EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

ibuprofen
benzeneacetic acid, a-methyl-4-(2-methylpropyl)-

Supplier Sponsors

CAS Number: 15687-27-1Picture of molecule3D/inchi
Other(deleted CASRN):139466-08-3
ECHA EINECS - REACH Pre-Reg:239-784-6
FDA UNII: WK2XYI10QM
Nikkaji Web:J3.134H
Beilstein Number:2049713
MDL:MFCD00010393
XlogP3:3.50 (est)
Molecular Weight:206.28486000
Formula:C13 H18 O2
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:cosmetic ingredient for skin conditioning
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
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Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Appearance:white powder (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 76.00 °C. @ 760.00 mm Hg
Boiling Point: 319.60 °C. @ 760.00 mm Hg (est)
Vapor Pressure:4.740000 mmHg @ 4.74 °C. (est)
Flash Point: 422.00 °F. TCC ( 216.70 °C. ) (est)
logP (o/w): 3.970
Soluble in:
 water, 21 mg/L @ 25 °C (exp)
 water, 41.05 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: skin conditioning
 
Suppliers:
BOC Sciences
For experimental / research use only.
Ibuprofen (Dolgesic)
Odor: characteristic
Use: An inhibitor of COX-1 and COX-2 with IC50 of 13 nM and 370 nM, respectively
Glentham Life Sciences
Ibuprofen
Santa Cruz Biotechnology
For experimental / research use only.
Ibuprofen ≥99%
Sigma-Aldrich: Sigma
For experimental / research use only.
Ibuprofen ≥98% (GC)
sds
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-child LDLo 469 mg/kg
LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Annals of Emergency Medicine. Vol. 15, Pg. 1308, 1986.

oral-child TDLo 480 mg/kg/17D-
LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), DIFFUSE"
Journal of Pediatrics. Vol. 90, Pg. 657, 1977.

oral-child TDLo 500 mg/kg
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"
Annals of Pharmacotherpy. Vol. 31, Pg. 432, 1997.

oral-guinea pig LD50 495 mg/kg
Archives of Toxicology, Supplement. Vol. 7, Pg. 365, 1984.

oral-hamster LD50 1690 mg/kg
Archives of Toxicology, Supplement. Vol. 7, Pg. 365, 1984.

oral-mammal (species unspecified) LD50 1000 mg/kg
Acta Poloniae Pharmaceutica. For English translation, see APPFAR. Vol. 42, Pg. 545, 1985.

oral-man LDLo 171 mg/kg
BEHAVIORAL: GENERAL ANESTHETIC VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION
British Medical Journal. Vol. 281, Pg. 1458, 1980.

oral-man TDLo 120 mg/kg/W-I
SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"
New York State Journal of Medicine. Vol. 78, Pg. 1239, 1978.

oral-man TDLo 180 mg/kg/3W-I
LIVER: "JAUNDICE, CHOLESTATIC"
American Journal of Gastroenterology. Vol. 91, Pg. 1626, 1996.

oral-man TDLo 429 mg/kg
KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" LUNGS, THORAX, OR RESPIRATION: RESPIRATORY OBSTRUCTION
Journal of Toxicology, Clinical Toxicology. Vol. 32, Pg. 315, 1994.

oral-man TDLo 800 mg/kg
BEHAVIORAL: COMA BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Postgraduate Medical Journal. Vol. 69, Pg. 575, 1993.

oral-man TDLo 1028 mg/kg
KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"
American Journal of Emergency Medicine. Vol. 13, Pg. 375, 1995.

intraperitoneal-mouse LD50 320 mg/kg
GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Toxicology and Applied Pharmacology. Vol. 15, Pg. 310, 1969.

oral-mouse LD50 740 mg/kg
BEHAVIORAL: ANALGESIA
Pharmaceutical Chemistry Journal Vol. 14, Pg. 119, 1980.

oral-rabbit LD50 1400 mg/kg
Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 32, Pg. 1032, 1990.

intraperitoneal-rat LD50 626 mg/kg
BEHAVIORAL: ANALGESIA
Arzneimittel-Forschung. Drug Research. Vol. 27, Pg. 1006, 1977.

oral-rat LD50 636 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 34, Pg. 280, 1984.

