| Name: | (8S,9R,10S,11S,13S,14S,16S,17R)-9-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one |
| CAS Number: | 378-44-9 |  3D/inchi
|
| ECHA EINECS - REACH Pre-Reg: | 206-825-4 |
| FDA UNII: | 9842X06Q6M |
| Nikkaji Web: | J2.038I |
| Beilstein Number: | 3176546 |
| MDL: | MFCD00062969 |
| XlogP3: | 1.90 (est) |
| Molecular Weight: | 392.46753320 |
| Formula: | C22 H29 F O5 |
| BioActivity Summary: | listing |
| NMR Predictor: | Predict (works with chrome, Edge or firefox) |
Category:pharmaceuticals / chemical synthisis
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00
|
| Food Chemicals Codex Listed: | No |
| Melting Point: | 232.00 °C. @ 760.00 mm Hg
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| Boiling Point: | 568.23 °C. @ 760.00 mm Hg (est)
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| Flash Point: | 567.00 °F. TCC ( 297.50 °C. ) (est)
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| logP (o/w): | 1.940 |
| Soluble in: |
| | water, 75.14 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
| |
| Hazards identification |
| |
| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
| |
| Pictogram | |
| |
| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
oral-mouse LD50 > 4500 mg/kg
Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 21, Pg. 2117, 1979.
|
| Dermal Toxicity: |
|
Not determined
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| Inhalation Toxicity: |
|
Not determined
|
Safety in Use Information:
| Category: | | pharmaceuticals / chemical synthisis |
| Recommendation for betamethasone usage levels up to: | | | not for fragrance use.
|
| |
| Recommendation for betamethasone flavor usage levels up to: |
| | not for flavor use.
|
Safety References:
European Food Safety Authority (EFSA) reference(s):
|
Report for 2014 on the results from the monitoring of veterinary medicinal product residues and other substances in live animals and animal products
View page or View pdf
|
| EPI System: View |
| ClinicalTrials.gov:search |
| Daily Med:search |
| AIDS Citations:Search |
| Cancer Citations:Search |
| Toxicology Citations:Search |
| EPA ACToR:Toxicology Data |
| EPA Substance Registry Services (SRS):Registry |
| Laboratory Chemical Safety Summary :9782 |
| National Institute of Allergy and Infectious Diseases:Data |
| WGK Germany:2 |
| (8S,9R,10S,11S,13S,14S,16S,17R)-9-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one |
| Chemidplus:0000378449 |
| RTECS:TU4000000 for cas# 378-44-9 |
References:
| | (8S,9R,10S,11S,13S,14S,16S,17R)-9-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 9782 |
| Pubchem (sid): | 134975144 |
Other Information:
| (IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| CHEBI: | View |
| CHEMBL: | View |
| KEGG (GenomeNet): | C06848 |
| HMDB (The Human Metabolome Database): | HMDB14586 |
| Export Tariff Code: | 2903.99.8001 |
| MedlinePlusSupp: | View |
| ChemSpider: | View |
| Wikipedia: | View |
Formulations/Preparations:
•available commercially as the alcohol and as the 17-valerate, 17-benzoate, 17,21-dipropionate, disodium 21-phosphate salt.
•beta-corlan, becort, betasolon, betnelan, celestene, celestone, dermabet, diprolene, visubeta
•celestovet betamethasone acetate
•bebate, beben, benisone, euvaderm, flurobate, parbetan, uticort betamethasone benzoate
•diproderm, diprophos, diprosis, diprosone, maxivate, rinderon-dp betamethasone dipropioniate
•bedremin, betnesol-v, betneval, betnovate, bextasol, celestan-v, celestoderm-v, dermosol, dermovaleas, ecoval 70, hormezon, tokuderm, valisone betamethasone valerate
•bentelan, betnesol, celestan, durabetason, vista-methasone betamethasone phosphate disodium salt
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Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | betaderm | | | betametasone | | | betamethasonum | | | betatrex | | | celestone | | b- | corlan | | | dermabet | | | diprolene | | (8S,9R,10S,11S,13S,14S,16S,17R)-9- | fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one | | (11b,16b)-9- | fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione | | | lotrisone | | b- | methasone | | b- | methasone alcohol | | | pregna-1,4-diene-3,20-dione, 9-fluoro-11,17,21-trihydroxy-16-methyl-, (11b,16b)- |
Articles:
| PubMed:Monitoring of 35 illegally added steroid compounds in foods and dietary supplements. |
| PubMed:Olanzapine and Betamethasone Are Effective for the Treatment of Nausea and Vomiting due to Metastatic Brain Tumors of Rectal Cancer. |
| PubMed:Validation of a liquid chromatography method for the simultaneous determination of several nonsteroidal anti-inflammatory drugs in human plasma for therapeutic drug monitoring. |
| PubMed:Fast and multiresidue determination of twenty glucocorticoids in bovine milk using ultra high performance liquid chromatography-tandem mass spectrometry. |
| PubMed:Validation of a recombinant cell bioassay for the detection of (gluco)corticosteroids in feed. |
| PubMed:Simultaneous determination of eight corticosteroids in bovine tissues using liquid chromatography-tandem mass spectrometry. |
| PubMed:Detection and quantitative analysis of 21 veterinary drugs in river water using high-pressure liquid chromatography coupled to tandem mass spectrometry. |
| PubMed:Prescription drug use in pregnancy: a retrospective, population-based study in British Columbia, Canada (2001-2006). |
| PubMed:[Detection of glucocorticoids by pressurized capillary electrochromatography with ultra-violet detection and its application in hair analysis]. |
