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sodium cyclamate
sulfamic acid, N-cyclohexyl-, sodium salt (1:1)

Supplier Sponsors

Name:sodium N-cyclohexylsulfamate
CAS Number: 139-05-9Picture of molecule3D/inchi
Other(deleted CASRN):53170-91-5
ECHA EINECS - REACH Pre-Reg:205-348-9
FDA UNII: 1I6F42RME1
Nikkaji Web:J813C
Beilstein Number:4166868
MDL:MFCD00003827
Molecular Weight:201.22100928
Formula:C6 H12 N Na O3 S
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:information only not used for fragrances or flavors
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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PubMed:Search
NCBI:Search
JECFA Food Additive: Sodium Cyclamate
GSFA Codex: Sodium cyclamate (952(iv))
DG SANTE Food Additives:sodium cyclamate
FDA Mainterm (SATF):139-05-9 ; SODIUM CYCLAMATE--PROHIBITED
FDA Regulation:
FDA PART 100 -- GENERAL


FDA PART 189 -- SUBSTANCES PROHIBITED FROM USE IN HUMAN FOOD
Subpart C--Substances Generally Prohibited From Direct Addition or Use as Human Food
Sec. 189.135 Cyclamate and its derivatives.
 
Physical Properties:
Appearance:white crystalline powder (est)
Assay: 98.00 to 100.00
Food Chemicals Codex Listed: No
Flash Point: 32.00 °F. TCC ( 0.00 °C. ) (est)
logP (o/w): 0.979 (est)
Soluble in:
 water, 1e+006 mg/L @ 25 °C (est)
Insoluble in:
 alcohol
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: fragrance
 
Suppliers:
Anhui Haibei
Sodium Cyclamate
Atlantic Chemicals
Sodium Cyclamate
BOC Sciences
For experimental / research use only.
Sodium cyclamate 98%
ECSA Chemicals
SODIUM CYCLAMATE
ECSA TRADE THE MOST UPDATED FINANCIAL PUBLICATION ON THE WORLD OF CHEMISTRY
EMD Millipore
For experimental / research use only.
Sodium Cyclamate
sds
Foodchem International
Sodium Cyclamate
Indis NV
For experimental / research use only.
Sodium Cyclamate
Jiangyin Healthway
Sodium Cyclamate
New functional food ingredients
Prinova
Sodium Cyclamate
Qingdao Dacon Trading
Sodium Cyclamate
Sigma-Aldrich: Aldrich
For experimental / research use only.
Sodium N-cyclohexylsulfamate ≥99.0% (T)
sds
Sinofi Food Ingredients
Sodium Cyclamate
Flavor: characteristic
Sugar Substitutes, Dairy Products, Confections, Baking Food, Yogurt, Desserts, Cookies, Juice, Soft Drink, Alcoholic Beverages, Beverage Powder, Chai Tea, Ice Cream, Dried Fruits, Gelatins, Puddings, Cosmetics, Pharmaceutical.
TCI AMERICA
For experimental / research use only.
Sodium N-Cyclohexylsulfamate >98.0%(N)
sds
Tianjin Talent Chemical
Sodium Cyclamate
United International
Sodium Cyclamate
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50 1280 mg/kg
Science Reports of the Research Institutes, Tohoku University, Series C: Medicine. Vol. 36(1-4), Pg. 10, 1989.

intravenous-rat LD50 3500 mg/kg
Food and Cosmetics Toxicology. Vol. 6, Pg. 313, 1968.

intraperitoneal-rat LD50 1350 mg/kg
National Cancer Institut by Bio-Research Consultants, Inc. Vol. NCI-E-68-1311, Pg. 1973

oral-mouse LD50 17000 mg/kg
Food and Cosmetics Toxicology. Vol. 6, Pg. 313, 1968.

intravenous-mouse LD50 4800 mg/kg
Food and Cosmetics Toxicology. Vol. 6, Pg. 313, 1968.

