5,6-dihydrouracil, 504-07-4

Articles:

PubMed:Development, validation and application of a novel liquid chromatography tandem mass spectrometry assay measuring uracil, 5,6-dihydrouracil, 5-fluorouracil, 5,6-dihydro-5-fluorouracil, α-fluoro-β-ureidopropionic acid and α-fluoro-β-alanine in human plasma.

PubMed:Probing the activity of NTHL1 orthologs by targeting conserved amino acid residues.

PubMed:Solvation of Uracil and Its Derivatives by DMSO: A DFT-Supported (1)H NMR and (13)C NMR Study.

PubMed:Base Release and Modification in Solid-Phase DNA Exposed to Low-Energy Electrons.

PubMed:Conformational Dynamics of DNA Repair by Escherichia coli Endonuclease III.

PubMed:Metabolomic markers of altered nucleotide metabolism in early stage adenocarcinoma.

PubMed:Effect of agronomical practices on carpology, fruit and oil composition, and oil sensory properties, in olive (Olea europaea L.).

PubMed:Communication: Electronic UV-Vis transient spectra of the ∙OH reaction products of uracil, thymine, cytosine, and 5,6-dihydrouracil by using the complete active space self-consistent field second-order perturbation (CASPT2//CASSCF) theory.

PubMed:Is uracil aromatic? The enthalpies of hydrogenation in the gaseous and crystalline phases, and in aqueous solution, as tools to obtain an answer.

PubMed:Gender-specific elimination of continuous-infusional 5-fluorouracil in patients with gastrointestinal malignancies: results from a prospective population pharmacokinetic study.

PubMed:Novel amidases of two Aminobacter sp. strains: Biotransformation experiments and elucidation of gene sequences.

PubMed:Profiling cytosine oxidation in DNA by LC-MS/MS.

PubMed:Validation of an ultra-high performance liquid chromatography tandem mass spectrometric method for quantifying uracil and 5,6-dihydrouracil in human plasma.

PubMed:Yields of damage to C4' deoxyribose and to pyrimidines in pUC18 by the direct effect of ionizing radiation.

PubMed:LC-MS/MS method for simultaneous analysis of uracil, 5,6-dihydrouracil, 5-fluorouracil and 5-fluoro-5,6-dihydrouracil in human plasma for therapeutic drug monitoring and toxicity prediction in cancer patients.

PubMed:Stereoselective hydrolysis of aryl-substituted dihydropyrimidines by hydantoinases.

PubMed:Opened-ring adducts of 5-methylcytosine and 1,5-dimethylcytosine with amines and water and evidence for an opened-ring hydrate of 2'-deoxycytidine.

PubMed:Time-dependent pharmacokinetics of 5-fluorouracil and association with treatment tolerability in the adjuvant setting of colorectal cancer.

PubMed:Escherichia coli dihydropyrimidine dehydrogenase is a novel NAD-dependent heterotetramer essential for the production of 5,6-dihydrouracil.

PubMed:The photochemistry of uracil: a reinvestigation.

PubMed:A (6-4) photoproduct of 5-bromouracil.

PubMed:Crystallization and preliminary X-ray analysis of human endonuclease 1 (APE1) in complex with an oligonucleotide containing a 5,6-dihydrouracil (DHU) or an alpha-anomeric 2'-deoxyadenosine (alphadA) modified base.

PubMed:Dihydropyrimidinase deficiency: Phenotype, genotype and structural consequences in 17 patients.

PubMed:Hydrolytic deamination of 5,6-dihydrocytosine in a protic medium: a theoretical study.

PubMed:The oxidative DNA glycosylases of Mycobacterium tuberculosis exhibit different substrate preferences from their Escherichia coli counterparts.

PubMed:Heavy metal ions affect the activity of DNA glycosylases of the fpg family.

PubMed:Coupling of the nucleotide incision and 3'-->5' exonuclease activities in Escherichia coli endonuclease IV: Structural and genetic evidences.

PubMed:Reaction of cytosine with bisulfite and hydroxylamine.