Dermal Toxicity:
subcutaneous-mouse LD50 395 mg/kg
Oyo Yakuri. Pharmacometrics. Vol. 24, Pg. 415, 1982.

subcutaneous-rat LD50 740 mg/kg
Oyo Yakuri. Pharmacometrics. Vol. 24, Pg. 415, 1982.

Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
cosmetic ingredient for skin conditioning
Recommendation for ibuprofen usage levels up to:
 not for fragrance use.
 
Recommendation for ibuprofen flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
ClinicalTrials.gov:search
Daily Med:search
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
Carcinogenic Potency Database:Search
EPA Substance Registry Services (TSCA):15687-27-1
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :3672
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
2-[4-(2-methylpropyl)phenyl]propanoic acid
Chemidplus:0015687271
RTECS:MU6640000 for cas# 15687-27-1
 
References:
 2-[4-(2-methylpropyl)phenyl]propanoic acid
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):3672
Pubchem (sid):134991986
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
KEGG (GenomeNet):C01588
HMDB (The Human Metabolome Database):HMDB01925
FooDB:FDB023583
Export Tariff Code:2916.39.1500
MedlinePlusSupp:View
ChemSpider:View
Wikipedia:View
Formulations/Preparations:
generic. tablets 200 (nonprescription), 300, 400, 600, and 800 mg. advil (whitehall), medipren (mcneil), midol 200 (glenbrook), nuprin (bristol-myers). tablets 200 mg (nonprescription). children's advil suspension (whitehall), pedia-profen (mcneil). suspension 100 mg5 ml. motrin (upjohn). tablets 200 (motrin ib, nonprescription), 300, 400 600, and 800 mg. rufen (boots). tablets 400, 600, and 800 mg.
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
 advil
 algofen
 amibufen
 antalfene
 bayer select pain relief
 benzeneacetic acid, a-methyl-4-(2-methylpropyl)-
 betaprofen
 bukrefen
 buprofen
4-isobutyl-a-methylphenylacetic Acid
4-isobutyl-alpha-methyl phenyl acetic acid
2-(4-isobutyl-phenyl)-propionic acid
4-isobutylhydratropic acid
para-isobutylhydratropic acid
(4-isobutylphenyl)-a-methylacetic acid
(±)-2-(4-isobutylphenyl)-propionic acid
2-(4-isobutylphenyl)-propionic acid
2-(4-isobutylphenyl)propanoic acid
(±)-2-(p-isobutylphenyl)propionic acid
2-(4-isobutylphenyl)propionic acid
2-(p-isobutylphenyl)propionic acid
 dignoflex
 dolmaral
 dolo-dolgit
 dolomax
 duralbuprofen
 femapirin
 ibufen
 ibuhexal
 ibumed
 ibuprin
 ibuprocin
(±)-ibuprofen
(RS)-ibuprofen
DL-ibuprofen
(±)-ibuprophen
 jenaprofen
 lebrufen
 librofem
 malafene
 melfen
(±)-a-methyl-4-(2-methylpropyl)benzeneacetic Acid
a-methyl-4-(2-methylpropyl)benzeneacetic acid
a-methyl-4-(isobutyl)phenylacetic acid
2-[4-(2-methylpropyl)phenyl]propanoic acid
 motrin
 mynosedin
 napacetin
 neobrufen
 novo-profen
 novoprofen
 pediaprofen
 ranofen
 relcofen
 salprofen
 sednafen
 sertraline
 seskafen
 suprafen
 suspren
 syntofene
 uprofen
 

Articles:

Info:Ibuprofen
PubMed:Reduction in Pain and Inflammation Associated With Chronic Low Back Pain With the Use of the Medical Food Theramine.
PubMed:The efficacy of different pre- and post-operative analgesics in the management of pain after orthodontic separator placement: A randomized clinical trial.
PubMed:Exploiting monitoring data in environmental exposure modelling and risk assessment of pharmaceuticals.
PubMed:Irrigation of root vegetables with treated wastewater: evaluating uptake of pharmaceuticals and the associated human health risks.
PubMed:Drugs associated with adverse events in children and adolescents.
PubMed:Urinary metabolomic fingerprinting after consumption of a probiotic strain in women with mastitis.
PubMed:Patient perception and knowledge of acetaminophen in a large family medicine service.
PubMed:Quantifying the release of lactose from polymer matrix tablets with an amperometric biosensor utilizing cellobiose dehydrogenase.
PubMed:An improved method for the characterization of supersaturation and precipitation of poorly soluble drugs using pulsatile microdialysis (PMD).
PubMed:Occurrence of acidic pharmaceuticals and personal care products in Turia River Basin: from waste to drinking water.
PubMed:Determination of non-opioid analgesics in adulterated food and dietary supplements by LC-MS/MS.
PubMed:Bone loss from high repetitive high force loading is prevented by ibuprofen treatment.
PubMed:Febrile seizures.
PubMed:Competitive interactions of anti-carcinogens with serum albumin: a spectroscopic study of bendamustine and dexamethasone with the aid of chemometrics.
PubMed:Authors' reply: NSAIDs and small kidneys in a workers' compensation death claim.
PubMed:Death related to Ibuprofen, valdecoxib, and medical errors: case report and medicolegal issues.
PubMed:Encapsulation altered starch digestion: toward developing starch-based delivery systems.
PubMed:Biodegradability of pharmaceutical compounds in agricultural soils irrigated with treated wastewater.
PubMed:An overview of the pediatric medications for the symptomatic treatment of allergic rhinitis, cough, and cold.
PubMed:Aspirin augments IgE-mediated histamine release from human peripheral basophils via Syk kinase activation.
PubMed:More pain for painkillers.
PubMed:Is Atyaephyra desmarestii a useful candidate for lethal and sub-lethal toxicity tests on pharmaceutical compounds?
PubMed:Simultaneous monitoring of superoxides and intracellular calcium ions in neutrophils by chemiluminescence and fluorescence: evaluation of action mechanisms of bioactive compounds in foods.
PubMed:Foliar sorption of emerging and priority contaminants under controlled conditions.
PubMed:Death related to Ibuprofen, valdecoxib, and medical errors: case report and medicolegal issues.
PubMed:Pharmacokinetic and bioequivalence studies of ibuprofen suspension after a single-dose administration in healthy Chinese volunteers.
PubMed:Organized polysaccharide fibers as stable drug carriers.
PubMed:Using milk fat to reduce the irritation and bitter taste of ibuprofen.
PubMed:Budget impact modeling for a single-tablet formulation of ibuprofen and famotidine for prevention of upper gastrointestinal ulcers in patients with osteoarthritis and/or rheumatoid arthritis.
PubMed:Development and validation of a sensitive and high-throughput LC-MS/MS method for the simultaneous determination of esomeprazole and naproxen in human plasma.
PubMed:Side-effects of analgesic kyotorphin derivatives: advantages over clinical opioid drugs.
PubMed:Paediatric anaphylaxis in a Singaporean children cohort: changing food allergy triggers over time.
PubMed:Extended-release hydrocodone - gift or curse?
PubMed:Palatability and treatment efficacy of various ibuprofen formulations in C57BL/6 mice with ulcerative dermatitis.
PubMed:Evaluation of Glucosamine sulfate and Ibuprofen effects in patients with temporomandibular joint osteoarthritis symptom.
PubMed:Gastrointestinal safety of NSAIDs and over-the-counter analgesics.
PubMed:Gene transcription and biomarker responses in the clam Ruditapes philippinarum after exposure to ibuprofen.
PubMed:Interaction of over-the-counter drugs with curcumin: influence on stability and bioactivities in intestinal cells.
PubMed:Risk assessment on the presence of pharmaceuticals in sediments, soils and waters of the Pego-Oliva Marshlands (Valencia, eastern Spain).
PubMed:Occurrence of micro-organic pollutants on phosphorus recovery from urine.