intraperitoneal-mouse LD50 1154 mg/kg
National Cancer Institut by Bio-Research Consultants, Inc. Vol. NCI-E-68-1311, Pg. 1973

intraperitoneal-mouse LD50 1154 mg/kg
Progress Report for Contract No. NIH-NCI-E-68-1311, Submitted to the National Cancer Institut by Bio-Research Consultants, Inc. Vol. NCI-E-68-1311, Pg. 1973

intraperitoneal-rat LD50 1350 mg/kg
Progress Report for Contract No. NIH-NCI-E-68-1311, Submitted to the National Cancer Institut by Bio-Research Consultants, Inc. Vol. NCI-E-68-1311, Pg. 1973

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
information only not used for fragrances or flavors
Recommendation for sodium cyclamate usage levels up to:
 not for fragrance use.
 
Recommendation for sodium cyclamate flavor usage levels up to:
 not for flavor use.
 
Safety References:
European Food Safety Authority (EFSA) reference(s):

Outcome of the public consultation on a draft protocol for assessing exposure to sweeteners as part of their safety assessment under the food additives re-evaluation programme
View page or View pdf

EPI System: View
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
Carcinogenic Potency Database:Search
EPA GENetic TOXicology:Search
EPA Substance Registry Services (TSCA):139-05-9
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :23665706
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
sodium N-cyclohexylsulfamate
Chemidplus:0000139059
EPA/NOAA CAMEO:hazardous materials
RTECS:GV7350000 for cas# 139-05-9
 
References:
 sodium N-cyclohexylsulfamate
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:139-05-9
Pubchem (cid):23665706
Pubchem (sid):134974075
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS):View
CHEBI:View
CHEMBL:View
KEGG (GenomeNet):C19378
HMDB (The Human Metabolome Database):Search
FooDB:FDB008419
Export Tariff Code:2921.30.5000
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
 aminocyclohexylsulfonic acid, sodium salt
 cyclamate sodium
 cyclamate, sodium
 Cyclamate, Sodium Salt
 cyclamic acid sodium salt
 cyclohexane sulfamic acid monosodium salt
 cyclohexanesulfamic acid sodium salt
 cyclohexanesulfamic acid, monosodium salt
 cyclohexanesulfamic acid, sodium salt
 cyclohexanesulphamic acid, monosodium salt
 cyclohexyl sulfamic acid sodium salt
 cyclohexylsulfamic acid monosodium salt
 cyclohexylsulfamic acid sodium salt
N-cyclohexylsulfamic acid sodium salt
 cyclohexylsulfamic acid, sodium salt
 cyclohexylsulphamate sodium
 cyclohexylsulphamic acid, monosodium salt
 hachi-sugar
 sodium cyclohexanesulfamate
monosodium cyclohexyl sulfamate
 sodium cyclohexylsulfamate
monosodium cyclohexylsulfamate
 sodium cyclohexylsulphamidate
 sodium N-cyclohexylsulfamate
 sodium sucaryl
 sodiumcyclamate
 sucaryl acid sodium salt
 sucaryl sodium
 sucrum 7
 sulfamic acid, cyclohexyl-, monosodium salt
 sulfamic acid, cylclohexyl-, monosodium salt
 sulfamic acid, N-cyclohexyl-, sodium salt (1:1)
 

Articles:

PubMed:[Determination of sodium cyclamate in liquor by high performance liquid chromatography-tandem mass spectrometry with linear trap technology].
PubMed:Induction of morphological changes in the urothelium of cultured adult rat bladder by sodium saccharin and sodium cyclamate.
PubMed:Multistage transformation of cultured rat urothelium: the effects of N-methyl-N-nitrosourea, sodium saccharin, sodium cyclamate and 12-O-tetradecanoylphorbol-13-acetate.
PubMed:[A rapid separation and quantitation of sodium cyclamate in food by ion-pair reversed-phase high performance liquid chromatography].
PubMed:Investigations on the carcinogenicity of the artificial sweeteners sodium cyclamate and sodium saccharin in rats in a two-generation experiment.
PubMed:Synthesis and bacterial metabolism of cis- and trans-2-alkyl analogues of sodium cyclamate.
PubMed:Studies on synthetic sweetening agents. XVI. Metabolism of sodium cyclamate. 5. The metabolism of sodium cyclamate in rabbits and rats after prolonged administration of sodium cyclamate.
PubMed:Protective effects of cholestyramine in rats fed a low-fiber diet containing toxic doses of sodium cyclamate or amaranth.
PubMed:Production of mouse urinary bladder carcinomas by sodium cyclamate.
PubMed:Structures of artificial sweeteners--cyclamic acid and sodium cyclamate with other cyclamates.
PubMed:Effects of sodium cyclamate and sodium saccharin on focus induction in explant cultures of rat bladder.
PubMed:Studies on synthetic sweetening agents. XVIII. Metabolism of sodium cyclamate. (7). Dicyclohexylamine, a metabolite of sodium cyclamate in rabbits and rats.
PubMed:Studies on synthetic sweetening agents. XV. Metabolism of sodium cyclamate. Influences of phenylbutaone, phenobarbital, and tolbutamide on metabolism of sodium cyclamate in rabbits.
PubMed:Determination of dicyclohexylamine in sodium cyclamate.
PubMed:Studies on synthetic sweetening agents. XVII. Metabolism of sodium cyclamate. (6). Influences of neomycin and sulfaguanidine on metabolism of sodium cyclamate.
PubMed:Studies on synthetic sweetening agents. XIV. Metabolism of sodium cyclamate. 3. On metabolites of sodium cyclamate in human.
PubMed:Studies on synthetic sweetening agents. 13. Metabolism of sodium cyclamate. (2). Detection of metabolites of sodium cyclamate in the rabbit and rat by gas-liquid chromatography.
PubMed:[Synthesis of cyclohexanone and 2-cyclohexenone from sodium cyclamate].
PubMed:Analysis of saccharin, acesulfame-K and sodium cyclamate by high-performance ion chromatography.
PubMed:Spectrophotometric determination of sodium cyclamate and saccharin sodium with Astrazone pink FG.
PubMed:Effects on oral health of mouthrinses containing xylitol, sodium cyclamate and sucrose sweeteners in the absence of oral hygiene. V. Response of hamster cheek pouch microcirculation to dental plaque.
PubMed:Effects on oral health of mouthrinses containing xylitol, sodium cyclamate and sucrose sweeteners in the absence of oral hygiene. IV. Analysis of whole saliva.
PubMed:Effects on oral health of mouthrinses containing xylitol, sodium cyclamate and sucrose sweeteners in the absence of oral hygiene. II. Relative composition of free amino acids in human crevicular fluid.
PubMed:Syncarcinogenic action of saccharin or sodium cyclamate in the induction of bladder tumours in MNU-pretreated rats.
PubMed:[Effect of sodium saccharin and sodium cyclamate on water-soluble vitamins and essential amino acids].
PubMed:Histological examination of perinatal eye development in the rat after ingestion of sodium cyclamate and sodium saccharin during pregnancy.
PubMed:Inhibitory effect of sodium cyclamate and sodium saccharin on tumor induction by 2-acetylaminofluorene in rats.
PubMed:Comparative effects of a purified diet and stock ration on sodium cyclamate toxicity in rats.
