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Category:flavor and fragrance agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Appearance: | colorless clear liquid (est) |
| Assay: | 99.00 to 100.00
|
| Food Chemicals Codex Listed: | No |
| Specific Gravity: | 0.80200 to 0.80800 @ 25.00 °C.
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| Pounds per Gallon - (est).: | 6.673 to 6.723
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| Refractive Index: | 1.40700 to 1.41400 @ 20.00 °C.
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| Melting Point: | -90.00 °C. @ 760.00 mm Hg
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| Boiling Point: | 132.00 °C. @ 760.00 mm Hg
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| Vapor Pressure: | 3.679000 mmHg @ 25.00 °C. (est) |
| Vapor Density: | 3.5 ( Air = 1 ) |
| Flash Point: | 106.00 °F. TCC ( 41.11 °C. )
|
| logP (o/w): | 1.546 (est) |
| Soluble in: |
| | alcohol | | | water, 1.38e+004 mg/L @ 25 °C (est) | | | water, 1.64E+04 mg/L @ 25 °C (exp) |
Organoleptic Properties:
| Odor Type: pungent |
| pungent alcoholic |
| Odor Description:at 1.00 % in dipropylene glycol. pungent alcohol |
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
| Arkema |
| Methylisobutylcarbinol
Odor: characteristic Use: MIBC (Methylisobutylcarbinol) is a colorless liquid C6 branched alcohol. It is used in the synthesis of lub oil addtives (ZDDP) for anti-wear and anti-corrosion. |
| Dow Chemical |
| Methyl Isobutyl Carbinol
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| EMD Millipore |
| For experimental / research use only. |
| 4-Methyl-2-pentanol
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| Penta International |
| 4-METHYL-2-PENTANOL
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| Sigma-Aldrich: Aldrich |
| For experimental / research use only. |
| (R)-(-)-4-Methyl-2-pentanol 97%, optical purity 99% (ee) (GLC)
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| Sigma-Aldrich: Aldrich |
| For experimental / research use only. |
| (S)-(+)-4-Methyl-2-pentanol 98%, optical purity 99%
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| Silver Fern Chemical |
| Methyl Isobutyl Carbinol (MIBC)
Odor: characteristic Use: MIBC is used as a solvent for dyestuffs, oils, gums, resins, waxes, nitrocellulose, and ethylcellulose. It’s also used in organic synthesis, mineral floatation, and in brake fluids. |
| TCI AMERICA |
| For experimental / research use only. |
| 4-Methyl-2-pentanol >98.0%(GC)
|
Safety Information:
| Preferred SDS: View |
| European information : |
| Most important hazard(s): | | Xi - Irritant |
R 10 - Flammable.
R 37 - Irritating to respiratory system.
S 02 - Keep out of the reach of children.
S 16 - Keep away from sources of ignition - No Smoking.
S 23 - Do not breath vapour.
S 24/25 - Avoid contact with skin and eyes.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 37/39 - Wear suitable gloves and eye/face protection.
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| |
| Hazards identification |
| |
| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
| |
| Pictogram | |
| |
| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
oral-rat LD50 2590 mg/kg
(Smyth et al., 1951)
oral-mouse LD50 1500 mg/kg
(McOmie & Anderson, 1949a)
intraperitoneal-mouse LD50 812 mg/kg
Shell Chemical Company. Unpublished Report. Vol. -, Pg. 7, 1961.
oral-mouse LDLo 1000 mg/kg
GASTROINTESTINAL: OTHER CHANGES
University of California, Berkeley, Publications in Pharmacology. Vol. 2, Pg. 217, 1949.
oral-rat LD50 2590 mg/kg
AMA Archives of Industrial Hygiene and Occupational Medicine. Vol. 4, Pg. 119, 1951.
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| Dermal Toxicity: |
skin-rabbit LD50 3560 ul/kg
AMA Archives of Industrial Hygiene and Occupational Medicine. Vol. 4, Pg. 119, 1951.
skin-rabbit LD50 3560 uL/kg
AMA Archives of Industrial Hygiene and Occupational Medicine. Vol. 4, Pg. 119, 1951.
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| Inhalation Toxicity: |
inhalation-rat LCLo 2000 ppm/4H
Journal of Industrial Hygiene and Toxicology. Vol. 31, Pg. 343, 1949.
