EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

4-chloro-3-methyl phenol
4-chloro-3-methylphenol

Supplier Sponsors

Name:4-chloro-3-methylphenol
CAS Number: 59-50-7Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:200-431-6
FDA UNII: 36W53O7109
Nikkaji Web:J4.604C
Beilstein Number:1237629
MDL:MFCD00002323
XlogP3:3.10 (est)
Molecular Weight:142.58399000
Formula:C7 H7 Cl O
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:preservatives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
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Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 FDA/DG SANTE Petitions, Reviews, Notices:
FCN 560 p-chloro-m-cresol View - notice
FDA Mainterm (IAUFC):59-50-7 ; 4-CHLORO-3-METHYLPHENOL
FDA Regulation:
FDA PART 175 -- INDIRECT FOOD ADDITIVES: ADHESIVES AND COMPONENTS OF COATINGS
Subpart B--Substances for Use Only as Components of Adhesives
Sec. 175.105 Adhesives.
 
Physical Properties:
Appearance:pinkish to white crystalline solid (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 67.00 °C. @ 760.00 mm Hg
Boiling Point: 235.00 °C. @ 760.00 mm Hg
Vapor Pressure:0.050000 mmHg @ 20.00 °C. (est)
Flash Point: 200.00 °F. TCC ( 93.40 °C. ) (est)
logP (o/w): 3.100
Soluble in:
 water, 699.3 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: preservatives
 
Suppliers:
EMD Millipore
For experimental / research use only.
4-Chloro-3-methylphenol
sds
Glentham Life Sciences
4-Chloro-3-methylphenol, BP, EP grade
Glentham Life Sciences
4-Chloro-3-methylphenol
Indis NV
For experimental / research use only.
Chlorocresol
Penta International
4-CHLORO-3-METHYLPHENOL
Santa Cruz Biotechnology
For experimental / research use only.
4-Chloro-3-methylphenol
Shiva Chemicals and Pharmaceuticals
p-Chloro-m-cresol
Sigma-Aldrich: Aldrich
For experimental / research use only.
4-Chloro-3-methylphenol 99%
sds
TCI AMERICA
For experimental / research use only.
4-Chloro-m-cresol >99.0%(GC)
sds
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intravenous-mouse LD50 70 mg/kg
BEHAVIORAL: COMA LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Quarterly Journal of Pharmacy & Pharmacology. Vol. 12, Pg. 212, 1939.

oral-mouse LD50 600 mg/kg
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Science Reports of the Research Institutes, Tohoku University, Series C: Medicine. Vol. 36(1-4), Pg. 10, 1989.

oral-rat LD50 1830 mg/kg
Personal Communication from P. Schmitz, Bayer AG, 5090 Leverkusen, Bayerwerk, Fed. Rep. Ger., April 4, 1986Vol. 04APR1986

Dermal Toxicity:
subcutaneous-mouse LD50 360 mg/kg
BEHAVIORAL: GENERAL ANESTHETIC LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES BEHAVIORAL: TREMOR
Quarterly Journal of Pharmacy & Pharmacology. Vol. 12, Pg. 212, 1939.

subcutaneous-rat LD50 400 mg/kg
Quarterly Journal of Pharmacy & Pharmacology. Vol. 12, Pg. 212, 1939.

Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
preservatives
Recommendation for 4-chloro-3-methyl phenol usage levels up to:
 not for fragrance use.
 
Recommendation for 4-chloro-3-methyl phenol flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
NIOSH International Chemical Safety Cards:search
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):59-50-7
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :1732
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
4-chloro-3-methylphenol
Chemidplus:0000059507
EPA/NOAA CAMEO:hazardous materials
RTECS:59-50-7
 
References:
 4-chloro-3-methylphenol
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:59-50-7
Pubchem (cid):1732
Pubchem (sid):134972461
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Indirect Additives used in Food Contact Substances:View
CHEBI:View
CHEMBL:View
KEGG (GenomeNet):C14331
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2908.19.6000
ChemSpider:View
Wikipedia:View
Formulations/Preparations:
formulation types registered: end use, manufacturing use; crystalline.
 
