|
Category:pharmaceuticals / chemical synthisis
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00
|
| Food Chemicals Codex Listed: | No |
| Melting Point: | 156.00 °C. @ 760.00 mm Hg
|
| Boiling Point: | 726.03 °C. @ 760.00 mm Hg (est)
|
| Vapor Pressure: | 3.200000 mmHg @ 25.00 °C. (est) |
| Flash Point: | 739.00 °F. TCC ( 392.90 °C. ) (est)
|
| logP (o/w): | 1.300 |
| Soluble in: |
| | water, 4.50E+04 mg/L @ 25 °C (exp) | | | water, 239.5 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
| Alfa Biotechnology |
| For experimental / research use only. |
| Colchicine 98%
|
| BOC Sciences |
| For experimental / research use only. |
| Colchicine
Odor: characteristic Use: Colchicine, a toxic plant-derived alkaloid extracted from plants of the genus Colchicum, inhibits microtubule polymerization (IC50 = 3.2 nM). |
| Coompo |
| For experimental / research use only. |
| Colchicine from Plants ≥98%
Odor: characteristic Use: Colchicine inhibits microtubule polymerization by binding to tubulin, one of the main constituents of microtubules. Availability of tubulin is essential to mitosis, and therefore colchicine effectively functions as a "mitotic poison" or spindle poison.
It is also used as an anti-inflammatory agent for long-term treatment of Behçet's disease.
The therapeutic value of colchicine against cancer is (as is typical with chemotherapy agents) limited by its toxicity against normal cells.
Colchicine is also used for constipation-predominant irritable bowel syndrome in women, and for treatment of severe or persistent aphthous stomatitis (canker sores).
Colchicine is used to prevent gout attacks (sudden, severe pain in one or more joints caused by abnormally high levels of a substance called uric acid in the blood) in adults, and to relieve the pain of gout attacks when they occur. Colchicine is in a class of medications called anti-gout agents. Colchicine is also used to treat familial Mediterranean fever (FMF; an inborn condition that causes episodes of fever, pain, and swelling of the stomach area, lungs, and joints) in adults and children 4 years of age and older. |
| Glentham Life Sciences |
| Colchicine
|
| Shaanxi Y-Herb Biotechnology |
| Raw 98% Colchicine Powder Autumn Crocus Meadow Saffron Extract CAS 64-86-8
|
| Sigma-Aldrich: Sigma |
| For experimental / research use only. |
| Colchicine ≥95% (HPLC), powder
|
| TCI AMERICA |
| For experimental / research use only. |
| Colchicine (contains 5% Ethyl Acetate at maximum) >97.0%(HPLC)
|
Safety Information:
| Preferred SDS: View |
| |
| Hazards identification |
| |
| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
| |
| Pictogram | |
| |
| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
oral-bird - wild LD50 31600 ug/kg
Archives of Environmental Contamination and Toxicology. Vol. 12, Pg. 355, 1983.
intravenous-cat LD50 250 ug/kg
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
GASTROINTESTINAL: NAUSEA OR VOMITING
Journal of Pharmacology and Experimental Therapeutics. Vol. 106, Pg. 261, 1952.
oral-cat LDLo 125 ug/kg
"Principles of Insect Chemosterilization," Labrecque, G.C., and C.N. Smith, eds., New York, Appleton-Century-Crofts, 1968Vol. -, Pg. 315, 1968.
parenteral-child TDLo 2400 ug/kg
BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"
BLOOD: CHANGES IN BONE MARROW NOT INCLUDED ABOVE
GASTROINTESTINAL: NAUSEA OR VOMITING
Veterinary and Human Toxicology. Vol. 37, Pg. 366, 1995.
oral-dog LDLo 125 ug/kg
"Principles of Insect Chemosterilization," Labrecque, G.C., and C.N. Smith, eds., New York, Appleton-Century-Crofts, 1968Vol. -, Pg. 315, 1968.
unreported-dog LDLo 5 mg/kg
Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 27, Pg. 119, 1890.
intraperitoneal-guinea pig LD50 500 ug/kg
Medicina Experimentalis. Vol. 6, Pg. 101, 1962.
oral-guinea pig LDLo 12500 ug/kg
LIVER: OTHER CHANGES
BLOOD: CHANGES IN SPLEEN
BLOOD: OTHER CHANGES
Virchows Archiv fuer Pathologische, Anatomie und Physiologie, und fuer Klinische Medizin. Vol. 320, Pg. 93, 1951.