| PubMed:Validation of a multi-residue enzyme-linked immunosorbent assay for qualitative screening of corticosteroids in liver, urine and milk. |
| PubMed:Recombinant cell bioassays for the detection of (gluco)corticosteroids and endocrine-disrupting potencies of several environmental PCB contaminants. |
| PubMed:Development of a liquid chromatography-tandem mass spectrometry with pressurized liquid extraction for determination of glucocorticoid residues in edible tissues. |
| PubMed:Development of a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the quantification of glucocorticoid residues in edible tissues of swine, cattle, sheep, and chicken. |
| PubMed:Cluster headache. |
| PubMed:Seborrhoeic dermatitis. |
| PubMed:Allergy-induced preterm labor after the ingestion of shellfish. |
| PubMed:Improving glucocorticoid replacement therapy using a novel modified-release hydrocortisone tablet: a pharmacokinetic study. |
| PubMed:The prolonged effect of repeated maternal glucocorticoid exposure on the maternal and fetal leptin/insulin-like growth factor axis in Papio species. |
| PubMed:Optimization of solid phase extraction clean up and validation of quantitative determination of corticosteroids in urine by liquid chromatography-tandem mass spectrometry. |
| PubMed:Hypersensitivity reaction to the ingestion of mango flesh. |
| PubMed:Cluster headache. |
| PubMed:Rapid multi-residue method for the quantitative determination and confirmation of glucocorticosteroids in bovine milk using liquid chromatography-electrospray ionization-tandem mass spectrometry. |
| PubMed:Multi-detection of corticosteroids in sports doping and veterinary control using high-resolution liquid chromatography/time-of-flight mass spectrometry. |
| PubMed:Seborrhoeic dermatitis. |
| PubMed:Detection of synthetic corticosteroids in bovine urine by chemiluminescence high-performance liquid chromatography. |
| PubMed:Pediatric drug labeling: improving the safety and efficacy of pediatric therapies. |
| PubMed:Effect of betamethasone on maternal glucose. |
| PubMed:Betamethasone valerate foam for treatment of nonscalp psoriasis. |
| PubMed:Clotrimazole/betamethasone diproprionate: a review of costs and complications in the treatment of common cutaneous fungal infections. |
| PubMed:Differentiation between dexamethasone and betamethasone in a mixture using multiple mass spectrometry. |
| PubMed:Simultaneous determination of betamethasone and dexamethasone residues in bovine liver by liquid chromatography/tandem mass spectrometry. |
| PubMed:Chemiluminescence detection of nine corticosteroids in liver. |
| PubMed:Suppression of food intake is linked to enteric inflammation in nematode-infected rats. |
| PubMed:Effects of Kakkon-to and Sairei-to on experimental elevation of aqueous flare in pigmented rabbits. |
| PubMed:Evaluation of the test system used for in vitro release of drugs for topical dermatological drug products. |
| PubMed:Assessment of pain during locomotion and the welfare of adult male turkeys with destructive cartilege loss of the hip joint. |
| PubMed:Local anti-inflammatory activity and systemic side effects of NM-135, a new prodrug glucocorticoid, in an experimental inflammatory rat model. |
| PubMed:Identification of main corticosteroids as illegal feed additives in milk replacers by liquid chromatography-atmospheric pressure chemical ionisation mass spectrometry. |
| PubMed:Factors associated with growth of extremely premature infants during initial hospitalization. |
| PubMed:Evaluation of the proposed FDA pilot dose-response methodology for topical corticosteroid bioequivalence testing. |
| PubMed:Assessment of the welfare of food restricted male broiler breeder poultry with musculoskeletal disease. |
| PubMed:Effect of BW B70C, a novel inhibitor of arachidonic acid 5-lipoxygenase, on allergen-induced bronchoconstriction and late-phase lung eosinophil accumulation in sensitised guinea-pigs. |
| PubMed:Topical corticosteroids: quality control considerations. |
| PubMed:Relationship between in vivo skin blanching and in vitro release rate for betamethasone valerate creams. |
| PubMed:[A case of asthma exacerbated by sulfite contained in betamethasone]. |
| PubMed:[Iatrogenic Cushing syndrome in infants. Report of a case with dwarfism]. |
| PubMed:Stability of betamethasone sodium phosphate, hydrocortisone sodium phosphate, and prednisolone sodium phosphate injections submitted by U.S. hospitals. |
| PubMed:Stability of sterile aqueous epinephrine injections submitted by U.S. hospitals. |
| PubMed:Stability of sterile aqueous lidocaine hydrochloride and epinephrine injections submitted by U.S. hospitals. |
| PubMed:The inhibitory effect of ketotifen on in vitro histamine release in allergic patients. |
| PubMed:[Studies of toxicity of hydrocortisone 17-butyrate 21-propionate -5. Chronic toxicity in rats by percutaneous administration (author's transl)]. |
| PubMed:Drugs released for clinical use. |
| PubMed:Corticosteroids in diseases of the oral mucosa. |
| PubMed:[Periocically occurring aphthae]. |
|
a glucocorticoid given orally, parenterally, by local injection, by inhalation, or applied topically in the management of various disorders in which corticosteroids are indicated. its lack of mineralocorticoid properties makes betamethasone particularly suitable for treating cerebral edema and congenital adrenal hyperplasia. (from martindale, the extra pharmacopoeia, 30th ed, p724)
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