Potential Blenders and core components note
None Found
 
Potential Uses:
 preservatives
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
 aptal
 baktol
 candaseptic
4-chloro-3-methylphenol
2-chloro-5-hydroxytoluene
4-chloro-m-cresol
p-chloro-m-cresol
4-chloro-meta-cresol
para-chloro-meta-cresol
p-chlorocresol
 parmatol
 parol
 PCMC
 peritonan
 phenol, 4-chloro-3-methyl-
 

Articles:

PubMed:In situ derivatization combined to automated microextraction by packed sorbents for the determination of chlorophenols in soil samples by gas chromatography mass spectrometry.
PubMed:Ammonium Increases Ca(2+) Signalling and Up-Regulates Expression of TRPC1 Gene in Astrocytes in Primary Cultures and in the In Vivo Brain.
PubMed:Functional characterisation of the R2452W ryanodine receptor variant associated with malignant hyperthermia susceptibility.
PubMed:The ryanodine receptor agonist 4-chloro-3-ethylphenol blocks ORAI store-operated channels.
PubMed:Functional characterization of 2 known ryanodine receptor mutations causing malignant hyperthermia.
PubMed:Capabilities and limitations of dispersive liquid-liquid microextraction with solidification of floating organic drop for the extraction of organic pollutants from water samples.
PubMed:Skeletal muscle-specific T-tubule protein STAC3 mediates voltage-induced Ca2+ release and contractility.
PubMed:Skeletal muscle ryanodine receptor mutations associated with malignant hyperthermia showed enhanced intensity and sensitivity to triggering drugs when expressed in human embryonic kidney cells.
PubMed:Ligand-dependent conformational changes in the clamp region of the cardiac ryanodine receptor.
PubMed:Contact and fumigant toxicities of 3-methylphenol isolated from Ostericum koreanum and its derivatives against house dust mites.
PubMed:Sequence capture and massively parallel sequencing to detect mutations associated with malignant hyperthermia.
PubMed:Molecular structure, spectroscopic studies (FTIR, FT-Raman and NMR) and HOMO-LUMO analysis of 6-chloro-o-cresol and 4-chloro-3-methyl phenol by density functional theoretical study.
PubMed:The Anx7(+/-) knockout mutation alters electrical and secretory responses to Ca(2+)-mobilizing agents in pancreatic β-cells.
PubMed:The antioxidant N-acetylcysteine prevents the mitochondrial fragmentation induced by soluble amyloid-β peptide oligomers.
PubMed:Residual sarcoplasmic reticulum Ca2+ concentration after Ca2+ release in skeletal myofibers from young adult and old mice.
PubMed:Mutated p.4894 RyR1 function related to malignant hyperthermia and congenital neuromuscular disease with uniform type 1 fiber (CNMDU1).
PubMed:Ryanodine receptors are expressed in epidermal keratinocytes and associated with keratinocyte differentiation and epidermal permeability barrier homeostasis.
PubMed:Analysis of human cultured myotubes responses mediated by ryanodine receptor 1.
PubMed:Alterations of excitation-contraction coupling and excitation coupled Ca(2+) entry in human myotubes carrying CAV3 mutations linked to rippling muscle.
PubMed:Muscle weakness in Ryr1I4895T/WT knock-in mice as a result of reduced ryanodine receptor Ca2+ ion permeation and release from the sarcoplasmic reticulum.
PubMed:Quantitative measurement of Ca²(+) in the sarcoplasmic reticulum lumen of mammalian skeletal muscle.
PubMed:Lymphocyte-based determination of susceptibility to malignant hyperthermia: a pilot study in swine.
PubMed:In vitro dermal penetration of 4-chloro-3-methylphenol from commercial metal working fluid and aqueous vehicles.
PubMed:Combined moxidectin and environmental therapy do not eliminate Chorioptes bovis infestation in heavily feathered horses.
PubMed:Functional studies of RYR1 mutations in the skeletal muscle ryanodine receptor using human RYR1 complementary DNA.