intraperitoneal-hamster LD50 7300 ug/kg
Medicina Experimentalis. Vol. 6, Pg. 101, 1962.
intravenous-human LDLo 129 ug/kg
VASCULAR: SHOCK
GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION
Human Toxicology. Vol. 2, Pg. 169, 1983.
oral-human LDLo 86 ug/kg
LUNGS, THORAX, OR RESPIRATION: DYSPNEA
GASTROINTESTINAL: OTHER CHANGES
"Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 184, 1969.
parenteral-human TDLo 710 ug/kg
GASTROINTESTINAL: NAUSEA OR VOMITING
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION
Archives of Internal Medicine. Vol. 137, Pg. 394, 1977.
intravenous-man LDLo 143 ug/kg/5D-I
MUSCULOSKELETAL: OTHER CHANGES
BLOOD: APLASTIC ANEMIA
New England Journal of Medicine. Vol. 309, Pg. 310, 1983.
oral-man LDLo 11 mg/kg
KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
Canadian Medical Association Journal. Vol. 138, Pg. 335, 1988.
oral-man TDLo 400 ug/kg
KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"
BLOOD: "CHANGES IN SERUM COMPOSITION (E.G., TP, BILIRUBIN, CHOLESTEROL)"
Critical Care Medicine. Vol. 7, Pg. 278, 1979.
oral-man TDLo 12514 ug/kg/2Y
BEHAVIORAL: MUSCLE WEAKNESS
New England Journal of Medicine. Vol. 316, Pg. 1562, 1987.
intramuscular-mouse LD50 1197 ug/kg
Journal of Medicinal Chemistry. Vol. 24, Pg. 257, 1981.
intraperitoneal-mouse LD50 1600 ug/kg
Journal of Medicinal Chemistry. Vol. 28, Pg. 1204, 1985.
intravenous-mouse LD50 1700 ug/kg
Drugs in Japan Vol. 6, Pg. 280, 1982.
oral-mouse LD50 5886 ug/kg
National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. Vol. JAN1986
oral-quail LD50 42 mg/kg
Journal of Reproduction and Fertility. Vol. 48, Pg. 371, 1976.
intravenous-rabbit LDLo 3 mg/kg
GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. Vol. 67, Pg. 768, 1909.
oral-rabbit LDLo 50 mg/kg
GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. Vol. 67, Pg. 768, 1909.
intravenous-rat LD50 1600 ug/kg
BEHAVIORAL: FOOD INTAKE (ANIMAL)
GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Toxicology and Applied Pharmacology. Vol. 13, Pg. 50, 1968.
intraperitoneal-rat LDLo 1400 ug/kg
GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
MUSCULOSKELETAL: OTHER CHANGES
BEHAVIORAL: MUSCLE WEAKNESS
Archives of Neurology Vol. 24, Pg. 72, 1971.
parenteral-rat LDLo 1000 ug/kg
Farmaco, Edizione Scientifica. Vol. 15, Pg. 533, 1960.
unreported-rat LDLo 1 mg/kg
"Principles of Insect Chemosterilization," Labrecque, G.C., and C.N. Smith, eds., New York, Appleton-Century-Crofts, 1968Vol. -, Pg. 315, 1968.
|
| Dermal Toxicity: |
subcutaneous-cat LDLo 500 ug/kg
"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1337, 1935.
subcutaneous-dog LDLo 571 ug/kg
"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1337, 1935.
subcutaneous-mouse LD50 1200 ug/kg
Drugs in Japan Vol. 6, Pg. 280, 1982.
subcutaneous-rabbit LDLo 5 mg/kg
GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. Vol. 67, Pg. 768, 1909.
subcutaneous-rat LDLo 4 mg/kg
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 84, Pg. 257, 1950.
|
| Inhalation Toxicity: |
|
Not determined
|
Safety in Use Information:
| Category: | | pharmaceuticals / chemical synthisis |
| Recommendation for colchicine usage levels up to: | | | not for fragrance use.
|
| |
| Recommendation for colchicine flavor usage levels up to: |
| | not for flavor use.