PubMed:Enantioselective binding interaction of the metolachlor pesticide enatiomers with bovine serum albumin--a spectroscopic analysis study.
PubMed:Age-related changes in core body temperature and activity in triple-transgenic Alzheimer's disease (3xTgAD) mice.
PubMed:Development and validation of two multiresidue liquid chromatography tandem mass spectrometry methods based on a versatile extraction procedure for isolating non-steroidal anti-inflammatory drugs from bovine milk and muscle tissue.
PubMed:Aggravation of exercise-induced intestinal injury by Ibuprofen in athletes.
PubMed:Performance of repetitive tasks induces decreased grip strength and increased fibrogenic proteins in skeletal muscle: role of force and inflammation.
PubMed:Inhibition of mitochondrial complex I by various non-steroidal anti-inflammatory drugs and its protection by quercetin via a coenzyme Q-like action.
PubMed:The potential of dietary polyunsaturated fatty acids to modulate eicosanoid synthesis and reproduction in Daphnia magna: a gene expression approach.
PubMed:Development of novel ibuprofen-loaded solid dispersion with enhanced bioavailability using cycloamylose.
PubMed:A comparative study of oral tramadol and ibuprofen in postoperative pain in operations of lower abdomen.
PubMed:NSAIDs: take with food or after fasting?
PubMed:Pharmaceutical and personal care products in groundwater, subsurface drainage, soil, and wheat grain, following a high single application of municipal biosolids to a field.
PubMed:Uptake of organic emergent contaminants in spath and lettuce: an in vitro experiment.
PubMed:Differences in the chemesthetic subqualities of capsaicin, ibuprofen, and olive oil.
PubMed:Emerging pollutants in sewage, surface and drinking water in Galicia (NW Spain).
PubMed:Bioequivalence assessment of two formulations of ibuprofen.
PubMed:Competitive binding of small molecules with biopolymers: a fluorescence spectroscopy and chemometrics study of the interaction of aspirin and ibuprofen with BSA.
PubMed:Development of a liquid chromatography tandem mass spectrometry method for simultaneous determination of eight adulterants in slimming functional foods.
PubMed:Anticounterfeit protection of pharmaceutical products with spatial mapping of X-ray-detectable barcodes and logos.
PubMed:Sickle cell disease.
PubMed:Simultaneous determination of 20 pharmacologically active substances in cow's milk, goat's milk, and human breast milk by gas chromatography-mass spectrometry.
PubMed:Nitrification activity and community structure of nitrite-oxidizing bacteria in the bioreactors operated with addition of pharmaceuticals.
PubMed:Cardiovascular safety of non-steroidal anti-inflammatory drugs: network meta-analysis.
PubMed:Ibuprofen and acute kidney injury in the newborn.
PubMed:An overview of clinical pharmacology of Ibuprofen.
PubMed:Analysis of the interactions of mixtures of two beta-agonists steroids with bovine serum albumin: a fluorescence spectroscopy and chemometrics investigation.
PubMed:Use of nonsteroidal anti-inflammatory drugs in patients with cardiovascular disease: a cautionary tale.
PubMed:In vitro enhancement of lactate esters on the percutaneous penetration of drugs with different lipophilicity.
PubMed:Housing environment influences the need for pain relief during post-operative recovery in mice.
PubMed:Dehydration-induced increase in aquaporin-2 protein abundance is blocked by nonsteroidal anti-inflammatory drugs.
PubMed:Febrile seizures.
PubMed:Anti-inflammatory drugs selectively target sporangium development in Mucor.
PubMed:Synthesis, biological evaluation, and molecular modeling of oleuropein and its semisynthetic derivatives as cyclooxygenase inhibitors.
PubMed:Interactions between quercetin and warfarin for albumin binding: A new eye on food/drug interference.
PubMed:Occurrence of pharmaceutically active compounds in surface waters of the Henares-Jarama-Tajo River system (Madrid, Spain) and a potential risk characterization.
PubMed:Reduction of low grade inflammation restores blunting of postprandial muscle anabolism and limits sarcopenia in old rats.
PubMed:Determination of ibuprofen, ketoprofen, diclofenac and phenylbutazone in bovine milk by gas chromatography-tandem mass spectrometry.
PubMed:Comparison of low-shear and high-shear granulation processes: effect on implantable calcium phosphate granule properties.
PubMed:Alginate-PLL cell encapsulation system Co-entrapping PLGA-microspheres for the continuous release of anti-inflammatory drugs.
PubMed:Development of a yeast bio-assay to screen anti-mitochondrial drugs.