PubMed:[In vitro effect of sodium cyclamate on human chromosomes].
PubMed:Whole-body autoradiography of 14 C sodium cyclamate in pregnant and fetal rats.
PubMed:[Noxious effects of various drugs and medicaments on the genetic material. 3. The case of sodium cyclamate].
PubMed:Cyclohexylamine production and physiological measurements in subjects ingesting sodium cyclamate.
PubMed:[Intestinal dialysis with sodium cyclamate--a new method for chronic uremia treatment].
PubMed:Sodium cyclamate and bladder carcinoma.
PubMed:Feeding studies on sodium cyclamate, saccharin and sucrose for carcinogenic and tumour-promoting activity.
PubMed:[Sodium cyclamate in the "in vitro test". Macomolecular syntheses and oxygen consumption].
PubMed:Toxicological studies with sodium cyclamate and saccharin.
PubMed:Studies on synthetic sweetening agents. XII. The binding of sodium cyclamate with bovine serum albumin.
PubMed:A new colorimetric method of sodium cyclamate by solvent extraction with tris(1,10-phenanthroline)iron+2 chelate.
PubMed:[Studies on the analytical methods of artificial sweeteners. I. Determination of sodium cyclamate. (1)].
PubMed:Studies on synthetic sweetening agents. VI. Absorption and excretion of sodium cyclamate.
PubMed:Studies on synthetic sweetening agents. VII. Absorption and excretion of sodium cyclamate.
PubMed:[STUDIES ON SYNTHETIC SWEETENING AGENTS. IV. ON THE COLORING MATTER IN COLORIMETRIC DETERMINATION OF SODIUM CYCLAMATE].
PubMed:[STUDIES ON SYNTHETIC SWEETENING AGENTS. II. COLORIMETRIC DETERMINATION OF SODIUM CYCLAMATE. (1)].
PubMed:Effects on oral health of mouthrinses containing xylitol, sodium cyclamate and sucrose sweeteners in the absence of oral hygiene. I. Clinical findings and analysis of gingival exudate.
PubMed:Effects on oral health of mouthrinses containing xylitol, sodium cyclamate and sucrose sweeteners in the absence of oral hygiene. III. Composition and bone resorbing potential of dental plaque.
PubMed:Stability of sodium cyclamate in simulated gastric and intestinal media.
PubMed:[Determination of sodium cyclamate by isotope dilution analysis (author's transl)].
PubMed:Effects of dietary carbohydrate on sodium cyclamate toxicity in rats feds a purified, low-fiber diet.
PubMed:Long-term toxicity of sodium cyclamate in mice.
PubMed:[Effect of sodium cyclamate on adolescent rats].
PubMed:Effects of simultaneous administration of drugs on absorption and excretion. I. Effect of phenylbutazone on absorption and excretion of sodium cyclamate in rabbits.
PubMed:[Cytogenetic effect of sodium cyclamate, cyclohexanone and cyclohexanol].
PubMed:Effects of sodium cyclamate on Haworthia callus cultured in vitro.
PubMed:[Influence of sodium cyclamate on the fertility and pre and post-natal development of the rat].
PubMed:[On the test methods of sodium cyclamate in dentifrices].
PubMed:Letters to the editor: effect of sodium cyclamate on protein-bound iodine.
PubMed:Sodium cyclamate, saccharin and food efficiency.
PubMed:Excretion of cyclohexylamine in subjects ingesting sodium cyclamate.
PubMed:[Saccharin and sodium cyclamate toxicity for the offspring of pregnant mice].
PubMed:Effects of sodium cyclamate on the growth of rats compared with other variations in the diet.
PubMed:[Colorimetric determination of cyclohexylamine in commerical sodium cyclamate].
PubMed:[Study of the possible activity of sodium cyclamate in the rat within the span of 3 generations].
PubMed:[Analyses of drugs and chemicals by infrared absorption spectroscopy. XI. Determination of saccharin sodium, dulcin, and sodium cyclamate in their mixture by use of methanol and water as solvents].
PubMed:Studies on synthetic sweetening agents. 8. Cyclohexylamine, a metabolite of sodium cyclamate.
PubMed:[STUDIES ON SYNTHETIC SWEETENING AGENTS. III. COLORIMETRIC DETERMINATION OF SODIUM CYCLAMATE. (2)].