|
Safety References:
References:
| | N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide |
| NIST Chemistry WebBook: | Search Inchi |
| Canada Domestic Sub. List: | 64-86-8 |
| Pubchem (cid): | 6167 |
| Pubchem (sid): | 134972467 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | acetamide, N- (5,6,7,9-tetrahydro-1,2,3, 10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)-, (S)- | | | acetamide, N-((7S)-5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo(a)heptalen-7-yl)- | | | acetamide, N-(5,6,7,9-tetrahydro-1,2,3, 10-tetramethoxy-9-oxobenzo(a)heptalen-7-yl)- | | | acetamide, N-(5,6,7,9-tetrahydro-1,2,3, 10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)- | | | acetamide, N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo(a)heptalen-7-yl)- | | | acetamide, N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo(a)heptalen-7-yl)-, (S)- | | | acetamide, N-[(7S)-5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl]- | | | colbenemid | | | colchicin | | (S)- | colchicine | | 7-a-H- | colchicine | | 7aH- | colchicine | | | colchicinum | | | colchisol | | | colsaloid | | | condylon | | N-((7S)-5,6,7,9- | tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo(a)heptalen-7-yl)-acetamide | | N-(5,6,7,9- | tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo(a)heptalen-7-yl)acetamide | | N-(5,6,7,9- | tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)-acetamide | | (S)-N-(5,6,7,9- | tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)acetamide | | N-[(7S)-5,6,7,9- | tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl]acetamide | | N-((7S)-1,2,3,10- | tetramethoxy-9-oxo-5,6,7-trihydrobenzo[d]heptalen-7-yl)acetamide | | N-((S)-1,2,3,10- | tetramethoxy-9-oxo-5,6,7,9-tetrahydro-benzo[a]heptalen-7-yl)-acetamide | | (S)-N-(1,2,3,10- | tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl)acetamide | | N-[(7S)-1,2,3,10- | tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl]acetamide | | N-[(7S)-1,2,3,10- | tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide |
Articles:
| PubMed:[ACCIDENTAL POISONING WITH A PLANT COLCHICUM AUTUMNALE: REPORT OF TWO CASES]. |
| PubMed:Mechanisms of DRA recycling in intestinal epithelial cells: effect of enteropathogenic E. coli. |
| PubMed:Phenotypic and Transcriptomic Analyses of Autotetraploid and Diploid Mulberry (Morus alba L.). |
| PubMed:A new synthetic allotetraploid (A1A1G2G2) between Gossypium herbaceum and G. australe: bridging for simultaneously transferring favorable genes from these two diploid species into upland cotton. |
| PubMed:Gout. |
| PubMed:Ruling revives gout drug competition. |
| PubMed:Colchicine: old and new. |
| PubMed:Protein extracts of Crassostrea gigas alleviate CCl₄-induced hepatic fibrosis in rats by reducing the expression of CTGF, TGF-β1 and NF-κB in liver tissues. |
| PubMed:Barley (Hordeum vulgare L.) transformation using embryogenic pollen cultures. |
| PubMed:Preheated autologous serum skin test in localized heat urticaria. |
| PubMed:The fate of chromosomes and alleles in an allohexaploid Brassica population. |
| PubMed:Meiotic chromosome pairing behaviour of natural tetraploids and induced autotetraploids of Actinidia chinensis. |
| PubMed:Effect of Cytochalasin B, Lantrunculin B, Colchicine, Cycloheximid, Dimethyl Sulfoxide and Ion Channel Inhibitors on Biospeckle Activity in Apple Tissue. |
| PubMed:Fatal colchicine poisoning by accidental ingestion of Colchicum persicum: a case report. |
| PubMed:Maori experiences and perceptions of gout and its treatment: a kaupapa Maori qualitative study. |
| PubMed:Intestinal absorption of lysozyme, an egg-white allergen, in rats: kinetics and effect of NSAIDs. |
| PubMed:Cellular uptake and transport of zein nanoparticles: effects of sodium caseinate. |
| PubMed:Leptin receptor neurons in the mouse hypothalamus are colocalized with the neuropeptide galanin and mediate anorexigenic leptin action. |
| PubMed:Latest evidence on gout management: what the clinician needs to know. |
| PubMed:Evaluation of drugs and stationary growth on the cell cycle of Giardia intestinalis. |
| PubMed:Rilonacept for colchicine-resistant or -intolerant familial Mediterranean fever: a randomized trial. |
| PubMed:Ovariectomized mouse uterotrophic assay of 36 chemicals. |
| PubMed:The role of the dentate gyrus in the formation of contextual representations. |
| PubMed:Assessment of the association between colchicine therapy and serious adverse events. |
