EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

chrysin
5,7-dihydroxyflavone

Supplier Sponsors

Name:5,7-dihydroxy-2-phenylchromen-4-one
CAS Number: 480-40-0Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:207-549-7
FDA UNII: 3CN01F5ZJ5
Nikkaji Web:J1.544J
Beilstein Number:0233276
MDL:MFCD00006834
XlogP3:2.10 (est)
Molecular Weight:254.24150000
Formula:C15 H10 O4
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:cosmetic agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 285.50 °C. @ 760.00 mm Hg
Boiling Point: 491.91 °C. @ 760.00 mm Hg (est)
Flash Point: 378.00 °F. TCC ( 192.50 °C. ) (est)
logP (o/w): 3.520
Soluble in:
 water, 84 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: skin conditioning
 
Suppliers:
AIDP
Chrysin Passiflora caerulea, flavone x 99% min.
Alfa Biotechnology
For experimental / research use only.
Chrysin 98%
BOC Sciences
For experimental / research use only.
Chrysin >98%
Odor: characteristic
Use: Chrysin is a naturally occurring flavone chemically extracted from the blue passion flower.At high concentrations, chrysin is reported to be an aromatase inhibitor in vitro.
Changsha Organic Herb
Chrysin Passiflora coerulea Extract
Changzhou Longo Chemical
Chrysin
ExtraSynthese
For experimental / research use only.
Chrysin (HPLC) ≥90%
Glentham Life Sciences
Chrysin
Maypro Industries
Chrysin
Sabinsa Corporation
Chrysin
Santa Cruz Biotechnology
For experimental / research use only.
Chrysin ≥96%
Shaanxi Y-Herb Biotechnology
Chrysine Chrysin Powder 98% 99% Oroxylum Indicum Extract 5 7- Dihydroxyflavone
Sigma-Aldrich: Aldrich
For experimental / research use only.
Chrysin 97%
sds
TCI AMERICA
For experimental / research use only.
Chrysin >98.0%(HPLC)(T)
sds
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
cosmetic agents
Recommendation for chrysin usage levels up to:
 not for fragrance use.
 
Recommendation for chrysin flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :5281607
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
5,7-dihydroxy-2-phenylchromen-4-one
Chemidplus:0000480400
RTECS:LK8329050 for cas# 480-40-0
 
References:
 5,7-dihydroxy-2-phenylchromen-4-one
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:480-40-0
Pubchem (cid):5281607
Pubchem (sid):134974344
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
Golm Metabolome Database:Search
KEGG (GenomeNet):C10028
HMDB (The Human Metabolome Database):HMDB36619
FooDB:FDB015535
Export Tariff Code:2932.99.7000
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 carrot seed
Search Trop Picture
 cherry sour cherry plant
Search Trop Picture
 dysphania graveolens
Search Trop Picture
 
Synonyms:
4H-1-benzopyran-4-one, 5,7-dihydroxy-2-phenyl-
4H-1-benzopyran-4-one, 5,7-dihydroxy-2-phenyl- (9CI)
 chrysidenon 1438
5,7-dihydroxy-2-phenyl-4H-1-benzopyran-4-one
5,7-dihydroxy-2-phenyl-4H-benzo(b)pyran-4-one
5,7-dihydroxy-2-phenyl-4H-chromen-4-one
5,7-dihydroxy-2-phenyl-chromen-4-one
5,7-dihydroxy-2-phenylchromen-4-one
5,7-dihydroxy-flavone
5,7-dihydroxyflavone
 galangin flavanone
5,7-hydroxyflavone
 

Articles:

PubMed:Chemical Composition of the Essential Oils of Three Endemic Species of Anthemis Sect. Hiorthia (DC.) R.Fern. Growing Wild in Sicily and Chemotaxonomic Volatile Markers of the Genus Anthemis L.: An Update.
PubMed:Anthelmintic activity of crude extract and essential oil of Tanacetum vulgare (Asteraceae) against adult worms of Schistosoma mansoni.
PubMed:TLC-direct bioautography for determination of antibacterial activity of Artemisia adamsii essential oil.
PubMed:Central α- and β-thujone: similar anxiogenic-like effects and differential modulation on GABAA receptors in neonatal chicks.
PubMed:Chemical characterization by GC-MS and in vitro activity against Candida albicans of volatile fractions prepared from Artemisia dracunculus, Artemisia abrotanum, Artemisia absinthium and Artemisia vulgaris.
PubMed:Chemical composition and general toxicity of essential oils extracted from the aerial parts of Artemisia armeniaca Lam. and A. incana (L.) Druce growing in Iran.
PubMed:Chemotype diversity of indigenous Dalmatian sage (Salvia officinalis L.) populations in Montenegro.
PubMed:Differences in shoot and root terpenoid profiles and plant responses to fertilisation in Tanacetum vulgare.
PubMed:Study on Gas Chromatography-Mass Spectrometry Fingerprint of Acanthopanax brachypus.
PubMed:Chemopreventive and antioxidant activity of the chamazulene-rich essential oil obtained from Artemisia arborescens L. growing on the Isle of La Maddalena, Sardinia, Italy.
PubMed:Comparison of different extraction methods for the determination of α- and β-thujone in sage (Salvia officinalis L.) herbal tea.
PubMed:Toxicokinetics of α-thujone following intravenous and gavage administration of α-thujone or α- and β-thujone mixture in male and female F344/N rats and B6C3F1 mice.
PubMed:Identification of 1,8-cineole, borneol, camphor, and thujone as anti-inflammatory compounds in a Salvia officinalis L. infusion using human gingival fibroblasts.
PubMed:Identification of genes in Thuja plicata foliar terpenoid defenses.
PubMed:Attempts to separate (-)-α-thujone, (+)-β-thujone epimers from camphor enantiomers by enantioselective HPLC with polarimetric detection.
PubMed:Monoterpene α-thujone exerts a differential inhibitory action on GABA(A) receptors implicated in phasic and tonic GABAergic inhibition.
PubMed:Antibacterial, allelopathic and antioxidant activities of essential oil of Salvia officinalis L. growing wild in the Atlas Mountains of Morocco.
PubMed:Thujone and thujone-containing herbal medicinal and botanical products: toxicological assessment.
PubMed:Essential oil variation in the populations of Artemisia spicigera from northwest of Iran: chemical composition and antibacterial activity.
PubMed:Essential oils and their compositions as spatial repellents for pestiferous social wasps.
PubMed:Chemical composition and antimicrobial activity of essential oils from Scabiosa arenaria Forssk: growing wild in Tunisia.
PubMed:Modulation of GABAergic synaptic currents and current responses by α-thujone and dihydroumbellulone.
PubMed:Chemical composition and antifungal activity of Artemisia nilagirica essential oil growing in northern hilly areas of India.
PubMed:Composition of the essential oil of Origanum tyttanthum from Tajikistan.
PubMed:Seasonal influence on gene expression of monoterpene synthases in Salvia officinalis (Lamiaceae).
PubMed:Toxicology and carcinogenesis studies of alpha,beta-thujone (CAS No. 76231-76-0) in F344/N rats and B6C3F1 mice (gavage studies).
PubMed:Distribution and chemical polymorphism of the essential oils of Achillea cartilaginea growing wild in Lithuania.
PubMed:Thujone inhibits lung metastasis induced by B16F-10 melanoma cells in C57BL/6 mice.
PubMed:Augmentation of humoral and cell mediated immune responses by Thujone.
PubMed:Determination of the biologically active flavour substances thujone and camphor in foods and medicines containing sage (Salvia officinalis L.).
PubMed:Thujone corrects cholesterol and triglyceride profiles in diabetic rat model.
PubMed:Modulation of genotoxicity and DNA repair by plant monoterpenes camphor, eucalyptol and thujone in Escherichia coli and mammalian cells.
PubMed:Skeletal muscle fatty acid oxidation is not directly associated with AMPK or ACC2 phosphorylation.
PubMed:Morphological characterisation and agronomical parameters of different species of Salvia sp. (Lamiaceae).
PubMed:Oil constituents of Artemisia nilagirica var. septentrionalis growing at different altitudes.
PubMed:Chemical composition and antibacterial potential of Artemisia arborescens L. essential oil.
PubMed:Metabolism of α-thujone in human hepatic preparations in vitro.