PubMed:Functional properties of RYR1 mutations identified in Swedish patients with malignant hyperthermia and central core disease.
PubMed:Sarcoplasmic reticulum Ca2+ depletion in adult skeletal muscle fibres measured with the biosensor D1ER.
PubMed:Determination of water pollutants by direct-immersion solid-phase microextraction using polymeric ionic liquid coatings.
PubMed:Commonly used ryanodine receptor activator, 4-chloro-m-cresol (4CmC), is also an inhibitor of SERCA Ca2+ pumps.
PubMed:A ryanodine receptor agonist promotes the consolidation of long-term memory in young chicks.
PubMed:Functional analysis of ryanodine receptor type 1 p.R2508C mutation in exon 47.
PubMed:Simultaneous recording of intramembrane charge movement components and calcium release in wild-type and S100A1-/- muscle fibres.
PubMed:Evaluation of irritancy and sensitization potential of metalworking fluid mixtures and components.
PubMed:Effects of plasticizers and their mixtures on estrogen receptor and thyroid hormone functions.
PubMed:Factors affecting SOCE activation in mammalian skeletal muscle fibers.
PubMed:Functional characterization of ryanodine receptor (RYR1) sequence variants using a metabolic assay in immortalized B-lymphocytes.
PubMed:[Disturbances in the function of cardiomyocyte ryanodine receptors of spontaneously hypertensive rats revealed by 4-chloro-m-cresol].
PubMed:Use of a programmed temperature vaporizer and an in situ derivatization reaction to improve sensitivity in headspace-gas chromatography. Application to the analysis of chlorophenols in water.
PubMed:Functional ryanodine receptors in the plasma membrane of RINm5F pancreatic beta-cells.
PubMed:Amperometric determination of chloroguaiacol at submicromolar levels after on-line preconcentration with molecularly imprinted polymers.
PubMed:Detection of phenolic compounds in flow systems based on tyrosinase-modified reticulated vitreous carbon electrodes.
PubMed:Simultaneous determination of 21 preservatives in cosmetics by ultra performance liquid chromatography.
PubMed:Novel ryanodine receptor mutation that may cause malignant hyperthermia.
PubMed:Altered stored calcium release in skeletal myotubes deficient of triadin and junctin.
PubMed:Faster and simpler determination of chlorophenols in water by fiber introduction mass spectrometry.
PubMed:Wide-ranging genomic effects of plasticisers and related compounds.
PubMed:Heterogeneous gene expression and functional activity of ryanodine receptors in resistance and conduit pulmonary as well as mesenteric artery smooth muscle cells.
PubMed:Ryanodine receptor expression correlates with tumor grade in breast cancer.
PubMed:Plastic components affect the activation of the aryl hydrocarbon and the androgen receptor.
PubMed:Identification and biochemical characterization of a novel ryanodine receptor gene mutation associated with malignant hyperthermia.
PubMed:Rem inhibits skeletal muscle EC coupling by reducing the number of functional L-type Ca2+ channels.
PubMed:Sarcoplasmic reticulum Ca2+ release declines in muscle fibers from aging mice.
PubMed:Dynamics of intracellular oxygen in PC12 Cells upon stimulation of neurotransmission.
PubMed:Quantitative determination of chlorophenols in leather by pressurized liquid extraction and liquid chromatography with diode-array detection.
PubMed:A catalytically active molecularly imprinted polymer that mimics peroxidase based on hemin: application to the determination of p-aminophenol.
PubMed:4-Chloro-m-cresol, an activator of ryanodine receptors, inhibits voltage-gated K(+) channels at the rat calyx of Held.
PubMed:Identification of functional type 1 ryanodine receptors in human dendritic cells.