| PubMed:Effects of grapefruit and Seville orange juices on the pharmacokinetic properties of colchicine in healthy subjects. |
| PubMed:Effect of cyclosporine on the pharmacokinetics of colchicine in healthy subjects. |
| PubMed:Are dosing adjustments required for colchicine in the elderly compared with younger patients? |
| PubMed:Purine-rich foods intake and recurrent gout attacks. |
| PubMed:G-protein-gated inwardly rectifying K+ channel 4 (GIRK4) immunoreactivity in chemically defined neurons of the hypothalamic arcuate nucleus that control body weight. |
| PubMed:Protective effect of isoorientin-2″-O-α-L-arabinopyranosyl isolated from Gypsophila elegans on alcohol induced hepatic fibrosis in rats. |
| PubMed:Therapeutic perspectives on uricases for gout. |
| PubMed:Triggers for attacks in familial Mediterranean fever: application of the case-crossover design. |
| PubMed:Forced degradation study of thiocolchicoside: characterization of its degradation products. |
| PubMed:Induced polyploidy dramatically increases the size and alters the shape of fruit in Actinidia chinensis. |
| PubMed:Pharmacokinetic optimization of 4-substituted methoxybenzoyl-aryl-thiazole and 2-aryl-4-benzoyl-imidazole for improving oral bioavailability. |
| PubMed:Gout. |
| PubMed:Nanocavity effect on photophysical properties of colchicine: a proof by circular dichroism study and picosecond time-resolved analysis in various reverse micellar assemblies. |
| PubMed:The effects of acrylamide on the frequency of megakaryocytic emperipolesis and the mitotic activity of rat bone marrow cells. |
| PubMed:Prevalence of contraindications and prescription of pharmacologic therapies for gout. |
| PubMed:Production of haploids and doubled haploids in oil palm. |
| PubMed:Incentives for drug development—the curious case of colchicine. |
| PubMed:Patients and providers view gout differently: a qualitative study. |
| PubMed:Protective effect of naringin, a citrus flavonoid, against colchicine-induced cognitive dysfunction and oxidative damage in rats. |
| PubMed:Campylobacter fetus translocation across Caco-2 cell monolayers. |
| PubMed:New agents for the treatment of gout and hyperuricemia: febuxostat, puricase, and beyond. |
| PubMed:Incentives for drug development--the curious case of colchicine. |
| PubMed:Febuxostat: a selective xanthine-oxidase/xanthine-dehydrogenase inhibitor for the management of hyperuricemia in adults with gout. |
| PubMed:Therapy of autoinflammatory syndromes. |
| PubMed:Something old, something new--colchicine in the 21st century. |
| PubMed:Multiple efflux pumps are involved in the transepithelial transport of colchicine: combined effect of p-glycoprotein and multidrug resistance-associated protein 2 leads to decreased intestinal absorption throughout the entire small intestine. |
| PubMed:Fabrication of an electrically heated indium-tin-oxide electrode for electrochemiluminescent detection system. |
| PubMed:AcMNPV EXON0 (AC141) which is required for the efficient egress of budded virus nucleocapsids interacts with beta-tubulin. |
| PubMed:Grapefruit juice and its constituents augment colchicine intestinal absorption: potential hazardous interaction and the role of p-glycoprotein. |
| PubMed:Carbendazim inhibits cancer cell proliferation by suppressing microtubule dynamics. |
| PubMed:Colchicine update: 2008. |
| PubMed:Simple and rapid extraction, separation, and detection of alkaloids in beverages. |
| PubMed:Drug interactions in dermatological practice. |
| PubMed:Simultaneous determination of thirteen plant alkaloids in a human specimen by SPE and HPLC. |
| PubMed:Gout. |
| PubMed:Deaths from intravenous colchicine resulting from a compounding pharmacy error--Oregon and Washington, 2007. |
| PubMed:Effect of curcumin on intracerebroventricular colchicine-induced cognitive impairment and oxidative stress in rats. |
| PubMed:Antimutagenic potential of curcumin on chromosomal aberrations in Allium cepa. |
| PubMed:Acute oral toxicity of colchicine in rats: effects of gender, vehicle matrix and pre-exposure to lipopolysaccharide. |
| PubMed:Hypothalamic proopiomelanocortin (POMC) neurons have a cholinergic phenotype. |
| PubMed:Essential mixed cryoglobulinemia type II. |
| PubMed:Specific effects of denaturation, hydrolysis and exposure to Lactococcus lactis on bovine beta-lactoglobulin transepithelial transport, antigenicity and allergenicity. |
| PubMed:[Sarcoidosis and obesity]. |