PubMed:Composition and intraspecific chemical variability of the essential oil from Artemisia herba-alba growing wild in a Tunisian arid zone.
PubMed:Influence of ionic interactions on essential oil and phenolic diterpene composition of Dalmatian sage (Salvia officinalis L.).
PubMed:Insecticidal activity and chemical composition of the essential oils of Artemisia lavandulaefolia and Artemisia sieversiana from China.
PubMed:Risk assessment of thujone in foods and medicines containing sage and wormwood--evidence for a need of regulatory changes?
PubMed:Chemical composition of the essential oil of Salvia officinalis L. from Romania.
PubMed:Thujone, a component of medicinal herbs, rescues palmitate-induced insulin resistance in skeletal muscle.
PubMed:Antimicrobial activity and essential oil composition of a new T. argyrophyllum (C. Koch) Tvzel var. argyrophyllum chemotype.
PubMed:Essential oil composition of Achillea clusiana from Bulgaria.
PubMed:Influence of gibberellin and daminozide on the expression of terpene synthases and on monoterpenes in common sage (Salvia officinalis).
PubMed:Artemisia fukudo essential oil attenuates LPS-induced inflammation by suppressing NF-kappaB and MAPK activation in RAW 264.7 macrophages.
PubMed:Antibacterial and antioxidant activities of the essential oil of Artemisia echegarayi Hieron. (Asteraceae).
PubMed:Chemosystematic value of the essential oil composition of Thuja species cultivated in Poland-antimicrobial activity.
PubMed:Variations in essential oil, phenolic compounds, and antioxidant activity of tunisian cultivated Salvia officinalis L.
PubMed:Absinthe, epileptic seizures and Valentin Magnan.
PubMed:Compositional variation of the essential oils of Artemisia afra Jacq. from three provinces in South Africa--a case study of its safety.
PubMed:Motile cilia of human airway epithelia are chemosensory.
PubMed:Essential oil composition of Tanacetum vulgare subsp. siculum (Guss.) Raimondo et Spadaro (Asteraceae) from Sicily.
PubMed:Essential oil composition of Artemisia herba-alba from southern Tunisia.
PubMed:Cytotoxicity, antimicrobial activity and composition of essential oil from Tanacetum balsamita L. subsp. balsamita.
PubMed:Long-term stability of thujone, fenchone, and pinocamphone in vintage preban absinthe.
PubMed:Chemical composition of the essential oil of Achillea umbellata growing in Greece.
PubMed:Cooperative effects on radical recombination in CYP3A4-catalyzed oxidation of the radical clock beta-thujone.
PubMed:Chemical composition of the essential oil of Artemisia absinthium growing wild in Iran.
PubMed:Tunisian Salvia officinalis L. and Schinus molle L. essential oils: their chemical compositions and their preservative effects against Salmonella inoculated in minced beef meat.
PubMed:[Thujone-attributable effects of absinthe are only an urban legend--toxicology uncovers alcohol as real cause of absinthism].
PubMed:Chemical composition of vintage preban absinthe with special reference to thujone, fenchone, pinocamphone, methanol, copper, and antimony concentrations.
PubMed:Tick repellent substances in the essential oil of Tanacetum vulgare.
PubMed:[Thujone].
PubMed:Absinthe and tobacco--a new look at an old problem? (Comment on: Absinthe--is its history relevant for current public health?).
PubMed:Insecticidal properties of essential oils from Lippia turbinata and Lippia polystachya (Verbenaceae) against Culex quinquefasciatus (Diptera: Culicidae).
PubMed:[Chemical diversity of the biological active ingredients of salvia officinalis and some closely related species].
PubMed:[Absinthe - history of dependence to thujone or to alcohol?].
PubMed:Composition of the essential oil of Salvia officinalis L. from various European countries.
PubMed:Chemical composition and antifungal activity of the essential oils of three species of Artemisia on some soil-borne phytopathogens.
PubMed:The essential oil of Solvia cabulica.
PubMed:Biotransformation of terpenoids by mammals, microorganisms, and plant-cultured cells.
PubMed:Phytochemical analysis of the essential oil of Achillea millefolium L. from various European Countries.
PubMed:Absinthe--a review.
PubMed:Antimutagenic effect of essential oil of sage (Salvia officinalis L.) and its monoterpenes against UV-induced mutations in Escherichia coli and Saccharomyces cerevisiae.
PubMed:Absinthe, the nervous system and painting.
PubMed:Radical intermediates in the catalytic oxidation of hydrocarbons by bacterial and human cytochrome P450 enzymes.
PubMed:Vapor phase toxicity of marjoram oil compounds and their related monoterpenoids to Blattella germanica (Orthoptera: Blattellidae).
PubMed:Antiviral activities of extracts and selected pure constituents of Ocimum basilicum.