PubMed:Runoff of pharmaceuticals and personal care products following application of dewatered municipal biosolids to an agricultural field.
PubMed:Pattern recognition analysis for the prediction of adverse effects by nonsteroidal anti-inflammatory drugs using 1H NMR-based metabolomics in rats.
PubMed:Tumor markers and rectal cancer: support for an inflammation-related pathway.
PubMed:Sickle cell disease.
PubMed:Pharmaceutical and personal care products in tile drainage following surface spreading and injection of dewatered municipal biosolids to an agricultural field.
PubMed:Investigation of some factors contributing to negative food effects.
PubMed:Evaluation of Enterococcus mundtii ST4SA and Lactobacillus plantarum 423 as probiotics by using a gastro-intestinal model with infant milk formulations as substrate.
PubMed:First attack of acute urticaria in pediatric emergency department.
PubMed:Potential analgesic and anti-inflammatory activities of Panax ginseng head butanolic fraction in animals.
PubMed:Stress fracture and military medical readiness: bridging basic and applied research.
PubMed:Anti-inflammatory effects of sinapic acid through the suppression of inducible nitric oxide synthase, cyclooxygase-2, and proinflammatory cytokines expressions via nuclear factor-kappaB inactivation.
PubMed:Influence of pharmaceutical residues on the structure of activated sludge bacterial communities in wastewater treatment bioreactors.
PubMed:Pharmaceutical and personal care products in tile drainage following land application of municipal biosolids.
PubMed:Runoff of pharmaceuticals and personal care products following application of biosolids to an agricultural field.
PubMed:[Eosinophilic esophagitis due to allergy to sheep and goat milk proteins].
PubMed:Patterns of pregnancy exposure to prescription FDA C, D and X drugs in a Canadian population.
PubMed:Confirmatory identification of sixteen non-steroidal anti-inflammatory drug residues in raw milk by liquid chromatography coupled with ion trap mass spectrometry.
PubMed:Febrile seizures.
PubMed:Desorption electrospray ionization of aerosol particles.
PubMed:The variability and quality of medication container labels.
PubMed:Concomitant use of ibuprofen and aspirin.
PubMed:Simultaneous spectrophotometric determination of paracetamol, ibuprofen and caffeine in pharmaceuticals by chemometric methods.
PubMed:Common clinical and practical questions on the use of intravenous Ibuprofen lysine for the treatment of patent ductus arteriosus.
PubMed:Role of racemization in optically active drugs development.
PubMed:Recent FDA warning of the concomitant use of aspirin and ibuprofen and the effects on platelet aggregation.
PubMed:Aspirin-ibuprofen coadministration--FDA issues consumer alert.
PubMed:Ibuprofen lysine (NeoProfen) for the treatment of patent ductus arteriosus.
PubMed:Comparative bioavailability study of two ibuprofen preparations after oral administration in healthy volunteers.
PubMed:Health benefits of herbs and spices: the past, the present, the future.
PubMed:Use of non-aspirin nonsteroidal antiinflammatory drugs and the risk of cardiovascular events.
PubMed:Do selective cyclo-oxygenase-2 inhibitors and traditional non-steroidal anti-inflammatory drugs increase the risk of atherothrombosis? Meta-analysis of randomised trials.
PubMed:Acoustic-resonance spectrometry as a process analytical technology for rapid and accurate tablet identification.
PubMed:Risk of cardiovascular events and celecoxib: a systematic review and meta-analysis.
PubMed:Chronic intracerebroventricular infusion of lipopolysaccharide: effects of ibuprofen treatment and behavioural and histopathological correlates.
PubMed:Effects of non-ionic surfactants on isotachophoretic separations of 2-arylpropionic acids.
PubMed:Ibuprofen extrudate, a novel, rapidly dissolving ibuprofen formulation: relative bioavailability compared to ibuprofen lysinate and regular ibuprofen, and food effect on all formulations.
PubMed:How celecoxib could be safer, how valdecoxib might have been.
PubMed:In vitro assessment of modes of toxic action of pharmaceuticals in aquatic life.
PubMed:Nonsteroidal anti-inflammatory drugs and hepatic toxicity: a systematic review of randomized controlled trials in arthritis patients.
PubMed:Interferon-beta1b for multiple sclerosis.
PubMed:Pharmacokinetic properties of combination oxycodone plus racemic ibuprofen: two randomized, open-label, crossover studies in healthy adult volunteers.