| PubMed:Determination of colchicine residues in sheep serum and milk using high-performance liquid chromatography combined with electrospray ionization ion trap tandem mass spectrometry. |
| PubMed:Adenomatous polyposis coli influences micronuclei induction by PhIP and acrylamide in mouse erythrocytes. |
| PubMed:Alterations of the M6p/Igf2 receptor gene in hepatocellular carcinomas induced by N-nitrosodiethylamine and a choline-deficient L-amino acid-defined diet in rats. |
| PubMed:Polymerization and calcium binding of the tubulin-colchicine complex in the GDP state. |
| PubMed:Active nuclear shuffling system using a swollen conidium of Trichoderma reesei. |
| PubMed:Peptides that regulate food intake: orexin gene expression is increased during states of hypertriglyceridemia. |
| PubMed:Campylobacter fetus adheres to and enters INT 407 cells. |
| PubMed:VMN/LHA functional inhibition in tumor-bearing rats suggests hypothalamic involvement in cancer anorexia. |
| PubMed:Deaths associated with inappropriate intravenous colchicine administration. |
| PubMed:Rapid selection system of strains with higher avicel degrading ability in a cellulolytic fungus, trichoderma. |
| PubMed:Effects of colchicine on parotid gland: structural and biochemical studies. |
| PubMed:Accidental plant poisoning with Colchicum autumnale: report of two cases. |
| PubMed:The ultrastructure of contractile tubules in the heliozoon Actinophrys sol and their possible involvement in rapid axopodial contraction. |
| PubMed:The stability of cytokeratin 18 in human liver cells during colchicine-induced microtubule disruption. |
| PubMed:Comparison of early feeding pattern dynamics in female and male rats after reversible ventromedial nucleus of hypothalamus block. |
| PubMed:Decreased 5-HT transporter mRNA in neurons of the dorsal raphe nucleus and behavioral depression in the obese leptin-deficient ob/ob mouse. |
| PubMed:Melanocortin signaling is decreased during neurotoxin-induced transient hyperphagia and increased body-weight gain. |
| PubMed:Dietary protection by iron against clastogenic effects of short-term exposure to arsenic in mice in vivo. |
| PubMed:Successive construction of cellulase hyperproducers of Trichoderma using hyperpolyploids. |
| PubMed:Absence of p16, p21 and p53 gene alterations in hepatocellular carcinomas induced by N-nitrosodiethylamine or a choline-deficient L-amino acid-defined diet in rats. |
| PubMed:Cellulase hyperproducers constructed from polyploids of Lentinus edodes. |
| PubMed:Miscellaneous treatments: thalidomide, potassium iodide, levamisole, clofazimine, colchicine, and D-penicillamine. |
| PubMed:Construction of cellulase hyperproducing strains derived from polyploids of Trichoderma reesei. |
| PubMed:Shiga toxins 1 and 2 translocate differently across polarized intestinal epithelial cells. |
| PubMed:Rats with hypothalamic obesity are insensitive to central leptin injections. |
| PubMed:Hypothalamic obesity: multiple routes mediated by loss of function in medial cell groups. |
| PubMed:Hypothalamic hypocretin (orexin): robust innervation of the spinal cord. |
| PubMed:Strain improvement of Aspergillus sp. and Penicillium sp. by induced mutation for biotransformation of alpha-pinene to verbenol. |
| PubMed:Potential strategies for ameliorating early cancer anorexia. |
| PubMed:Chromosome numbers of Tritrichomonas foetus and Tritrichomonas suis. |
| PubMed:Serotonin is not synthesized, but specifically transported in the neurons of the hypothalamic dorsomedial nucleus. |
| PubMed:Increased receptor sensitivity to neuropeptide Y in the hypothalamus may underlie transient hyperphagia and body weight gain. |
| PubMed:Hypothalamic ventromedial nuclei amplify circadian rhythms: do they contain a food-entrained endogenous oscillator? |
| PubMed:Lesions of the hippocampus or fornix do not interfere with the relative validity effect on a discrete stimulus or the context. |
| PubMed:Neuropeptide Y (NPY) Y1 receptor mRNA is upregulated in association with transient hyperphagia and body weight gain: evidence for a hypothalamic site for concurrent development of leptin resistance. |
| PubMed:Colchicine down-regulates lipopolysaccharide-induced granulocyte-macrophage colony-stimulating factor production in murine macrophages. |
| PubMed:Systematic comparison of the effects of hippocampal and fornix-fimbria lesions on acquisition of three configural discriminations. |