PubMed:Thujone--cause of absinthism?
PubMed:Absinthe: attention performance and mood under the influence of thujone.
PubMed:Biosynthesis of the irregular monoterpene artemisia ketone, the sesquiterpene germacrene D and other isoprenoids in Tanacetum vulgare L. (Asteraceae).
PubMed:Alpha- and beta-thujone radical rearrangements and isomerizations. A new radical clock.
PubMed:Radical rebound mechanism in cytochrome P-450-catalyzed hydroxylation of the multifaceted radical clocks alpha- and beta-thujone.
PubMed:The human taste receptor hTAS2R14 responds to a variety of different bitter compounds.
PubMed:Chemotypical variation of tansy (Tanacetum vulgare L.) from 40 different locations in Norway.
PubMed:Alpha-thujone reduces 5-HT3 receptor activity by an effect on the agonist-reduced desensitization.
PubMed:GC analysis of essential oils in the rumen fluid after incubation of Thuja orientalis twigs in the Rusitec system.
PubMed:Plant odour processing in the antennal lobe of male and female grapevine moths, Lobesia botrana (Lepidoptera: Tortricidae).
PubMed:Volatile metabolites from Salvia fruticosa as antifungal agents in soilborne pathogens.
PubMed:Essential oils produced by in vitro shoots of sage (Salvia officinalis L.).
PubMed:Composition and antimicrobial activity of the essential oil of Artemisia absinthium from Croatia and France.
PubMed:[Studies of volatile oils from the flowers of Chrysanthemum nankingense and Chrysanthemum indicum].
PubMed:Monoterpene effect on feeding choice by deer.
PubMed:Absinthe: enjoying a new popularity among young people?
PubMed:Composition and antimicrobial activity of the essential oil of Achillea multifida.
PubMed:Absinthe: return of the Green Fairy.
PubMed:Seasonal changes in the composition of the essential oil extract of East Mediterranean sage (Salvia libanotica) and its toxicity in mice.
PubMed:Detoxification of alpha- and beta-Thujones (the active ingredients of absinthe): site specificity and species differences in cytochrome P450 oxidation in vitro and in vivo.
PubMed:Towards the industrial production of medicinal tincture by ultrasound assisted extraction.
PubMed:alpha- and beta-Thujones (herbal medicines and food additives): synthesis and analysis of hydroxy and dehydro metabolites.
PubMed:Acaricidal properties of Artemisia absinthium and Tanacetum vulgare (Asteraceae) essential oils obtained by three methods of extraction.
PubMed:Absinthe and gamma-aminobutyric acid receptors.
PubMed:Alpha-thujone (the active component of absinthe): gamma-aminobutyric acid type A receptor modulation and metabolic detoxification.
PubMed:Absinthe: what's your poison? Though absinthe is intriguing, it is alcohol in general we should worry about.
PubMed:Essential oils from dalmatian sage (Salvia officinalis l.): variations among individuals, plant parts, seasons, and sites.
PubMed:Thujone exhibits low affinity for cannabinoid receptors but fails to evoke cannabimimetic responses.
PubMed:Absinthe--return of the green fairy.
PubMed:Comparison of conventional and ultrasonically assisted extractions of pharmaceutically active compounds from Salvia officinalis.
PubMed:Porphyrogenic properties of the terpenes camphor, pinene, and thujone (with a note on historic implications for absinthe and the illness of Vincent van Gogh).
PubMed:Floral volatiles ofTanacetum vulgare L. attractive toLobesia botrana den. et schiff. females.
PubMed:Volatile Constituents of Achillea grandifolia.
PubMed:Another diagnosis for Vincent Van Gogh?
PubMed:Terpenoid biotransformation in mammals. V. Metabolism of (+)-citronellal, (+-)-7-hydroxycitronellal, citral, (-)-perillaldehyde, (-)-myrtenal, cuminaldehyde, thujone, and (+-)-carvone in rabbits.
PubMed:Absinthe.
PubMed:Vincent van Gogh and the thujone connection.
PubMed:Metabolism of monoterpenes: specificity of the dehydrogenases responsible for the biosynthesis of camphor, 3-thujone, and 3-isothujone.
PubMed:A study on tansy chemotypes.
PubMed:Isolation and identification of mosquito repellents inArtemisia vulgaris.
PubMed:Quantitative analysis of alpha, beta-thujone, pulegone, safrole, coumarin and beta-asarone in alcoholic beverages by selected-ion monitoring.
PubMed:Constituents of the Essential Oil of Artemisia coerulescens.
PubMed:[Condensation of thujone with biogenic amines and amino acids].
PubMed:Absinthe: behind the emerald mask.
PubMed:Van Gogh's vision: thujone intoxication.
 
Notes:
Chrysin is a naturally occurring flavone chemically extracted from the blue passion flower (Passiflora caerulea). Honeycomb also contains small amounts. It is also reported in Oroxylum indicum or Indian trumpetflower. [Wikipedia]
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