy.
PubMed:Molecular characterisation of three avian paramyxovirus type 1 isolated from pigeons in France.
PubMed:Methylenetetrahydrofolate reductase (MTHFR) 677C>T and methionine synthase reductase (MTRR) 66A>G polymorphisms: association with serum homocysteine and angiographic coronary artery disease in the era of flour products fortified with folic acid.
PubMed:Methylenetetrahydrofolate reductase 677C-->T variant modulates folate status response to controlled folate intakes in young women.
PubMed:[Determination of guanine plus cytosine content of Pseudomonas cocovenenans subsp farinofermantans with two methods and the comparative study].
PubMed:Organization of the plasmid cpe Locus in Clostridium perfringens type A isolates.
PubMed:Detection of ochratoxin A-induced DNA damage in MDCK cells by alkaline single cell gel electrophoresis (comet assay).
PubMed:The molecular basis of inhibition and toxicity of modified cytosine analogues targetting HIV-1 reverse transcriptase.
PubMed:Mycoplasmas, plants, insect vectors: a matrimonial triangle.
PubMed:Transcriptional analysis and regulation of expression of the ScrFI restriction-modification system of Lactococcus lactis subsp. cremoris UC503.
PubMed:Mutational analysis of the high-affinity BvgA binding site in the fha promoter of Bordetella pertussis.
PubMed:Drug-resistant herpes: cidofovir gel in limbo. Interview with Jay Lalezari, M.D. Interview by John S. James.
PubMed:Resolution of recalcitrant human papillomavirus gingival infection with topical cidofovir.
PubMed:Genomic DNA methylation decreases in response to moderate folate depletion in elderly women.
PubMed:Development of a transformation and gene reporter system for group II, non-proteolytic Clostridium botulinum type B strains.
PubMed:Gene Regulation and Clinical Roles for Interferons in Neoplastic Diseases.
PubMed:Characterisation of Listeria ivanovii isolates from the UK using pulsed-field gel electrophoresis.
PubMed:Molecular characterization of the Lactococcus lactis LlaKR2I restriction-modification system and effect of an IS982 element positioned between the restriction and modification genes.
PubMed:Maternal epigenetics and methyl supplements affect agouti gene expression in Avy/a mice.
PubMed:Effect of CTP synthetase regulation by CTP on phospholipid synthesis in Saccharomyces cerevisiae.
PubMed:Cloning and characterization of the lactococcal plasmid-encoded type II restriction/modification system, LlaDII.
PubMed:Cidofovir use in acyclovir-resistant herpes infection.
PubMed:Expression systems for industrial Gram-positive bacteria with low guanine and cytosine content.
PubMed:Gilead announces phase I/II data insufficient for marketing clearance of FORVADE topical gel to treat refractory herpes in patients with AIDS.
PubMed:Host-mediated modification of Sau3AI restriction in Listeria monocytogenes: prevalence in epidemic-associated strains.
PubMed:Arsenic alters cytosine methylation patterns of the promoter of the tumor suppressor gene p53 in human lung cells: a model for a mechanism of carcinogenesis.
PubMed:Alterations in hepatic p53 gene methylation patterns during tumor progression with folate/methyl deficiency in the rat.
PubMed:NDA filed to treat refractory herpes.
PubMed:Establishment of methylation-sensitive-representational difference analysis and isolation of hypo- and hypermethylated genomic fragments in mouse liver tumors.
PubMed:From the Food and Drug Administration.
PubMed:FDA grants marketing clearance of Vistide for the treatment of CMV retinitis.
PubMed:Cidofovir approved.
PubMed:An open letter to the FDA regarding changes in reporting procedures for drugs and biologics proposed in the wake of the FIAU tragedy.
PubMed:Cleavage of oligodeoxyribonucleotides from controlled-pore glass supports and their rapid deprotection by gaseous amines.
PubMed:Gram-positive, catalase-positive cocci from dry cured Iberian ham and their enterotoxigenic potential.
PubMed:Bovine herpesvirus 1 isolates contain variable copy numbers of GC-rich tandem repeats in the gI non-coding regions of their genomes.
PubMed:Differential sensitivity to loss of cytosine methyl groups within the hepatic p53 gene of folate/methyl deficient rats.
PubMed:Pyrimidine synthesis in Burkholderia cepacia ATCC 25416.
PubMed:From the Food and Drug Administration.
PubMed:Bioavailability of bropirimine 250 mg tablet in dogs: effect of food.
PubMed:Breaks in genomic DNA and within the p53 gene are associated with hypomethylation in livers of folate/methyl-deficient rats.
PubMed:Bacteriophage resistance in Lactococcus: molecular characterization of the ScrFI restriction/modification system from Lactococcus lactis subsp. cremoris UC503.
PubMed:Phylogenetic analysis of species of the meso-diaminopimelic acid-containing genera Brevibacterium and Dermabacter.