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Safety in Use Information:
| Category: | | flavor and fragrance agents |
| RIFM Fragrance Material Safety Assessment: Search |
| IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice |
| |
| Maximised Survey-derived Daily Intakes (MSDI-EU): | 0.0012 (μg/capita/day) |
| Modified Theoretical Added Maximum Daily Intake (mTAMDI): | 3900 (μg/person/day) |
| Threshold of Concern: | 1800 (μg/person/day) |
| Structure Class: | I |
| |
| Food categories according to Commission Regulation EC No. 1565/2000 (EC, 2000) in FGE.06 (EFSA, 2002a). According to the Industry the "normal" use is defined as the average of reported usages and "maximum use" is defined as the 95th percentile of reported usages (EFSA, 2002i). |
| Note: mg/kg = 0.001/1000 = 0.000001 = 1/1000000 = ppm. |
| | average usage mg/kg | maximum usage mg/kg |
| Dairy products, excluding products of category 02.0 (01.0): | 7.00000 | 35.00000 |
| Fats and oils, and fat emulsions (type water-in-oil) (02.0): | 5.00000 | 25.00000 |
| Edible ices, including sherbet and sorbet (03.0): | 10.00000 | 50.00000 |
| Processed fruit (04.1): | 7.00000 | 35.00000 |
| Processed vegetables (incl. mushrooms & fungi, roots & tubers, pulses and legumes), and nuts & seeds (04.2): | - | - |
| Confectionery (05.0): | 10.00000 | 50.00000 |
| Chewing gum (05.3): | - | - |
| Cereals and cereal products, incl. flours & starches from roots & tubers, pulses & legumes, excluding bakery (06.0): | 5.00000 | 25.00000 |
| Bakery wares (07.0): | 10.00000 | 50.00000 |
| Meat and meat products, including poultry and game (08.0): | 2.00000 | 10.00000 |
| Fish and fish products, including molluscs, crustaceans and echinoderms (MCE) (09.0): | 2.00000 | 10.00000 |
| Eggs and egg products (10.0): | - | - |
| Sweeteners, including honey (11.0): | - | - |
| Salts, spices, soups, sauces, salads, protein products, etc. (12.0): | 5.00000 | 25.00000 |
| Foodstuffs intended for particular nutritional uses (13.0): | 10.00000 | 50.00000 |
| Non-alcoholic ("soft") beverages, excl. dairy products (14.1): | 5.00000 | 25.00000 |
| Alcoholic beverages, incl. alcohol-free and low-alcoholic counterparts (14.2): | 10.00000 | 50.00000 |
| Ready-to-eat savouries (15.0): | 20.00000 | 100.00000 |
| Composite foods (e.g. casseroles, meat pies, mincemeat) - foods that could not be placed in categories 01.0 - 15.0 (16.0): | 5.00000 | 25.00000 |
Safety References:
European Food Safety Athority(EFSA):Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...
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European Food Safety Authority (EFSA) reference(s):
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Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) related to Flavouring Group Evaluation 7 (FGE.07): Saturated and unsaturated aliphatic secondary alcohols, ketones and esters of secondary alcohols and saturated linear or branched-chain carboxylic acids from chemical group 5
View page or View pdf
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Flavouring Group Evaluation 63 (FGE.63): Consideration of aliphatic secondary alcohols, ketones and related esters evaluated by JECFA (59th meeting) structurally related to saturated and unsaturated aliphatic secondary alcohols, ketones and esters of secondary alcohols and saturated linear or branched-chain carboxylic acids evaluated by EFSA in FGE.07 (2005) (Commission Regulation (EC) No 1565/2000 of 18 July 2000)
View page or View pdf
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Flavouring Group Evaluation 7, Revision 1 (FGE.07Rev1): Saturated and unsaturated aliphatic secondary alcohols, ketones and esters of secondary alcohols and saturated linear or branched-chain carboxylic acids from chemical group 5 (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Scientific opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) on a request from the Commission
View page or View pdf
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Flavouring Group Evaluation 7, Revision 2 (FGE.07Rev2) : Saturated and unsaturated aliphatic secondary alcohols, ketones and esters of secondary alcohols and saturated linear or branched-chain carboxylic acids from chemical group 5
View page or View pdf
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Flavouring Group Evaluation 7, Revision 3 (FGE.07Rev3): Saturated and unsaturated aliphatic secondary alcohols, ketones and esters of secondary alcohols and saturated linear or branched-chain carboxylic acids from chemical group 5
View page or View pdf
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Scientific Opinion on Flavouring Group Evaluation 7, Revision 4 (FGE.07Rev4): Saturated and unsaturated aliphatic secondary alcohols, ketones and esters of secondary alcohols and saturated linear or branched-chain carboxylic acids from chemical group 5
View page or View pdf
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Scientific Opinion on Flavouring Group Evaluation 7, Revision 5 (FGE.07Rev5): saturated and unsaturated aliphatic secondary alcohols, ketones and esters of secondary alcohols and saturated linear or branched-chain carboxylic acids from chemical group 5
View page or View pdf
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| EPI System: View |
| NIOSH International Chemical Safety Cards:search |
| NIOSH Pocket Guide:search |
| Chemical Carcinogenesis Research Information System:Search |
| AIDS Citations:Search |
| Cancer Citations:Search |
| Toxicology Citations:Search |
| EPA Substance Registry Services (TSCA):108-11-2 |
| EPA ACToR:Toxicology Data |
| EPA Substance Registry Services (SRS):Registry |
| Laboratory Chemical Safety Summary :7910 |
| National Institute of Allergy and Infectious Diseases:Data |
| WISER:UN 2053 |
| WGK Germany:1 |
| 4-methylpentan-2-ol |
| Chemidplus:0000108112 |
| EPA/NOAA CAMEO:hazardous materials |
| RTECS:108-11-2 |
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| iso | butyl methyl carbinol | | iso | butylmethylcarbinol | | iso | butylmethylmethanol | | | methyl isobutyl carbinol | | p- | methyl isobutyl carbinol | | para- | methyl isobutyl carbinol | | 4- | methyl pentan-2-ol | | 4- | methyl-2-amyl alcohol | | (±)-4- | methyl-2-pentanol | | 4- | methyl-2-pentanol | | 4- | methyl-2-pentyl alcohol | | 2- | methyl-4-pentanol | | | methylisobutylcarbinol | | DL- | methylisobutylcarbinol | | 4- | methylpentan-2-ol | | | pentan-2-ol, 4-methyl- | | 4- | pentanol, 2-methyl- | | 2- | pentanol, 4-methyl- |
Articles:
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3D/inchi