4-aminophenyl sulfone
4,4'-diaminodiphenyl sulphone

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  CODE119895 CODE119895
  Product(s):
  80-08-0 Dapsone >98%
  Dapsone is a sulfone active against a wide range of bacteria but mainly employed for its actions against mycobacterium leprae, which has anti-inflammatory and immunomodulatory effects.

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  Glentham Life Sciences Ltd

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  CODE119895 CODE119895
  Product(s):
  GA5546 Dapsone

Name: 4-(4-aminophenyl)sulfonylaniline CAS Number: 80-08-0 3D/inchi Other(deleted CASRN): 1246638-15-2 ECHA EINECS - REACH Pre-Reg: 201-248-4 FDA UNII: 8W5C518302 Nikkaji Web: J4.247A Beilstein Number: 0788055 MDL: MFCD00007887 XlogP3-AA: 1.00 (est) Molecular Weight: 248.30504000 Formula: C12 H12 N2 O2 S NMR Predictor: Predict (works with chrome, Edge or firefox) Category:indirect food additives: adhesives and components of coatings   US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information: Google Scholar: Search Google Books: Search Google Scholar: with word "volatile" Search Google Scholar: with word "flavor" Search Google Scholar: with word "odor" Search Google Patents: Search US Patents: Search EU Patents: Search Pubchem Patents: Search PubMed: Search NCBI: Search DG SANTE Food Contact Materials: 4,4'-diaminodiphenyl sulphone   Physical Properties: Appearance: white crystalline powder crystalline powder (est) Assay: 95.00 to 100.00 Food Chemicals Codex Listed: No Soluble in:   water, 380mg/L @ 37 °C (exp)   Organoleptic Properties: Odor and/or flavor descriptions from others (if found).   Cosmetic Information: None found   Suppliers: BOC Sciences For experimental / research use only. Dapsone >98% Odor: characteristic Use: Dapsone is a sulfone active against a wide range of bacteria but mainly employed for its actions against mycobacterium leprae, which has anti-inflammatory and immunomodulatory effects. Glentham Life Sciences Dapsone Sigma-Aldrich: Aldrich For experimental / research use only. 4-Aminophenyl Sulfone 97% sds   Safety Information: Preferred SDS: View   Hazards identification   Classification of the substance or mixture GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) None found. GHS Label elements, including precautionary statements   Pictogram   Hazard statement(s) None found. Precautionary statement(s) None found. Oral/Parenteral Toxicity: oral-cat LDLo 357 mg/kg Archives of Neurology and Psychiatry. Vol. 54, Pg. 319, 1945. oral-child TDLo 5 mg/kg LUNGS, THORAX, OR RESPIRATION: CYANOSIS Journal of Toxicology, Clinical Toxicology. Vol. 19, Pg. 1061, 1982/1983. oral-child TDLo 37500 ug/kg GASTROINTESTINAL: NAUSEA OR VOMITING BLOOD: METHEMOGLOBINEMIA-CARBOXYHEMOGLOBIN LUNGS, THORAX, OR RESPIRATION: CYANOSIS Pediatric Emergency Care. Vol. 13, Pg. 127, 1997. oral-guinea pig LD50 300 mg/kg Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 22, Pg. 967, 1991. oral-human TDLo 18000 mg/kg/15Y KIDNEY, URETER, AND BLADDER: OTHER CHANGES MUSCULOSKELETAL: JOINTS British Medical Journal. Vol. 1, Pg. 78, 1978. unreported-mammal (species unspecified) LD50 1400 mg/kg Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 43(9), Pg. 23, 1978. oral-man TDLo 36 mg/kg BLOOD: METHEMOGLOBINEMIA-CARBOXYHEMOGLOBIN Human Toxicology. Vol. 2, Pg. 507, 1983. intraperitoneal-mouse LD50 313 mg/kg Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 48, Pg. 336, 1952. intravenous-mouse LD50 225 mg/kg Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 48, Pg. 336, 1952. oral-mouse LD50 250 mg/kg American Review of Tuberculosis. Vol. 60, Pg. 62, 1949. intraperitoneal-rat LD50 196 mg/kg PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Archives Internationales de Pharmacodynamie et de Therapie. Vol. 183, Pg. 36, 1970. oral-rat LD50 1000 mg/kg Arzneimittel-Forschung. Drug Research. Vol. 5, Pg. 213, 1955. Dermal Toxicity: subcutaneous-mouse LD50 250 mg/kg American Review of Tuberculosis. Vol. 60, Pg. 62, 1949. skin-rabbit LD50 > 4000 mg/kg Toxicology and Applied Pharmacology. Vol. 28, Pg. 313, 1974. Inhalation Toxicity: Not determined   Safety in Use Information: Category: indirect food additives: adhesives and components of coatings Recommendation for 4-aminophenyl sulfone usage levels up to:   not for fragrance use.   Recommendation for 4-aminophenyl sulfone flavor usage levels up to:   not for flavor use.   Safety References: European Food Safety Authority (EFSA) reference(s): Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) related to a 9th list of substances for food contact materials View page or View pdf EPI System: View ClinicalTrials.gov:search Daily Med:search Chemical Carcinogenesis Research Information System:Search AIDS Citations:Search Cancer Citations:Search Toxicology Citations:Search Carcinogenic Potency Database:Search EPA Substance Registry Services (TSCA):80-08-0 EPA ACToR:Toxicology Data EPA Substance Registry Services (SRS):Registry Laboratory Chemical Safety Summary :2955 National Institute of Allergy and Infectious Diseases:Data WGK Germany:1 4-(4-aminophenyl)sulfonylaniline Chemidplus:0000080080 EPA/NOAA CAMEO:hazardous materials RTECS:BY8925000 for cas# 80-08-0   References:   4-(4-aminophenyl)sulfonylaniline NIST Chemistry WebBook: Search Inchi Canada Domestic Sub. List: 80-08-0 Pubchem (cid): 2955 Pubchem (sid): 134971843   Other Information: (IUPAC): Atomic Weights of the Elements 2011 (pdf) Videos: The Periodic Table of Videos tgsc: Atomic Weights use for this web site (IUPAC): Periodic Table of the Elements FDA Indirect Additives used in Food Contact Substances: View CHEBI: View CHEMBL: View KEGG (GenomeNet): C07666 HMDB (The Human Metabolome Database): Search Export Tariff Code: 2921.42.7500 ChemSpider: View Wikipedia: View   Potential Blenders and core components note None Found   Potential Uses: None Found   Occurrence (nature, food, other):note   not found in nature   Synonyms: 4-(4- aminophenyl)sulfonylaniline   avlosulfone   benzenamine, 4,4'-sulfonylbis-   dapsone 4,4'- diaminodiphenyl sulphone 4,4'- sulfonylbisbenzenamine   sumicure S   Articles:   None found yet. Try the PubMed Search.

Notes: None found