PubMed:Metal-triggered changes in the stability and secondary structure of a tetrameric dihydropyrimidinase: a biophysical characterization.

PubMed:X-ray crystallographic identification of bisulfite-uracil adduct as sodium 5,6-dihydrouracil 6-sulfonate.

PubMed:[Interactions of human ribosomal protein S3 with undamaged and damaged DNA].

PubMed:5-fluorouracil pharmacokinetics predicts disease-free survival in patients administered adjuvant chemotherapy for colorectal cancer.

PubMed:[Pro or con the phenotyping/genotyping of patients treated by 5-Fluorouracil to prevent adverse drug reactions?].

PubMed:Clinical, biochemical and genetic findings in two siblings with a dihydropyrimidinase deficiency.

PubMed:Crystallization and preliminary crystallographic studies of the recombinant dihydropyrimidinase from Sinorhizobium meliloti CECT4114.

PubMed:A pharmacokinetic-based test to prevent severe 5-fluorouracil toxicity.

PubMed:Catalytic mechanism of Escherichia coli endonuclease VIII: roles of the intercalation loop and the zinc finger.

PubMed:Liquid chromatography-tandem mass spectrometric assay for the analysis of uracil, 5,6-dihydrouracil and beta-ureidopropionic acid in urine for the measurement of the activities of the pyrimidine catabolic enzymes.

PubMed:Purification, crystallization and X-ray diffraction analysis of dihydropyrimidinase from Dictyostelium discoideum.

PubMed:Crystallization and X-ray diffraction analysis of dihydropyrimidinase from Saccharomyces kluyveri.

PubMed:Physiologically based pharmacokinetic modelling of the three-step metabolism of pyrimidine using C-uracil as an in vivo probe.

PubMed:Feasibility of measuring 5-fluorouracil catabolic potential by oral loading.

PubMed:A series of 5-(5,6)-dihydrouracil substituted 8-hydroxy-[1,6]naphthyridine-7-carboxylic acid 4-fluorobenzylamide inhibitors of HIV-1 integrase and viral replication in cells.

PubMed:Improved analysis of 5-Fluorouracil and 5,6-dihydro-5-Fluorouracil by HPLC with diode array detection for determination of cellular dihydropyrimidine dehydrogenase activity and pharmacokinetic profiling.

PubMed:5-Fluorouracil catabolism to 5-fluoro-5,6-dihydrouracil is reduced by acute liver impairment in mice.

PubMed:Mouse NEIL1 protein is specific for excision of 2,6-diamino-4-hydroxy-5-formamidopyrimidine and 4,6-diamino-5-formamidopyrimidine from oxidatively damaged DNA.

PubMed:Plasma concentrations of 5-fluorouracil and its metabolites in colon cancer patients.

PubMed:[Assay method for uracil, dihydrouracil, 5-fluorouracil and 5-fluoro-5, 6-dihydrouracil by high-performance liquid chromatography].

PubMed:Quantification of 5,6-dihydrouracil by HPLC-electrospray tandem mass spectrometry.

PubMed:Orchestration of base excision repair by controlling the rates of enzymatic activities.

PubMed:Synthesis and anti-HIV-1 activity of novel 10-thiaisoalloxazines, a structural analog of C-5 and/or C-6 substituted pyrimidine acyclonucleoside.

PubMed:Crystallization and preliminary X-ray diffraction analysis of thermophilic imidase from pig liver.

PubMed:The novel DNA glycosylase, NEIL1, protects mammalian cells from radiation-mediated cell death.

PubMed:Severe 5-fluorouracil toxicity associated with a marked alteration of pharmacokinetics of 5-fluorouracil and its catabolite 5-fluoro-5,6-dihydrouracil: a case report.

PubMed:Chalcone isomerase gene from rice (Oryza sativa) and barley (Hordeum vulgare): physical, genetic and mutation mapping.

PubMed:Limited sampling model for the analysis of 5-fluorouracil pharmacokinetics in adjuvant chemotherapy for colorectal cancer.