PubMed:Functional ryanodine receptors are expressed by human microglia and THP-1 cells: Their possible involvement in modulation of neurotoxicity.
PubMed:Increased Ca2+ storage capacity of the skeletal muscle sarcoplasmic reticulum of transgenic mice over-expressing membrane bound calcium binding protein junctate.
PubMed:Evaluation of estrogenic activity of organic biocides using ER-binding and YES assay.
PubMed:Na+ entry via glutamate transporter activates the reverse Na+/Ca2+ exchange and triggers Ca(i)2+-induced Ca2+ release in rat cerebellar Type-1 astrocytes.
PubMed:The Sonogel-Carbon materials as basis for development of enzyme biosensors for phenols and polyphenols monitoring: a detailed comparative study of three immobilization matrixes.
PubMed:[Effects of agonists and antagonists of rhyanodine receptors on potassium contractures in twitch and tonic frog skeletal muscle fibers].
PubMed:Pharmacologic and functional characterization of malignant hyperthermia in the R163C RyR1 knock-in mouse.
PubMed:Alterations in calcium homeostasis reduce membrane excitability in amphibian skeletal muscle.
PubMed:Amino acid residues Gln4020 and Lys4021 of the ryanodine receptor type 1 are required for activation by 4-chloro-m-cresol.
PubMed:Characterization of ryanodine receptor-mediated calcium release in human B cells: relevance to diagnostic testing for malignant hyperthermia.
PubMed:Structural determinants of 4-chloro-m-cresol required for activation of ryanodine receptor type 1.
PubMed:Knocking down type 2 but not type 1 calsequestrin reduces calcium sequestration and release in C2C12 skeletal muscle myotubes.
PubMed:Development of a high analytical performance-tyrosinase biosensor based on a composite graphite-Teflon electrode modified with gold nanoparticles.
PubMed:Can 4-chloro-m-cresol be substituted for caffeine as an activator of calcium oscillation in bullfrog sympathetic ganglion cells?
PubMed:Oxidation of myosin heavy chain and reduction in force production in hyperthyroid rat soleus.
PubMed:Effects of caffeine, halothane, and 4-chloro-m-cresol on skeletal muscle lactate and pyruvate in malignant hyperthermia-susceptible and normal swine as assessed by microdialysis.
PubMed:Functional properties of ryanodine receptors carrying three amino acid substitutions identified in patients affected by multi-minicore disease and central core disease, expressed in immortalized lymphocytes.
PubMed:Blockade of intracellular calcium release induces an antidepressant-like effect in the mouse forced swimming test.
PubMed:Non-specific effects of 4-chloro-m-cresol may cause calcium flux and respiratory burst in human neutrophils.
PubMed:Ryanodine receptors are involved in muscarinic antinociception in mice.
PubMed:Simultaneous determination of phenolic compounds by means of an automated voltammetric "electronic tongue".
PubMed:Membrane-assisted solvent extraction of seven phenols combined with large volume injection-gas chromatography-mass spectrometric detection.
PubMed:Caffeine induced Ca2+ release and capacitative Ca2+ entry in human embryonic kidney (HEK293) cells.
PubMed:Enhanced response to caffeine and 4-chloro-m-cresol in malignant hyperthermia-susceptible muscle is related in part to chronically elevated resting [Ca2+]i.
PubMed:Role of intracellular calcium in acute thermal pain perception.
PubMed:Mutational analysis of putative calcium binding motifs within the skeletal ryanodine receptor isoform, RyR1.
PubMed:Effect of ryanodine receptor mutations on interleukin-6 release and intracellular calcium homeostasis in human myotubes from malignant hyperthermia-susceptible individuals and patients affected by central core disease.