| PubMed:The hypothalamic ventromedial nuclei couple activity in the hypothalamo-pituitary-adrenal axis to the morning fed or fasted state. |
| PubMed:Effect of colchicine-induced cell loss in the dentate gyrus and Ammon's horn on the olfactory control of feeding in rats. |
| PubMed:Clastogenic activity of pure chlorophyll and anticlastogenic effects of equivalent amounts of crude extract of Indian spinach leaf and chlorophyllin following dietary supplementation to mice. |
| PubMed:Axonal transport of manganese and its relevance to selective neurotoxicity in the rat basal ganglia. |
| PubMed:Studies on the mechanism of intestinal passage of the food comutagen harman, in the rabbit. |
| PubMed:Review of alcoholic hepatitis, and its treatment. |
| PubMed:[An inhibitory analysis of the role of the enterocyte cytoskeleton in the absorption of food substances in the small intestine]. |
| PubMed:Structure and function of the cytoskeleton in heliozoa: 2. Measurement of the force of rapid axopodial contraction in Echinosphaerium. |
| PubMed:Drugs affecting microtubule dynamics increase alpha-tubulin mRNA accumulation via transcription in Tetrahymena thermophila. |
| PubMed:Interaction of forskolin with the P-glycoprotein multidrug transporter. |
| PubMed:Metabolism and secretion of retinol transport complex in acute renal failure. |
| PubMed:Processing of the lipid-mobilizing peptide beta-lipotropin in rabbit adipose tissue. |
| PubMed:Quantitative contribution of factors regulating rat colonic crypt epithelium: role of parenteral and enteral feeding, caloric intake, dietary cellulose level and the colon carcinogen DMH. |
| PubMed:The in vivo erythrocyte micronucleus test: measurement at steady state increases assay efficiency and permits integration with toxicity studies. |
| PubMed:Ultrastructural localization of neuropeptide Y in the hypothalamus. |
| PubMed:Effect of colchicine and vincristine on DNA synthesis in regenerating rat liver. |
| PubMed:Colchicine-induced alterations of reference memory in rats: role of spatial versus non-spatial task components. |
| PubMed:Transport of beta-lactoglobulin across rabbit ileum in vitro. |
| PubMed:Fetal hippocampal cell suspensions ameliorate behavioral effects of intradentate colchicine in the rat. |
| PubMed:Radial-arm maze deficits produced by colchicine administered into the area of the nucleus basalis are ameliorated by cholinergic agents. |
| PubMed:The effects of a reversible colchicine-induced lesion of the anterior ventral region of the third cerebral ventricle in rats. |
| PubMed:Enhancement of concurrent yield of spermatogonial, meiotic I, and meiotic II metaphase chromosomes from Chinese hamster testes. |
| PubMed:Sister chromatid exchange induced by metanil yellow and nitrite singly and in combination in vivo on mice. |
| PubMed:The 'tomato effect' in clinical nutrition. New treatments languishing on the vine? |
| PubMed:Cyclic nucleotides in goats' milk: changes with physiological state. |
| PubMed:The efficacy of colchicine prophylaxis in articular gout--a reappraisal after 20 years. |
| PubMed:Mobilization of a peptide neurohormone for release during a physiological secretion cycle. |
| PubMed:Rapid taste-aversion learning by an isolated molluscan central nervous system. |
| PubMed:Changes in proliferation and surface morphology in the rat ileum in response to total parenteral nutrition. |
| PubMed:Effects of intranasal irrigation with mitotic inhibitors on olfactory behavior and biochemistry in mice. |
| PubMed:Reversible hyperphagia and obesity following intracerebral microinjections of colchicine into the ventromedial hypothalamus of the rat. |
| PubMed:DNA synthesis and cell proliferation in the simple liver acinus of 10 to 20-day-old rats: evidence for cell fusion. |
| PubMed:Effects of colchicine and cycloheximide on the functional and non-functional lipoprotein lipase fractions of rat heart. |
| PubMed:Motility in Echinosphaerium nucleofilum. II. Cytoplasmic contractility and its molecular basis. |
| PubMed:Colchicine-induced inhibition of plasma lipoprotein lipase release in the intact rat. |
| PubMed:Current medical practice and the Food and Drug Administration. Some evidence for the existing gap. |
| PubMed:A new method of measuring the rate of shedding of epithelial cells from the intestinal villus of the rat. |
| PubMed:The effect of colchicine on visible alimentary lipemia. |
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3D/inchi