PubMed:Pre-emptive effects of ibuprofen syrup and lidocaine infiltration on post-operative analgesia in children undergoing adenotonsillectomy.
PubMed:Risk of acute myocardial infarction and sudden cardiac death in patients treated with cyclo-oxygenase 2 selective and non-selective non-steroidal anti-inflammatory drugs: nested case-control study.
PubMed:Commonly used drugs impair oral tolerance in mice.
PubMed:Physical solid-state properties and dissolution of sustained-release matrices of polyvinylacetate.
PubMed:Nabumetone: therapeutic use and safety profile in the management of osteoarthritis and rheumatoid arthritis.
PubMed:Influence of acidic beverage (Coca-Cola) on pharmacokinetics of ibuprofen in healthy rabbits.
PubMed:Analgesics for acute pain: Meeting the United States Food and Drug Administration's requirements for proof of efficacy.
PubMed:Effects of pharmaceutical mixtures in aquatic microcosms.
PubMed:The "high solubility" definition of the current FDA Guidance on Biopharmaceutical Classification System may be too strict for acidic drugs.
PubMed:Parental satisfaction with sumatriptan nasal spray in childhood migraine.
PubMed:Effect of Tamarindus indica. L on the bioavailability of ibuprofen in healthy human volunteers.
PubMed:Inhibition of cyclooxygenase (COX) enzymes by compounds from Daucus carota L. Seeds.
PubMed:Inhibition of proliferation of human cancer cells and cyclooxygenase enzymes by anthocyanidins and catechins.
PubMed:Severity of baseline pain and degree of analgesia in the third molar post-extraction dental pain model.
PubMed:Glucuronidation of 1'-hydroxyestragole (1'-HE) by human UDP-glucuronosyltransferases UGT2B7 and UGT1A9.
PubMed:Cyclooxygenase inhibitory and antioxidant compounds from crabapple fruits.
PubMed:[Cataract prevention. Therapeutic approaches and critical review of current status].
PubMed:High-voltage capacitively coupled contactless conductivity detection for microchip capillary electrophoresis.
PubMed:Why aren't lower, effective, OTC doses available earlier by prescription?
PubMed:Validation of a liquid chromatographic method for the determination of ibuprofen in human plasma.
PubMed:Serum leptin concentrations after surgery in young rats.
PubMed:Bioactivity of alkamides isolated from Echinacea purpurea (L.) Moench.
PubMed:Characterization, quantification, and bioactivities of anthocyanins in Cornus species.
PubMed:Combination hydrocodone and ibuprofen versus combination oxycodone and acetaminophen in the treatment of moderate or severe acute low back pain.
PubMed:Cyclooxygenase inhibitory and antioxidant cyanidin glycosides in cherries and berries.
PubMed:The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse.
PubMed:Degradation products of cyanidin glycosides from tart cherries and their bioactivities.
PubMed:Prospective, randomized, comparative study of Misgav Ladach versus traditional cesarean section at Nazareth Hospital, Kenya.
PubMed:An evaluation of analgesic regimens for abdominal surgery in mice.
PubMed:Elucidation of solution state complexation in wet-granulated oven-dried ibuprofen and beta-cyclodextrin: FT-IR and 1H-NMR studies.
PubMed:Enhancement of ibuprofen dissolution via wet granulation with beta-cyclodextrin.
PubMed:Beating HIV at its own game: the success of IL-2.
PubMed:Ibuprofen effects on behavioral thermoregulation with microwave radiation in albino rats.
PubMed:Investigation of foreign substances in food.
PubMed:A search for sex differences in response to analgesia.
PubMed:In vivo selectivity of nonsteroidal antiinflammatory drugs and gastrointestinal ulcers in rats.
PubMed:Tumor necrosis factor alpha and interleukin-6 have differential effects on food intake and gastric emptying in fasted rats.
PubMed:Over-the-counter analgesics and antipyretics: a critical assessment.
PubMed:The effect of alcohol abuse on the risk of NSAID-related gastrointestinal events.
PubMed:Prophylactic ibuprofen therapy of patent ductus arteriosus in preterm infants.
PubMed:Antioxidant and cyclooxygenase inhibitory phenolic compounds from Ocimum sanctum Linn.
PubMed:Baseline pain and response to analgesic medications in the postsurgery dental pain model.
PubMed:Morning versus evening dosing of ibuprofen using conventional and time-controlled release formulations.
PubMed:Inhibitors of prostaglandin synthesis do not improve food intake or body weight of tumor-bearing rats.
PubMed:Pharmacokinetics of ibuprofen after intravenous and oral administration and assessment of safety of administration to healthy foals.