PubMed:4-chloro-m-cresol cannot detect malignant hyperthermia equivocal cells in an alternative minimally invasive diagnostic test of malignant hyperthermia susceptibility.
PubMed:Human muscle sarcoplasmic reticulum function during submaximal exercise in normoxia and hypoxia.
PubMed:Functional characterization of malignant hyperthermia-associated RyR1 mutations in exon 44, using the human myotube model.
PubMed:Prolonged exercise to fatigue in humans impairs skeletal muscle Na+-K+-ATPase activity, sarcoplasmic reticulum Ca2+ release, and Ca2+ uptake.
PubMed:Differential regulation of calcium homeostasis in adenocarcinoma cell line A549 and its Taxol-resistant subclone.
PubMed:Optimization by experimental design and artificial neural networks of the ion-interaction reversed-phase liquid chromatographic separation of twenty cosmetic preservatives.
PubMed:Influence of intracellular Ca2+ release modulating drugs on bupivacaine infiltration anesthesia in mice.
PubMed:Comparison of gas chromatography-mass spectrometry and capillary electrophoresis in analysis of phenolic compounds extracted from solid matrices with pressurized hot water.
PubMed:The calmodulin binding region of the skeletal ryanodine receptor acts as a self-modulatory domain.
PubMed:Calcium release from sarcoplasmic reticulum is facilitated in human myotubes derived from carriers of the ryanodine receptor type 1 mutations Ile2182Phe and Gly2375Ala.
PubMed:Supramolecular structures of 2-chloro-5-methylphenol and 4-chloro-3-methylphenol (chlorocresol).
PubMed:Ryanodine receptor mutations associated with stress-induced ventricular tachycardia mediate increased calcium release in stimulated cardiomyocytes.
PubMed:Multicentre evaluation of in vitro contracture testing with bolus administration of 4-chloro-m-cresol for diagnosis of malignant hyperthermia susceptibility.
PubMed:Critical amino acid residues determine the binding affinity and the Ca2+ release efficacy of maurocalcine in skeletal muscle cells.
PubMed:Ca(2+)-induced Ca(2+) release in the pancreatic beta-cell: direct evidence of endoplasmic reticulum Ca(2+) release.
PubMed:The Ile2453Thr mutation in the ryanodine receptor gene 1 is associated with facilitated calcium release from sarcoplasmic reticulum by 4-chloro-m-cresol in human myotubes.
PubMed:Identification of a key determinant of ryanodine receptor type 1 required for activation by 4-chloro-m-cresol.
PubMed:Myoplasmic calcium regulation in myotubes from horses with recurrent exertional rhabdomyolysis.
PubMed:Calcium homeostasis and glucose uptake of murine myotubes exposed to insulin, caffeine and 4-chloro-m-cresol.
PubMed:In situ modulation of the human cardiac ryanodine receptor (hRyR2) by FKBP12.6.
PubMed:Detection of proton release from cultured human myotubes to identify malignant hyperthermia susceptibility.
PubMed:Patients with malignant hyperthermia demonstrate an altered calcium control mechanism in B lymphocytes.
PubMed:H2O2 activates ryanodine receptor but has little effect on recovery of releasable Ca2+ content after fatigue.
PubMed:Increased sensitivity to 4-chloro-m-cresol and caffeine in primary myotubes from malignant hyperthermia susceptible individuals carrying the ryanodine receptor 1 Thr2206Met (C6617T) mutation.
PubMed:Calmodulin binding to the 3614-3643 region of RyR1 is not essential for excitation-contraction coupling in skeletal myotubes.
PubMed:Comparison of two screening level risk assessment approaches for six disinfectants and pharmaceuticals.
PubMed:Functional properties of EGFP-tagged skeletal muscle calcium-release channel (ryanodine receptor) expressed in COS-7 cells: sensitivity to caffeine and 4-chloro-m-cresol.
PubMed:Silver ions induce Ca2+ release from the SR in vitro by acting on the Ca2+ release channel and the Ca2+ pump.
