EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

6-hydroxyflavone
4H-1-benzopyran-4-one, 6-hydroxy-2-phenyl-

Supplier Sponsors

Name:6-hydroxy-2-phenylchromen-4-one
CAS Number: 6665-83-4Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:229-704-8
FDA UNII: 148S6Z78H6
Nikkaji Web:J298.052E
MDL:MFCD00017329
XlogP3:3.60 (est)
Molecular Weight:238.24230000
Formula:C15 H10 O3
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:natural substances and extractives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 450.12 °C. @ 760.00 mm Hg (est)
Flash Point: 349.00 °F. TCC ( 176.30 °C. ) (est)
logP (o/w): 4.445 (est)
Soluble in:
 water, 270.9 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
BOC Sciences
For experimental / research use only.
6-Hydroxyflavone ≥97%
Odor: characteristic
Use: 6-Hydroxyflavone, a naturally occurring flavonoid, binds to GABAA receptors with moderate affinity and acts as a partial agonis
ExtraSynthese
For experimental / research use only.
6-Hydroxyflavone (HPLC) ≥90%
Penta International
6-HYDROXYFLAVONE
Santa Cruz Biotechnology
For experimental / research use only.
6-Hydroxyflavone
Sigma-Aldrich: Aldrich
For experimental / research use only.
6-Hydroxyflavone 98%
sds
TCI AMERICA
For experimental / research use only.
6-Hydroxyflavone >98.0%(T)(HPLC)
sds
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
natural substances and extractives
Recommendation for 6-hydroxyflavone usage levels up to:
 not for fragrance use.
 
Recommendation for 6-hydroxyflavone flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :72279
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
6-hydroxy-2-phenylchromen-4-one
Chemidplus:0006665834
 
References:
 6-hydroxy-2-phenylchromen-4-one
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):72279
Pubchem (sid):135030366
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
KEGG (GenomeNet):C14137
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2932.99.7000
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 found in nature
 
Synonyms:
4H-1-benzopyran-4-one, 6-hydroxy-2-phenyl-
6-hydroxy-2-phenyl-4-benzopyrone
6-hydroxy-2-phenyl-4H-chromen-4-one
6-hydroxy-2-phenyl-chromen-4-one
6-hydroxy-2-phenylchromen-4-one
6-hydroxy-flavone
 

Articles:

PubMed:Effects of 6-Hydroxyflavone on Osteoblast Differentiation in MC3T3-E1 Cells.
PubMed:β-Cyclodextrin assisted solubilization of Cu and Cr complexes of flavonoids in aqueous medium: a DNA-interaction study.
PubMed:Influences of glucose on the dietary hydroxyflavonoid-plasma protein interaction.
PubMed:Interference of selected flavonoid aglycons in platelet aggregation assays.
PubMed:A new strategy to rapidly evaluate kinetics of glucuronide efflux by breast cancer resistance protein (BCRP/ABCG2).
PubMed:Non-covalent interaction of dietary polyphenols with total plasma proteins of type II diabetes: molecular structure/property-affinity relationships.
PubMed:Noncovalent interaction of dietary polyphenols with common human plasma proteins.
PubMed:Sulfation of selected mono-hydroxyflavones by sulfotransferases in vitro: a species and gender comparison.
PubMed:[Effect of seven kinds of flavonoids on recombinant human protein tyrosine phosphatase].
PubMed:A comparative study of flavonoid analogues on streptozotocin-nicotinamide induced diabetic rats: quercetin as a potential antidiabetic agent acting via 11beta-hydroxysteroid dehydrogenase type 1 inhibition.
PubMed:GABA(A) receptor subtype selectivity underlying anxiolytic effect of 6-hydroxyflavone.
PubMed:Mechanism of CYP2C9 inhibition by flavones and flavonols.
PubMed:Secretion of cortisol and aldosterone as a vulnerable target for adrenal endocrine disruption - screening of 30 selected chemicals in the human H295R cell model.
PubMed:Microbial metabolism part 9. Structure and antioxidant significance of the metabolites of 5,7-dihydroxyflavone (chrysin), and 5- and 6-hydroxyflavones.
PubMed:[Effects of flavonoids with different structures on proliferation of leukemia cell line HL-60].
PubMed:Analysis of flavonoids by CE using capacitively coupled contactless conductivity detection.
PubMed:Flavonoid inhibition of overexpressed human 3beta-hydroxysteroid dehydrogenase type II.
PubMed:Relaxant effects of flavonoids in isolated guinea pig trachea and their structure-activity relationships.
PubMed:Effects of flavonoid phytochemicals on cortisol production and on activities of steroidogenic enzymes in human adrenocortical H295R cells.
PubMed:Covalent alteration of the CYP3A4 active site: evidence for multiple substrate binding domains.
PubMed:Effects of flavonoids on the growth and cell cycle of cancer cells.
PubMed:Development of a simple method for the determination of genistein, daidzein, biochanin A, and formononetin (biochanin B) in human urine.
PubMed:Expression of p56lck in B-cell neoplasias.
PubMed:Methylated C-glycosylflavones as taxonomic markers in orchids of the subtribe Ornithocephalinae.
PubMed:Antimutagenic effects of flavonoids, chalcones and structurally related compounds on the activity of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) and other heterocyclic amine mutagens from cooked food.
PubMed:Antiproliferative effects of synthetic and naturally occurring flavonoids on tumor cells of the human breast carcinoma cell line, ZR-75-1.
 
Notes:
None found
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