PubMed:Repair of dihydrouracil supported by base excision repair in mNTH1 knock-out cell extracts.

PubMed:Relationship between plasma concentrations of 5-fluorouracil and 5-fluoro-5,6-dihydrouracil and toxicity of 5-fluorouracil infusions in cancer patients.

PubMed:Screening and diagnosis of beta-ureidopropionase deficiency by gas chromatographic/mass spectrometric analysis of urine.

PubMed:Identification and characterization of a novel human DNA glycosylase for repair of cytosine-derived lesions.

PubMed:Porous graphitic carbon shows promise for the rapid screening partial DPD deficiency in lymphocyte dihydropyrimidine dehydrogenase in Chinese, Indian and Malay in Singapore by using semi-automated HPLC-radioassay.

PubMed:Alternative nucleotide incision repair pathway for oxidative DNA damage.

PubMed:DNA polymerase beta is the major dRP lyase involved in repair of oxidative base lesions in DNA by mammalian cell extracts.

PubMed:Unique misinsertion specificity of poliota may decrease the mutagenic potential of deaminated cytosines.

PubMed:Relationship between 5-fluorouracil disposition, toxicity and dihydropyrimidine dehydrogenase activity in cancer patients.

PubMed:Determination of pH using water protons and chemical exchange dependent saturation transfer (CEST).

PubMed:Comparative pharmacokinetic analysis of 5-fluorouracil and its major metabolite 5-fluoro-5,6-dihydrouracil after conventional and reduced test dose in cancer patients.

PubMed:Mechanism-based inactivation of human dihydropyrimidine dehydrogenase by (E)-5-(2-bromovinyl)uracil in the presence of NADPH.

PubMed:alpha-fluoro-beta-alanine: effects on the antitumor activity and toxicity of 5-fluorouracil.

PubMed:Radiochemical assay for determination of dihydropyrimidinase activity using reversed-phase high-performance liquid chromatography.

PubMed:Purification, characterization, gene cloning, and expression of Saccharomyces cerevisiae redoxyendonuclease, a homolog of Escherichia coli endonuclease III.

PubMed:Direct effects of gamma-radiation on 2'-deoxycytidine in frozen aqueous solution.

PubMed:Properties of D-hydantoinase from Agrobacterium tumefaciens and its use for the preparation of N-carbamyl D-amino acids.

PubMed:Reaction of bromotrichloromethane derived free radicals with uracil in a model system. Structures of products formed.

PubMed:Formation of 5-hydroxy-5,6-dihydrouracil and release of undamaged uracil as a result of poly(U) irradiation in N2O-saturated aqueous solution.

PubMed:Purification and cloning of Micrococcus luteus ultraviolet endonuclease, an N-glycosylase/abasic lyase that proceeds via an imino enzyme-DNA intermediate.

PubMed:Attenuation of the antitumor activity of 5-fluorouracil by (R)-5-fluoro-5,6-dihydrouracil.

PubMed:Dehalogenating and NADPH-modifying activities of dihydropyrimidine dehydrogenase.

PubMed:(R)-5-fluoro-5,6-dihydrouracil: kinetics of oxidation by dihydropyrimidine dehydrogenase and hydrolysis by dihydropyrimidine aminohydrolase.

PubMed:Determination of the concentrations of 5-fluorouracil and its metabolites in rabbit plasma and tissues by high-performance liquid chromatography.

PubMed:Purification, characterization and inhibition of dihydropyrimidinase from rat liver.

PubMed:Substrate specificity of the Escherichia coli endonuclease III: excision of thymine- and cytosine-derived lesions in DNA produced by radiation-generated free radicals.

PubMed:Dihydropyrimidine dehydrogenase. Kinetic mechanism for reduction of uracil by NADPH.

PubMed:Acid-base catalytic mechanism of dihydropyrimidinase from pH studies.

PubMed:Detection of new metabolites of trifluridine (F3TdR) using 19F NMR spectroscopy.

PubMed:Stereochemistry of NADPH oxidation by dihydropyrimidine dehydrogenase from pig liver.