PubMed:Rapid analysis of cyclamate in foods and beverages by gas chromatography-electron capture detector (GC-ECD).
PubMed:Interlaboratory testing of Insent e-tongues.
PubMed:[Simultaneous determination of five synthetic sweeteners in food by solid phase extraction-high performance liquid chromatography-evaporative light scattering detection].
PubMed:High-performance ion mobility spectrometry with direct electrospray ionization (ESI-HPIMS) for the detection of additives and contaminants in food.
PubMed:Determination of artificial sweeteners in beverages and special nutritional products using high performance liquid chromatography.
PubMed:Application of dispersive solid-phase extraction and ultra-fast liquid chromatography-tandem quadrupole mass spectrometry in food additive residue analysis of red wine.
PubMed:[Influence of several weeks' treatment of male and female mice with saccharin, cyclamate or cyclohexylamine sulfate on fertility and dominant lethal effects (author's transl)].
PubMed:[Determination of five synthetic sweeteners in wines using high performance liquid chromatography-tandem mass spectrometry].
PubMed:Sensory quality of functional beverages: bitterness perception and bitter masking of olive leaf extract fortified fruit smoothies.
PubMed:[Determination of three sweeteners in vinegars by solid phase extraction-high performance liquid chromatography/tandem mass spectrometry].
PubMed:[Use of diet sweeteners by adults in Pelotas, Rio Grande do Sul State, Brazil: a population-based study].
PubMed:[Study on optimization of formulation of Danggui Liuhuang effervescent granules].
PubMed:[Simultaneous determination of six synthetic sweeteners in food by high performance liquid chromatography-tandem mass spectrometry].
PubMed:Moderate intake of sucrose does not impair metabolic control in pump-treated diabetic out-patients.
PubMed:Evaluation of a new model to detect bladder carcinogens or co-carcinogens; results obtained with saccharin, cyclamate and cyclophosphamide.
PubMed:Asymmetric organocatalytic Michael addition of ketones to vinyl sulfone.
PubMed:[Compound preservative and cyclamat determinated by gas chromatography].
PubMed:Improved water solubility of neohesperidin dihydrochalcone in sweetener blends.
PubMed:[Sensitive and selective HPLC methods with prechromatographic derivatization for the determination of cyclamate in foods].
PubMed:Developmental toxicity testing with FETAX: evaluation of five compounds.
PubMed:The determination of mixtures of some artificial sweeteners.
PubMed:Method for testing mutagenic effects of chemicals on spermatogonia of the Chinese hamster: results obtained with cyclophosphamide, saccharin, and cyclamate.
PubMed:Indirect determination of cyclamate by an on-line continuous precipitation-dissolution flow system.
PubMed:[Optimization of preparative technique for banxia-houpu effervescent tablets by orthogonal design].
PubMed:Separation and simultaneous determination of four artificial sweeteners in food and beverages by ion chromatography.
PubMed:Aspartame: effect on lunch-time food intake, appetite and hedonic response in children.
PubMed:Effects of treatment with N-methyl-N-nitrosourea, artificial sweeteners, and cyclophosphamide on adult rat urinary bladder in vitro.
PubMed:Effect on hepatic ornithine decarboxylase of some food additives and synthetic elastomers.
PubMed:Effects of solute concentration on vasopressin stimulated cyclic AMP generation in the rat medullary thick ascending limbs of Henle's loop.
PubMed:Carcinogen-induced chromosomal breakage decreased by antioxidants.
PubMed:Bladder tumors in rats fed cyclohexylamine or high doses of a mixture of cyclamate and saccharin.
PubMed:Development of a new oat-based probiotic drink.
PubMed:Oral zinc sulfate solutions inhibit sweet taste perception.
PubMed:Long-term toxicity and carcinogenicity study of cyclamate in nonhuman primates.