PubMed:Nutraceuticals as therapeutic agents in osteoarthritis. The role of glucosamine, chondroitin sulfate, and collagen hydrolysate.
PubMed:Inhibition by piroxicam of oxidative DNA damage, liver cirrhosis and development of enzyme-altered nodules caused by a choline-deficient, L-amino acid-defined diet in rats.
PubMed:Determination of enantiomeric composition of ibuprofen in bulk drug by proton nuclear magnetic resonance spectroscopy with a chiral lanthanide chelate.
PubMed:Bioequivalence of chiral drugs. Stereospecific versus non-stereospecific methods.
PubMed:Peri-operative multimodal pain therapy for caesarean section: analgesia and fitness for discharge.
PubMed:Fasting and postprandial disposition of R(-)- and S(+)-ibuprofen following oral administration of racemic drug in healthy individuals.
PubMed:Ibuprofen and paracetamol: relative safety in non-prescription dosages.
PubMed:Chemoprevention of colon cancer by dietary administration of naturally-occurring and related synthetic agents.
PubMed:The effect of food on the bioavailability of ibuprofen and flurbiprofen from sustained release formulations.
PubMed:Nutritional, immunologic and psychological responses to a 7250 km run.
PubMed:Significance of mobile phase composition in enantioseparation of chiral drugs by HPLC on a cellulose-based chiral stationary phase.
PubMed:Chemoprevention of colon cancer by minor dietary constituents and their synthetic analogues.
PubMed:[Phytotherapeutic aspects of diseases of the circulatory system. 4. Chitin and chitosan].
PubMed:Evaluation of bromfenac and ibuprofen for pain after orthopedic surgery.
PubMed:Resolution of the enantiomers of ibuprofen; comparison study of diastereomeric method and chiral stationary phase method.
PubMed:The pharmacokinetics of ibuprofen after burn injury.
PubMed:Our front-line leaders deserve more than ibuprofen, junk food.
PubMed:The effects of cyclooxygenase inhibitors on tumor-induced anorexia in rats.
PubMed:The effect of food or sucralfate on the bioavailability of S(+) and R(-) enantiomers of ibuprofen.
PubMed:An alternative approach for assessment of rate of absorption in bioequivalence studies.
PubMed:The role of prostaglandins in interleukin-1 induced gastroparesis.
PubMed:Nonsteroidal anti-inflammatory drug-associated pulmonary infiltrates with eosinophilia. Review of the literature and Food and Drug Administration Adverse Drug Reaction reports.
PubMed:Bioavailability of two ibuprofen oral paste formulations in fed or nonfed ponies.
PubMed:Ibuprofin safety.
PubMed:Both cyclooxygenase and lipoxygenase inhibitor partially restore the anorexia by interleukin-1 beta.
PubMed:Enhanced sensitivity to anorexia and consumption of drinking water induced by interleukin-1 beta in obese yellow mice.
PubMed:Central administration of ibuprofen failed to block the anorexia induced by interleukin-1.
PubMed:Fish oil and interleukin-1--induced anorexia.
PubMed:The effect of food on gastrointestinal (GI) transit of sustained-release ibuprofen tablets as evaluated by gamma scintigraphy.
PubMed:Pharmacists' evaluations of the nonprescription availability of metaproterenol, cimetidine, ibuprofen, and nystatin.
PubMed:Interleukin-1-induced anorexia in the rat. Influence of prostaglandins.
PubMed:Probable hypersensitivity vasculitis in a dog.
PubMed:Effects of aspirin-like drugs on Walker 256 tumor growth and cachexia in rats.
PubMed:Effect of cytoprotective and antiulcer drugs on the healing process of subacute gastric ulcer in rat (a new model).
PubMed:Novel method for producing standard subacute gastric ulcer in rats and for the quantitative evaluation of the healing process. Effect of several drugs on healing.
PubMed:Assessment of gastric bleeding in rats: effects of cyclooxygenase inhibitors and 16,16-dimethyl prostaglandin E2 on gastric bleeding.
PubMed:Salicylate potentiates valproate-induced hyperammonemia in the rat.
PubMed:The role of pharmacologic agents in the prevention or treatment of allergic food disorders.
PubMed:Ibuprofen without a prescription.
PubMed:Ibuprofen-induced gastrointestinal changes.
PubMed:[Prevention of food hypersensitivities with aspirin].
PubMed:Interim report: National Registry of possible Drug-induced Ocular Side Effects.
PubMed:Prostaglandin synthetase inhibitors and food intolerance.
PubMed:Prostaglandin-synthesis inhibitors in prophylaxis of food intolerance.
PubMed:New drugs and new treatments.
PubMed:Ibuprofen (Motrin)-a new drug for arthritis.
 