PubMed:Inactivation of dihydropyrimidine dehydrogenase by 5-iodouracil.

PubMed:Formation and stability of repairable pyrimidine photohydrates in DNA.

PubMed:Pulmonary elimination and metabolism of 5-fluoro-2'-deoxyuridine in isolated perfused rat lung and lung slices.

PubMed:UV-induced pyrimidine hydrates in DNA are repaired by bacterial and mammalian DNA glycosylase activities.

PubMed:Purification and properties of 5,6-dihydropyrimidine amidohydrolase from calf liver.

PubMed:Nicotinamide and selenium stimulate the repair of DNA damage produced by N-nitrosobis (2-oxopropyl) amine.

PubMed:Induction of hyperplastic liver nodules in Wistar and MRC-Wistar rats by phenobarbital and the liver carcinogens acetoxime, 1-nitroso-5,6-dihydrouracil and 3-nitroso-2-oxazolidinone.

PubMed:Radiation chemistry of 2'-deoxycytidylyl-(3'-5')-2'-deoxyguanosine and its sequence isomer in N2O- and O2-saturated solutions.

PubMed:Bovine liver dihydropyrimidine amidohydrolase: pH dependencies of the steady-state kinetic and proton relaxation rate properties of the Mn(II)-containing enzyme.

PubMed:In vitro and in vivo formation of 7-(2'-carboxyethyl)guanine from the liver carcinogen 1-nitroso-5,6-dihydrouracil and its reactions with water and methanol.

PubMed:Persistence of DNA single-strand breaks and other tests as indicators of the liver carcinogenicity of 1-nitroso-5,6-dihydrouracil and the noncarcinogenicity of 1-nitroso-5,6-dihydrothymine.

PubMed:[Infrared spectra of uracil and thymine in an argon matrix].

PubMed:Isolation and characterization of two 5-fluorouracil-substituted Escherichia coli initiator methionine transfer ribonucleic acids.

PubMed:Specific effects of 5-fluoropyrimidines and 5-azapyrimidines on modification of the 5 position of pyrimidines, in particular the synthesis of 5-methyluracil and 5-methylcytosine in nucleic acids.

PubMed:N-Alkylated derivatives of 5-fluorouracil.

PubMed:Carcinogenicity test of six nitrosamides and a nitrosocyanamide administered orally to rats.

PubMed:GABA transaminase provides an alternative route of beta-alanine synthesis in Aspergillus nidulans.

PubMed:Synthesis of uracil and thymine under simulated prebiotic conditions.

PubMed:Role of enzymatically catalyzed 5-iodo-5,6-dihydrouracil ring hydrolysis on the dehalogenation of 5-iodouracil.

PubMed:Histology of chemically induced mesotheliomas in MRC-Wistar rats.

PubMed:Structure and stereochemistry of nucleic acid components and their reaction products. II. Crystal and molecular structure of a product obtained in the reaction of isocyanates with uracil (N1-(N-methylcarbamoyl)-N3-methyl-5,6-dihydrouracil).

PubMed:Induction by an hepatic carcinogen, 1-nitroso-5,6-dihydrouracil, of single and double strand breaks of liver DNA with rapid repair.

PubMed:6 Beta-hydroxylation of triamcinolone acetonide by a hepatic enzyme system. The effect of phenobarbital and 1-benzyl-2-thio-5,6-dihydrouracil.

PubMed:5,6-dihydrouracil: its occurrence and metabolism in rat brain.

PubMed:Effect of 1-benzyl-2-thio-5,6-dihydrouracil on hepatic metabolic activity in the rat.

PubMed:The occurrence and source of beta-alanine in alkaline hydrolysates of sRNA: a sensitive method for the detection and assay of 5,6-dihydrouracil residues in RNA.

5,6-dihydrouracil
hexahydropyrimidine-2,4-dione

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5,6-dihydrouracil hexahydropyrimidine-2,4-dione

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5,6-dihydrouracil
hexahydropyrimidine-2,4-dione