EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

catechol
2-hydroxyphenol

Supplier Sponsors

Name:benzene-1,2-diol
CAS Number: 120-80-9Picture of molecule3D/inchi
Other(deleted CASRN):16474-89-8
ECHA EINECS - REACH Pre-Reg:204-427-5
FDA UNII: LF3AJ089DQ
Nikkaji Web:J2.921A
Beilstein Number:0471401
MDL:MFCD00055728
CoE Number:680
XlogP3:0.90 (est)
Molecular Weight:110.11222000
Formula:C6 H6 O2
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:indirect food additives: adhesives and components of coatings
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
DG SANTE Food Flavourings:04.029 benzene-1,2-diol
DG SANTE Food Contact Materials:benzene-1,2-diol
 
Physical Properties:
Appearance:white to tan powder (est)
Assay: 97.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 103.00 to 105.00 °C. @ 760.00 mm Hg
Boiling Point: 244.00 to 246.00 °C. @ 760.00 mm Hg
Vapor Pressure:1.000000 mmHg @ 75.00 °C.
Vapor Density:3.8 ( Air = 1 )
Flash Point: 279.00 °F. TCC ( 137.22 °C. )
logP (o/w): 0.880
Soluble in:
 alcohol
 water, 4.61E+05 mg/L @ 25 °C (exp)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: hair dyeing agents
not used anymore
 
Suppliers:
Alfa Biotechnology
For experimental / research use only.
Catechol 98%
Charkit Chemical
CATECHOL
ExtraSynthese
For experimental / research use only.
Catechol (HPLC) ≥95%
Glentham Life Sciences
1,2-Dihydroxybenzene
Indenta Group
Catechol
Penta International
PYROCATECHOL
Shiva Chemicals and Pharmaceuticals
Catechol
Sigma-Aldrich
For experimental / research use only.
1,2-Dihydroxybenzene ReagentPlus®, ≥99%
TCI AMERICA
For experimental / research use only.
Catechol >99.0%(GC)
sds
 
Safety Information:
Preferred SDS: View
European information :
Most important hazard(s):
Xn - Harmful.
R 21/22 - Harmful in contact with skin and if swallowed.
R 36/38 - Irritating to skin and eyes.
S 02 - Keep out of the reach of children.
S 22 - Do not breath dust.
S 24/25 - Avoid contact with skin and eyes.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 36/37/39 - Wear suitable clothing, gloves and eye/face protection.
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-guinea pig LD50 210 mg/kg
Advances in Food Research. Vol. 3, Pg. 197, 1951.

intraperitoneal-mouse LD50 68 mg/kg
Pharmacology and Toxicology Vol. 64, Pg. 247, 1989.

oral-mouse LD50 260 mg/kg
Advances in Food Research. Vol. 3, Pg. 197, 1951.

oral-rabbit LDLo 200 mg/kg
BLOOD: METHEMOGLOBINEMIA-CARBOXYHEMOGLOBIN BLOOD: LEUKOPENIA BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
"Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2n rev. ed. in 1985.Vol. 2A, Pg. 2585, 1981.

oral-rat LD50 260 mg/kg
Advances in Food Research. Vol. 3, Pg. 197, 1951.

oral-cat LD50 100 mg/kg
International Polymer Science and Technology. Vol. 3, Pg. 93, 1976.

oral-dog LD50 130 mg/kg
International Polymer Science and Technology. Vol. 3, Pg. 93, 1976.

intravenous-dog LDLo 40 mg/kg
"Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59Vol. 1, Pg. 62, 1955.

parenteral-frog LDLo 160 mg/kg
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE
Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 166, Pg. 437, 1932.

intraperitoneal-guinea pig LDLo 150 mg/kg
"Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59Vol. 1, Pg. 62, 1955.

oral-mammal (species unspecified) LD50 240 mg/kg
LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)
Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. Vol. 15, Pg. 136, 1979.

