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Category:cosmetic ingredient for skin conditioning
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00
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| Food Chemicals Codex Listed: | No |
| Boiling Point: | 493.28 °C. @ 760.00 mm Hg (est)
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| Flash Point: | 480.00 °F. TCC ( 248.80 °C. ) (est)
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| logP (o/w): | 10.542 (est) |
| Soluble in: |
| | water, 9.679e-006 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
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Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | | cosmetic ingredient for skin conditioning |
| Recommendation for cholesteryl acetate usage levels up to: | | | not for fragrance use.
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| Recommendation for cholesteryl acetate flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | acetic acid cholesteryl ester | | | cholest-5-en-3-beta-yl acetate | | (3b)- | cholest-5-en-3-yl acetate | | | cholesterin acetate | | | cholesterol acetate | | | cholesterylacetate |
Articles:
| PubMed:The caveolin-binding motif of the pathogen-related yeast protein Pry1, a member of the CAP protein superfamily, is required for in vivo export of cholesteryl acetate. |
| PubMed:3β,6α-Diacet-oxy-5,9α-dihy-droxy-5α-cholest-7-en-11-one. |
| PubMed:3β,6β-Diacet-oxy-5,9α-dihy-droxy-5α-cholest-7-en-11-one acetic acid 0.04-solvate. |
| PubMed:Pathogen-Related Yeast (PRY) proteins and members of the CAP superfamily are secreted sterol-binding proteins. |
| PubMed:Conformational analyses of bacillomycin D, a natural antimicrobial lipopeptide, alone or in interaction with lipid monolayers at the air-water interface. |
| PubMed:Interaction of annexin A6 with cholesterol rich membranes is pH-dependent and mediated by the sterol OH. |
| PubMed:A robust, sensitive, and versatile HMBC experiment for rapid structure elucidation by NMR: IMPACT-HMBC. |
| PubMed:Deconvolution of complex NMR spectra in small molecules by multi frequency homonuclear decoupling (MDEC). |
| PubMed:Prediction of solubility of drugs and other compounds in organic solvents. |
| PubMed:Cholesterol hemisuccinate: a selective inhibitor of family X DNA polymerases. |
| PubMed:Steroid structural requirements for interaction of ostreolysin, a lipid-raft binding cytolysin, with lipid monolayers and bilayers. |
| PubMed:Regio and stereoselective oxidations of unsaturated steroidal compounds with H2O2 mediated by CH3ReO3. |
| PubMed:High throughput quantification of cholesterol and cholesteryl ester by electrospray ionization tandem mass spectrometry (ESI-MS/MS). |
| PubMed:Cholesterol and its anionic derivatives inhibit 5-lipoxygenase activation in polymorphonuclear leukocytes and MonoMac6 cells. |
| PubMed:Polar head group interactions in mixed Langmuir monolayers. |
| PubMed:Percolation phenomenon in mixed reverse micelles: the effect of additives. |
| PubMed:Theoretical and vibrational spectroscopic analysis of the CO stretching mode of cholesteryl alkanoates: the particular case of the cholesteryl acetate. |
| PubMed:Methylene spectral editing in solid-state 13C NMR by three-spin coherence selection. |
| PubMed:Synthesis of polyhydroxysterols (V): efficient and stereospecific synthesis of 24-methylene-cholest-5-ene-3beta,7alpha-diol and its C-7 epimer. |
| PubMed:A new electrochemical system for stereoselective allylic hydroxylation of cholesteryl acetate with dioxygen induced by iron picolinate complexes. |
| PubMed:In vitro fibrillogenesis of the amyloid beta 1-42 peptide: cholesterol potentiation and aspirin inhibition. |
| PubMed:Rhodium(II,II) dimer as an efficient catalyst for aziridination of sulfonamides and amidation of steroids. |
| PubMed:Interaction of the Vibrio cholerae cytolysin (VCC) with cholesterol, some cholesterol esters, and cholesterol derivatives: a TEM study. |
| PubMed:Metalloporphyrin-mediated asymmetric nitrogen-atom transfer to hydrocarbons: aziridination of alkenes and amidation of saturated C-H bonds catalyzed by chiral ruthenium and manganese porphyrins. |
| PubMed:Platelet-activating factor acetylhydrolase and transacetylase activities in human plasma low-density lipoprotein. |
| PubMed:Sterols and sphingolipids strongly affect the growth of fusion pores induced by the hemagglutinin of influenza virus. |
| PubMed:ORSAT and modifications of SEFT and APT. |
| PubMed:Simultaneous quantitation of ceramides and 1,2-diacylglycerol in tissues by Iatroscan thin-layer chromatography-flame-ionization detection. |
| PubMed:Enhanced arachidonic acid and calcium metabolism in cholesteryl sulfate-enriched rat platelets. |
| PubMed:Influence of the molecular structure of steroids on their ability to interrupt gap junctional communication. |
| PubMed:Occurrence and biological effects of cholesteryl sulfate on blood platelets. |
| PubMed:Effect of sterol structure on molecular interactions and lateral domain formation in monolayers containing dipalmitoyl phosphatidylcholine. |
| PubMed:Enhanced susceptibility of cholesteryl sulfate-enriched low density lipoproteins to copper-mediated oxidation. |