PubMed:Mutation spectra of Glu-P-1 in Salmonella: induction of hotspot frameshifts and site-specific base substitutions.
PubMed:Transformation of BALB/c-3T3 cells: IV. Rank-ordered potency of 24 chemical responses detected in a sensitive new assay procedure.
PubMed:Transformation of BALB/c-3T3 cells: III. Development of a co-culture clonal survival assay for quantification of chemical cytotoxicity in high-density cell cultures.
PubMed:Beta 0-thalassemia due to a cytosine deletion in codon 41 associated with hemoglobin E.
PubMed:ScrFI restriction-modification system of Lactococcus lactis subsp. cremoris UC503: cloning and characterization of two ScrFI methylase genes.
PubMed:Mycoplasma phocidae sp. nov., isolated from harbor seals (Phoca vitulina L.).
PubMed:Phylogenetic analysis of Alloiococcus otitis gen. nov., sp. nov., an organism from human middle ear fluid.
PubMed:Maternal and developmental toxicity of low doses of cytosine arabinoside in mice.
PubMed:Classification of the spoilage flora of fish, with special reference to Shewanella putrefaciens.
PubMed:Mycoplasma lactucae sp. nov., a sterol-requiring mollicute from a plant surface.
PubMed:Actual identity of six micrococcal strains selected as potential starter for dry fermented sausages production.
PubMed:The relationship between the base composition of bacterial DNA and its intracellular melting temperature as determined by differential scanning calorimetry.
PubMed:NMR study of stacking interactions and conformational adjustments in the dinucleotide-carcinogen adduct 2'-deoxycytidylyl-(3----5)-2'-deoxy-8-(N-fluoren-2-ylac etamido)guanosi ne.
PubMed:Characterization of the bacteriophage B2 of Lactobacillus plantarum ATCC 8014.
PubMed:Increased aortic DNA synthesis precedes renal hypertension in rats. An obligatory step?
PubMed:Isolation and characterization of a novel thermophilic, freshwater methanogen.
PubMed:A numerical taxonomic study of lactic acid bacteria from vacuum-packed beef, pork, lamb and bacon.
PubMed:Effect of fasting on the metabolism of cytidine nucleotides in the liver of intact and alpha-hexachlorocyclohexane-treated rats.
PubMed:Relative incidence of Alteromonas putrefaciens and Pseudomonas putrefaciens in ground beef.
PubMed:Wheat Storage Proteins : ISOLATION AND CHARACTERIZATION OF THE GLIADIN MESSENGER RNAs.
PubMed:Atypical biogroups of Escherichia coli found in clinical specimens and description of Escherichia hermannii sp. nov.
PubMed:Sulphite toxicity: a critical review of in vitro and in vivo data.
PubMed:Effect of some dietary additions to either an arginine-devoid diet or a diet supplemented with orotic acid refed after starvation on liver lipid content during essential fatty acid deficiency in rats.
PubMed:[DNA nucleotide composition of Gram-positive cocci isolated from food products of animal origin].
PubMed:Effects of intranasal irrigation with mitotic inhibitors on olfactory behavior and biochemistry in mice.
PubMed:Patterns of cell division, DNA base compositions, and fine structures of some radiation-resistant vegetative bacteria found in food.
PubMed:Crosslinking of nucleic acids and proteins by bisulfite.
PubMed:The effect of RNA supplementation of rat diets on the composition of body fluids.
PubMed:Characteristics of heavily mucoid bacterial isolated from fish pen slime.
PubMed:Deoxyribonucleic acid base composition and biochemical properties of certain coagulase-negative enterotoxigenic cocci.
PubMed:Transfer of the methyl group of methionine to choline and to tRNA in the honeybee Apis mellifica L.
PubMed:Error in flucytosine dosage?
PubMed:Cytological and deoxyribonucleic acid-deoxyribonucleic acid hybridization studies on lactobacillus isolates from San Francisco sourdough.
PubMed:Lactic acid production in milk and DNA homology relationships in the species Lactobacillus jugurt.
PubMed:DNA base composition of soil arthrobacters and other coryneforms from cheese and sea fish.
PubMed:Characteristics of three phages infectious for psychrophilic fishery isolates of Pseudomonas putrefaciens.
PubMed:Correlation of DNA base composition and metabolism of Pseudomonas putrefaciens isolates from food, human clinical specimens, and other sources.
PubMed:Use of alkali in a rapid procedure for the isolation of partly-degraded deoxyribonucleic acid: investigation of the method introduced by W. Jones.
 
Notes:
a pyrimidine base that is a fundamental unit of nucleic acids. A pyrimidine base that is a fundamental unit of nucleic acids. The deamination of cytosine alone is apparent and the nucleotide of cytosine is the prime mutagenic nucleotide in leukaemia and cancer. [HMDB]
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