Dermal Toxicity:
skin-rabbit LD50 800 mg/kg
Advances in Food Research. Vol. 3, Pg. 197, 1951.

subcutaneous-mouse LD50 247 mg/kg
Industrial Health. Vol. 5, Pg. 143, 1967.

subcutaneous-rabbit LDLo 225 mg/kg
Journal of Agricultural and Food Chemistry. Vol. 17, Pg. 497, 1969.

subcutaneous-frog LDLo 160 mg/kg
"Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59Vol. 1, Pg. 62, 1955.

subcutaneous-guinea pig LDLo 200 mg/kg
"Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59Vol. 1, Pg. 62, 1955.

skin-rabbit LD50 800 mg/kg
SKIN AND APPENDAGES (SKIN): PRIMARY IRRITATION: AFTER TOPICAL EXPOSURE
American Industrial Hygiene Association Journal. Vol. 37, Pg. 596, 1976.

subcutaneous-rat LDLo 110 mg/kg
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 176, Pg. 193, 1968.

Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
indirect food additives: adhesives and components of coatings
Recommendation for catechol usage levels up to:
 not for fragrance use.
 
Recommendation for catechol flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
NIOSH International Chemical Safety Cards:search
NIOSH Pocket Guide:search
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
Carcinogenic Potency Database:Search
EPA GENetic TOXicology:Search
EPA Substance Registry Services (TSCA):120-80-9
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :289
National Institute of Allergy and Infectious Diseases:Data
WISER:UN 2811
WGK Germany:2
benzene-1,2-diol
Chemidplus:0000120809
EPA/NOAA CAMEO:hazardous materials
RTECS:120-80-9
 
References:
 benzene-1,2-diol
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:120-80-9
Pubchem (cid):289
Pubchem (sid):134975212
Pherobase:View
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Indirect Additives used in Food Contact Substances:View
CHEBI:View
CHEMBL:View
Metabolomics Database:Search
UM BBD:Search
KEGG (GenomeNet):C00090
HMDB (The Human Metabolome Database):HMDB00957
FooDB:FDB001512
Export Tariff Code:2907.29.6000
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
 medical
 
Occurrence (nature, food, other):note
 avocado plant
Search Trop Picture
 bulbophyllum involutum
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 Bulbophyllum weddellii
Search Trop Picture
 cacao plant
Search Trop Picture
 castoreum
Search PMC Picture
 chicory root
Search Trop Picture
 coffee
PbMd Search PMC Picture
 ginkgo biloba leaf
Search Trop Picture
 olive fruit
Search Trop Picture
 onion bulb
Search Trop Picture
 oregano plant
Search Trop Picture
 purslane plant
Search Trop Picture
 tea tissue culture
Search Trop Picture
 
Synonyms:
 benzcatechin
1,2-benzene diol
 benzene-1,2-diol
 benzene, o-dihydroxy-
1,2-benzenediol
1,2-dihydroxybenzene
 durafur developer C
 fouramine PCH
 fourrine 68
o-hydroquinone
ortho-hydroquinone
2-hydroxyphenol
o-hydroxyphenol
ortho-hydroxyphenol
 lopac-C-9510
 phthalhydroquinone
 pyrocatechinic acid
 pyrocatechol
 

Articles:

PubMed:Effect of high-pressure processing and thermal treatment on quality attributes and nutritional compounds of "Songold" plum purée.
PubMed:In situ inactivation of polyphenol oxidase in mamey fruit (Pouteria sapota) by microwave treatment.
PubMed:A Solanum lycopersicum catechol-O-methyltransferase involved in synthesis of the flavor molecule guaiacol.
PubMed:The effects of high hydrostatic pressure treatment on the flavor and color of grated ginger.
PubMed:Biochemical changes during the storage of high hydrostatic pressure processed avocado paste.
PubMed:Enhancement of fermentation process in Pu-erh tea by tea-leaf extract.
PubMed:Role of roasting conditions in the profile of volatile flavor chemicals formed from coffee beans.
PubMed:Electrochemically deposited boronate affinity extracting phase for covalent solid phase microextraction of cis-diol biomolecules.
PubMed:Formation of strecker aldehydes from polyphenol-derived quinones and alpha-amino acids in a nonenzymic model system.
PubMed:Evolution of robusta green coffee redox enzymatic activities with maturation.
PubMed:The role of iron and the factors affecting off-color development of polyphenols.
PubMed:In vitro studies of biological effects of cigarette smoke condensate. II. Induction of sister-chromatid exchanges in human lymphocytes by weakly acidic, semivolatile constituents.
PubMed:Polyphenol oxidase and peroxidase in fruits and vegetables.
 
Notes:
Constit. of var. foodstuffs esp. coffee, cocoa, bread crust, roasted malt and beer; Isol. from various plant sources and by hydrol. of tannins (CCD)
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