PubMed:Selective inhibition of sweetness by the sodium salt of +/-2-(4-methoxyphenoxy)propanoic acid.
PubMed:Effects of artificial sweeteners on insulin release and cationic fluxes in rat pancreatic islets.
PubMed:Gustatory responses of the hamster Mesocricetus auratus to various compounds considered sweet by humans.
PubMed:The use of chlorophenol red for the selective determination of chlorine dioxide in drinking water.
PubMed:Investigation of synergism in binary mixtures of sweeteners.
PubMed:Taste as a highly discriminative system: a hamster intrapapillar single unit study with 18 compounds.
PubMed:Correlation of results of agglutination assays with concanavalin A and carcinogenesis experiments on promoters of bladder cancer.
PubMed:Transforming growth factors induce markers of neoplasia in cultured adult rat bladder.
PubMed:[Failure to activate Epstein-Barr virus genome in a latently-infected human lymphoblastoid cell line with urine containing a bladder carcinogenesis promoter].
PubMed:Preference for sugars and nonnutritive sweeteners in young beagles.
PubMed:Vagotomy abolishes the differential palatability of food.
PubMed:Promotion in urinary bladder carcinogenesis.
PubMed:Effect of partial cystectomy on the induction of pre-neoplastic lesions in rat bladder initiated with N-butyl-N-(4-hydroxybutyl)nitrosamine followed by bladder carcinogens and promoters.
PubMed:Urinary bladder carcinogenesis with N-substituted aryl compounds: initiation and promotion.
PubMed:Modification by fiber of toxic dietary effects.
PubMed:[Infrared spectroscopy of the dry residue of liquor crystallograms in various diseases].
PubMed:The comet assay with 8 mouse organs: results with 39 currently used food additives.
PubMed:Effect of temperature, pH, and ions on sweet taste.
PubMed:Solution properties and sweetness response of selected bulk and intense sweeteners.
PubMed:Primate sense of taste: behavioral and single chorda tympani and glossopharyngeal nerve fiber recordings in the rhesus monkey, Macaca mulatta.
PubMed:Bitterness of sweeteners as a function of concentration.
PubMed:Flow injection potentiometric determination of saccharin in dietary products with relocation of filtration unit.
PubMed:Adaptation of sweeteners in water and in tannic acid solutions.
PubMed:Potentiometric determination of saccharin in dietary products using mercurous nitrate as titrant.
PubMed:Pedagogical patronizing of the pharmacodynamic promises of illicit drugs.
PubMed:Interactive effects of aldrin, cyclohexylamine, 2,4-diaminotoluene and two phorbol esters on metabolic cooperation between V79 cells.
PubMed:Aspartame: effects on learning, behavior, and mood.
PubMed:[Ion pair-HPLC of a pharmaceutical multicomponent system].
PubMed:Inactivation of antiadherence effect of bladder surface glycosaminoglycans as possible mechanism for carcinogenesis.
PubMed:Metabolic adaptation of rat faecal microflora to cyclamate in vitro.
PubMed:Reduced trisialoganglioside synthesis in chemically but not mos-transformed mouse epidermal cells.
PubMed:Drugs, food additives and natural products as promoters in rat urinary bladder carcinogenesis.
PubMed:[Glycine uptake in brush border vesicles isolated from the rat intestinal cells].
PubMed:Trihalogenated benzamides--a new class of artificial sweeteners.
PubMed:Effect of tumor promoters on soft-agar growth of Swiss 3T3 cells infected with SV40 tsA mutants.
PubMed:Purification and some properties of cyclohexylamine oxidase from a Pseudomonas sp.
PubMed:Experiences with the dominant lethal test in female mice: effects of alkylating agents and artificial sweeteners on pre-ovulatory oocyte stages.
 
Notes:
Non-nutritive sweetener Cyclamate is an artificial sweetener that was discovered in 1937 at the University of Illinois by graduate student Michael Sveda.
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