PubMed:Identification of functional type 1 ryanodine receptors in mouse dendritic cells.
PubMed:Sarcoplasmic reticulum Ca(2+) content affects 4-CmC and caffeine contractures of rat skinned skeletal muscle fibers.
PubMed:Requirement of functional ryanodine receptor type 3 for astrocyte migration.
PubMed:Phenolic xenoestrogens in surface water, sediments, and sewage sludge from Baden-Württemberg, south-west Germany.
PubMed:Mutations to Gly2370, Gly2373 or Gly2375 in malignant hyperthermia domain 2 decrease caffeine and cresol sensitivity of the rabbit skeletal-muscle Ca2+-release channel (ryanodine receptor isoform 1).
PubMed:Expression of the ryanodine receptor isoforms in immune cells.
PubMed:B-lymphocytes from malignant hyperthermia-susceptible patients have an increased sensitivity to skeletal muscle ryanodine receptor activators.
PubMed:Oxidation of 4-chloro-3-methylphenol in pressurized hot water/supercritical water with potassium persulfate as oxidant.
PubMed:Trace level determination of phenols as pentafluorobenzyl derivatives by gas chromatography-negative-ion chemical ionization mass spectrometry.
PubMed:Selective trace level analysis of phenolic compounds in water by flow injection analysis--membrane introduction mass spectrometry.
PubMed:Hyperbolic Spirals as Surface Structures in Thin Layers.
PubMed:Fiberoptic biosensors based on chemiluminescent reactions.
PubMed:Multiple effects of caffeine on Ca2+ release and influx in human B lymphocytes.
PubMed:Divergent functional properties of ryanodine receptor types 1 and 3 expressed in a myogenic cell line.
PubMed:Differential effects of 4-chloro-m-cresol and caffeine on skinned fibers from rat fast and slow skeletal muscles.
PubMed:Evidence of functional ryanodine receptor involved in apoptosis of prostate cancer (LNCaP) cells.
PubMed:Polyamine triggering of exocytosis in Paramecium involves an extracellular Ca(2+)/(polyvalent cation)-sensing receptor, subplasmalemmal Ca-store mobilization and store-operated Ca(2+)-influx via unspecific cation channels.
PubMed:Input/output balance of estrogenic active compounds in a major municipal sewage plant in Germany.
PubMed:Development and validation of a GC/MS method for determination of phenolic xenoestrogens in aquatic samples.
PubMed:Mobilization of Ca2+ stores in individual pancreatic beta-cells permeabilized or not with digitonin or alpha-toxin.
PubMed:The impact of 4-chloro-m-cresol in heparin formulas on malignant hyperthermia: in vitro and in vivo.
PubMed:A multicenter study of 4-chloro-m-cresol for diagnosing malignant hyperthermia susceptibility.
PubMed:Generation of novel bacterial regulatory proteins that detect priority pollutant phenols.
PubMed:Voltage-dependent block of normal and mutant muscle sodium channels by 4-Chloro-m-Cresol.
PubMed:The role of calcium stores in fatigue of isolated single muscle fibres from the cane toad.
PubMed:Sarcoplasmic reticulum Ca(2+) release by 4-chloro-m-cresol (4-CmC) in intact and chemically skinned ferret cardiac ventricular fibers.
PubMed:Intracellular Ca2+ transients in mouse soleus muscle after hindlimb unloading and reloading.
PubMed:Measurement of sarcoplasmic reticulum Ca2+ content in intact amphibian skeletal muscle fibres with 4-chloro-m-cresol.
PubMed:A transient and a persistent calcium release are induced by chlorocresol in cultivated mouse myotubes.
PubMed:4-chloro-m-cresol is a trigger of malignant hyperthermia in susceptible swine.
PubMed:4-chloro-m-cresol triggers malignant hyperthermia in susceptible swine at doses greatly exceeding those found in drug preparations.
PubMed:Solid-phase microextraction of the antifouling Irgarol 1051 and the fungicides dichlofluanid and 4-chloro-3-methylphenol in water samples.
