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chloromethyl methyl ether
methylchloromethyl ether

Supplier Sponsors

Name:	chloro(methoxy)methane
CAS Number:	107-30-2	3D/inchi
ECHA EINECS - REACH Pre-Reg:	203-480-1
FDA UNII:	334G5B96VG
Nikkaji Web:	J4.063K
Beilstein Number:	0505943
MDL:	MFCD00000885
XlogP3-AA:	0.80 (est)
Molecular Weight:	80.51305000
Formula:	C2 H5 Cl O
BioActivity Summary:	listing
NMR Predictor:	Predict (works with chrome, Edge or firefox)

Category:polymer substances and polymer adjuvants for food treatment

US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:

Google Scholar:	Search
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EU Patents:	Search
Pubchem Patents:	Search
PubMed:	Search
NCBI:	Search
FDA Mainterm (SATF):	107-30-2 ; CHLOROMETHYL METHYL ETHER
FDA Regulation:
FDA PART 173 -- SECONDARY DIRECT FOOD ADDITIVES PERMITTED IN FOOD FOR HUMAN CONSUMPTION Subpart A--Polymer Substances and Polymer Adjuvants for Food Treatment Sec. 173.20 Ion-exchange membranes.

Physical Properties:

Assay:	95.00 to 100.00
Food Chemicals Codex Listed:	No
Specific Gravity:	1.06000 @ 25.00 °C.
Boiling Point:	59.00 to 60.00 °C. @ 760.00 mm Hg
Vapor Pressure:	30.000000 mmHg @ 22.00 °C.
Flash Point:	60.00 °F. TCC ( 15.56 °C. )
logP (o/w):	0.320
Soluble in:
	water, 6.944e+004 mg/L @ 25 °C (est)

Organoleptic Properties:

Odor and/or flavor descriptions from others (if found).

Cosmetic Information:

CosIng:	cosmetic data
Cosmetic Uses:

Suppliers:

Sigma-Aldrich: Aldrich

For experimental / research use only.

Chloromethyl methyl ether technical grade

Safety Information:

Preferred SDS: View
European information :
Most important hazard(s):
R 02 - Risk of explosion by shock, friction, fire or other sources of ignition.
R 11 - Highly flammable. R 20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R 45 - May cause cancer. S 01/02 - Keep locked up and out of the reach of children. S 53 - Avoid exposure - obtain special instructions before use. S 45 - In case of accident or if you feel unwell seek medical advice immediately.

Hazards identification

Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements

Pictogram

Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
inhalation-rat LC50 55 ppm/7H LUNGS, THORAX, OR RESPIRATION: CHRONIC PULMONARY EDEMA BLOOD: HEMORRHAGE Archives of Environmental Health. Vol. 30, Pg. 61, 1975. inhalation-hamster LC50 65 ppm/7H (65 LUNGS, THORAX, OR RESPIRATION: CHRONIC PULMONARY EDEMA BLOOD: HEMORRHAGE Archives of Environmental Health. Vol. 30, Pg. 61, 1975. inhalation-mouse LC50 1030 mg/m3/2H "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 89, 1982.

Safety in Use Information:

Category:
polymer substances and polymer adjuvants for food treatment
Recommendation for chloromethyl methyl ether usage levels up to:
	not for fragrance use.

Recommendation for chloromethyl methyl ether flavor usage levels up to:
	not for flavor use.

Safety References:

EPI System: View

EPA-Iris:IRIS

NIOSH International Chemical Safety Cards:search

NIOSH Pocket Guide:search

Chemical Carcinogenesis Research Information System:Search

AIDS Citations:Search

Cancer Citations:Search

Toxicology Citations:Search

Carcinogenic Potency Database:Search

EPA GENetic TOXicology:Search

EPA Substance Registry Services (TSCA):107-30-2

EPA ACToR:Toxicology Data

EPA Substance Registry Services (SRS):Registry

Laboratory Chemical Safety Summary :7864

National Institute of Allergy and Infectious Diseases:Data

WISER:UN 1239

chloro(methoxy)methane

Chemidplus:0000107302

EPA/NOAA CAMEO:hazardous materials

References:

	chloro(methoxy)methane
NIST Chemistry WebBook:	Search Inchi
Canada Domestic Sub. List:	107-30-2
Pubchem (cid):	7864
Pubchem (sid):	134972416

Other Information:

(IUPAC):	Atomic Weights of the Elements 2011 (pdf)
Videos:	The Periodic Table of Videos
tgsc:	Atomic Weights use for this web site
(IUPAC):	Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS):	View
CHEBI:	View
CHEMBL:	View
KEGG (GenomeNet):	C19160
HMDB (The Human Metabolome Database):	HMDB31332
FooDB:	FDB003395
Export Tariff Code:	2909.19.1090
FDA Listing of Food Additive Status:	View
Wikipedia:	View
Formulations/Preparations: commercial chloromethyl methyl ether contains a minimum of 95% of the active ingredient