Notes:
a nonsteroidal anti-inflammatory agent with analgesic properties used in the therapy of rheumatism and arthritis. Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) widely marketed under various trademarks including Act-3, Advil, Brufen, Motrin, Nuprin, and Nurofen. It is used for relief of symptoms of arthritis, primary dysmenorrhoea, and fever; Ibuprofen is an NSAID which is believed to work through inhibition of cyclooxygenase (COX), thus inhibiting prostaglandin synthesis. There are at least 2 variations of cyclooxygenase (COX-1 and COX-2), ibuprofen inhibits both COX-1 and COX-2. It appears that its analgesic, antipyretic, and anti-inflammatory activity are achieved principally through COX-2 inhibition; whereas COX-1 inhibition is responsible for its unwanted effects on platelet aggregation and the GI mucosa. As with other NSAIDs, ibuprofen inhibits platelet aggregation, but is not used therapeutically for this action since it is a minor and reversible effect. -- Wikipedia [HMDB] A selective serotonin uptake inhibitor that is used in the treatment of depression.; Sertraline hydrochloride (also labeled under numerous brand names: Zoloft, Sertralin, Lustral, Apo-Sertral, Asentra, Gladem, Serlift, Stimuloton, Xydep, Serlain, Concorz) is an orally administered antidepressant of the selective serotonin reuptake inhibitor (SSRI) type. It was first approved by the Food and Drug Administration (FDA) in 1991.; Sertraline is an odorless, white, sparingly soluble crystalline solid. The minimum effective dose is usually 50 mg per day (it can be still effective at 25 mg or 37.5 mg), but lower doses may be used in the initial weeks of treatment to acclimate the patient's body, especially the liver, to the drug and to minimize the severity of any side effects. Patients who do not experience relief of symptoms at 50 mg a day may have their dose increased, up to 200 mg a day.; Sertraline (HCl) is used medically mainly to treat the symptoms of depression and anxiety. It is also prescribed for the treatment of obsessive-compulsive disorder (OCD), post-traumatic stress disorder (PTSD), premenstrual dysphoric disorder (PMDD), panic disorder (PD) and social phobia/social anxiety disorder.; A study has shown that sertraline is an effective treatment for impulsive aggressive behavior in personality disordered patients. [HMDB]
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