PubMed:Secretagogues modulate the calcium concentration in the endoplasmic reticulum of insulin-secreting cells. Studies in aequorin-expressing intact and permeabilized ins-1 cells.
PubMed:Skeletal muscle type ryanodine receptor is involved in calcium signaling in human B lymphocytes.
PubMed:Modification of excitation-contraction coupling by 4-chloro-m-cresol in voltage-clamped cut muscle fibres of the frog (R. pipiens).
PubMed:Validation and application of a rapid in vitro assay for assessing the estrogenic potency of halogenated phenolic chemicals.
PubMed:Functional consequences of mutations of conserved, polar amino acids in transmembrane sequences of the Ca2+ release channel (ryanodine receptor) of rabbit skeletal muscle sarcoplasmic reticulum.
PubMed:Effects of ryanodine receptor agonist 4-chloro-m-cresol on myoplasmic free Ca2+ concentration and force of contraction in mouse skeletal muscle.
PubMed:Effects of varied fatigue protocols on sarcoplasmic reticulum calcium uptake and release rates.
PubMed:Functional aspects of skeletal muscle contractile apparatus and sarcoplasmic reticulum after fatigue.
PubMed:E-C coupling failure in mouse EDL muscle after in vivo eccentric contractions.
PubMed:Gas-phase postderivatization following solid-phase microextraction for determining acidic herbicides in water.
PubMed:[4-chloro-m-cresol-induced contractures of skeletal muscle specimen from patients at risk for malignant hyperthermia].
PubMed:4-Chloro-m-cresol test--a possible supplementary test for diagnosis of malignant hyperthermia susceptibility.
PubMed:Classification of malignant hyperthermia-equivocal patients by 4-chloro-M-cresol.
PubMed:Functional characterization of a distinct ryanodine receptor mutation in human malignant hyperthermia-susceptible muscle.
PubMed:4-Chloro-m-cresol: a specific tool to distinguish between malignant hyperthermia-susceptible and normal muscle.
PubMed:Oscillations of cytosolic free calcium in bombesin-stimulated HIT-T15 cells.
PubMed:4-Chloro-m-cresol, a potent and specific activator of the skeletal muscle ryanodine receptor.
PubMed:Alteration of intracellular Ca2+ transients in COS-7 cells transfected with the cDNA encoding skeletal-muscle ryanodine receptor carrying a mutation associated with malignant hyperthermia.
PubMed:Development of an amperometric biosensor for the determination of phenolic compounds in reversed micelles.
PubMed:Chlorocresol: an activator of ryanodine receptor-mediated Ca2+ release.
PubMed:Degradation of phenol and phenolic compounds by Pseudomonas putida EKII.
PubMed:The synergistic effect of chlorinated chemicals (trichlorosalicylanilid, 4-chloro-m-cresol, trichlorophenoxyacetic acid, trichloroethanol, trichloromethiazide, trichlorofon and trichloroacetaldehyde) and low concentrations of griseofulvin on porphyrin metabolism.
PubMed:Use of polymeric sorbents for the off-line preconcentration of priority pollutant phenols from water for high-performance liquid chromatographic analysis.
PubMed:The effect of chlorinated chemicals on porphyrin metabolism--the synergistic effect with chlorinated chemicals and low concentrations of griseofulvin.
PubMed:Irritant dermatitis from tri-butyl tin oxide and contact allergy from chlorocresol.
PubMed:4-Chloro-3-methylphenol: Salmonella/mammalian-microsome mutagenicity test and subacute toxicity test in rats.
PubMed:Effects of heparin on prostacyclin binding and platelet adenylate cyclase activity stimulated by iloprost and forskolin.
PubMed:[On the bacteriostatic and antifungal activity of some benzyl derivatives of 4-chloro-m-cresol].
 
Notes:
injections for relief of intractable pain.
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