Potential Blenders and core components note

None Found

Potential Uses:

None Found

Occurrence (nature, food, other):note

not found in nature

Synonyms:

	chlordimethylether
	chloro(methoxy)methane
	chlorodimethyl ether
	chloromethoxymethane
alpha,alpha-	dichlorodimethyl ether
	dimethylchloroether
	ether, chloromethyl methyl
	methane, chloromethoxy-
	methoxychloromethane
	methoxymethyl chloride
	methoxymethylchloride
	methyl chloromethyl ether [UN1239] [Poison]
	methylchloromethyl ether

Articles:

PubMed:Mesopolymer modified with palladium phthalocyaninesulfonate as a versatile photocatalyst for phenol and bisphenol A degradation under visible light irradiation.

PubMed:Easy synthesis of hierarchical carbon spheres with superior capacitive performance in supercapacitors.

PubMed:Dimethoxymethane-hydrogen chloride interaction: gas phase versus low-temperature behavior studied using matrix isolation infrared and density functional theory methods.

PubMed:Retrospective exposure assessment in a chemical research and development facility.

PubMed:Bis(chloromethyl) ether and technical-grade chloromethyl methyl ether.

PubMed:Cross-linked poly(vinyl alcohol)-poly(acrylonitrile-co-2-dimethylamino ethylmethacrylate) based anion-exchange membranes in aqueous media.

PubMed:Fluorescent chemosensor for reactive organohalides in micellar solution with an example of autocatalysis.

PubMed:Simple, rapid procedure for the synthesis of chloromethyl methyl ether and other chloro alkyl ethers.

PubMed:bis(Chloromethyl) ether and technical-grade chloromethyl methyl ether.

PubMed:Bis(Chloromethyl) ether and technical-grade chloromethyl methyl ether.

PubMed:Solid-phase synthesis of a modified 13-residue seminalplasmin fragment on 1,6-hexanediol diacrylate-crosslinked polystyrene support.

PubMed:Electrophilic Aromatic Substitution. 13.(1) Kinetics and Spectroscopy of the Chloromethylation of Benzene and Toluene with Methoxyacetyl Chloride or Chloromethyl Methyl Ether and Aluminum Chloride in Nitromethane or Tin Tetrachloride in Dichloromethane. The Methoxymethyl Cation as a Remarkably Selective Common Electrophile.

PubMed:Reactive chemicals and cancer.

PubMed:Incidence of respiratory cancer among workers exposed to chloromethyl-ethers.

PubMed:Synthesis and biological activities of 5-deaza analogues of aminopterin and folic acid.

PubMed:Monitoring chloromethyl methyl ether in air.

PubMed:Lung cancer associated with chloromethyl methyl ether manufacture: an investigation at two factories in the United Kingdom.

PubMed:Toxic activity of seventeen industrial solvents and halogenated compounds on human lymphocytes cultured in vitro.

PubMed:High-dose ascorbic acid prophylaxis in workers occupationally exposed to halogenated ethers.

PubMed:DNA damage by haloalkanes in human lymphocytes cultured in vitro.

PubMed:Prediction of carcinogenicity based on structure, chemical reactivity and possible metabolic pathways.

PubMed:Lung cancer following exposure to bis(chloromethyl)ether: a case report.

PubMed:A new personal monitoring device for the detection of beta-propiolactone and other alkylating agents.

PubMed:Modulation of rat guanylate cyclase activity in vitro by chemical carcinogens.

PubMed:On-column reaction gas chromatography for determination of chloromethyl methyl ether at one part-per-billion level in ambient air.

PubMed:Lung cancer following exposure to chloromethyl methyl ether. An epidemiological study.

PubMed:Analytical methods for chloromethyl methyl ether (CMME) and bis-chloromethyl ether (BCME) in air.

PubMed:The respiratory effects of chloromethyl methyl ether.

PubMed:Mortality patterns among workers exposed to chloromethyl ethers--a preliminary report.

PubMed:Determination of chloromethyl methyl ether and bis-chloromethyl ether in air at the part per billion level by gas-liquid chromatography.

PubMed:Inhalation carcinogenicity of alpha halo ethers. II. Chronic inhalation studies with chloromethyl methyl ether.

PubMed:Inhalation carcinogenicity of alpha halo ethers. I. The acute inhalation toxicity of chloromethyl methyl ether and bis(chloromethyl)ether.

PubMed:Letter: Lung cancer in chloromethyl methyl ether workers.

PubMed:Chloromethyl methyl ether.

PubMed:Lung cancer in chloromethyl methyl ether workers.

PubMed:Lung cancer in chloromethyl methyl ether workers.

Notes:

an alpha halo ether alkylating agent used widely in chemical & plastic industries; it causes lung hyperplasias & neoplasms & skin neoplasms. Used to modify ion-exchange membranes used in the production of grapefruit juice

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