| PubMed:Structures of nanoparticles prepared from oil-in-water emulsions. |
| PubMed:Identification of thermal oxidation products of cholesteryl acetate. |
| PubMed:Cholesteryl esters on the body surfaces of the camel tick, Hyalomma dromedarii (Koch, 1844) and the brown dog tick, Rhipicephalus sanguineus (Latreille, 1806). |
| PubMed:Protection against carbon tetrachloride-induced hepatotoxicity by pretreating rats with the hemisuccinate esters of tocopherol and cholesterol. |
| PubMed:A method for the preparation of submicron particles of sparingly water-soluble drugs by precipitation in oil-in-water emulsions. II: Influence of the emulsifier, the solvent, and the drug substance. |
| PubMed:A method for the preparation of submicron particles of sparingly water-soluble drugs by precipitation in oil-in-water emulsions. I: Influence of emulsification and surfactant concentration. |
| PubMed:Crystal structure and thermal vibrations of cholesteryl acetate from neutron diffraction at 123 and 20 K. |
| PubMed:Quantitative determination of 1,2-diacylglycerol in thoracic aorta of the rat using Iatroscan TLC/FID: effect of norepinephrine. |
| PubMed:Thermodynamics of water-induced precipitation of cholesterol and its acetate, benzoate and stearate derivatives dissolved in 1,4-dioxane and 2-propanol. |
| PubMed:Chromatographic separation of cholesteryl acetate and its chloro analogues. |
| PubMed:Covalent interaction of chloroacetic and acetic acids with cholesterol. |
| PubMed:Quantitation of 1,2-diacylglycerol in rat heart by iatroscan TLC/FID. |
| PubMed:Acyl-chain specificity and properties of cholesterol esterases from normal and Wolman lymphoid cell lines. |
| PubMed:Characterization of multiple forms of cholesteryl ester hydrolase in the rat testis. |
| PubMed:The effect of the sterol oxygen function on the interaction with phospholipids. |
| PubMed:Structural requirement of sterol nucleus for the silkworm growth and development. |
| PubMed:On the role of the sterol hydroxyl group in membranes. |
| PubMed:Tissue fixation by osmium tetroxide. A possible role for proteins. |
| PubMed:Surface tension lowering and dissolution rate of hydrocortisone from solid solutions of selected n-acyl esters of cholesterol. |
| PubMed:Studies on the cholesterol ester hydrolase of Trogoderma (Coleoptera). |
| PubMed:Cholesterol in amniotic fluid, determined by gas chromatography. |
| PubMed:Oral absorption efficiency of acid-labile antibiotics from lipid-drug delivery systems. |
| PubMed:Properties of cholesteryl esters in pure and mixed monolayers. |
| PubMed:The interaction of nitrogen dioxide with monomolecular films of cholesterol, dihydrocholesterol, and cholesteryl acetate. |
| PubMed:Ionic channels and nerve membrane lipids. Cholesterol-tetrodotoxin interaction. |
| PubMed:Purification and properties of esterases characteristic of adult rat brain. |
| PubMed:Synthesis, purification and characterization of 7-ketocholesterol and epimeric 7-hydroxycholesterols. |
| PubMed:Substrate and inhibitor specificity of the cholesterol oxidase in bovine adrenal cortex. |
| PubMed:Preparation of bicholestatriene from cholesteryl-acetate. |
| PubMed:THE MECHANISM OF THE INHIBITION OF HEMOLYSIS : III. INHIBITION BY SOLS OF SUBSTANCES RELATED TO CHOLESTEROL. |
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Cholesteryl acetate is a normal human cholesteryl ester present in diverse fluids and organs. Cholesteryl acetate is also present in foods. Food oxidation affects the quality and safety of the human diet by generating compounds with biological activities that can adversely affect health. In particular the susceptibility of cholesterol to oxidation is well known; certain products of cholesterol oxidation have been reported to produce cytotoxic, angiotoxic and carcinogenic effects. Cholesteryl ester (CE) is the major transport and storage form of cholesterol in lipoprotein particles and most cell types. Molecular composition of CE species is of high interest for arteriosclerosis research, i.e., as components of lipoprotein subclasses or in studies investigating the mechanisms involved in the generation of lipid laden foam cells. Thus, it has been shown that CE species in circulating plasma are strongly correlated with development of coronary heart disease. This may be related to specific CE species profiles generated by enzymes involved in lipoprotein metabolism like lecithin:cholesterol acyltransferase (EC 2.3.1.43, LCAT), acyl-coenzyme A:cholesterol acyltransferase 2 (EC 2.3.1.26, ACAT2) or cholesteryl ester transfer protein (CETP). The cholesteryl ester transfer protein has a key role in the metabolism of high-density lipoprotein (HDL), mediating the exchange of lipids between lipoproteins, resulting in the net transfer of cholesteryl ester from HDL to other lipoproteins and in the subsequent uptake of cholesterol by hepatocytes. By increasing the cholesteryl ester content of low-density and very-low-density lipoproteins, CETP promotes the atherogenicity of these lipoproteins. In addition, high plasma concentrations of CETP are associated with reduced concentrations of HDL cholesterol. (PMID: 10918380, 16458590, 9420339, 3343104, 6721900, 7278520) [HMDB]
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3D/inchi